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Reviews

Pharmacodynamic considerations in the treatment of pulmonary hypertension in infants: challenges and future perspectives

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Bibliography

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•• Excellent review article of pulmonary hypertension in children.

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•• Recent guidelines for pulmonary hypertension management.

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• First study over the prevention of rebound-PH after weaning from inhaled NO through a single dose of sildenafil.

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•• Results of the STARTS-2 study. This study resulted in the FDA warning concerning the use of sildenafil in small children.

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• Results of a member of a new class of PH treatment (soluble guanylate cyclase stimulators) in adults.

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• Comprehensive review focusing on the special problems of diagnosing and treating infants with PH.

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• Analysis of the registered adverse events and side effects using FDA data of the commonly used PH medication.

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• A paper focusing on echocardiography in monitoring the effects of milrinone in PH.

  • Samiee-Zafarghandy S, Raman SR, van den Anker JN, et al. Safety of milrinone use in neonatal intensive care units. Early Hum Dev. 2015;91(1):31–35.
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• A paper over reference values for NT-pro BNP levels in normal infants and children. The data were obtained from four studies.

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