321
Views
4
CrossRef citations to date
0
Altmetric
Drug Evaluations

Pharmacokinetic profile of once-daily cyclobenzaprine extended-release

, PhD & , PhD
Pages 1425-1436 | Published online: 30 Sep 2010

Bibliography

  • Browning R, Jackson JL, O'Malley PG. Cyclobenzaprine and back pain: a meta-analysis. Arch Intern Med 2001;161:1613-20
  • Nibbelink DW, Strickland SC, McLean LF, Gould AL. Cyclobenzaprine, diazepam and placebo in the treatment of skeletal muscle spasm of local origin. Clin Ther 1978;1:409-24
  • Malanga GA, Ruoff GE, Weil AJ, Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. Curr Med Res Opin 2009;25:1179-96
  • Share NN, McFarlane CS. Cyclobenzaprine: novel centrally acting skeletal muscle relaxant. Neuropharmacology 1975;14:675-84
  • Share NN. Cyclobenzaprine: effect on segmental monosynaptic and tonic vibration reflexes in the cat. Neuropharmacology 1978;17:721-7
  • Nibbelink DW, Strickland SC. Cyclobenzaprine (Flexeril™): report of a postmarketing surveillance program. Curr Ther Res 1980;28:894-903
  • Darwish M, Hellriegel ET, Xie F. Single-dose pharmacokinetics of once-daily cyclobenzaprine extended release 30 mg versus cyclobenzaprine immediate release 10 mg three times daily in healthy young adults: a randomized, open-label, two-period crossover, single-centre study. Clin Drug Investig 2008;28:793-801
  • Darwish M, Xie F. Comparison of the single-dose pharmacokinetics of once-daily cyclobenzaprine extended-release 30 mg and cyclobenzaprine immediate-release 10 mg three times daily in the elderly: a randomized, open-label, crossover study. Drugs Aging 2009;26:95-101
  • Darwish M, Chang S, Hellriegel ET. A pharmacokinetic comparison of single doses of once-daily cyclobenzaprine extended-release 15 mg and 30 mg: a randomized, double-blind, two-period crossover study in healthy volunteers. Clin Ther 2009;31:108-14
  • Darwish M, Xie F. Effect of food on the pharmacokinetics of once-daily cyclobenzaprine extended-release 30 mg: a randomized, open-label, crossover, single-centre study. Clin Drug Investig 2009;29:145-52
  • World Medical Association. Declaration of Helsinki: ethical principles for medical research involving human subjects. 2008. Available from: http://www.wma.net/en/30publications/10policies/b3/17c.pdf [Last accessed 26 April 2010]
  • International Conference on Harmonisation Working Group. ICH Harmonised Tripartite Guideline: Guideline for Good Clinical Practice E6 (R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use; 10 June 1996; Washington, DC. 1996. Available from: http://www.ich.org/LOB/media/MEDIA482.pdf [Last accessed 26 April 2010]
  • Winchell GA, King JD, Chavez-Eng CM, Cyclobenzaprine pharmacokinetics, including the effects of age, gender, and hepatic insufficiency. J Clin Pharmacol 2002;42:61-9
  • Shah J, Wesnes KA, Kovelesky RA, Henney HR III. Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. Clin Ther 2006;28:1308-17
  • Soma [package insert]. Somerset, NJ: MedPointe Pharmaceuticals; 2007
  • Guay DR. Clinical pharmacokinetics of drugs used to treat urge incontinence. Clin Pharmacokinet 2003;42:1243-85
  • Wagstaff AJ, Figgitt DP. Extended-release metformin hydrochloride. Single-composition osmotic tablet formulation. Treat Endocrinol 2004;3:327-32
  • Wilder BJ, Leppik I, Hietpas TJ, Effect of food on absorption of Dilantin Kapseals and Mylan extended phenytoin sodium capsules. Neurology 2001;57:582-9
  • AMRIX [package insert]. Frazer, PA: Cephalon, Inc.; December 2008
  • Darwish M, Altman C, Hellriegel E, Xie F. Relationship between the efficacy profile and pharmacokinetics of once-daily, extended-release cyclobenzaprine [poster 63]. PM&R 2009;1(9 Suppl):S131
  • Borenstein DG, Korn S. Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. Clin Ther 2003;25:1056-73
  • Katz WA, Dube J. Cyclobenzaprine in the treatment of acute muscle spasm: review of a decade of clinical experience. Clin Ther 1988;10:216-28
  • Chou R, Peterson K, Helfand M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage 2004;28:140-75
  • Weil AJ, Ruoff GE, Nalamachu S, Efficacy and tolerability of cyclobenzaprine extended release for acute muscle spasm: a pooled analysis. Postgrad Med 2010;122:158-69

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.