1,059
Views
52
CrossRef citations to date
0
Altmetric
Drug Evaluations

Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections

& (Professor of Therapeutics and Infectious Diseases)
Pages 759-765 | Published online: 25 Apr 2012

Bibliography

  • Denning DW, Hope WW. Therapy for fungal diseases: opportunities and priorities. Trends Microbiol. 2010;18(5):195-204
  • Available from: WWW.CLINICALTRIALS.GOV
  • Chowdhary A, Kathuria S, Randhawa , Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India. J Antimicrob Chemother 2012;67(2):362-6
  • Howard SJ, Cerar D, Anderson MJ, Frequency and evolution of azole resistance in aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 2009;15:1068-76
  • Schmitt-Hoffmann A, Roos B, Heep M, Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers. Antimicrob Agents Chemother 2006;50:279-85
  • Schmitt-Hoffmann A, Roos B, Maares J, Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers. Antimicrob Agents Chemother 2006;50:286-93
  • Schmitt-Hoffmann A, Roos B, Spickermann J, Effect of mild and moderate liver disease on the pharmacokinetics of isavuconazole after intravenous and oral administration of a single dose of the prodrug BAL8557. Antimicrob Agents Chemother 2009;53:4885-90
  • Warn PA, Sharp A, Parmar A, Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect. Antimicrob Agents Chemother 2009;53:3453-61
  • Hope WW. Population pharmacokinetics of voriconazole in adults. Antimicrob Agents Chemother 2012;56(1):526-31
  • Schmitt-Hoffmann A, Roos Bspickerman J. No relevant food effect in man on isavuconazole oral pharmacokinetics preliminary data. 48th International Conference on Antimicrobial Agents and Chemotherapy; Washington, D.C; 2008
  • Schmitt-Hoffmann A, Roos Bsauer J. Effect of rifampicin on the pharmacokinetics of BAL4815 at steady state after multiple oral daily doses of BAL8557 (WSA) and rifampicin. 16th Congress of the International Society of Human and Animal Mycology; Paris, France; 2006
  • Schmitt-Hoffmann A, Roos Bsauer J. Effect of ketoconazole on the pharmacokinetics of BAL4815 at steady state after multiple oral daily doses of BAL8557 (WSA) and ketoconazole. 16th Congress of the International Society of Human and Animal Mycology; Paris, France; 2006
  • Schmitt-Hoffmann A, Roos Bsauer J. Effect of BAL8557, a water-soluble azole pro-drug (WSA) on the pharmacokinetics of S- and R- warfarin. 16th Congress of the International Society of Human and Animal Mycology; Paris, France; 2006
  • Schmitt-Hoffmann A, Roos Bsauer J. Effect of BAL8557, a water-soluble azole pro-drug (WSA) on the pharmacokinetics of tacrolimus. 16th Congress of the International Society of Human and Animal Mycology; Paris, France; 2006
  • Schmitt-Hoffmann A, Roos Bsauer J. Effect of BAL8557, a water-soluble azole pro-drug (WSA) on the pharmacokinetics of cicosporin. 16th Congress of the International Society of Human and Animal Mycology; Paris, France; 2006
  • Thompson GR III, Wiederhold NP. Isavuconazole: a comprehensive review of spectrum of activity of a new triazole. Mycopathologia 2010;170:291-313
  • Majithiya J, Sharp A, Parmar A, Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei. J Antimicrob Chemother 2009;63:161-6
  • Warn PA, Sharp A, Mosquera J, Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus. J Antimicrob Chemother 2006;58:1198-207
  • Viljoen J. Efficacy, safety and tolerability of three different dosing regimens of BAL8557 vs. fluconazole in a double-blind, randomised, multicentre trial for the treatment of esophageal candidiasis in immunocompromised adults. 45th International Conference on Antimicrobial Agents and Chemotherapy; Washingon, D.C; 2005

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.