232
Views
26
CrossRef citations to date
0
Altmetric
Reviews

Novel biomarkers for bipolar disorder

, , , , &
Pages 147-159 | Published online: 16 Dec 2012

Bibliography

  • Novick DM, Swartz HA, Frank E. Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 2010;12(1):1-9
  • Dutta R, Boydell J, Kennedy N, Suicide and other causes of mortality in bipolar disorder: a longitudinal study. Psychol Med 2007;37(6):839-47
  • Fajutrao L, Locklear J, Priaulx J, A systematic review of the evidence of the burden of bipolar disorder in Europe. Clin Pract Epidemiol Ment Health 2009;23(5-3):1-8
  • Bertram L, Hampel H. The role of genetics for biomarker development in neurodegeneration. Prog Neurobiol 2011;95(4):501-4
  • Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci 2005;6(8):603-14
  • Teixeira AL, Barbosa IG, Diniz BS, Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function. Biomark Med 2010;4(6):871-87
  • Klein AB, Williamson R, Santini MA, Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 2011;14(3):347-53
  • Yasutake C, Kuroda K, Yanagawa T, Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. Eur Arch Psychiatry Clin Neurosci 2006;256(7):402-6
  • Shirayama Y, Chen AC, Nakagawa S, Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 2002;22(8):3251-61
  • Jornada LK, Moretti M, Valvassori SS, Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain. J Psychiatr Res 2010;44(8):506-10
  • Frey BN, Andreazza AC, Cereser KM, Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life Sci 2006;79(3):281-6
  • Fernandes BS, Gama CS, Cereser KM, Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J Psychiatr Res 2011;45(8):995-1004
  • Lin PY. State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study. Neurosci Lett 2009;466(3):139-43
  • Barbosa IG, Huguet RB, Mendonca VA, Increased plasma levels of brain-derived neurotrophic factor in patients with long-term bipolar disorder. Neurosci Lett 2010;475(2):95-8
  • Reis HJ, Nicolato R, Barbosa IG, Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia. Neurosci Lett 2008;439(2):157-9
  • Barbosa IG, Huguet RB, Neves FS, Impaired nerve growth factor homeostasis in patients with bipolar disorder. World J Biol Psychiatry 2011;12(3):228-32
  • Nockher WA, Renz H. Neurotrophins in clinical diagnostic: pathophysioplogy and laboratory investigation. Clin Chim Acta 2005;352:49-74
  • Fernandes BS, Gama CS, Walz JC, Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. J Psychiatr Res 2010;44(9):561-5
  • Walz JC, Andreazza AC, Frey BN, Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder. Neurosci Lett 2007;415(1):87-9
  • Kapczinski F, Dal-Pizzol F, Teixeira AL, Peripheral biomarkers and illness activity in bipolar disorder. J Psychiatr Res 2011;45(2):156-61
  • Walz JC, Magalhaes PV, Giglio LM, Increased serum neurotrophin-4/5 levels in bipolar disorder. J Psychiatr Res 2009;43(7):721-3
  • Miller CA. Stressed and depressed? Check your GDNF for epigenetic repression. Neuron 2011;69(2):188-90
  • Barbosa IG, Huguet RB, Sousa LP, Circulating levels of GDNF in bipolar disorder. Neurosci Lett 2011;502(2):103-6
  • Rosa AR, Frey BN, Andreazza AC, Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder. Neurosci Lett 2006;407(2):146-50
  • Zhang X, Zhang Z, Sha W, Effect of treatment on serum glial cell line-derived neurotrophic factor in bipolar patients. J Affect Disord 2010;126(1-2):326-9
  • Takebayashi M, Hisaoka K, Nishida A, Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders. Int J Neuropsychopharmacol 2006;9(5):607-12
  • Berk M, Kapczinski F, Andreazza AC, Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 2011;35(3):804-17
  • Kapczinski F, Dal-Pizzol F, Teixeira AL, A systemic toxicity index developed to assess peripheral changes in mood episodes. Mol Psychiatry 2010;15(8):784-6
  • Hope S, Dieset I, Agartz I, Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. J Psychiatr Res 2011;45(12):1608-16
  • Ortiz-Dominguez A, Hernandez ME, Berlanga C, Immune variations in bipolar disorder: phasic differences. Bipolar Disord 2007;9(6):596-602
  • O'Brien SM, Scully P, Scott LV, Cytokine profiles in bipolar affective disorder: focus on acutely ill patients. J Affect Disord 2006;90(2-3):263-7
  • Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009;65(9):732-41
  • Barbosa IG, Rocha NP, Huguet RB, Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. J Affect Disord 2012;137(1-3):151-5
  • Barbosa IG, Huguet RB, Mendonca VA, Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder. Eur Arch Psychiatry Clin Neurosci 2011;261(2):139-43
  • Kauer-Sant'anna M, Kapczinski F, Andreazza AC, Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. Int J Neuropsychopharmacol 2008;4:1-12
  • Brietzke E, Stertz L, Fernandes BS, Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. J Affect Disord 2009;116(3):214-17
  • Soderlund J, Olsson SK, Samuelsson M, Elevation of cerebrospinal fluid interleukin-1ß in bipolar disorder. J Psychiatry Neurosci 2011;36(2):114-18
  • Hope S, Melle I, Aukrust P, Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor. Bipolar Disord 2009;11(7):726-34
  • Lee BH, Kim YK. Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders. J Affect Disord 2012;136(1-2):181-4
  • Brietzke E, Kauer-Sant'Anna M, Teixeira AL, Abnormalities in serum chemokine levels in euthymic patients with bipolar disorder. Brain Behav Immun 2009;23(8):1079-82
  • Barbosa IG, Rocha NP, Bauer ME, Chemokines in bipolar disorder: trait or state? Eur Arch Psychiatry Clin Neurosci 2012; In press
  • Barbosa IG, Rocha NP, de Miranda AS, Increased levels of adipokines in bipolar disorder. J Psychiatr Res 2012;46(3):389-93
  • Elmslie JL, Porter RJ, Joyce PR, Comparison of insulin resistance, metabolic syndrome and adiponectin in overweight bipolar patients taking sodium valproate and controls. Aust N Z J Psychiatry 2009;43(1):53-60
  • Sourlingas TG, Issidorides MR, Havaki S, Peripheral blood lymphocytes of bipolar affective patients have a histone synthetic profile indicative of an active cell state. Prog Neuropsychopharmacol Biol Psychiatry 1998;22(1):81-96
  • Abeer A, El-Sayed A, Ramy HA. Immunological changes in patients with mania: changes in cell mediated immunity in a sample from Egyptian patients. Egypt J Immunol 2006;13(1):79-85
  • Darko DF, Rose J, Gillin JC, Neutrophilia and lymphopenia in major mood disorders. Psychiatry Res 1988;25(3):243-51
  • McAdams C, Leonard BE. Neutrophil and monocyte phagocytosis in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 1993;17(6):971-84
  • Drexhage RC, Hoogenboezem TH, Versnel MA, The activation of monocyte and T cell networks in patients with bipolar disorder. Brain Behav Immun 2011;25(6):1206-13
  • Torres KC, Souza BR, Miranda DM, The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(2):214-19
  • Knijff EM, Breunis MN, Kupka RW, An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment. Bipolar Disord 2007;9(7):743-53
  • Padmos RC, Hillegers MH, Knijff EM, A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry 2008;65(4):395-407
  • Smith RS. The macrophage theory of depression. Med Hypotheses 1991;35(4):298-306
  • Padmos RC, Van Baal GC, Vonk R, Genetic and environmental influences on pro-inflammatory monocytes in bipolar disorder: a twin study. Arch Gen Psychiatry 2009;66(9):957-65
  • Breunis MN, Kupka RW, Nolen WA, High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder. Biol Psychiatry 2003;53(2):157-65
  • Rapaport MH. Immune parameters in euthymic bipolar patients and normal volunteers. J Affect Disord 1994;32:149-56
  • Sakaguchi S, Ono M, Setoguchi R, Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27
  • Eaton WW, Pedersen MG, Nielsen PR, Mortensen PB. Autoimmune diseases, bipolar disorder, and non-affective psychosis. Bipolar Disord 2010;12(6):638-46
  • Daban C, Vieta E, Mackin P, Young AH. Hypothalamic-pituitary-adrenal axis and bipolar disorder. Psychiatr Clin North Am 2005;28(2):469-80
  • Schmider J, Lammers CH, Gotthardt U, Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biol Psychiatry 1995;38(12):797-802
  • Watson S, Gallagher P, Ritchie JC, Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder. Br J Psychiatry 2004;184:496-502
  • Havermans R, Nicolson NA, Berkhof J, deVries MW. Patterns of salivary cortisol secretion and responses to daily events in patients with remitted bipolar disorder. Psychoneuroendocrinology 2011;36(2):258-65
  • Vieta E, Gasto C, Martinez de Osaba MJ, Prediction of depressive relapse in remitted bipolar patients using corticotrophin-releasing hormone challenge test. Acta Psychiatr Scand 1997;95(3):205-11
  • Vieta E, Martinez-De-Osaba MJ, Colom F, Enhanced corticotropin response to corticotropin-releasing hormone as a predictor of mania in euthymic bipolar patients. Psychol Med 1999;29(4):971-8
  • Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS. Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder? J Affect Disord 2011;132(1-2):265-9
  • Lewy AJ, Wehr TA, Goodwin FK, Manic-depressive patients may be supersensitive to light. Lancet 1981;1(8216):383-4
  • Lam RW, Berkowitz AL, Berga SL, Melatonin suppression in bipolar and unipolar mood disorders. Psychiatry Res 1990;33(2):129-34
  • Nurnberger JI Jr, Adkins S, Lahiri DK, Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch Gen Psychiatry 2000;57(6):572-9
  • Calabrese JR, Guelfi JD, Perdrizet-Chevallier C. Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. Bipolar Disord 2007;9(6):628-35
  • Livianos L, Sierra P, Arques S, Is melatonin an adjunctive stabilizer? Psychiatry Clin Neurosci 2012;66(1):82-3
  • Amsterdam JD, Winokur A, Lucki I, A neuroendocrine test battery in bipolar patients and healthy subjects. Arch Gen Psychiatry 1983;40(5):515-21
  • Extein I, Pottash AL, Gold MS, The thyroid-stimulating hormone response to thyrotropin-releasing hormone in mania and bipolar depression. Psychiatry Res 1980;2(2):199-204
  • Andreazza AC, Cassini C, Rosa AR, Serum S100B and antioxidant enzymes in bipolar patients. J Psychiatr Res 2007;41(6):523-9
  • Andreazza AC, Frey BN, Erdtmann B, DNA damage in bipolar disorder. Psychiatry Res 2007;153(1):27-32
  • Kunz M, Gama CS, Andreazza AC, Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2008;32(7):1677-81
  • Hoekstra R, Fekkes D, Pepplinkhuizen L, Nitric oxide and neopterin in bipolar affective disorder. Neuropsychobiology 2006;54(1):75-81
  • Savas HA, Gergerlioglu HS, Armutcu F, Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: impact of past episodes. World J Biol Psychiatry 2006;7(1):51-5
  • Elvsashagen T, Vera E, Boen E, The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder. J Affect Disord 2011;135(1-3):43-50
  • Machado-Vieira R, Andreazza AC, Viale CI, Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci Lett 2007;421(1):33-6
  • Khairova R, Pawar R, Salvadore G, Effects of lithium on oxidative stress parameters in healthy subjects. Mol Med Report 2012;5(3):680-2
  • Kempton MJ, Geddes JR, Ettinger U, Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder. Arch Gen Psychiatry 2008;65(9):1017-32
  • Drevets WC, Price JL, Simpson JR Jr, Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997;386(6627):824-7
  • Hirayasu Y, Shenton ME, Salisbury DF, Subgenual cingulate cortex volume in first-episode psychosis. Am J Psychiatry 1999;156(7):1091-3
  • Sharma V, Menon R, Carr TJ, An MRI study of subgenual prefrontal cortex in patients with familial and non-familial bipolar I disorder. J Affect Disord 2003;77(2):167-71
  • Brambilla P, Glahn DC, Balestrieri M, Soares JC. Magnetic resonance findings in bipolar disorder. Psychiatr Clin North Am 2005;28(2):443-67
  • Konarski JZ, McIntyre RS, Soczynska JK, Kennedy SH. Neuroimaging approaches in mood disorders: technique and clinical implications. Ann Clin Psychiatry 2007;19(4):265-77
  • Lyoo IK, Sung YH, Dager SR, Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord 2006;8(1):65-74
  • Moore GJ, Bebchuk JM, Wilds IB, Lithium-induced increase in human brain grey matter. Lancet 2000;356(9237):1241-2
  • Haznedar MM, Roversi F, Pallanti S, Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry 2005;57(7):733-42
  • Adler CM, Adams J, DelBello MP, Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am J Psychiatry 2006;163(2):322-4
  • Drevets WC, Price JL, Bardgett ME, Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacol Biochem Behav 2002;71(3):431-47
  • Silverstone PH, McGrath BM, Kim H. Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar Disord 2005;7(1):1-10
  • Winsberg ME, Sachs N, Tate DL, Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biol Psychiatry 2000;47(6):475-81
  • Yildiz-Yesiloglu A, Ankerst DP. Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Res 2006;147(1):1-25
  • Quiroz JA, Gray NA, Kato T, Manji HK. Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 2008;33(11):2551-65
  • Phillips ML, Travis MJ, Fagiolini A, Kupfer DJ. Medication effects in neuroimaging studies of bipolar disorder. Am J Psychiatry 2008;165(3):313-20
  • Houenou J, Frommberger J, Carde S, Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses. J Affect Disord 2011;132(3):344-55
  • Chen CH, Suckling J, Lennox BR, A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord 2011;13(1):1-15
  • Houenou J, d'Albis MA, Vederine FE, Neuroimaging biomarkers in bipolar disorder. Front Biosci (Elite Ed) 2012;4:593-606
  • Brooks JO III, Wang PW, Bonner JC, Decreased prefrontal, anterior cingulate, insula, and ventral striatal metabolism in medication-free depressed outpatients with bipolar disorder. J Psychiatr Res 2009;43:181-8
  • Strakowski S, Delbello M, Adler C. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 2005;10:105-16
  • Bearden CE, Woogen M, Glahn DC. Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder. Curr Psychiatry Rep 2010;12(6):499-504
  • Blumberg HP, Stern E, Martinez D, Increased anterior cingulate and caudate activity in bipolar mania. Biol Psychiatry 2000;48(11):1045-52
  • Kempton M, Haldane M, Jogia J, Dissociable brain structural changes associated with predisposition, resilience, and disease expression in bipolar disorder. J Neurosci 2009;29:10863-8
  • Gonul AS, Coburn K, Kula M. Cerebral blood flow, metabolic, receptor, and transporter changes in bipolar disorder: the role of PET and SPECT studies. Int Rev Psychiatry 2009;21(4):323-35
  • O'Bryant SE, Xiao G, Barber R, Texas Alzheimer's Research Consortium. A serum protein-based algorithm for the detection of Alzheimer disease. Arch Neurol 2010;67:1077-81
  • Papakostas GI, Shelton RC, Kinrys G, Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a Pilot and Replication Study. Mol Psychiatry 2011; [Epub ahead of print]
  • Guloksuz S, Cetin EA, Cetin T, Cytokine levels in euthymic bipolar patients. J Affect Disord 2010;126(3):458-62
  • Kunz M, Cereser KM, Goi PD, Serum levels of IL-6, IL-10 and TNF-alpha in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance. Rev Bras Psiquiatr 2011;33(3):268-74
  • Hung YJ, Hsieh CH, Chen YJ, Insulin sensitivity, proinflammatory markers and adiponectin in young males with different subtypes of depressive disorder. Clin Endocrinol (Oxf) 2007;67(5):784-9
  • Tsai SY, Chung KH, Wu JY, Inflammatory markers and their relationships with leptin and insulin from acute mania to full remission in bipolar disorder. J Affect Disord 2012;136(1-2):110-16
  • Maes M, Bosmans E, Calabrese J, Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers. J Psychiatr Res 1995;29(2):141-52
  • Kim YK, Myint AM, Lee BH, T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients. Psychiatry Res 2004;129(3):267-72
  • Gergerlioglu HS, Savas HA, Celik A, Atypical antipsychotic usage-related higher serum leptin levels and disabled lipid profiles in euthymic bipolar patients. Neuropsychobiology 2006;53(2):108-12

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.