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In vitro three-dimensional tumor microenvironment models for anticancer drug discovery

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Pages 1-10 | Published online: 19 Dec 2007

Bibliography

  • Roskelley CD, Srebrow A, Bissell MJ. A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr Opin Cell Biol 1995;7(5):736-47
  • Weaver VM, Lelievre S, Lakins JN, et al. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2002;2(3):205-16
  • Kim M, Datta A, Brakeman P, et al. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3β in 3D epithelial morphogenesis. J Cell Sci 2007;120(Part 14):2309-17
  • Hsu MY, Meier FE, Nesbit M, et al. E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am J Pathol 2000;156(5):1515-25
  • Berking C, Herlyn M. Human skin reconstruct models: a new application for studies of melanocyte and melanoma biology. Histol Histopathol 2001;16(2):669-74
  • Meier F, Nesbit M, Hsu MY, et al. Human melanoma progression in skin reconstructs – biological significance of bFGF. Am J Pathol 2000;156(1):193-200
  • Haass NK, Smalley KSM, et al. Adhesion, migration and communication in melanocytes and melanoma. Pigment Cell Res 2005;18(3):150-9
  • Hsu MY, Shih DT, Meier FE, et al. Adenoviral gene transfer of β3 integrin subunit induces conversion from radial to vertical growth Phase in primary human melanoma. Am J Pathol 1998;153(5):1435-42
  • Kalabis J, Patterson MJ, Enders GH, et al. Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture. FASEB J 2003;17(6):1115-17
  • Andl CD, Mizushima T, Nakagawa H, et al. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem 2003;278(3):1824-30
  • Lioni M, Brafford P, Andl C, et al. Dysregulation of claudin-7 leads to loss of e-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. Am J Pathol 2007;170(2):709-21
  • Oyama K, Okawa T, Nakagawa H, et al. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene 2007;26(16):2353-64
  • Meier F, Busch S, Lasithiotakis K, et al. Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Br J Dermatol 2007;156(6):1204-13
  • Paszek MJ, Zahir N, Johnson KR, et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 2005;8(3):241-54
  • Ghajar CM, Suresh V, Peyton SR, et al. A novel three-dimensional model to quantify metastatic melanoma invasion. Mol Cancer Ther 2007;6(2):552-61
  • Mueller-Klieser W. Tumor biology and experimental therapeutics. Crit Rev Oncol Hematol 2000;36(2-3):123-39
  • Mellor HR, Ferguson DJ, Callaghan R. A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs. Br J Cancer 2005;93(3):302-9
  • LaRue KE, Khalil M, Freyer JP. Microenvironmental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors. Cancer Res 2004;64(5):1621-31
  • Leek RD, Stratford I, Harris AL. The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway. Cancer Res 2005;65(10):4147-52
  • Smalley KS, Herlyn M. Towards the targeted therapy of melanoma. Mini Rev Med Chem 2006;6(4):387-93
  • Smalley KSM. A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 2003;104(5):527-32
  • Zhuang L, Lee CS, Scolyer RA, et al. Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma. J Clin Pathol 2005;58(11):1163-9
  • Rinehart J, Adjei AA, Lorusso PM, et al. Multicenter Phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol 2004;22(22):4456-62
  • Lorusso PM, Adjei AA, Varterasian M, et al. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J Clin Oncol 2005;23(23):5281-93
  • Desoize B, Gimonet D, Jardiller JC. Cell culture as spheroids: an approach to multicellular resistance. Anticancer Res 1998;18(6A):4147-58
  • Wartenberg M, Frey C, Diedershagen H, et al. Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids. Int J Cancer 1998;75(6):855-63
  • Tredan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 2007;99(19):1441-54
  • Smalley KSM, Haass NK, Brafford P, et al. Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 2006;1136-44
  • Smalley KS, Lioni M, Herlyn M. Life isn't flat: taking cancer biology to the next dimension. In Vitro Cell Dev Biol Anim 2006;42(8-9):242-7
  • Smalley KS, Lioni M, Herlyn M. Targeting the stromal fibroblasts: a novel approach to melanoma therapy. Expert Rev Anticancer Ther 2005;5(6):1069-78
  • Smalley KS, Herlyn M. Targeting intracellular signaling pathways as a novel strategy in melanoma therapeutics. Ann NY Acad Sci 2005;1059:16-25
  • Sethi T, Rintoul RC, Moore SM, et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 1999;5(6):662-8
  • Bao W, Stromblad S. Integrin αv-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen. J Cell Biol 2004;167(4):745-56
  • Gottfried E, Kunz-Schughart LA, Ebner S, et al. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 2006;107(5):2013-21
  • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
  • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350(23):2335-42
  • Folkins C, Man S, Xu P, et al. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res 2007;67(8):3560-4
  • Sharma A, Trivedi NR, Zimmerman MA, et al. Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res 2005;65(6):2412-21
  • Izumi Y, Xu L, di Tomaso E, et al. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature 2002;416(6878):279-80
  • Velazquez OC, Snyder R, Liu ZJ, et al. Fibroblast-dependent differentiation of human microvascular endothelial cells into capillary-like, three-dimensional networks. FASEB J 2002;16(8):1316-18

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