101
Views
18
CrossRef citations to date
0
Altmetric
Review

Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions

&
Pages 835-846 | Published online: 24 Nov 2006

Bibliography

  • LEE WM: Drug-induced hepatotoxicity. N. Engl. J. Med. (2003) 349(5):474-485.
  • KAPLOWITZ N: Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. (2005) 4(6):489-499.
  • YANG Y, BLOMME EA, WARING JF: Toxicogenomics in drug discovery: from preclinical studies to clinical trials. Chem. Biol. Interact. (2004) 150(1):71-85.
  • WARING JF, HALBERT DN: The promise of toxicogenomics. Curr. Opin. Mol. Ther. (2002) 4(3):229-235.
  • WALGREN JL, MITCHELL MD, THOMPSON DC: Role of metabolism in drug-induced idiosyncratic hepatotoxicity. Crit. Rev. Toxicol. (2005) 35(4):325-361.
  • GALE EA: Lessons from the glitazones: a story of drug development. Lancet (2001) 357(9271):1870-1875.
  • KAWAI K, KAWASAKI-TOKUI Y, ODAKA T et al.: Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs. Arzneimittelforschung (1997) 47(4):356-368.
  • LOI CM, ALVEY CW, RANDINITIS EJ et al.: Meta-analysis of steady-state pharmacokinetics of troglitazone and its metabolites. J. Clin. Pharmacol. (1997) 37(11):1038-1047.
  • HE K, TALAAT RE, POOL WF et al.: Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved. Drug Metab. Dispos. (2004) 32(6):639-646.
  • HONMA W, SHIMADA M, SASANO H et al.: Phenol sulfotransferase, ST-1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver. Drug Metab. Dispos. (2002) 30(8):944-949.
  • KASSAHUN K, PEARSON PG, TANG W et al.: Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission. Chem. Res. Toxicol. (2001) 14(1):62-70.
  • RAMACHANDRAN V, KOSTRUBSKY VE, KOMOROSKI BJ et al.: Troglitazone increases cytochrome P450 3A protein and activity in primary cultures of human hepatocytes. Drug Metab. Dispos. (1999) 27(10):1194-1199.
  • SMITH KS, SMITH PL, HEADY TN et al.: In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity. Chem. Res. Toxicol. (2003) 16(2):123-128.
  • JU C: Immunological mechanisms of drug-induced liver injury. Curr. Opin. Drug Discov. Devel. (2005) 8(1):38-43.
  • ROBIN MA, LE ROY M, DESCATOIRE V, PESSAYRE D: Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. J. Hepatol. (1997) 26(Suppl. 1):23-30.
  • LIU ZX, KAPLOWITZ N: Immune-mediated drug-induced liver disease. Clin. Liver Dis. (2002) 6(3):755-774.
  • JAESCHKE H, GORES GJ, CEDERBAUM AI et al.: Mechanisms of hepatotoxicity. Toxicol. Sci. (2002) 65(2):166-176.
  • GREAVES RR, AGARWAL A, PATCH D et al.: Inadvertent diclofenac rechallenge from generic and non-generic prescribing, leading to liver transplantation for fulminant liver failure. Eur. J. Gastroenterol. Hepatol. (2001) 13(1):71-73.
  • NAVARRO VJ, SENIOR JR: Drug-related hepatotoxicity. N. Engl. J. Med. (2006) 354(7):731-739.
  • VIDELA LA, FERNANDEZ V, TAPIA G, VARELA P: Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals (2003) 16(1):103-111.
  • MANIRATANACHOTE R, SHIBATA A, KANEKO S et al.: Detection of autoantibody to aldolase B in sera from patients with troglitazone-induced liver dysfunction. Toxicology (2005) 216(1):15-23.
  • OBERMAYER-STRAUB P, STRASSBURG CP, MANNS MP: Autoimmune hepatitis. J. Hepatol. (2000) 32(Suppl. 1):181-197.
  • OBERMAYER-STRAUB P, STRASSBURG CP, MANNS MP: Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases. Can. J. Gastroenterol. (2000) 14(5):429-439.
  • AITHAL GP, RAMSAY L, DALY AK et al.: Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology (2004) 39(5):1430-1440.
  • JU C, POHL LR: Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions. Toxicology (2005) 209(2):109-112.
  • NJOKU DB, MELLERSON JL, TALOR MV et al.: Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis. Clin. Vaccine Immunol. (2006) 13(2):258-265.
  • PARK BK, NAISBITT DJ, GORDON SF, KITTERINGHAM NR, PIRMOHAMED M: Metabolic activation in drug allergies. Toxicology (2001) 158(1-2):11-23.
  • SHEU SS, NAUDURI D, ANDERS MW: Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim. Biophys. Acta (2006) 1762(2):256-265.
  • GOMEZ-LECHON MJ, PONSODA X, BORT R, CASTELL JV: The use of cultured hepatocytes to investigate the metabolism of drugs and mechanisms of drug hepatotoxicity. Altern Lab. Anim. (2001) 29(3):225-231.
  • NISSINEN E, KAHEINEN P, PENTTILA KE, KAIVOLA J, LINDEN IB: Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson’s disease, does not impair mitochondrial energy production. Eur. J. Pharmacol. (1997) 340(2-3):287-294.
  • HAASIO K, NISSINEN E, SOPANEN L, HEINONEN EH: Different toxicological profile of two COMT inhibitors in vivo: the role of uncoupling effects. J. Neural Transm. (2002) 109(11):1391-1401.
  • ULRICH RG, BACON JA, BRASS EP et al.: Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon. Chem. Biol. Interact. (2001) 134(3):251-270.
  • MASUBUCHI Y, NAKAYAMA S, HORIE T: Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology (2002) 35(3):544-551.
  • NEBERT DW, INGELMAN-SUNDBERG M, DALY AK: Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metab. Rev. (1999) 31(2):467-487.
  • AITHAL GP, DAY CP, LEATHART JB, DALY AK: Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis. Pharmacogenetics (2000) 10(6):511-518.
  • ACUNA G, FOERNZLER D, LEONG D et al.: Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity. Pharmacogenomics J. (2002) 2(5):327-334.
  • WATANABE I, TOMITA A, SHIMIZU M et al.: A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with Type 2 diabetes mellitus. Clin. Pharmacol. Ther. (2003) 73(5):435-455.
  • YOSHIGAE Y, KONNO K, TAKASAKI W, IKEDA T: Characterization of UDP-glucuronosyltransferases (UGTs) involved in the metabolism of troglitazone in rats and humans. J. Toxicol. Sci. (2000) 25(5):433-441.
  • GANEY PE, LUYENDYK JP, MADDOX JF, ROTH RA: Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chem. Biol. Interact. (2004) 150(1):35-51.
  • ROTH RA, LUYENDYK JP, MADDOX JF, GANEY PE: Inflammation and drug idiosyncrasy-is there a connection? J. Pharmacol. Exp. Ther. (2003) 307(1):1-8.
  • YEE SB, KINSER S, HILL DA et al.: Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline. Toxicol. Appl. Pharmacol. (2000) 166(3):173-185.
  • LUYENDYK JP, SHORES KC, GANEY PE, ROTH RA: Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury. Toxicol. Sci. (2002) 68(1):220-225.
  • SU GL, KLEIN RD, AMINLARI A et al.: Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology (2000) 31(4):932-936.
  • SU GL, GONG KQ, FAN MH et al.: Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology (2005) 41(1):187-195.
  • LUYENDYK JP, MADDOX JF, COSMA GN et al.: Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J. Pharmacol. Exp. Ther. (2003) 307(1):9-16.
  • BUCHWEITZ JP, GANEY PE, BURSIAN SJ, ROTH RA: Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? J. Pharmacol. Exp. Ther. (2002) 300(2):460-467.
  • SHENTON JM, POPOVIC M, CHEN J, MASSON MJ, UETRECHT JP: Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown–Norway rat. Chem. Res. Toxicol. (2005) 18(12):1799-1813.
  • SHENTON JM, TERANISHI M, ABU-ASAB MS, YAGER JA, UETRECHT JP: Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat. Chem. Res. Toxicol. (2003) 16(9):1078-1089.
  • SEGUIN B, BOUTROS PC, LI X, OKEY AB, UETRECHT JP: Gene expression profiling in a model of d-penicillamine-induced autoimmunity in the Brown–Norway rat: predictive value of early signs of danger. Chem. Res. Toxicol. (2005) 18(8):1193-1202.
  • BOURDI M, MASUBUCHI Y, REILLY TP et al.: Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology (2002) 35(2):289-298.
  • DENG X, STACHLEWITZ RF, LIGUORI MJ et al.: Modest inflammation enhances diclofenac hepatotoxicity in rats: a potential animal model of idiosyncratic drug reaction. Society of Toxicology 2006 Annual Meeting. Toxicol. Sci. (2006) 90(1):Abstract 1711.
  • ROTH RA, HARKEMA JR, PESTKA JP, GANEY PE: Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents? Toxicol. Appl. Pharmacol. (1997) 147(2):300-311.
  • VIAL T, GOUBIER C, BERGERET A et al.: Side effects of ranitidine. Drug Saf. (1991) 6(2):94-117.
  • LUYENDYK JP, MATTES WB, BURGOON LD et al.: Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Toxicol. Sci. (2004) 80(1):203-213.
  • LUYENDYK JP, SHAW PJ, GREEN CD et al.: Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J. Pharmacol. Exp. Ther. (2005) 314(3):1023-1031.
  • LUYENDYK JP, LEHMAN-MCKEEMAN LD, NELSON DM et al.: Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine. J. Pharmacol. Exp. Ther. (2006) 317(2):635-643.
  • LUYENDYK JP, LEHMAN-MCKEEMAN LD, NELSON DM et al.: Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine. Toxicol. Sci. (2006) 90(2):569-585.
  • MADDOX JF, LUYENDYK JP, COSMA GN et al.: Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicol. Appl. Pharmacol. (2006) 212(1):35-44.
  • WARING JF, LIGUORI MJ, LUYENDYK JP et al.: Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J. Pharmacol. Exp. Ther. (2006) 316(3):1080-1087.
  • BERTINO J Jr, FISH D: The safety profile of the fluoroquinolones. Clin. Ther. (2000) 22(7):798-817; discussion 797.
  • LIGUORI MJ, ANDERSON LM, BUKOFZER S et al.: Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin. Hepatology (2005) 41(1):177-186.
  • JAESCHKE H, SMITH CW, CLEMENS MG, GANEY PE, ROTH RA: Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol. Appl. Pharmacol. (1996) 139(2):213-226.
  • ABDULLA D, GORALSKI KB, RENTON KW: The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat. Toxicol. Appl. Pharmacol. (2006) 216(1):1-10.
  • RICHERT L, LIGUORI MJ, ABADIE C et al.: Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating. Drug Metab. Dispos. (2006) 34(5):870-879.
  • KIER LD, NEFT R, TANG L et al.: Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague–Dawley rats in vivo and human hepatocytes in vitro. Mutat. Res. (2004) 549(1-2):101-113.
  • SPIGSET O, HAGG S, BATE A: Hepatic injury and pancreatitis during treatment with serotonin reuptake inhibitors: data from the World Health Organization (WHO) database of adverse drug reactions. Int. Clin. Psychopharmacol. (2003) 18(3):157-161.
  • KOSTRUBSKY SE, STROM SC, KALGUTKAR AS et al.: Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicol. Sci. (2006) 90(2):451-459.
  • KOSTRUBSKY VE, STROM SC, HANSON J et al.: Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicol. Sci. (2003) 76(1):220-228.
  • KALGUTKAR AS, VAZ AD, LAME ME et al.: Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4. Drug Metab. Dispos. (2005) 33(2):243-253.
  • DAMBACH DM, ANDREWS BA, MOULIN F: New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicol. Pathol. (2005) 33(1):17-26.
  • GAO J, ANN GARULACAN L, STORM SM et al.: Identification of in vitro protein biomarkers of idiosyncratic liver toxicity. Toxicol In Vitro (2004) 18(4):533-541.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.