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Reviews

Tools for studying drug transport and metabolism in the brain

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Pages 161-168 | Received 03 Sep 2015, Accepted 11 Dec 2015, Published online: 08 Jan 2016

References

  • Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.
  • Pangalos MN, Schechter LE, Hurko O. Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nat Rev Drug Discov. 2007;6(7):521–532.
  • Wolak DJ, Thorne RG. Diffusion of macromolecules in the brain: implications for drug delivery. Mol Pharm. 2013;10(5):1492–1504.

• A review of fluid dynamics of the brain interstitial fluid.

  • Hladky SB, Barrand MA. Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence. Fluids Barriers CNS. 2014;11(1):26.

•• An excellent discussion of the current knowledge and caveats of the interactions between brain interstitial fluid and cerebrospinal fluid.

  • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2005;2(1):3–14.
  • Sanchez-Covarrubias L, Slosky LM, Thompson BJ, et al. Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des. 2014;20(10):1422–1449.

• An excellent review of drug delivery aspects to the brain.

  • Syvanen S, Lindhe O, Palner M, et al. Species differences in blood-brain barrier transport of three positron emission tomography radio ligands with emphasis on P-glycoprotein transport. Drug Metab Dispos. 2009;37(3):635–643.
  • O’Brien FE, O’Connor RM, Clarke G, et al. P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents. Neuropsychopharmacology. 2013;38(11):2209–2219.
  • Sadeque AJ, Wandel C, He H, et al. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther. 2000;68(3):231–237.
  • Batrakova EV, Miller DW, Li S, et al. Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies. J Pharmacol Exp Ther. 2001;296(2):551–557.
  • Agundez JA, Jimenez-Jimenez FJ, Alonso-Navarro H, et al. Drug and xenobiotic biotransformation in the blood-brain barrier: a neglected issue. Front Cell Neurosci. 2014;8:335.
  • Kondo A, Inoue T, Nagara H, et al. Neurotoxicity of adriamycin passed through the transiently disrupted blood-brain barrier by mannitol in the rat brain. Brain Res. 1987;412(1):73–83.
  • Neuwelt EA, Pagel M, Barnett P, et al. Pharmacology and toxicity of intracarotid adriamycin administration following osmotic blood-brain barrier modification. Cancer Res. 1981;41(11 Pt 1):4466–4470.
  • Aryal M, Vykhodtseva N, Zhang YZ, et al. Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study. J Control Release. 2015;204:60–69.
  • Doolittle ND, Muldoon LL, Culp AY, et al. Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances. Adv Pharmacol. 2014;71:203–243.
  • McDannold N, Arvanitis CD, Vykhodtseva N, et al. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res. 2012;72(14):3652–3663.
  • Alonso A. Ultrasound-induced blood-brain barrier opening for drug delivery. Front Neurol Neurosci. 2015;36:106–115.
  • Miller DS. Confocal imaging of xenobiotic transport across the choroid plexus. Adv Drug Deliv Rev. 2004;56(12):1811–1824.
  • Benarroch EE. Circumventricular organs: receptive and homeostatic functions and clinical implications. Neurology. 2011;77(12):1198–1204.

•• A thorough review and description of the circumventricular organs.

•• A description of the applications and design in BBB Trojan horse technology.

  • Zhao Y, Qu B, Wu X, et al. Design, synthesis and biological evaluation of brain targeting l-ascorbic acid prodrugs of ibuprofen with “lock-in” function. Eur J Med Chem. 2014;82:314–323.
  • Yang H. Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis. Pharm Res. 2010;27(9):1759–1771.
  • Di L, Umland JP, Chang G, et al. Species independence in brain tissue binding using brain homogenates. Drug Metab Dispos. 2011;39(7):1270–1277.
  • Tarasoff-Conway JM, Carare RO, Osorio RS, et al. Clearance systems in the brain-implications for Alzheimer disease. Nat Reviews Neurol. 2015;11(8):457–470.
  • Spector R, Robert Snodgrass S, Johanson CE. A balanced view of the cerebrospinal fluid composition and functions: focus on adult humans. Exp Neurol. 2015;273:57–68.
  • Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337–341.

• A description of the recently discovered CNS lymphatic vasculature.

  • Mehdipour AR, Hamidi M. Brain drug targeting: a computational approach for overcoming blood-brain barrier. Drug Discov Today. 2009;14(21–22):1030–1036.
  • Passeleu-Le Bourdonnec C, Carrupt PA, Scherrmann JM, et al. Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research. Pharm Res. 2013;30(11):2729–2756.
  • Garberg P, Ball M, Borg N, et al. In vitro models for the blood-brain barrier. Toxicol In Vitro. 2005;19(3):299–334.
  • Thomsen LB, Burkhart A, Moos T. A triple culture model of the blood-brain barrier using porcine brain endothelial cells, astrocytes and pericytes. Plos One. 2015;10(8):e0134765.
  • Burkhart A, Thomsen LB, Thomsen MS, et al. Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties. Fluids Barriers CNS. 2015;12(1):19.
  • Parikh NU, Aalinkeel R, Reynolds JL, et al. Galectin-1 suppresses methamphetamine induced neuroinflammation in human brain microvascular endothelial cells: neuroprotective role in maintaining blood brain barrier integrity. Brain Res. 2015;1624:175–187. DOI:10.1016/j.brainres.2015.07.033.
  • Hu HH, Bian YC, Liu Y, et al. Evaluation of blood-brain barrier and blood-cerebrospinal fluid barrier permeability of 2-phenoxy-indan-1-one derivatives using in vitro cell models. Int J Pharm. 2014;460(1–2):101–107.
  • Wang Q, Rager JD, Weinstein K, et al. Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier. Int J Pharm. 2005;288(2):349–359.
  • Pastan I, Gottesman MM, Ueda K, et al. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci U S A. 1988;85(12):4486–4490.
  • Shi LZ, Li GJ, Wang S, et al. Use of Z310 cells as an in vitro blood-cerebrospinal fluid barrier model: tight junction proteins and transport properties. Toxicol In Vitro. 2008;22(1):190–199.
  • Hammarlund-Udenaes M. The use of microdialysis in CNS drug delivery studies. Pharmacokinetic perspectives and results with analgesics and antiepileptics. Adv Drug Deliv Rev. 2000;45(2–3):283–294.
  • de Lange EC, Danhof M, de Boer AG, et al. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Res Brain Res Rev. 1997;25(1):27–49.
  • Singh AB, Bousman CA, Ng CH, et al. ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression. Transl Psychiatry. 2012;2:e198.
  • Lin KM, Chiu YF, Tsai IJ, et al. ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. Pharmacogenet Genomics. 2011;21(4):163–170.
  • Yang FY, Lin YL, Chou FI, et al. Pharmacokinetics of BPA in gliomas with ultrasound induced blood-brain barrier disruption as measured by microdialysis. Plos One. 2014;9(6):e100104.
  • Gunn RN, Murthy V, Catafau AM, et al. Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1. Synapse. 2011;65(12):1319–1332.
  • Uchida H, Suzuki T. Dose and dosing frequency of long-acting injectable antipsychotics: a systematic review of PET and SPECT data and clinical implications. J Clin Psychopharmacol. 2014;34(6):728–735.
  • Strohbehn G, Coman D, Han L, et al. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. J Neurooncol. 2015;121(3):441–449.
  • Puttick S, Bell C, Dowson N, et al. PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma. Drug Discov Today. 2015;20(3):306–317.
  • Spector R, Keep RF, Robert Snodgrass S, et al. A balanced view of choroid plexus structure and function: focus on adult humans. Exp Neurol. 2015;267:78–86.
  • Lee H, Xie L, Yu M, et al. The effect of body posture on brain glymphatic transport. J Neuroscience. 2015;35(31):11034–11044.
  • Ali Khan A, Mudassir J, Mohtar N, et al. Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. Int J Nanomedicine. 2013;8:2733–2744.

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