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Review

The role of exhaled nitric oxide and exhaled breath condensates in evaluating airway inflammation in asthma

, PhD & , BMed PhD FRACP
Pages 607-620 | Published online: 04 Jun 2008

Bibliography

  • Simpson JL, Scott R, Boyle M, et al. Infl ammatory subtypes in asthma: assessment and identifi cation using induced sputum. Respirology 2006;11:54-61
  • Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002;30:1715-21
  • Brightling CE, McKenna S, Hargadon B, et al. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax 2005;60:193-8
  • Gibson PG, Fujimura M, Niimi A. Eosinophilic bronchitis: clinical manifestations and implications of treatment. Thorax 2002;57:178-82
  • Brightling CE, Symon FA, Birring SS, et al. Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax 2003;58:528-32
  • Jayaram L, Pizzichini MM, Cook RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J 2006;27:483-94
  • Gustafsson LE, Leone AM, Persson MG, et al. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991;181:852-7
  • Lane C, Knight DA, Burgess S, et al. Epithelial inducible nitric oxide synthetase activity is the major determinant of nitric oxide concentration in exhaled breath. Thorax 2004;196:340-4
  • Jatakonen A, Lim S, Kharitonov S, et al. Correlation between exhaled nitric oxide, sputum eosinophils and methacholine responsiveness in patients with mild asthma. Thorax 1998;53:91-5
  • Yates DH, Kharitonov S, Thomas PS, et al. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 1996;1995(152):892-6
  • Massaro AF, Gaston B, Kita D, et al. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995;152:800-3
  • Kharitonov S, Yates DH, Robbins RA, et al. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5
  • Lundberg JO, Nordvall SL, Weitzberg E, et al. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child 1996;75:323-6
  • Byrnes CA, Dinarevic S, Shinebourne EA, et al. Exhaled nitric oxide measurements in normal and asthmatic children. Paediatr Pulmonol 1997;24:312-8
  • Franklin P, Turner SW, Le Souef PN, et al. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children. Thorax 2003;58:1048-52
  • Kharitonov S, Yates DH, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995;8:295-7
  • Maziak W, Loukides S, Culpitt S, et al. Exhaled nitric oxide in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:998-1002
  • Ferreira IM, Hazari MS, Gutierrez C, et al. Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease: effects of inhaled beclomethasone. Am J Respir Crit Care Med 2001;164:1012-5
  • Ho LP, Innes JA, Greening AP. Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis. Eur Respir J 1998;12:1290-4
  • Tsang KW, Leung R, Fung PC, et al. Exhaled and sputum nitric oxide in bronchiectasis: correlation with clinical parameters. Chest 2002;121:88-94
  • Rolla G, Brussino L, Bertero MT, et al. Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus. J Rheumatol 1997;24:1066-71
  • Soderman C, Leone A, Furst V, et al. Endogenous nitric oxide in exhaled air from patients with liver cirrhosis. Scand J Gastroenterol 1997;32:591-7
  • Silkoff PE, Caramori M, Tremblay L, et al. Exhaled nitric oxide in human lung transplantation: a noninvasive marker of acute rejection. Am J Respir Crit Care Med 1998;157:1822-8
  • Gabbay E, Walters EH, Orsida B, et al. Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase. Am J Respir Crit Care Med 2000;162:2182-7
  • Riley MS, Porszasz J, Miranda J, et al. Exhaled nitric oxide during exercise in primary pulmonary hypertension and pulmonary fibrosis. Chest 1997;111:44-50
  • Loveless MO, Phillips CR, Giraud GD, et al. Decreased exhaled nitric oxide in subjects with HIV infection. Thorax 1997;52:185-6
  • Taylor DR, Pijnenburg MW, Smith AD, et al. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax 2006;61(9):817-27
  • American Thoracic Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005;172:912-30
  • Travers J, Marsh S, Aldington S, et al. Reference ranges for exhaled nitric oxide derived from a random community survey of adults. Am J Respir Crit Care Med 2007;176:238-42
  • Olin AC, Rosengren A, Thelle DS, et al. Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample. Chest 2006;130:1319-25
  • Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Chest 2008;133:169-75
  • Malmberg LP, Petäys T, Haahtela T, et al. Exhaled nitric oxide in healthy nonatopic school-age children: determinants and height-adjusted reference values. Pediatric Pulmonol 2006;41:635-42
  • Berlyne GS, Parameswaran K, Kamada D, et al. A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation. J Allergy Clin Immunol 2000;106:638-44
  • Payne DN, Adcock I, Wilson NM, et al. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisone. Am J Respir Crit Care Med 2001;164:1376-81
  • Fabbri LM, Romagnoli M, Corbetta L, et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;167:418-24
  • Berry MA, Shaw DE, Green RH, et al. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation an observational study in adults with asthma. Clin Exp Allergy 2005;35:1175-9
  • Prescott GW, Khashayar R, Lazarus SC, et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 2001;108:753-8
  • Douwes J, Gibson P, Pekkanen J, et al. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002;57:643-8
  • Jatakanon A, Lim S, Kharitonov SA, et al. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 1998;53:91-5
  • Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest 2003;123:751-6
  • Smith AD, Cowan JO, Filsell S, et al. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med 2004;169(4):473-8
  • Fortuna AM, Feixas T, Gonzalez M, et al. Diagnostic utility of inflammatory biomarkers in asthma: exhaled nitric oxide and induced sputum eosinophil count. Respir Med 2007;101:2416-21
  • Malmberg LP, Pelkonen AS, Haahtela T, et al. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax 2003;58:494-9
  • Brussee JE, Smit HA, Kerkhof M, et al. Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy. Eur Respir J 2005;25(3):455-61
  • Olin AC, Alving K, Toren K. Exhaled nitric oxide: relation to sensitisation and respiratory symptoms. Clin Exp Allergy 2004;34:221-6
  • Buchvald F, Baraldi E, Carrao S, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005;115:1130-6
  • Smith AD, Cowan JO, Brassett KP, et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005;352(21):2163-73
  • Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med 2007;176(3):231-7
  • Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005;171(10):1077-82
  • Pijnenburg MW, Hofhuis W, Hop WC, et al. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005;60(3):215-8
  • Pijnenburg MW, Bakker EM, Hop WC, et al. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am J Respir Crit Care Med 2005;172(7):831-6
  • Formanek WID, Lauener RP, Wildhaber JH, et al. Elevated nitrite in breath condensates of children with respiratory disease. Eur Respir J 2002;19:487-91
  • Effors RM, Biller J, Foss B, et al. A simple method for estimating respiratory solute dilutino in exhaled breath condensates. Am J Respir Crit Care Med 2003;168:1500-5
  • Debley JS, Hallstrand TS, Monge T, et al. Methods to improve measurement of cysteinyl leukotrienes in exhaled breath condensate from subjects with asthma and healthy controls. J Allergy Clin Immunol 2007;120(5):1216-7
  • Griese M, Noss J, von Bredow C. Protein pattern of exhaled breath condensate and saliva. Proteomics 2002;2:690-6
  • Simpson JL, Timmins NL, Fakes K, et al. Effect of salivary contamination on induced sputum cell counts, IL-8 and eosinophil cationic protein levels. Eur Respir J 2004;23:759-62
  • Gaber F, Acevedo F, Delin I, et al. Saliva is one likely source of leukotriene B4 in exhaled breath condensate. Eur Respir J 2006;28:1229-35
  • Simpson JL, Wood LG, Gibson PG. Inflammatory mediators in exhaled breath, induced sputum and saliva. Clin Exp Allergy 2005;35:1180-5
  • Rosias PPR, Robroeks CMH, Niemarkt HJ, et al. The coating of condenser systems influences the detection of 8-isoprostane in exhaled breath condensate (EBC). Eur Respir J 2004;24:P2930
  • Tufvesson E, Bjermer L. Methodological improvements for measuring eicosanoids and cytokines in exhaled breath condensate. Respir Med 2006;100(1):34-8
  • Prieto L, Ferrer A, Palop J, et al. Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices. Respir Med 2007;101:1715-20
  • Liu J, Conrad DH, Chow S, et al. Collection devices influence the constituents of exhaled breath condensate. Eur Respir J 2007;30:807-8
  • Van Hoydonck PG, Wuyts WA, Vanaudenaerde BM, et al. Quantitative analysis of 8-isoprostane and hydrogen peroxide in exhaled breath condensate. Eur Respir J 2004;23:189-92
  • Jobsis Q, Raatgeep HC, Schellekens SL, et al. Hydrogen peroxide in exhaled air of healthy children: reference values. Eur Respir J 1998;12:483-5
  • Schleiss MB, Holz O, Behnke M, et al. The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate. Eur Respir J 2000;16:1115-8
  • Zacharasiewicz A, Wilson N, Lex C, et al. Repeatability of sodium and chloride in exhaled breath condensates. Pediatr Pulmonol 2004;37:273-5
  • Hunt JF, Fang K, Malik R, et al. Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 2000;161:694-9
  • Kostikas K, Papatheodorou G, Ganas K, et al. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 2002;165:1364-70
  • Carpagnano GE, Barnes PJ, Francis J, et al. Breath condensate pH in children with cystic fibrosis and asthma. Chest 2004;125:2005-10
  • Vaughan J, Ngamtrakulpanit L, Pajewski TN, et al. Exhaled breath condensate pH is a robust and reproducible assay of airway acidity. Eur Respir J 2003;22:889-94
  • Borrill Z, Starkey C, Vestbo J, et al. Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease. Eur Respir J 2005;25:269-74
  • Fireman E, Shtark M, Priel IE, et al. Hydrogen peroxide in exhaled breath condensate (EBC) vs eosinophil count in induced sputum (IS) in parenchymal vs airways lung diseases. Inflammation 2007;30:44-51
  • Jackson AS, Sandrini A, Campbell C, et al. Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage. Am J Respir Crit Care Med 2007;175:222-7
  • Piotrowski WJ, Antczak A, Marczak J, et al. Eicosanoids in exhaled breath condensate and BAL fluid of patients with sarcoidosis. Chest 2007;132:589-96
  • Corradi M, Pignatti P, Manini P, et al. Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation. Eur Respir J 2004;24:1011-7
  • Loukides S, Bouros D, Papatheodorou G, et al. The relationships among hydrogen peroxide in expired breath condensate, airway inflammation and asthma severity. Chest 2002;121:338-46
  • Ganas K, Loukides S, Papatheodorou G, et al. Total nitrite/nitrate in expired breath condensate in patients with asthma. Respir Med 2001;95:649-54
  • Emelyanov A, Fedoseev G, Abulimity A, et al. Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001;120:1136-9
  • Antczak A, Kurmanowska Z, Kasielski M, et al. Inhaled glucocorticoids decrease hydrogen peroxide level in expired air condensate in asthmatic patients. Respir Med 2000;94:416-21
  • Antczak A, Nowak D, Shariati B, et al. Increased hydrogen peroxide and thiobabituric acid-reactive products in expired breath condensate of asthmatic patients. Eur Respir J 1997;10:1235-41
  • Dohlman AW, Black HR, Royall JA. Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma. Am Rev Respir Dis 1993;148:955-60
  • Jobsis Q, Raatgeep HC, Hermans PW, et al. Hydrogen peroxide in exhaled air is increased in stable asthmatic children. Eur Respir J 1997;10:519-21
  • Zanconato S, Carraro S, Corradi M, et al. Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma. J Allergy Clin Immunol 2004;113:257-63
  • Zhang X, Moilanen E, Kankaanranta H. Beclomethasone, budesonide and fluticasone propionate inhibit neutrophil apoptosis. Eur J Pharmacol 2001;431:365-71
  • Baraldi E, Carraro S, Alinovi R, et al. Cysteinyl leukotriens and 8-isoprostanes in exhaled breath condensate of children with asthma exacerbations. Thorax 2003;58:505-9
  • Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol 2002;109:615-20
  • Montuschi PCM, Ciabattoni G, Nightingale J, et al. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med 1999;160:216-20
  • Hanazawa T, Kharitonov SA, Barnes PJ. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med 2000;162:1273-6
  • Csoma Z, Kharitonov SA, Balint B, et al. Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med 2002;166:1345-9
  • Kostikas K, Gaga M, Papatheodorou G, et al. Leukotriene B4 in exhaled breaeth condensate and sputum supernatant in patients with COPD and asthma. Chest 2005;127:1553-9
  • Cap P, Chladek J, Pehal F, et al. Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients. Thorax 2004;59:465-70
  • Carraro S, Corradi M, Zanconato S, et al. Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise induced bronchoconstriction. J Allergy Clin Immunol 2005;115:764-70
  • Baraldi E, Ghiro L, Piovan V, et al. Increased exhaled 8-isoprostane in childhood asthma. Chest 2003;124:25-31
  • Mondino C, Ciabattoni G, Koch M, et al. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J Allergy Clin Immunol 2004;114:761-7
  • Horvath I, Donnelly LE, Kiss A, et al. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998;158:1042-6
  • Sandrini A, Ferreira IM, Gutierrez C, et al. Effect of montelukast on exhaled nitric oxide and nonvolatile markers of inflammation in mild asthma. Chest 2003;124:1334-40
  • Emelyanov A, Fedoseev G, Krasnoschekova O, et al. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J 2002;20:596-600
  • Horvath I, Donnelly LE, Kiss A, et al. Exhaled nitric oxide and hydrogen peroxide concentrations in asthmatic smokers. Respiration 2004;71:463-8
  • Niimi A, Nguyen LT, Usmani O, et al. Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax 2004;59:608-12
  • Carraro S, Folesani G, Carradi M, et al. Acid-base equilibrium in exhaled breath condensate of allergic asthmatic children. Allergy 2005;60:476-81
  • Rosias PPR, Dompeling E, Dentener MA, et al. Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests. Pediatr Pulmonol 2004;38:107-14
  • Ojoo JC, Mulrennan SA, Kastelik JA, et al. Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis. Thorax 2005;60:22-6
  • Robroeks CM, Jöbsis Q, Damoiseaux JG, et al. Cytokines in exhaled breath condensate of children with asthma and cystic fibrosis. Ann Allergy Asthma Immunol 2006;96:349-55
  • Leung TF, Wong GW, Ko FW, et al. Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Int Arch Allergy Immunol 2005;137:66-72
  • Carpagnano GE, Foschino Barbaro MP, Cagnazzo M, et al. Use of exhaled breath condensate in the study of airway inflammation after hypertonic saline solution challenge. Chest 2005;128:3159-66
  • Ko FW, Lau CY, Leung TF, et al. Exhaled breath condensate levels of eotaxin and macrophage-derived chemokine in stable adult asthma patients. Clin Exp Allergy 2006;36:44-51
  • Profita M, La Grutta S, Carpagnano E, et al. Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. J Allergy Clin Immunol 2006;118:1068-74
  • Shahid SK, Kharitonov SA, Wilson NM, et al. Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. Am J Respir Crit Care Med 2002;165:1290-3
  • Matsunaga K, Yanagisawa S, Ichikawa T, et al. Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients. J Allergy Clin Immunol 2006;118:84-90
  • Soyer OU, Dizdar EA, Keskin O, et al. Comparison of two methods for exhaled breath condensate collection. Allergy 2006;61:1016-8
  • Horvath I, Hunt J, Barnes PJ. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523-48
  • Goldoni M, Caglieri A, Andreoli R, et al. Influence of condensation temperature on selected exhaled breath parameters. BMC Pulm Med 2005;5:10
  • Wood LG, Timmins NL, Simpson JL, et al. Optimising exhaled breath condensate collection. Am J Respir Crit Care Med 2007;174:A684
  • Davidson A, Naidu Sjosward K, Lundman L, et al. Quantitative assessment and repeatability of chorine in exhaled breath condensate. Respiration 2005;72:529-36

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