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The apelin peptides as putative targets in cardiovascular drug discovery and development

, PhD
Pages 51-64 | Published online: 19 Dec 2007

Bibliography

  • O'Dowd BF, Heiber M, Chan A, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 1993;136:355-60
  • Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998;251:471-6
  • Habata Y, Fuji R, Hosoya M, et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrums. Biochim Biophys Acta 1999;1452:25-35
  • Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine. Pharmacol Ther 2005;107:198-211
  • Masri B, Knibiehler B, Audigier Y. Apelin signaling: a promising pathway from cloning to pharmacology. Cell Signal 2005;17:415-26
  • Kawamata Y, Habata Y, Fukusumi S, et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta 2001;1538:162-71
  • Tatemoto K, Takayama K, Zou M, et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Reg Peptides 2001;99:87-92
  • Vickers C, Hales P, Kaushik V, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 2002;277:14838-43
  • Lee DK, Cheng R, Nguyen T, et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 2000;74:34-41
  • Matsumoto M, Hidakaidaka K, Akiho H, et al. Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain. Neurosci Lett 1996;219:119-22
  • Edinger AL, Hoffman TL, Sharron M, et al. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a co-receptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol 1998;72:7934-40
  • Hosoya M, Kawamata S, Fukusumi R, et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem 2000;275:21061-7
  • O'Carroll AM, Don ALJ, Lolait SJ. APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. J Neuroendocrinol 2003;15:1095-101
  • O'Carroll AM, Lolait SJ. Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurons of the paraventricular and supraoptic nuclei by osmotic stimuli. J Neuroendocrinol 2003;15:661-6
  • Kleinz MJ, Davenport AP. Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Reg Peptides 2004;118:119-25
  • Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Reg Peptides 2005;126:233-40
  • Katugampola SD, MacGuire JJ, Mathewson SR, Davenport AP. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 2001;132:1255-60
  • Szokodi I, Tavi P, Foldes G, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 2002;91:434-40
  • Iwanaga Y, Kihara Y, Takenaka H, Kita T. Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system. J Mol Cell Cardiol 2006;41:798-806
  • Zhang J, Ren CX, Qi YF, et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci 2006;79:1153-9
  • Ronkainen V-P, Ronkainen JJ, Hanninen SL, et al. Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. FASEB J 2007;21:1821-30
  • Alturi P, Morine KJ, Liao GP, et al. Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression. Cell Mol Biol Lett 2007;12:127-38
  • Foldes G, Horkay F, Szokodi I, et al. Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. Biochem Biophys Res Commun 2003;308:480-5
  • Chen MM, Ashley EA, Deng DXF, et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 2003;108:1432-9
  • Castan-Laurell I, Boucher J, Dray C, et al. Apelin, a novel adipokine over-produced in obesity: friend or foe? Mol Cell Endocrinol 2005;245:7-9
  • Boucher J, Masri B, Daviaud D, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 2005;146:1764-71
  • Heinonen MV, Purhonen AK, Miettinen P, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Reg Peptides 2005;130:7-13
  • Garcia-Diaz D, Campion J, Milagro FI, Martinez JA. Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers. Mol Cell Biochem 2007;305:87-94
  • Higuchi K, Masaki T, Gotoh K, et al. Apelin, an APJ receptor lgand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Endocrinology 2007;148:2690-7
  • Masri B, Lahlou H, Mazarguil H, et al. Apelin (65 – 77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Biochem Biophys Res Commun 2002;290:539-45
  • Jia YX, Lu ZF, Zhang J, et al. Apelin activates L-arginine/nitric oxides synthase/nitric oxide pathways in rat aortas. Peptides 2007;28:2023-9
  • Zhong JC, Yu XY, Huang Y, et al. Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovasc Res 2007;74:388-95
  • Hashimoto T, Kihara M, Ishida J, et al. Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2006;26:1267-72
  • Masri B, Morin N, Cornu M, et al. Apelin (65 – 77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J 2004;18:1909-11
  • Masri B, Morin N, Pedebernade L, et al. The apelin receptor is coupled to gi1 or gi2 protein and is differentially desensitized by apelin fragments. J Biol Chem 2006;281:18317-26
  • Kasai A, Shintani N, Oda M, et al. Apelin is a novel angiogenic factor in retinal endothelial cells. Biochem Biophys Res Commun 2004;325:395-400
  • Farfasfalvi K, Stagg MA, Coppen SR, et al. Direct effects of apelin on cardiomyocytes contractility and electrophysiology. Biochem Biophys Res Commun 2007;357:889-95
  • Simpkin JC, Yellon DM, Davidson SM, et al. Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia reperfusion injury. Basic Res Cardiol 2007;102:518-28
  • El Messari S, Iturrioz X, Fassot C, et al. Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. J Neurochem 2004;90:1290-301
  • Cheng X, Cheng XS, Pang CCY. Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. Eur J Pharmacol 2003;470:171-5
  • Kagiyama S, Fukuhara M, Matsumura K, et al. Central and peripheral cardiovascular actions of apelin in conscious rats. Reg Peptides 2005;125:55-9
  • Charles CJ, Rademaker MT, Richards AM. Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep. J Endocrinol 2006;189:701-10
  • King AJ, Pfeffer JM, Pfeffer MA, Brenner BM. Systemic hemodynamic effects of endothelin in rats. Am J Physiol 1990;258:H787-H92
  • Rohmeiss P, Photiadis J, Rohmeiss S, Unger T. Hemodynamic actions of intravenous endothelin in rats: comparison with sodium nitroprusside and methoxamine. Am J Physiol 1990;258:H337-H346
  • Gardiner SM, March JE, Kemp PA, Bennet T. Bolus injection of human urotensin II in conscious rats evoke a biphasic haemodynamic response. Br J Pharmacol 2004;143:422-30
  • Lee DK, Saldivia VR, Nguyen T, et al. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology 2005;146:231-6
  • Graser T, Vanhoute PM. Hypoxic contraction of canine coronary arteries: role of endothelium and cGMP. Am J Physiol 1991;261:H1769-H77
  • Rastaldo R, Pagliaro P, Cappello S, et al. Nitric oxide and cardiac function. Life Sci 2007;81:779-93
  • Dai T, Ramirez-Correa G, Gao WD. Apelin increases contractility in failing cardiac muscles. Eur J Pharmacol 2006;553:222-8
  • Berry MF, Pirolli TJ, Jayasankar V, et al. Apelin has in vivo inotropic effects on normal and failing hearts. Circulation 2004;110:187-93
  • Ashley EA, Powers J, Chen M, et al. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res 2005;65:73-82
  • Seyedabadi M, Goodchild AK, Pilowski PM. Site-specific effects of apelin-13 in the rat medulla oblongata on arterial pressure and respiration. Autonomic NeuroSci Basic Clin 2002;101:32-8
  • Taheri S, Murphy K, Cohen M, et al. The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochem Biophys Res Commun 2002;291:1208-12
  • Reaux A, De Mota N, Skultetyova I, et al. Physiological role of a novel neuropeptide, apelin, and its receptor in the brain. J Neurochem 2001;77:1085-96
  • De Mota N, Reaux-Le Goazigo A, El Messari S, et al. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Nat Acad Sci USA 2004;101:10464-9
  • Jaszeberenyi M, Bujdoso E, Telegdy G. Behavioural, neuroendocrine and thermoregulatory actions of apelin-13. Neuroscience 2004;129:811-16
  • Reaux-Le Goazigo A, Alvear-Perez R, Zizzari P, et al. Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release. Am J Physiol 2007;292:E7-E15
  • Kuba K, Zhang L, Imai Y, et al. Impaired heart contractility in apelin gene-deficient mice associated with aging and pressure overload. Circ Res 2007;101:E32-E42
  • Ishida J, Hashimoto T, Hashimoto Y, et al. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem 2004;279:26274-9
  • Hashimoto T, Kihura M, Imai N, et al. Requirement of apelin–apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 2007;171:1705-12
  • Jia Y-X, Pan C-S, Zhang J et al. Apelin protects myocardial injury induced by isoproterenol in rats. Reg Peptides 2006;133:147-54
  • Ellinor PT, Low AF, MacRae CA. Reduced apelin levels in lone atrial fibrillation. Eur Heart J 2006;27:222-6
  • Goetze JP, Rehfeld JF, Carlsen J, et al. Apelin: a new plasma marker of cardiopulmonary disease. Reg Peptides 2006;133:134-8
  • Chong KS, Gardiner RS, Morton JJ, et al. Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Eur J Heart Failure 2006;8:355-60
  • Francia P, Salvati A, Balla C, et al. Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin. Eur J Heart Failure 2007;9:306-9
  • Van Kimmenade RR, Januzzi JL, Ellinor PT, et al. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3 and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 2006;48:1217-24
  • Wikipedia. Apelin. Available from: URL: http://en.wikipedia.org/wiki/Apelin [last accessed 27 November, 2007].
  • Charles CJ. Putative role for apelin in pressure/volume homeostasis and cardiovascular disease. Cardiovasc Hematol Agents Med Chem 2007;5:1-24

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