Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems

Bibliography

• Medina C, Santos-Martinez MJ, Radomski A, Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 2007;150:552-8
   PubMed Web of Science ®Google Scholar
• Tang MF, Lei L, Guo SR, Recent progress in nanotechnology for cancer therapy. Chin J Cancer 2010;8:775-80
   Google Scholar
• De Jong WH, Borm PJ. Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine 2008;3:133-49
   PubMed Web of Science ®Google Scholar
• Leucuta SE. Nanotechnology for delivery of drugs and biomedical applications. Curr Clin Pharmacol 2010;5:257-80
   PubMedGoogle Scholar
• Jain KK. Role of nanobiotechnology in the development of personalized medicine. Nanomedicine (Lond) 2009;4:249-52
   PubMed Web of Science ®Google Scholar
• Bharali DJ, Khalil M, Gurbuz M, Nanoparticles and cancer therapy: a concise review with emphasis on dendrimers. Int J Nanomedicine 2009;4:1-7
   PubMed Web of Science ®Google Scholar
• Yoshioka Y, Yoshikawa T, Tsutsumi Y. Nano-safety science for assuring the safety of nanomaterials. Nippon Eiseigaku Zasshi 2010;65:487-92
   PubMedGoogle Scholar
• Dhawan A, Sharma V. Toxicity assessment of nanomaterials: methods and challenges. Anal Bioanal Chem 2010;398:589-605
   PubMed Web of Science ®Google Scholar
• Oberdoster G. Safety assessment for nanotechnology and nanomedicine: concept of nanotoxicology. J Intern Med 2009;267:89-105
   Web of Science ®Google Scholar
• Oberdorster G, Maynard A, Donaldson K, Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2005;2:8
   PubMed Web of Science ®Google Scholar
• Alexis F, Pridgen EM, Langer R, Nanoparticle technologies for cancer therapy. Handb Exp Pharmacol 2010;55-86
   PubMedGoogle Scholar
• Farokhzad OC, Cheng J, Teply BA, Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci USA 2006;103:6315-20
   PubMed Web of Science ®Google Scholar
• Youns M, Hoheisel JD, Efferth T. Therapeutic and Diagnostic Applications of Nanoparticles. Curr Drug Targets 2010;12:357-65
   Web of Science ®Google Scholar
• Puri A, Loomis K, Smith B, Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic. Crit Rev Ther Drug Carrier Syst 2009;26:523-80
   PubMed Web of Science ®Google Scholar
• Luo H, Li J, Chen X. Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells. Biomed Pharmacother 2010;64:521-6
   PubMed Web of Science ®Google Scholar
• Hobel S, Aigner A. Nonviral delivery platform for therapeutic RNAi: pegylated siRNA/cationic liposome complexes for targeting of the proto-oncogene bcl-2. Future Oncol 2009;5:13-17
   PubMed Web of Science ®Google Scholar
• Mikhaylova M, Stasinopoulos I, Kato Y, Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA. Cancer Gene Ther 2009;16:217-26
   PubMed Web of Science ®Google Scholar
• Podesta JE, Kostarelos K. Chapter 17 - Engineering cationic liposome siRNA complexes for in vitro and in vivo delivery. Methods Enzymol 2009;464:343-54
   PubMed Web of Science ®Google Scholar
• Aumelas A, Serrero A, Durand A, Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems. Colloids Surf B Biointerfaces 2007;59:74-80
   PubMed Web of Science ®Google Scholar
• Nagpal K, Singh SK, Mishra DN. Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull (Tokyo) 2010;58:1423-30
   PubMed Web of Science ®Google Scholar
• Bisht S, Maitra A. Dextran-doxorubicin/chitosan nanoparticles for solid tumor therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009;1:415-25
   PubMed Web of Science ®Google Scholar
• Simi CK, Emilia Abraham T. Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery. Bioprocess Biosyst Eng 2007;30:173-80
   PubMed Web of Science ®Google Scholar
• Shen C, Brozena AH, Wang Y. Double-walled carbon nanotubes: challenges and opportunities. Nanoscale 2010;3:503-18
   PubMed Web of Science ®Google Scholar
• Tran MA, Smith CD, Kester M, Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res 2008;14:3571-81
   PubMed Web of Science ®Google Scholar
• Cloninger M. Dendrimers and protein cages as nanoparticles in drug delivery. Drug Discov Today 2004;9:111-12
   PubMed Web of Science ®Google Scholar
• Caminade AM, Majoral JP. Dendrimers and nanotubes: a fruitful association. Chem Soc Rev 2010;39:2034-47
   PubMed Web of Science ®Google Scholar
• Thakare VS, Das M, Jain AK, Carbon nanotubes in cancer theragnosis. Nanomedicine (Lond) 2010;5:1277-301
   PubMed Web of Science ®Google Scholar
• Huang N, Wang H, Zhao J, Single-wall carbon nanotubes assisted photothermal cancer therapy: animal study with a murine model of squamous cell carcinoma. Lasers Surg Med 2010;42:638-48
   PubMed Web of Science ®Google Scholar
• Kah JC, Wong KY, Neoh KG, Critical parameters in the pegylation of gold nanoshells for biomedical applications: an in vitro macrophage study. J Drug Target 2009;17:181-93
   PubMed Web of Science ®Google Scholar
• Melancon MP, Lu W, Yang Z, In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 2008;7:1730-9
   PubMed Web of Science ®Google Scholar
• Hauck TS, Chan WC. Gold nanoshells in cancer imaging and therapy: towards clinical application. Nanomedicine (Lond) 2007;2:735-8
   PubMedGoogle Scholar
• Ji X, Shao R, Elliott AM, Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both MR imaging and photothermal therapy. J Phys Chem C Nanomater Interfaces 2007;111:6245
   PubMed Web of Science ®Google Scholar
• Yang C, Rait A, Pirollo KF, Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo. Nanomedicine 2008;4:318-29
   PubMed Web of Science ®Google Scholar
• Rhyner MN, Smith AM, Gao X, Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Nanomedicine (Lond) 2006;1:209-17
   PubMed Web of Science ®Google Scholar
• Tran MA, Watts RJ, Robertson GP. Use of liposomes as drug delivery vehicles for treatment of melanoma. Pigment Cell Melanoma Res 2009;22:388-99
   PubMed Web of Science ®Google Scholar
• Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965;13:238-52
   PubMed Web of Science ®Google Scholar
• Balazs DA, Godbey W. Liposomes for use in gene delivery. J Drug Deliv 2011;2011:326497
   PubMedGoogle Scholar
• Park YS. Tumor-directed targeting of liposomes. Biosci Rep 2002;22:267-81
   PubMed Web of Science ®Google Scholar
• Farhood HGX, Son K, Yang Y-Y, Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases†. Gene Therapy for Neoplastic Diseases. Ann NY Acad Sci 1994;716:23-35
   PubMed Web of Science ®Google Scholar
• Dadashzadeh S, Mirahmadi N, Babaei MH, Peritoneal retention of liposomes: Effects of lipid composition, PEG coating and liposome charge. J Control Release 2010;148:177-86
   PubMed Web of Science ®Google Scholar
• Felgner PL, Gadek TR, Holm M, Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-17
   PubMed Web of Science ®Google Scholar
• Landen CN Jr, Chavez-Reyes A, Bucana C, Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 2005;65:6910-18
   PubMed Web of Science ®Google Scholar
• Miller CR, Bondurant B, McLean SD, Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. Biochemistry 1998;37:12875-83
   PubMed Web of Science ®Google Scholar
• Ozpolat B, Sood AK, Lopez-Berestein G. Nanomedicine based approches for the delivery of siRNA in cancer. J Intern Med 2009;267:44-53
   Web of Science ®Google Scholar
• Gewirtz AM. RNA targeted therapeutics for hematologic malignancies. Blood Cells Mol Dis 2007;38:117-19
   PubMed Web of Science ®Google Scholar
• Spagnou S, Miller AD, Keller M. Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA. Biochemistry 2004;43:13348-56
   PubMed Web of Science ®Google Scholar
• Akar U, Chaves-Reyez A, Barria M, Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells. Autophagy 2008;4:669-79
   PubMed Web of Science ®Google Scholar
• Huwyler J, Drewe J, Krahenbuhl S. Tumor targeting using liposomal antineoplastic drugs. Int J Nanomedicine 2008;3:21-9
   PubMed Web of Science ®Google Scholar
• Yu D, Peng P, Dharap SS, Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo. J Control Release 2005;110:90-102
   PubMed Web of Science ®Google Scholar
• Johansen PB. Doxorubicin pharmacokinetics after intravenous and intraperitoneal administration in the nude mouse. Cancer Chemother Pharmacol 1981;5:267-70
   PubMed Web of Science ®Google Scholar
• Lindner LH, Eichhorn ME, Eibl H, Novel temperature-sensitive liposomes with prolonged circulation time. Clin Cancer Res 2004;10:2168-78
   PubMed Web of Science ®Google Scholar
• Alberts DS, Garcia DJ. Safety aspects of pegylated liposomal doxorubicin in patients with cancer. Drugs 1997;54(Suppl 4):30-5
   PubMed Web of Science ®Google Scholar
• Alberts DS, Liu PY, Wilczynski SP, Randomized trial of pegylated liposomal doxorubicin (PLD) plus carboplatin versus carboplatin in platinum-sensitive (PS) patients with recurrent epithelial ovarian or peritoneal carcinoma after failure of initial platinum-based chemotherapy (Southwest Oncology Group Protocol S0200). Gynecol Oncol 2008;108:90-4
   PubMed Web of Science ®Google Scholar
• Holloway RW, Finkler NJ, Nye LP, Doxil and gemcitabine combination therapy for recurrent ovarian cancer: results of a phase II trial. 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2004;22:5090
   Google Scholar
• Muggia FM, Hainsworth JD, Jeffers S, Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation. J Clin Oncol 1997;15:987-93
   PubMed Web of Science ®Google Scholar
• Muggia FM. Clinical efficacy and prospects for use of pegylated liposomal doxorubicin in the treatment of ovarian and breast cancers. Drugs 1997;54(Suppl 4):22-9
   PubMed Web of Science ®Google Scholar
• Barenholz Y. Liposome application: problems and prospects. Curr Opin Colloid Interface Sci 2001;6:66-77
   Web of Science ®Google Scholar
• Zolnik BS, Gonzalez-Fernandez A, Sadrieh N, Nanoparticles and the immune system. Endocrinology 2010;151:458-65
   PubMed Web of Science ®Google Scholar
• Dokka S, Toledo D, Shi X, Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes. Pharm Res 2000;17:521-5
   PubMed Web of Science ®Google Scholar
• Lv H, Zhang S, Wang B, Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 2006;114:100-9
   PubMed Web of Science ®Google Scholar
• Akhtar S, Benter I. Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv Drug Deliv Rev 2007;59:164-82
   PubMed Web of Science ®Google Scholar
• Dokka S TD, Shi X, Castranova V, Rojanasakul Y. Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes. Pharm Res 2000;17:521-5
   PubMed Web of Science ®Google Scholar
• Filion MaP NC. Major limitations in the use of cationic liposomes for DNA delivery. Int J Pharm 1998;162:159-70
   Web of Science ®Google Scholar
• Immordino ML, Dosio F, Cattel L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine 2006;1:297-315
   PubMed Web of Science ®Google Scholar
• Larocque J, Bharali DJ, Mousa SA. Cancer detection and treatment: the role of nanomedicine. Mol Biotechnol 2003;42:358-66
   Google Scholar
• Berry G, Billingham M, Alderman E, The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin. Ann Oncol 1998;9:711-16
   PubMed Web of Science ®Google Scholar
• Perez AT, Domenech GH, Frankel C, Pegylated liposomal doxorubicin (Doxil) for metastatic breast cancer: the Cancer Research Network, Inc., experience. Cancer Invest 2002;20(Suppl 2):22-9
   PubMedGoogle Scholar
• Goram AL, Richmond PL. Pegylated liposomal doxorubicin: tolerability and toxicity. Pharmacotherapy 2001;21:751-63
   PubMed Web of Science ®Google Scholar
• Dhaneshwar SS, Kandpal M, Gairola N, Kadam SS. Dextran: a promising macromolecular drug carrier. Indian J Pharm Sci 2006;68:705-14
   Google Scholar
• Gervelas C, Avramoglou T, Crepin M, Growth inhibition of human melanoma tumor cells by the combination of sodium phenylacetate (NaPA) and substituted dextrans and one NaPA-dextran conjugate. Anticancer Drugs 2002;13:37-45
   PubMed Web of Science ®Google Scholar
• Ichinose K, Tomiyama N, Nakashima M, Antitumor activity of dextran derivatives immobilizing platinum complex (II). Anticancer Drugs 2000;11:33-8
   PubMed Web of Science ®Google Scholar
• Lam W, Leung CH, Chan HL, Toxicity and DNA binding of dextran-doxorubicin conjugates in multidrug-resistant KB-V1 cells: optimization of dextran size. Anticancer Drugs 2000;11:377-84
   PubMed Web of Science ®Google Scholar
• Shrivastava SK, Jain DK, Trivedi P. Dextrans–potential polymeric drug carriers for suprofen. Pharmazie 2003;58:804-6
   PubMed Web of Science ®Google Scholar
• Porter KA, Blackburn GL, Bistrian BR. Safety of iron dextran in total parenteral nutrition: a case report. J Am Coll Nutr 1988;7:107-10
   PubMed Web of Science ®Google Scholar
• Dhaneshwar S, Kandpal M, Gairola N, Kadam SS. Dextran: a promising macromolecular drug carrier. Indian J Pharm Sci 2006;68:705-14
   Google Scholar
• Darrell B, Phillip O, Buncke J, Harry J. Dextran-induced acute renal failure after microvascular muscle transplantation. Plast Reconstr Surg 2001;108:2057-60
   PubMed Web of Science ®Google Scholar
• Hawker CJ, Wooley KL. The convergence of synthetic organic and polymer chemistries. Science 2005;309:1200-5
   PubMed Web of Science ®Google Scholar
• Jain R, Shah NH, Malick AW, Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches. Drug Dev Ind Pharm 1998;24:703-27
   PubMed Web of Science ®Google Scholar
• Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003;55:329-47
   PubMed Web of Science ®Google Scholar
• Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000;21:2475-90
   PubMed Web of Science ®Google Scholar
• Wickline SA, Neubauer AM, Winter PM, Molecular imaging and therapy of atherosclerosis with targeted nanoparticles. J Magn Reson Imaging 2007;25:667-80
   PubMed Web of Science ®Google Scholar
• Astete CE, Sabliov CM. Synthesis and characterization of PLGA nanoparticles. J Biomater Sci Polym Ed 2006;17:247-89
   PubMed Web of Science ®Google Scholar
• Athanasiou KA, Niederauer GG, Agrawal CM. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 1996;17:93-102
   PubMed Web of Science ®Google Scholar
• Kitchell JP, Wise DL. Poly(lactic/glycolic acid) biodegradable drug-polymer matrix systems. Methods Enzymol 1985;112:436-48
   PubMed Web of Science ®Google Scholar
• Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997;28:5-24
   PubMed Web of Science ®Google Scholar
• Musumeci T, Ventura CA, Giannone I, PLA/PLGA nanoparticles for sustained release of docetaxel. Int J Pharm 2006;325:172-9
   PubMed Web of Science ®Google Scholar
• Musumeci T, Vicari L, Ventura CA, Lyoprotected nanosphere formulations for paclitaxel controlled delivery. J Nanosci Nanotechnol 2006;6:3118-25
   PubMed Web of Science ®Google Scholar
• Saxena V, Sadoqi M, Shao J. Polymeric nanoparticulate delivery system for Indocyanine green: biodistribution in healthy mice. Int J Pharm 2006;308:200-4
   PubMed Web of Science ®Google Scholar
• Vorp DA, Maul T, Nieponice A. Molecular aspects of vascular tissue engineering. Front Biosci 2005;10:768-89
   PubMed Web of Science ®Google Scholar
• Lim HJ, Nam HY, Lee BH, A novel technique for loading of paclitaxel-PLGA nanoparticles onto ePTFE vascular grafts. Biotechnol Prog 2007;23:693-7
   PubMed Web of Science ®Google Scholar
• Semete B, Booysen L, Lemmer Y, In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems. Nanomedicine 2010;6:662-71
   PubMed Web of Science ®Google Scholar
• Mintzer MA, Grinstaff MW. Biomedical applications of dendrimers: a tutorial. Chem Soc Rev 2011;40:173-90
   PubMed Web of Science ®Google Scholar
• Medina SH, El-Sayed ME. Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 2009;109:3141-57
   PubMed Web of Science ®Google Scholar
• Nanjwade BK, Bechra HM, Derkar GK, Dendrimers: emerging polymers for drug-delivery systems. Eur J Pharm Sci 2009;38:185-96
   PubMed Web of Science ®Google Scholar
• Svenson S, Tomalia DA. Dendrimers in biomedical applications–reflections on the field. Adv Drug Deliv Rev 2005;57:2106-29
   PubMed Web of Science ®Google Scholar
• Surendiran A, Sandhiya S, Pradhan SC, Novel applications of nanotechnology in medicine. Indian J Med Res 2009;130:689-701
   PubMed Web of Science ®Google Scholar
• Chandrasekar D, Sistla R, Ahmad FJ, The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats. Biomaterials 2007;28:504-12
   PubMed Web of Science ®Google Scholar
• Svenson S. Dendrimers as versatile platform in drug delivery applications. Eur J Pharm Biopharm 2009;71:445-62
   PubMed Web of Science ®Google Scholar
• Balogh L, Swanson DR, Tomalia DA, Dendrime-silver complexes and nanocomposites as antimicrobial agents. Nano Lett 2000;1:18-21
   Web of Science ®Google Scholar
• Bhadra D, Bhadra S, Jain S, A PEGylated dendritic nanoparticulate carrier of fluorouracil. Int J Pharm 2003;257:111-24
   PubMedGoogle Scholar
• Chauhan AS, Sridevi S, Chalasani KB, Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin. J Control Release 2003;90:335-43
   PubMed Web of Science ®Google Scholar
• Jevprasesphant R, Penny J, Jalal R, The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int J Pharm 2003;252:263-6
   PubMed Web of Science ®Google Scholar
• Fischer D, Li Y, Ahlemeyer B, In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003;24:1121-31
   PubMed Web of Science ®Google Scholar
• El-Sayed M, Ginski M, Rhodes C, Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers. J Control Release 2002;81:355-65
   PubMed Web of Science ®Google Scholar
• Bourne N, Stanberry LR, Kern ER, Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection. Antimicrob Agents Chemother 2000;44:2471-4
   PubMed Web of Science ®Google Scholar
• Liu Z, Tabakman S, Welsher K, Carbon Nanotubes in Biology and Medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res 2009;2:85-120
   PubMed Web of Science ®Google Scholar
• Liu Z, Chen K, Davis C, Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 2008;68:6652-60
   PubMed Web of Science ®Google Scholar
• Chaudhuri P, Soni S, Sengupta S. Single-walled carbon nanotube-conjugated chemotherapy exhibits increased therapeutic index in melanoma. Nanotechnology 2010;21:025102
   Web of Science ®Google Scholar
• Liu Z, Fan AC, Rakhra K, Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chem Int Ed Engl 2009;48:7668-72
   PubMed Web of Science ®Google Scholar
• Singh S, Nalwa HS. Nanotechnology and health safety–toxicity and risk assessments of nanostructured materials on human health. J Nanosci Nanotechnol 2007;7:3048-70
   PubMed Web of Science ®Google Scholar
• Radomski A, Jurasz P, Alonso-Escolano D, Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 2005;146:882-93
   PubMed Web of Science ®Google Scholar
• Sayes CM, Liang F, Hudson JL, Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 2006;161:135-42
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Castranova V, Kisin ER, Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 2003;66:1909-26
   PubMed Web of Science ®Google Scholar
• Warheit DB, Laurence BR, Reed KL, Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 2004;77:117-25
   PubMed Web of Science ®Google Scholar
• Ravichandran P, Periyakaruppan A, Sadanandan B, Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes. J Biochem Mol Toxicol 2009;23:333-44
   PubMed Web of Science ®Google Scholar
• Reddy AR, Reddy YN, Krishna DR, Pulmonary toxicity assessment of multiwalled carbon nanotubes in rats following intratracheal instillation. Environ Toxicol 2010; [Epub ahead of print]
   Web of Science ®Google Scholar
• Muller J, Huaux F, Moreau N, Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 2005;207:221-31
   PubMed Web of Science ®Google Scholar
• Bhattacharya R, Mukherjee P. Biological properties of "naked" metal nanoparticles. Adv Drug Deliv Rev 2008;60:1289-306
   PubMed Web of Science ®Google Scholar
• Geddes CD, Parfenov A, Lakowicz JR. Photodeposition of silver can result in metal-enhanced fluorescence. Appl Spectrosc 2003;57:526-31
   PubMed Web of Science ®Google Scholar
• Loo C, Lin A, Hirsch L, Nanoshell-enabled photonics-based imaging and therapy of cancer. Technol Cancer Res Treat 2004;3:33-40
   PubMed Web of Science ®Google Scholar
• Niidome T, Yamagata M, Okamoto Y, PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release 2006;114:343-7
   PubMed Web of Science ®Google Scholar
• Kawano T, Yamagata M, Takahashi H, Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses. J Control Release 2006;111:382-9
   PubMed Web of Science ®Google Scholar
• Hainfeld JF, Slatkin DN, Smilowitz HM. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 2004;49:N309-15
   PubMed Web of Science ®Google Scholar
• O'Neal DP, Hirsch LR, Halas NJ, Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 2004;209:171-6
   PubMed Web of Science ®Google Scholar
• Murphy CJ, Gole AM, Stone JW, Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc Chem Res 2008;41:1721-30
   PubMed Web of Science ®Google Scholar
• Zwiorek K, Kloeckner J, Wagner E, Gelatin nanoparticles as a new and simple gene delivery system. J Pharm Pharm Sci 2005;7:22-8
   PubMedGoogle Scholar
• Zamiri R, Azmi BZ, Sadrolhosseini AR, Preparation of silver nanoparticles in virgin coconut oil using laser ablation. Int J Nanomedicine 2011;6:71-5
   PubMed Web of Science ®Google Scholar
• Ahmad N, Sharma S, Singh VN, Biosynthesis of silver nanoparticles from desmodium triflorum: a novel approach towards weed utilization. Biotechnol Res Int 2011;2011:454090
   Google Scholar
• Keelan JA. Nanotoxicology: nanoparticles versus the placenta. Nat Nanotechnol 2011;6:263-4
   PubMed Web of Science ®Google Scholar
• Chang C. The immune effects of naturally occurring and synthetic nanoparticles. J Autoimmun 2010;34:J234-46
   PubMed Web of Science ®Google Scholar
• Zhang L, Yu F, Cole AJ, Gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging. AAPS J 2009;11:693-9
   PubMed Web of Science ®Google Scholar
• Shahverdi AR, Fakhimi A, Shahverdi HR, Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli. Nanomedicine 2007;3:168-71
   PubMed Web of Science ®Google Scholar
• Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci 2004;275:177-82
   PubMed Web of Science ®Google Scholar
• Rutberg FG, Dubina MV, Kolikov VA, Effect of silver oxide nanoparticles on tumor growth in vivo. Dokl Biochem Biophys 2008;421:191-3
   PubMed Web of Science ®Google Scholar
• Hussain SM, Hess KL, Gearhart JM, In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 2005;19:975-83
   PubMed Web of Science ®Google Scholar
• Neuberger T, Schopfa B, Hofmannb H, Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system. J Magnetism Magn Mater 2005;293:483-96
   Web of Science ®Google Scholar
• Hofmann-Amtenbrink M, Rechenberg Von B, Hofmann H. Superparamagnetic nanoparticles for biomedical applications. Transworld Research Network 2009;121-49
   Google Scholar
• Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005;26:3995-4021
   PubMed Web of Science ®Google Scholar
• Saboktakin MR, Maharramov A, Ramazanov MA. Synthesis and characterization of superparamagnetic nanoparticles coated with carboxymethyl starch (CMS) for magnetic resonance imaging technique. J Carbohydr Polym 2009;78(2):292-5
   Web of Science ®Google Scholar
• Meng J, Fan J, Galiana G, LHR- Functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI. [J] Mat Sci Eng C-BioS. Science 2009;29:1467-79
   Web of Science ®Google Scholar
• Torchilin VP. Drug targeting. Eur J Pharm Sci 2000;11(Suppl 2):S81-91
   PubMed Web of Science ®Google Scholar
• Rudge S, Peterson C, Vessely C, Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC). J Control Release 2001;74:335-40
   PubMed Web of Science ®Google Scholar
• Strom V, Hultenby K, Gruttner C, B, Holgersson J, A novel and rapid method for quantification of magnetic nanoparticle–cell interactions using a desktop susceptometer. Nanotechnology 2004;15:457-66
   Web of Science ®Google Scholar
• Buyukhatipoglu K, Clyne AM. Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation. J Biomed Mater Res A 2011;96:186-95
   PubMed Web of Science ®Google Scholar
• Smith AM, Dave S, Nie S, Multicolor quantum dots for molecular diagnostics of cancer. Expert Rev Mol Diagn 2006;6:231-44
   PubMed Web of Science ®Google Scholar
• Tang M, Xing T, Zeng J, Unmodified CdSe quantum dots induce elevation of cytoplasmic calcium levels and impairment of functional properties of sodium channels in rat primary cultured hippocampal neurons. Environ Health Perspect 2008;116:915-22
   PubMed Web of Science ®Google Scholar
• Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ Health Perspect 2006;114:165-72
   PubMed Web of Science ®Google Scholar
• Chan WC, Maxwell DJ, Gao X, Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 2002;13:40-6
   PubMed Web of Science ®Google Scholar
• Colton HM, Falls JG, Ni H, Visualization and quantitation of peroxisomes using fluorescent nanocrystals: treatment of rats and monkeys with fibrates and detection in the liver. Toxicol Sci 2004;80:183-92
   PubMed Web of Science ®Google Scholar
• Dubertret B, Skourides P, Norris DJ, In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 2002;298:1759-62
   PubMed Web of Science ®Google Scholar
• Gao X, Cui Y, Levenson RM, In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004;22:969-76
   PubMed Web of Science ®Google Scholar
• Lidke DS, Nagy P, Heintzmann R, Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat Biotechnol 2004;22:198-203
   PubMed Web of Science ®Google Scholar
• Wu X, Liu H, Liu J, Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 2003;21:41-6
   PubMed Web of Science ®Google Scholar
• Rudge SR, Kurtz TL, Vessely CR, Preparation, characterization, and performance of magnetic iron-carbon composite microparticles for chemotherapy. Biomaterials 2000;21:1411-20
   PubMed Web of Science ®Google Scholar
• Scherer F, Anton M, Schillinger U, Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 2002;9:102-9
   PubMed Web of Science ®Google Scholar
• Choi AO, Cho SJ, Desbarats J, Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells. J Nanobiotechnology 2007;5:1
   PubMedGoogle Scholar
• Hoshino A, Fujioka K, Oku T, Quantum dots targeted to the assigned organelle in living cells. Microbiol Immunol 2004;48:985-94
   PubMed Web of Science ®Google Scholar
• Shiohara A, Hoshino A, Hanaki K, On the cyto-toxicity caused by quantum dots. Microbiol Immunol 2004;48:669-75
   PubMed Web of Science ®Google Scholar
• Hoshino A, Hanaki K, Suzuki K, Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem Biophys Res Commun 2004;314:46-53
   PubMed Web of Science ®Google Scholar
• El-Ansary A, Al-Daihan S. On the toxicity of therapeutically used nanoparticles: an overview. J Toxicol 2009;2009:754810
   PubMedGoogle Scholar
• Hall JB, Dobrovolskaia MA, Patri AK, Characterization of nanoparticles for therapeutics. Nanomedicine (Lond) 2007;2:789-803
   PubMed Web of Science ®Google Scholar
• Murdock RC, Braydich-Stolle L, Schrand AM, Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicol Sci 2008;101:239-53
   PubMed Web of Science ®Google Scholar
• Powers KW, Brown SC, Krishna VB, Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 2006;90:296-303
   PubMed Web of Science ®Google Scholar
• Barreto JA, O'Malley W, Kubeil M, Nanomaterials: applications in cancer imaging and therapy. Adv Mater 2011;23:H18-40
   PubMed Web of Science ®Google Scholar
• Owens DE III, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006;307:93-102
   PubMed Web of Science ®Google Scholar
• Manocha B, Margaritis A. Production and characterization of Œ ≥ -polyglutamic acid nanoparticles for controlled anticancer drug release. Crit Rev Biotechnol 2008;28:83-99
   PubMed Web of Science ®Google Scholar
• Borm P, Klaessig FC, Landry TD, Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles. Toxicol Sci 2006;90:23-32
   PubMed Web of Science ®Google Scholar
• Hall JBD, Patriak MA, McNeil SE. Characterization of nanoparticles for therapeutics. Nanomedicine (Lond) 2007;2:789-803
   PubMed Web of Science ®Google Scholar
• Lewinski N, Colvin V, Drezek R. Cytotoxicity of nanoparticles. Small 2008;4:26-49
   PubMed Web of Science ®Google Scholar
• United States Pharmacopeia (United States Pharmacopeial Convention IURPT.
   Google Scholar
• Li N, Sioutas C, Cho A, Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 2003;111:455-60
   PubMed Web of Science ®Google Scholar
• Dhawan A, Sharma V, Parmar D. Nanomaterials: a challenge for toxicologists. Nanotoxicology 2008;3:1-9
   Web of Science ®Google Scholar
• Gosens I, Post JA, de la Fonteyne LJ, Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation. Part Fibre Toxicol 2010;7:37
   PubMed Web of Science ®Google Scholar
• Skebo JE, Grabinski CM, Schrand AM, Assessment of metal nanoparticle agglomeration, uptake, and interaction using high-illuminating system. Int J Toxicol 2007;26:135-41
   PubMed Web of Science ®Google Scholar
• Hatziantoniou S, Deli G, Nikas Y, Scanning electron microscopy study on nanoemulsions and solid lipid nanoparticles containing high amounts of ceramides. Micron 2007;38:819-23
   PubMed Web of Science ®Google Scholar
• Somani PR, Umeno M. Importance of transmission electron microscopy for carbon nanomaterials research. in Modern Research and Educational Topics in Microscopy (Number 3 of the Microscopy Book Series), Editors : A. Mendez-Vilas and J. Diaz, Formatex 2007;2:634-42
   Google Scholar
• Berne BPR. Dynamic Light Scattering: With Applications to Chemistry, Biology and Physics. Dover Publications; NY, USA: 2000
   Google Scholar
• United States Pharmacopeia (United States Pharmacopeial Convention IBET.
   Google Scholar
• Mickuviene I, Kirveliene V, Juodka B. Experimental survey of non-clonogenic viability assays for adherent cells in vitro. Toxicol In Vitro 2004;18:639-48
   PubMed Web of Science ®Google Scholar
• Decker T. Lohmann-Matthes, ML. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 1998;115:61-9
   Google Scholar
• Hong S, Bielinska AU, Mecke A, Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. Bioconjug Chem 2004;15:774-82
   PubMed Web of Science ®Google Scholar
• Tuschl H, Schwab CE. Flow cytometric methods used as screening tests for basal toxicity of chemicals. Toxicol In Vitro 2004;18:483-91
   PubMed Web of Science ®Google Scholar
• Stone V, Shaw J, Brown DM, The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicol In Vitro 1998;12:649-59
   PubMed Web of Science ®Google Scholar
• Foucaud L, Wilson MR, Brown DM, Measurement of reactive species production by nanoparticles prepared in biologically relevant media. Toxicol Lett 2007;174:1-9
   PubMed Web of Science ®Google Scholar
• Schins RP, Duffin R, Hohr D, Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells. Chem Res Toxicol 2002;15:1166-73
   PubMed Web of Science ®Google Scholar
• Wilson MR, Lightbody JH, Donaldson K, Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol 2002;184:172-9
   PubMed Web of Science ®Google Scholar
• Stone V, Johnston H, Schins RP. Development of in vitro systems for nanotoxicology: methodological considerations. Crit Rev Toxicol 2009;39:613-26
   PubMed Web of Science ®Google Scholar
• Xiao GG, Wang M, Li N, Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. J Biol Chem 2003;278:50781-90
   PubMed Web of Science ®Google Scholar
• Landsiedel R, Kapp MD, Schulz M, Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations–many questions, some answers. Mutat Res 2009;681:241-58
   PubMed Web of Science ®Google Scholar
• Jacobsen NR, Pojana G, White P, Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells. Environ Mol Mutagen 2008;49:476-87
   PubMed Web of Science ®Google Scholar
• Mroz RM, Schins RP, Li H, Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways. Eur Respir J 2008;31:241-51
   PubMed Web of Science ®Google Scholar
• Grainger DW. Nanotoxicity assessment: all small talk? Adv Drug Deliv Rev 2009;61:419-21
   PubMed Web of Science ®Google Scholar
• Home - Nanotechnology Characterization Lab. 2011. Available from: http://ncl.cancer.gov/ [Cited 2011 11]
   Google Scholar
• Jang J, Lim DH, Choi IH. The impact of nanomaterials in immune system. Immune Netw 2010;10:85-91
   PubMedGoogle Scholar
• Mohanraj VaC Y. Nanoparticles – a review. Trop J Pharm Res 2006;5:561-73
   Google Scholar
• Tran MA, Gowda R, Sharma A, Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development. Cancer Res 2008;68:7638-49
   PubMed Web of Science ®Google Scholar
• Emerich DF, Thanos CG. The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis. Biomol Eng 2006;23:171-84
   PubMedGoogle Scholar
• Li SD, Chono S, Huang L. Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol Ther 2008;16:942-6
   PubMed Web of Science ®Google Scholar
• Gardikis K, Hatziantoniou S, Bucos M, New drug delivery nanosystem combining liposomal and dendrimeric technology (liposomal locked-in dendrimers) for cancer therapy. J Pharm Sci 2010;99:3561-71
   PubMed Web of Science ®Google Scholar
• Hirsch LR, Stafford RJ, Bankson JA, Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 2003;100:13549-54
   PubMed Web of Science ®Google Scholar