Role of organic cation transporters in drug-induced toxicity

Bibliography

• Dobson PD, Kell DB. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 2008;7:205-20
   PubMed Web of Science ®Google Scholar
• Zhou SF. Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica 2008;38:802-32
   PubMed Web of Science ®Google Scholar
• Izzedine H, Hulot JS, Villard E, Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. J Infect Dis 2006;194:1481-91
   PubMed Web of Science ®Google Scholar
• Neuhoff S, Ungell AL, Zamora I, Artursson P. pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res 2003;20:1141-8
   PubMed Web of Science ®Google Scholar
• Hediger MA, Romero MF, Peng JB, The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch 2004;447:465-8
   PubMed Web of Science ®Google Scholar
• Koepsell H, Endou H. The SLC22 drug transporter family. Pflugers Arch 2004;447:666-76
   PubMed Web of Science ®Google Scholar
• Grundemann D, Gorboulev V, Gambaryan S, Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994;372:549-52
   PubMed Web of Science ®Google Scholar
• Gorboulev V, Ulzheimer JC, Akhoundova A, Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 1997;16:871-81
   PubMed Web of Science ®Google Scholar
• Zhang L, Dresser MJ, Gray AT, Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 1997;51:913-21
   PubMed Web of Science ®Google Scholar
• Terashita S, Dresser MJ, Zhang L, Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim Biophys Acta 1998;1369:1-6
   PubMed Web of Science ®Google Scholar
• Schweifer N, Barlow DP. The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome 1996;7:735-40
   PubMed Web of Science ®Google Scholar
• Okuda M, Saito H, Urakami Y, cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 1996;224:500-7
   PubMed Web of Science ®Google Scholar
• Grundemann D, Babin-Ebell J, Martel F, Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J Biol Chem 1997;272:10408-13
   PubMed Web of Science ®Google Scholar
• Mooslehner KA, Allen ND. Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus. Mamm Genome 1999;10:218-24
   PubMed Web of Science ®Google Scholar
• Zhang X, Evans KK, Wright SH. Molecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1. Am J Physiol Renal Physiol 2002;283:F124-33
   PubMed Web of Science ®Google Scholar
• Motohashi H, Sakurai Y, Saito H, Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 2002;13:866-74
   PubMed Web of Science ®Google Scholar
• Grundemann D, Schechinger B, Rappold GA, Schomig E. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1998;1:349-51
   PubMed Web of Science ®Google Scholar
• Kekuda R, Prasad PD, Wu X, Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 1998;273:15971-9
   PubMed Web of Science ®Google Scholar
• Wu X, Kekuda R, Huang W, Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem 1998;273:32776-86
   PubMed Web of Science ®Google Scholar
• Verhaagh S, Schweifer N, Barlow DP, Zwart R. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics 1999;55:209-18
   PubMed Web of Science ®Google Scholar
• Vialou V, Amphoux A, Zwart R, Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci 2004;24:2846-51
   PubMed Web of Science ®Google Scholar
• Vialou V, Balasse L, Callebert J, Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice. J Neurochem 2008;106:1471-82
   PubMed Web of Science ®Google Scholar
• Baganz NL, Horton RE, Calderon AS, Organic cation transporter 3: keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Proc Natl Acad Sci U S A 2008;105:18976-81
   PubMed Web of Science ®Google Scholar
• Wright SH, Dantzler WH. Molecular and cellular physiology of renal organic cation and anion transport. Physiol Rev 2004;84:987-1049
   PubMed Web of Science ®Google Scholar
• Koepsell H, Schmitt BM, Gorboulev V. Organic cation transporters. Rev Physiol Biochem Pharmacol 2003;150:36-90
   PubMed Web of Science ®Google Scholar
• Moriyama Y, Hiasa M, Matsumoto T, Omote H. Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics. Xenobiotica 2008;38:1107-18
   PubMed Web of Science ®Google Scholar
• Tanihara Y, Masuda S, Sato T, Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol 2007;74:359-71
   PubMed Web of Science ®Google Scholar
• Yabuuchi H, Tamai I, Nezu J, Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther 1999;289:768-73
   PubMed Web of Science ®Google Scholar
• Tzvetkov MV, Vormfelde SV, Balen D, The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther 2009;86:299-306
   PubMed Web of Science ®Google Scholar
• Ciarimboli G, Schlatter E. Regulation of organic cation transport. Pflugers Arch 2005;449:423-41
   PubMed Web of Science ®Google Scholar
• Eraly SA, Hamilton BA, Nigam SK. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun 2003;300:333-42
   PubMed Web of Science ®Google Scholar
• Eraly SA, Monte JC, Nigam SK. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics 2004;18:12-24
   PubMed Web of Science ®Google Scholar
• Martel F, Ribeiro L, Calhau C, Azevedo I. Inhibition by levamisole of the organic cation transporter rOCT1 in cultured rat hepatocytes. Pharmacol Res 1999;40:275-9
   PubMed Web of Science ®Google Scholar
• Chen R, Jonker JW, Nelson JA. Renal organic cation and nucleoside transport. Biochem Pharmacol 2002;64:185-90
   PubMed Web of Science ®Google Scholar
• Chen R, Nelson JA. Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol 2000;60:215-19
   PubMed Web of Science ®Google Scholar
• Takeda M, Khamdang S, Narikawa S, Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 2002;300:918-24
   PubMed Web of Science ®Google Scholar
• Dudley AJ, Bleasby K, Brown CD. The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol 2000;131:71-9
   PubMed Web of Science ®Google Scholar
• Khamdang S, Takeda M, Noshiro R, Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 2002;303:534-9
   PubMed Web of Science ®Google Scholar
• Bourdet DL, Pritchard JB, Thakker DR. Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther 2005;315:1288-97
   PubMed Web of Science ®Google Scholar
• Hasannejad H, Takeda M, Narikawa S, Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs. Eur J Pharmacol 2004;499:45-51
   PubMed Web of Science ®Google Scholar
• Li Q, Sai Y, Kato Y, Transporter-mediated renal handling of nafamostat mesilate. J Pharm Sci 2004;93:262-72
   PubMed Web of Science ®Google Scholar
• Ming X, Ju W, Wu H, Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metab Dispos 2009;37:424-30
   PubMed Web of Science ®Google Scholar
• Ciarimboli G, Ludwig T, Lang D, Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 2005;167:1477-84
   PubMed Web of Science ®Google Scholar
• Ciarimboli G, Deuster D, Knief A, Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol 2010;176:1169-80
   PubMed Web of Science ®Google Scholar
• Yonezawa A, Masuda S, Nishihara K, Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat. Biochem Pharmacol 2005;70:1823-31
   PubMed Web of Science ®Google Scholar
• Yonezawa A, Masuda S, Yokoo S, Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther 2006;319:879-86
   PubMed Web of Science ®Google Scholar
• More SS, Li S, Yee SW, Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther 2010;9:1058-69
   PubMed Web of Science ®Google Scholar
• Zhang S, Lovejoy KS, Shima JE, Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res 2006;66:8847-57
   PubMed Web of Science ®Google Scholar
• Kimura N, Okuda M, Inui K. Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm Res 2005;22:255-9
   PubMed Web of Science ®Google Scholar
• Kimura N, Masuda S, Tanihara Y, Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet 2005;20:379-86
   PubMedGoogle Scholar
• Wang DS, Kusuhara H, Kato Y, Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Mol Pharmacol 2003;63:844-8
   PubMed Web of Science ®Google Scholar
• Wang DS, Jonker JW, Kato Y, Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 2002;302:510-15
   PubMed Web of Science ®Google Scholar
• Sirtori CR, Franceschini G, Galli-Kienle M, Disposition of metformin (N,N-dimethylbiguanide) in man. Clin Pharmacol Ther 1978;24:683-93
   PubMed Web of Science ®Google Scholar
• Tucker GT, Casey C, Phillips PJ, Metformin kinetics in healthy subjects and in patients with diabetes mellitus. Br J Clin Pharmacol 1981;12:235-46
   PubMed Web of Science ®Google Scholar
• Brown JB, Pedula K, Barzilay J, Lactic acidosis rates in type 2 diabetes. Diabetes Care 1998;21:1659-63
   PubMed Web of Science ®Google Scholar
• El-Mir MY, Nogueira V, Fontaine E, Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000;275:223-8
   PubMed Web of Science ®Google Scholar
• Davidson MB, Peters AL. An overview of metformin in the treatment of type 2 diabetes mellitus. Am J Med 1997;102:99-110
   PubMed Web of Science ®Google Scholar
• Somogyi A, Stockley C, Keal J, Reduction of metformin renal tubular secretion by cimetidine in man. Br J Clin Pharmacol 1987;23:545-51
   PubMed Web of Science ®Google Scholar
• Somogyi A, Gugler R. Clinical pharmacokinetics of cimetidine. Clin Pharmacokinet 1983;8:463-95
   PubMed Web of Science ®Google Scholar
• Shu Y, Sheardown SA, Brown C, Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-31
   PubMed Web of Science ®Google Scholar
• Dresser MJ, Xiao G, Leabman MK, Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm Res 2002;19:1244-7
   PubMed Web of Science ®Google Scholar
• Becker ML, Visser LE, van Schaik RH, Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes 2009;58:745-9
   PubMed Web of Science ®Google Scholar
• Meyer Zu Schwabedissen HE, Verstuyft C, Kroemer HK, Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol 2010;298:F997-F1005
   PubMed Web of Science ®Google Scholar
• Tsuda M, Terada T, Ueba M, Involvement of human multidrug and toxin extrusion 1 (MATE1) in the drug interaction between cimetidine and metformin in renal epithelial cells. J Pharmacol Exp Ther 2009;329:185-91
   Google Scholar
• Chen L, Pawlikowski B, Schlessinger A, Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet Genomics 2010;20:687-99
   PubMed Web of Science ®Google Scholar
• Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 2002;110:835-42
   PubMed Web of Science ®Google Scholar
• Rabik CA, Dolan ME. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 2007;33:9-23
   PubMed Web of Science ®Google Scholar
• Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 2008;73:994-1007
   PubMed Web of Science ®Google Scholar
• Skinner R. Best practice in assessing ototoxicity in children with cancer. Eur J Cancer 2004;40:2352-4
   PubMed Web of Science ®Google Scholar
• Urakami Y, Nakamura N, Takahashi K, Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett 1999;461:339-42
   PubMed Web of Science ®Google Scholar
• Filipski KK, Mathijssen RH, Mikkelsen TS, Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Clin Pharmacol Ther 2009;86:396-402
   PubMed Web of Science ®Google Scholar
• Burger H, Zoumaro-Djayoon A, Boersma AW, Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). Br J Pharmacol 2010;159:898-908
   PubMed Web of Science ®Google Scholar
• Yokoo S, Yonezawa A, Masuda S, Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol 2007;74:477-87
   PubMed Web of Science ®Google Scholar
• Shnitsar V, Eckardt R, Gupta S, Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine. Cancer Res 2009;69:1494-501
   PubMed Web of Science ®Google Scholar
• Pabla N, Murphy RF, Liu K, Dong Z. The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. Am J Physiol Renal Physiol 2009;296:F505-11
   PubMed Web of Science ®Google Scholar
• Kerb R. Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 2006;234:4-33
   PubMed Web of Science ®Google Scholar
• Kalow W, Endrenyi L, Tang B. Repeat administration of drugs as a means to assess the genetic component in pharmacological variability. Pharmacology 1999;58:281-4
   PubMed Web of Science ®Google Scholar
• Kerb R, Brinkmann U, Chatskaia N, Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics 2002;12:591-5
   PubMedGoogle Scholar
• Leabman MK, Huang CC, DeYoung J, Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci USA 2003;100:5896-901
   PubMed Web of Science ®Google Scholar
• Shu Y, Leabman MK, Feng B, Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci USA 2003;100:5902-7
   PubMed Web of Science ®Google Scholar
• Takeuchi A, Motohashi H, Okuda M, Inui K. Decreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transporter hOCT1. Drug Metab Pharmacokinet 2003;18:409-12
   PubMedGoogle Scholar
• Sakata T, Anzai N, Shin HJ, Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. Biochem Biophys Res Commun 2004;313:789-93
   PubMed Web of Science ®Google Scholar
• Itoda M, Saito Y, Maekawa K, Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1). Drug Metab Pharmacokinet 2004;19:308-12
   PubMedGoogle Scholar
• Jonker JW, Wagenaar E, Mol CA, Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol 2001;21:5471-7
   PubMed Web of Science ®Google Scholar
• Shikata E, Yamamoto R, Takane H, Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. J Hum Genet 2007;52:117-22
   Google Scholar
• Leabman MK, Huang CC, Kawamoto M, Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics 2002;12:395-405
   PubMedGoogle Scholar
• Song IS, Shin HJ, Shim EJ, Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther 2008;84:559-62
   PubMed Web of Science ®Google Scholar
• Song IS, Shin HJ, Shin JG. Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes. Xenobiotica 2008;38:1252-62
   PubMed Web of Science ®Google Scholar
• Fujita T, Urban TJ, Leabman MK, Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J Pharm Sci 2006;95:25-36
   PubMed Web of Science ®Google Scholar
• Yeager M, Orr N, Hayes RB, Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 2007;39:645-9
   PubMed Web of Science ®Google Scholar
• Tomlins SA, Mehra R, Rhodes DR, Integrative molecular concept modeling of prostate cancer progression. Nat Genet 2007;39:41-51
   PubMed Web of Science ®Google Scholar
• Tregouet DA, Konig IR, Erdmann J, Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 2009;41:283-5
   PubMed Web of Science ®Google Scholar
• Sakata T, Anzai N, Kimura T, Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms. J Pharmacol Sci 2010;113:263-6
   PubMed Web of Science ®Google Scholar
• Ciarimboli G, Koepsell H, Iordanova M, Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation. J Am Soc Nephrol 2005;16:1562-70
   PubMed Web of Science ®Google Scholar
• Gorboulev V, Shatskaya N, Volk C, Koepsell H. Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region. Mol Pharmacol 2005;67:1612-19
   PubMed Web of Science ®Google Scholar
• Popp C, Gorboulev V, Muller TD, Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol Pharmacol 2005;67:1600-11
   PubMed Web of Science ®Google Scholar
• Urakami Y, Kimura N, Okuda M, Inui K. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res 2004;21:976-81
   PubMed Web of Science ®Google Scholar
• Eisner C, Faulhaber-Walter R, Wang Y, Major contribution of tubular secretion to creatinine clearance in mice. Kidney Int 2010;77:519-26
   PubMed Web of Science ®Google Scholar
• Tsuruoka S, Ioka T, Wakaumi M, Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2. Clin Pharmacol Ther 2006;79:389-96
   PubMed Web of Science ®Google Scholar
• Reitman ML, Schadt EE. Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest 2007;117:1226-9
   PubMed Web of Science ®Google Scholar
• Maeda T, Oyabu M, Yotsumoto T, Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats. Drug Metab Dispos 2007;35:1580-6
   PubMed Web of Science ®Google Scholar
• Urakami Y, Okuda M, Saito H, Inui K. Hormonal regulation of organic cation transporter OCT2 expression in rat kidney. FEBS Lett 2000;473:173-6
   PubMed Web of Science ®Google Scholar
• Wilde S, Schlatter E, Koepsell H, Calmodulin-associated post-translational regulation of rat organic cation transporter 2 in the kidney is gender dependent. Cell Mol Life Sci 2009;66:1729-40
   PubMed Web of Science ®Google Scholar
• Muller J, Lips KS, Metzner L, Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol 2005;70:1851-60
   PubMed Web of Science ®Google Scholar
• Lips KS, Volk C, Schmitt BM, Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol 2005;33:79-88
   PubMed Web of Science ®Google Scholar
• Minuesa G, Purcet S, Erkizia I, Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells. J Pharmacol Exp Ther 2008;324:558-67
   PubMed Web of Science ®Google Scholar
• Kimura N, Masuda S, Katsura T, Inui K. Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2. Biochem Pharmacol 2009;77:1429-36
   PubMed Web of Science ®Google Scholar
• Ciarimboli G, Struwe K, Arndt P, Regulation of the human organic cation transporter hOCT1. J Cell Physiol 2004;201:420-8
   PubMed Web of Science ®Google Scholar
• Lee WK, Reichold M, Edemir B, The organic cation transporters OCT1, 2, and 3 mediate high affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule. Am J Physiol Renal Physiol 2009;296:F1504-13
   PubMed Web of Science ®Google Scholar
• Kang HJ, Lee SS, Lee CH, Neurotoxic pyridinium metabolites of haloperidol are substrates of human organic cation transporters. Drug Metab Dispos 2006;34:1145-51
   PubMed Web of Science ®Google Scholar
• Thomas J, Wang L, Clark RE, Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004;104:3739-45
   PubMed Web of Science ®Google Scholar
• Wang L, Giannoudis A, Lane S, Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clin Pharmacol Ther 2008;83:258-64
   PubMed Web of Science ®Google Scholar
• Minuesa G, Volk C, Molina-Arcas M, Transport of lamivudine [(-)-beta-L-2′,3′-dideoxy-3′-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther 2009;329:252-61
   PubMed Web of Science ®Google Scholar
• Zhang L, Schaner ME, Giacomini KM. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther 1998;286:354-61
   PubMed Web of Science ®Google Scholar
• Busch AE, Karbach U, Miska D, Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 1998;54:342-52
   PubMed Web of Science ®Google Scholar
• Taubert D, Grimberg G, Stenzel W, Schomig E. Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. PLoS ONE 2007;2:e385
   PubMed Web of Science ®Google Scholar
• Grundemann D, Hahne C, Berkels R, Schomig E. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). J Pharmacol Exp Ther 2003;304:810-17
   PubMed Web of Science ®Google Scholar
• Biermann J, Lang D, Gorboulev V, Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol 2006;290:C1521-31
   PubMed Web of Science ®Google Scholar
• Barendt WM, Wright SH. The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. J Biol Chem 2002;277:22491-6
   PubMed Web of Science ®Google Scholar
• Ciarimboli G, Holle SK, Vollenbroker B, New clues for nephrotoxicity induced by ifosfamide: preferential renal uptake via the human organic cation transporter 2. Mol Pharm 2010; DOI: 10.1021/mp100329u
   Google Scholar
• Chen Y, Zhang S, Sorani M, Giacomini KM. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther 2007;322:695-700
   PubMed Web of Science ®Google Scholar
• Grundemann D, Liebich G, Kiefer N, Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol 1999;56:1-10
   PubMed Web of Science ®Google Scholar
• Tamai I, Yabuuchi H, Nezu J, Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 1997;419:107-11
   PubMed Web of Science ®Google Scholar
• Tamai I, Nakanishi T, Kobayashi D, Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Mol Pharm 2004;1:57-66
   PubMedGoogle Scholar
• McBride BF, Yang T, Liu K, The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. J Cardiovasc Pharmacol 2009;54:63-71
   PubMed Web of Science ®Google Scholar
• Garrett Q, Xu S, Simmons PA, Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium. Invest Ophthalmol Vis Sci 2008;49:4844-9
   PubMed Web of Science ®Google Scholar
• Lamhonwah AM, Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun 2006;345:1315-25
   PubMed Web of Science ®Google Scholar
• Grundemann D, Harlfinger S, Golz S, Discovery of the ergothioneine transporter. Proc Natl Acad Sci U S A 2005;102:5256-61
   PubMed Web of Science ®Google Scholar
• Urban TJ, Brown C, Castro RA, Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther 2008;83:416-21
   PubMed Web of Science ®Google Scholar
• Nakamura T, Nakanishi T, Haruta T, Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm 2010;7:187-95
   PubMed Web of Science ®Google Scholar
• Wu X, Prasad PD, Leibach FH, Ganapathy V. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 1998;246:589-95
   PubMed Web of Science ®Google Scholar
• Tamai I, Ohashi R, Nezu J, Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 1998;273:20378-82
   PubMed Web of Science ®Google Scholar
• Kido Y, Tamai I, Ohnari A, Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. J Neurochem 2001;79:959-69
   PubMed Web of Science ®Google Scholar
• Wagner CA, Lukewille U, Kaltenbach S, Functional and pharmacological characterization of human Na+-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol 2000;279:F584-91
   PubMed Web of Science ®Google Scholar
• Ganapathy ME, Huang W, Rajan DP, ß-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 2000;275:1699-707
   PubMed Web of Science ®Google Scholar
• Hu S, Franke RM, Filipski KK, Interaction of imatinib with human organic ion carriers. Clin Cancer Res 2008;14:3141-8
   PubMed Web of Science ®Google Scholar
• Grigat S, Fork C, Bach M, The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. Drug Metab Dispos 2009;37:330-7
   PubMed Web of Science ®Google Scholar
• Grube M, Meyer Zu Schwabedissen HE, Prager D, Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5). Circulation 2006;113:1114-22
   PubMed Web of Science ®Google Scholar
• Ohashi R, Tamai I, Yabuuchi H, Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther 1999;291:778-84
   PubMed Web of Science ®Google Scholar
• Otsuka M, Matsumoto T, Morimoto R, A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 2005;102:17923-8
   PubMed Web of Science ®Google Scholar
• Ohta KY, Inoue K, Yasujima T, Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds. J Pharm Pharm Sci 2009;12:388-96
   PubMedGoogle Scholar
• Yasujima T, Ohta KY, Inoue K, Evaluation of 4′,6-diamidino-2-phenylindole as a fluorescent probe substrate for rapid assays of the functionality of human multidrug and toxin extrusion proteins. Drug Metab Dispos 2010;38:715-21
   PubMed Web of Science ®Google Scholar
• Matsushima S, Maeda K, Inoue K, The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine. Drug Metab Dispos 2009;37:555-9
   PubMed Web of Science ®Google Scholar
• Masuda S, Terada T, Yonezawa A, Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 2006;17:2127-35
   PubMed Web of Science ®Google Scholar