692
Views
52
CrossRef citations to date
0
Altmetric
Reviews

S2RPgrmc1: the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling

, PhD (Associate Researcher) , (Associate Researcher) & , PhD (Associate Professor)
Pages 361-370 | Published online: 01 Feb 2012

Bibliography

  • Peluso JJ. Progesterone signaling mediated through progesterone receptor membrane component-1 in ovarian cells with special emphasis on ovarian cancer. Steroids 2011;76(9):903-9
  • Rohe HJ, Ahmed IS, Twist KE, Craven RJ. PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. Pharmacol Ther 2009;121(1):14-19
  • Cahill MA. Progesterone receptor membrane component 1: an integrative review. J Steroid Biochem Mol Biol 2007;105(1-5):16-36
  • Mach RH, Wheeler KT. Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo. Cent Nerv Syst Agents Med Chem 2009;9(3):230-45
  • Xu J, Zeng C, Chu W, Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2011;2:380
  • Ahmed IS, Rohe HJ, Twist KE, Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J Pharmacol Exp Ther 2010;333(2):564-73
  • Wheeler KT, Wang LM, Wallen CA, Sigma-2 receptors as a biomarker of proliferation in solid tumours. Br J Cancer 2000;82(6):1223-32
  • Bem WT, Thomas GE, Mamone JY, Overexpression of sigma receptors in nonneural human tumors. Cancer Res 1991;51(24):6558-62
  • Hellewell SB, Bruce A, Feinstein G, Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling. Eur J Pharmacol 1994;268(1):9-18
  • Vilner BJ, John CS, Bowen WD. Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. Cancer Res 1995;55(2):408-13
  • Hou C, Tu Z, Mach R, Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker. Nucl Med Biol 2006;33(2):203-9
  • Crudden G, Loesel R, Craven RJ. Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors. Tumour Biol 2005;26(3):142-6
  • Difilippantonio S, Chen Y, Pietas A, Gene expression profiles in human non-small and small-cell lung cancers. Eur J Cancer 2003;39(13):1936-47
  • Peluso JJ, Liu X, Saunders MM, Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1. J Clin Endocrinol Metab 2008;93(5):1592-9
  • Neubauer H, Clare SE, Wozny W, Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. Breast Cancer Res 2008;10(5):R85
  • Brent PJ, Pang GT. Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture. Eur J Pharmacol 1995;278(2):151-60
  • Crawford KW, Bowen WD. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 2002;62(1):313-22
  • Ahmed IS, Rohe HJ, Twist KE, Craven RJ. Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity. J Biol Chem 2010;285(32):24775-82
  • Ostenfeld MS, Fehrenbacher N, Hoyer-Hansen M, Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res 2005;65(19):8975-83
  • Craven RJ, Mallory JC, Hand RA. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. J Biol Chem 2007;282(50):36543-51
  • Meyer C, Schmieding K, Falkenstein E, Wehling M. Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the sigma receptor family? Eur J Pharmacol 1998;347(2-3):293-9
  • Selmin O, Lucier GW, Clark GC, Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis 1996;17(12):2609-15
  • Selmin O, Thorne PA, Blachere FM, Transcriptional activation of the membrane-bound progesterone receptor (mPR) by dioxin, in endocrine-responsive tissues. Mol Reprod Dev 2005;70(2):166-74
  • Nie AY, McMillian M, Parker JB, Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity. Mol Carcinog 2006;45(12):914-33
  • Meyer C, Schmid R, Scriba PC, Wehling M. Purification and partial sequencing of high-affinity progesterone-binding site(s) from porcine liver membranes. Eur J Biochem 1996;239(3):726-31
  • Falkenstein E, Meyer C, Eisen C, Full-length cDNA sequence of a progesterone membrane-binding protein from porcine vascular smooth muscle cells. Biochem Biophys Res Commun 1996;229(1):86-9
  • Falkenstein E, Schmieding K, Lange A, Localization of a putative progesterone membrane binding protein in porcine hepatocytes. Cell Mol Biol (Noisy-le-grand) 1998;44(4):571-8
  • Gerdes D, Wehling M, Leube B, Falkenstein E. Cloning and tissue expression of two putative steroid membrane receptors. Biol Chem 1998;379(7):907-11
  • Wu W, Shi SQ, Huang HJ, Changes in PGRMC1, a potential progesterone receptor, in human myometrium during pregnancy and labour at term and preterm. Mol Hum Reprod 2011;17(4):233-42
  • Wendler A, Keller D, Albrecht C, Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. Oncol Rep 2011;25(1):273-9
  • Intlekofer KA, Petersen SL. 17beta-estradiol and progesterone regulate multiple progestin signaling molecules in the anteroventral periventricular nucleus, ventromedial nucleus and sexually dimorphic nucleus of the preoptic area in female rats. Neuroscience 2011;176:86-92
  • Aparicio IM, Garcia-Herreros M, O'Shea LC, Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in vitro maturation. Biol Reprod 2011;84(5):910-21
  • Luciano AM, Lodde V, Franciosi F, Ceciliani F, Peluso JJ. Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development. Reproduction 2010;140(5):663-72
  • Lodde V, Peluso JJ. A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis. Biol Reprod 2011;84(4):715-22
  • Min L, Strushkevich NV, Harnastai IN, Molecular identification of adrenal inner zone antigen as a heme-binding protein. Febs J 2005;272(22):5832-43
  • Peluso JJ, Pappalardo A, Losel R, Wehling M. Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Endocrinology 2006;147(6):3133-40
  • Peluso JJ, Romak J, Liu X. Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 mutations. Endocrinology 2008;149(2):534-43
  • Su TP. Sigma receptors. Putative links between nervous, endocrine and immune systems. Eur J Biochem 1991;Sep15200(3):633-42
  • Su TP, London ED, Jaffe JH. Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science 1988;240(4849):219-21
  • Johannessen M, Fontanilla D, Mavlyutov T, Antagonist action of progesterone at sigma-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol 2011;300(2):C328-37
  • Palmer CP, Mahen R, Schnell E, Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines. Cancer Res 2007;67(23):11166-75
  • Hand RA, Jia N, Bard M, Craven RJ. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. Eukaryot Cell 2003;2(2):306-17
  • Waterman MR, Lepesheva GI. Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase. Biochem Biophys Res Commun 2005;338(1):418-22
  • Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochim Biophys Acta 2007;1770(3):467-77
  • Mallory J, Craven R. Candida albicans Dap1p promotes ergosterol synthesis via the P450 protein Erg11p/Cyp51p, regulating susceptibility to azole antifungal drugs, morphogenesis and damage resistance. Pharmacologia 2011;3(7):179-89
  • Mallory JC, Crudden G, Johnson BL, Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mol Cell Biol 2005;25(5):1669-79
  • Ono T, Takahashi K, Odani S, Purification of squalene epoxidase from rat liver microsomes. Biochem Biophys Res Commun 1980;96(1):522-8
  • Sue Masters B, Marohnic CC. Cytochromes P450–a family of proteins and scientists-understanding their relationships. Drug Metab Rev 2006;38(1-2):209-25
  • Nebert DW, Dalton TP. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev 2006;6(12):947-60
  • Mifsud W, Bateman A. Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain. Genome Biol 2002;3(12):RESEARCH0068
  • Ghosh K, Thompson AM, Goldbeck RA, Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Biochemistry 2005;44(50):16729-36
  • Thompson AM, Reddi AR, Shi X, Measurement of the Heme Affinity for Yeast Dap1p, and its Importance in Cellular Function. Biochemistry 2007;46:14629-37
  • Hughes AL, Powell DW, Bard M, Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metab 2007;5(2):143-9
  • Min L, Takemori H, Nonaka Y, Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis. Mol Cell Endocrinol 2004;215(1-2):143-8
  • Crudden G, Chitti RE, Craven RJ. Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs. J Pharmacol Exp Ther 2006;316(1):448-55
  • Debose-Boyd RA. A helping hand for cytochrome p450 enzymes. Cell Metab 2007;5(2):81-3
  • Szczesna-Skorupa E, Kemper B. Progesterone Receptor Membrane Component 1 (Pgrmc1) inhibits the activity of drug-metabolizing cytochromes P450 and binds to cytochrome P450 reductase. Mol Pharmacol 2010;79:340-50
  • Mansouri MR, Schuster J, Badhai J, Alterations in the expression, structure and function of progesterone receptor membrane component-1 (PGRMC1) in premature ovarian failure. Hum Mol Genet 2008;17(23):3776-83
  • LaBella FS. Cytochrome P450 enzymes: ubiquitous "receptors" for drugs. Can J Physiol Pharmacol 1991;69(8):1129-32
  • Laird SM, Vinson GP, Whitehouse BJ. Monoclonal antibodies against rat adrenocortical cell antigens. Acta Endocrinol (Copenh) 1988;119(3):420-6
  • Raza FS, Takemori H, Tojo H, Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor. Eur J Biochem 2001;268(7):2141-7
  • Oda S, Nakajima M, Toyoda Y, Progesterone receptor membrane component 1 modulates human cytochrome P450 activities in an isoform-dependent manner. Drug Metab Dispos 2011;39:2057-65
  • Miki Y, Suzuki T, Sasano H. Controversies of aromatase localization in human breast cancer–stromal versus parenchymal cells. J Steroid Biochem Mol Biol 2007;106(1-5):97-101
  • Bulun SE, Lin Z, Imir G, Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol Rev 2005;57(3):359-83
  • Bulun SE, Chen D, Lu M, Aromatase excess in cancers of breast, endometrium and ovary. J Steroid Biochem Mol Biol 2007;106(1-5):81-96
  • Weinberg OK, Marquez-Garban DC, Fishbein MC, Aromatase inhibitors in human lung cancer therapy. Cancer Res 2005;65(24):11287-91
  • Kudo S, Ishizaki T. Pharmacokinetics of haloperidol: an update. Clin Pharmacokinet 1999;37(6):435-56
  • Sanchez-Wandelmer J, Davalos A, de la Pena G, Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells. Neuroscience 2010;167(1):143-53
  • Meyer JM, Koro CE. The effects of antipsychotic therapy on serum lipids: a comprehensive review. Schizophr Res 2004;70(1):1-17
  • Perez-Iglesias R, Mata I, Pelayo-Teran JM, Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naive population. Schizophr Res 2009;107(2-3):115-21
  • Suchanek M, Radzikowska A, Thiele C. Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells. Nat Methods 2005;2(4):261-7
  • Mach RH, Smith CR, al-Nabulsi I, Sigma 2 receptors as potential biomarkers of proliferation in breast cancer. Cancer Res 1997;57(1):156-61
  • Peluso JJ, Gawkowska A, Liu X, Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice. Endocrinology 2009;150(11):4846-54
  • Lodde V, Peluso JJ. A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis. Biol Reprod 2010;140:663-72

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.