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Expert Opinion on Drug Metabolism & Toxicology Volume 4, 2008 - Issue 9
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Drug Evaluation

Clinical development of metformin extended-release tablets for type 2 diabetes: an overview

Sherwin L Schwartz Diabetes and Glandular Diseases Clinic, San Antonio, TX, USA
, MD,
Toufigh Gordi Depomed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA +1 650 462 5900; +1 650 462 9993; [email protected]
, PhD,
Eddie Hou Depomed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA +1 650 462 5900; +1 650 462 9993; [email protected]
, PhD,
Marilou Cramer Depomed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA +1 650 462 5900; +1 650 462 9993; [email protected]
, BS,
Michelle Heritier Depomed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA +1 650 462 5900; +1 650 462 9993; [email protected]
, PhD &
Verne E Cowles Depomed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA +1 650 462 5900; +1 650 462 9993; [email protected]
, PhD
Pages 1235-1243 | Published online: 24 Aug 2008

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  • Berner B, Cowles VE. Case studies in swelling polymeric gastric retentive tablets. Expert Opin Drug Deliv 2006;3:541-8
  • Hou SY, Cowles VE, Berner B. Gastric retentive dosage forms: a review. Crit Rev Ther Drug Carrier Syst 2003;20:459-97
  • Schwartz S, Fonseca V, Berner B, et al. Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes. Diabetes Care 2006;29:759-64
  • Glumetza prescribing information. 2006. Available from: http://www.glumetzaxr.com/pdf/current_PI_PW2.pdf
  • Fujioka K, Brazg RL, Raz I, et al. Efficacy, dose-response relationship and safety of once-daily extended-release metformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemic control despite prior treatment with diet and exercise: results from two double-blind, placebo-controlled studies. Diabetes Obes Metab 2005;7:28-39
  • Lewin A, Lipetz R, Wu J, Schwartz S. Comparison of extended-release metformin in combination with a sulfonylurea (glyburide) to sulfonylurea monotherapy in adult patients with type 2 diabetes: a multicenter, double-blind, randomized, controlled, phase III study. Clin Ther 2007;29:844-55

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