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Review

Animal models for exploring the pharmacokinetics of breast cancer therapies

, MD JD & , MD PhD FACS

Bibliography

  • Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin 2014;64(1):9-29
  • Light DW. Global drug discovery: Europe is ahead. Health Aff (Millwood) 2009;28(5):w969-77
  • Adams CP, Brantner VV. Estimating the cost of new drug development: is it really 802 million dollars? Health Aff (Millwood) 2006;25(2):420-8
  • Schuh JC. Trials, tribulations, and trends in tumor modeling in mice. Toxicol Pathol 2004;32(Suppl 1):53-66
  • Burger MM. UICC study group on basic and clinical cancer research: animal models for the natural history of cancer. Meeting held at Woods hole, MA (USA), June 21-23, 1999. International Union Against Cancer. Int J Cancer 2000;85(3):303-5
  • Johnson JI, Decker S, Zaharevitz D, et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 2001;84(10):1424-31
  • Bibby MC, Sleigh NR, Loadman PM, et al. Potentiation of EO9 anti-tumour activity by hydralazine. Eur J Cancer 1993;29A(7):1033-5
  • Talmadge JE, Singh RK, Fidler IJ, et al. Murine models to evaluate novel and conventional therapeutic strategies for cancer. Am J Pathol 2007;170(3):793-804
  • T Corbett FV, LoRusso P, et al. In vivo methods for screening and preclinical testing. Humana Press, Inc; Totowa, NJ: 1998
  • Hann B, Balmain A. Building ’validated’ mouse models of human cancer. Curr Opin Cell Biol 2001;13(6):778-84
  • Le Devedec SE, van Roosmalen W, Maria N, et al. An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse. Clin Exp Metastasis 2009;26(7):673-84
  • Jonkers J, Derksen PW. Modeling metastatic breast cancer in mice. J Mammary Gland Biol Neoplasia 2007;12(2-3):191-203
  • Teicher BA. Tumor models for efficacy determination. Mol Cancer Ther 2006;5(10):2435-43
  • Ottewell PD, Coleman RE, Holen I. From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies. Breast Cancer Res Treat 2006;96(2):101-13
  • Breyer MD. Improving productivity of modern-day drug discovery. Expert Opin Drug Discov 2014;9(2):115-18
  • Ding L, Ellis MJ, Li S, et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 2010;464(7291):999-1005
  • Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual 7th edition. Springer; New York, NY: 2010
  • Rashid OM, Nagahashi M, Ramachandran S, et al. Is tail vein injection a relevant breast cancer lung metastasis model? J Thorac Dis 2013;5(4):385-92
  • Rashid OM, Nagahashi M, Ramachabdran S, et al. An improved syngeneic orthotopic murine model of human breast cancer progression. Breast Cancer Res Treat 2014;147(3):501-12
  • Gravekamp C, Sypniewska R, Gauntt S, et al. Behavior of metastatic and nonmetastatic breast tumors in old mice. Exp Biol Med (Maywood) 2004;229(7):665-75
  • Tao K, Fang M, Alroy J, Sahagian GG. Imagable 4t1 model for the study of late stage breast cancer. BMC Cancer 2008;8:228
  • Miller FR. Tumor subpopulation interactions in metastasis. Invasion Metastasis 1983;3(4):234-42
  • Miller FR, Miller BE, Heppner GH. Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability. Invasion Metastasis 1983;3(1):22-31
  • Lelekakis M, Moseley JM, Martin TJ, et al. A novel orthotopic model of breast cancer metastasis to bone. Clin Exp Metastasis 1999;17(2):163-70
  • Lin EY, Jones JG, Li P, et al. Progression to malignancy in the polyoma middle t oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003;163(5):2113-26
  • Herschkowitz JI, Simin K, Weigman VJ, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007;8(5):R76.1-R76.17
  • Zheng L, Zhou B, Meng X, et al. A model of spontaneous mouse mammary tumor for human estrogen receptor- and progesterone receptor-negative breast cancer. Int J Oncol 2014;45:2241-9
  • Howe LR, Brown PH. Targeting the HER/EGFR/ErbB family to prevent breast cancer. Cancer Prev Res (Phila) 2011;4(8):1149-57
  • Bertotti A, Migliardi G, Galimi F, et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov 2011;1(6):508-23
  • Wang X, Fu X, Hoffman RM. A new patient-like metastatic model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice. Int J Cancer 1992;51(6):992-5
  • Metildi CA, Kaushal S, Luiken GA, et al. Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model. J Surg Oncol 2014;109(5):451-8
  • Hiroshima Y, Maawy A, Sato S, et al. Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice. J Surg Res 2014;187(2):510-17
  • Furukawa T, Kubota T, Watanabe M, et al. A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice. Cancer Res 1993;53(13):3070-2
  • Furukawa T, Fu X, Kubota T, et al. Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. Cancer Res 1993;53(5):1204-8
  • Fu X, Le P, Hoffman RM. A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer. Anticancer Res 1993;13(4):901-4
  • Fu X, Guadagni F, Hoffman RM. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc Natl Acad Sci USA 1992;89(12):5645-9
  • Garber K. From human to mouse and back: ’Tumorgraft’ models surge in popularity. J Natl Cancer Inst 2009;101(1):6-8
  • Garralda E, Paz K, Lopez-Casas PP, et al. Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment. Clin Cancer Res 2014;20(9):2476-84
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144(5):646-74
  • Rosland GV, Svendsen A, Torsvik A, et al. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res 2009;69(13):5331-9
  • Kang Y. Analysis of cancer stem cell metastasis in xenograft animal models. Springer; New York: 2008
  • Cabioglu N, Summy J, Miller C, et al. CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res 2005;65(15):6493-7
  • Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated sdf-1/cxcl12 secretion. Cell 2005;121(3):335-48
  • Viola RJ, Provenzale JM, Li F, et al. In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR Am J Roentgenol 2008;191(6):1779-84
  • Averbook BJ, Schuh JL, Papay R, et al. Antitumor effects of Flt3 ligand in transplanted murine tumor models. J Immunother 2002;25(1):27-35
  • Gershwin ME, Ikeda RM, Kawakami TG, et al. Immunobiology of heterotransplanted human tumors in nude mice. J Natl Cancer Inst 1977;58(5):1455-61
  • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406(6797):747-52
  • van ’t Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415(6871):530-6
  • Wang Y, Klijn JG, Zhang Y, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005;365(9460):671-9
  • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436(7050):518-24
  • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117(7):927-39
  • Naito S, Giavazzi R, Walker SM, et al. Growth and metastatic behavior of human tumor cells implanted into nude and beige nude mice. Clin Exp Metastasis 1987;5(2):135-46
  • Naito S, von Eschenbach AC, Fidler IJ. Different growth pattern and biologic behavior of human renal cell carcinoma implanted into different organs of nude mice. J Natl Cancer Inst 1987;78(2):377-85
  • Furukawa T, Kubota T, Watanabe M, et al. Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice. Int J Cancer 1993;54(3):397-401
  • An Z, Jiang P, Wang X, et al. Development of a high metastatic orthotopic model of human renal cell carcinoma in nude mice: benefits of fragment implantation compared to cell-suspension injection. Clin Exp Metastasis 1999;17(3):265-70
  • Zhang Z, Yin L, Zhang Y, et al. In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models. Chin Med J (Engl) 2002;115(2):227-31
  • Boyd DD, Kim SJ, Wang H, et al. A urokinase-derived peptide (a6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis. Am J Pathol 2003;162(2):619-26
  • Boyd M. Status of the nci preclinical antitumor drug discovery screen. Lippincott; Philadelphia: 1989
  • Kuo TH, Kubota T, Watanabe M, et al. Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in scid mice: the importance of orthotopic models to obtain relevant drug evaluation data. Anticancer Res 1993;13(3):627-30
  • Manzotti C, Audisio RA, Pratesi G. Importance of orthotopic implantation for human tumors as model systems: relevance to metastasis and invasion. Clin Exp Metastasis 1993;11(1):5-14
  • Hoffman RM. Orthotopic is orthodox: why are orthotopic-transplant metastatic models different from all other models? J Cell Biochem 1994;56(1):1-3
  • Hoffman RM. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs 1999;17(4):343-59
  • Bloomston M, Zervos EE, Rosemurgy ASII. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol 2002;9(7):668-74
  • Fidler IJ, Wilmanns C, Staroselsky A, et al. Modulation of tumor cell response to chemotherapy by the organ environment. Cancer Metastasis Rev 1994;13(2):209-22
  • Dong Z, Radinsky R, Fan D, et al. Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. J Natl Cancer Inst 1994;86(12):913-20
  • Killion JJ, Radinsky R, Fidler IJ. Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev 1998;17(3):279-84
  • Yang M, Jiang P, Sun FX, et al. A fluorescent orthotopic bone metastasis model of human prostate cancer. Cancer Res 1999;59(4):781-6
  • Rosol TJ, Tannehill-Gregg SH, LeRoy BE, et al. Animal models of bone metastasis. Cancer 2003;97(3 Suppl):748-57
  • Bibby MC. Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages. Eur J Cancer 2004;40(6):852-7
  • Denekamp J. Endothelial cell proliferation as a novel approach to targeting tumour therapy. Br J Cancer 1982;45(1):136-9
  • Chan RC, Babbs CF, Vetter RJ, et al. Abnormal response of tumor vasculature to vasoactive drugs. J Natl Cancer Inst 1984;72(1):145-50
  • Chaplin DJ, Acker B. The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gain. Int J Radiat Oncol Biol Phys 1987;13(4):579-85
  • Brown J. Exploitation of bioreductive agents with vaso-active drugs. Taylor & Francis; London: 1987
  • Cowen SE, Bibby MC, Double JA. Characterisation of the vasculature within a murine adenocarcinoma growing in different sites to evaluate the potential of vascular therapies. Acta Oncol 1995;34(3):357-60
  • Stratford IJ, Adams GE, Godden J, et al. Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine. Br J Cancer 1988;58(2):122-7
  • Quinn PK, Bibby MC, Cox JA, et al. The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours. Br J Cancer 1992;66(2):323-30
  • Field SB, Burney IA, Needham S, et al. Are transplanted tumours suitable as models for studies on vasculature? Int J Radiat Biol 1991;60(1-2):255-60
  • Myers JN, Holsinger FC, Jasser SA, et al. An orthotopic nude mouse model of oral tongue squamous cell carcinoma. Clin Cancer Res 2002;8(1):293-8
  • O’Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994;79(2):315-28
  • Price JE, Polyzos A, Zhang RD, et al. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res 1990;50(3):717-21
  • Rashid OM, Nagahashi M, Ramachandran S, et al. Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden. Surgery 2013;153(6):771-8
  • Rashid OM, Takabe K. Does removal of the primary tumor in metastatic breast cancer improve survival? J Womens Health 2014;23(2):184-8
  • Fisher ER, Fisher B. Experimental studies of factors influencing the development of hepatic metastases. Xiii. Effect of hepatic trauma in parabiotic pairs. Cancer Res 1963;23:896-900
  • Kim LS, Price JE. Clinically relevant metastatic breast cancer models to study chemosensitivity. Methods Mol Med 2005;111:285-95

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