81
Views
0
CrossRef citations to date
0
Altmetric
Review

Pharmacological approach to treating eosinophilic granulomatosis with polyangiitis (Churg–Strauss)

, MD MSc, , MD MSc & , MD

Bibliography

  • ATMasi, GGHunder, JTLie, et al. The American College of Rheumatology 1990 criteria for the classification of Churg–Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 1990;33(8):1094-100
  • JCJennette, RJFalk, PABacon, et al. 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 2013;65(1):1-11
  • CComarmond, CPagnoux, MKhellaf, et al. Eosinophilic granulomatosis with polyangiitis (Churg–Strauss): clinical characteristics and long-term follow-up of the 383 patients enrolled in the French Vasculitis Study Group cohort. Arthritis Rheum 2013;65(1):270-81
  • RASinico, LDi Toma, UMaggiore, et al. Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg–Strauss syndrome. Arthritis Rheum 2005;52(9):2926-35
  • RSablé-Fourtassou, PCohen, AMahr, et al. Antineutrophil cytoplasmic antibodies and the Churg–Strauss syndrome. Ann Intern Med 2005;143(9):632-8
  • FMoosig. Eosinophilic granulomatosis with polyangiitis: future therapies. Presse Méd 2013;42(4 Pt 2):510-12
  • JGLanham, KBElkon, CDPusey, GRHughes. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg–Strauss syndrome. Medicine (Baltimore) 1984;63(2):65-81
  • LGuillevin, JAmouroux, BArbeille, RBoura. Churg–Strauss angiitis. Arguments favoring the responsibility of inhaled antigens. Chest 1991;100(5):1472-3
  • PBottero, MBonini, FVecchio, et al. The common allergens in the Churg–Strauss syndrome. Allergy 2007;62(11):1288-94
  • SWieczorek, BHellmich, WLGross, JTEpplen. Associations of Churg–Strauss syndrome with the HLA-DRB1 locus, and relationship to the genetics of antineutrophil cytoplasmic antibody-associated vasculitides: comment on the article by Vaglio et al. Arthritis Rheum 2008;58(1):329-30
  • AVaglio, DMartorana, UMaggiore, et al. HLA-DRB4 as a genetic risk factor for Churg–Strauss syndrome. Arthritis Rheum 2007;56(9):3159-66
  • SWieczorek, BHellmich, LArning, et al. Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg–Strauss syndrome, but not with Wegener’s granulomatosis. Arthritis Rheum 2008;58(6):1839-48
  • ATsukadaira, YOkubo, KKitano, et al. Eosinophil active cytokines and surface analysis of eosinophils in Churg–Strauss syndrome. Allergy Asthma Proc 1999;20(1):39-44
  • PCTai, MEHolt, PDenny, et al. Deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis: the Churg–Strauss syndrome. Br Med J 1984;289(6442):400-2
  • WHSchmitt, ECsernok, SKobayashi, et al. Churg–Strauss syndrome: serum markers of lymphocyte activation and endothelial damage. Arthritis Rheum 1998;41(3):445-52
  • EPeen, PHahn, GLauwers, et al. Churg–Strauss syndrome: localization of eosinophil major basic protein in damaged tissues. Arthritis Rheum 2000;43(8):1897-900
  • VCottin, FTardy, DGindre, et al. Urinary eosinophil-derived neurotoxin in Churg–Strauss syndrome. J Allergy Clin Immunol 1995;96(2):261-4
  • NHigashi, HMita, MTaniguchi, et al. Urinary eicosanoid and tyrosine derivative concentrations in patients with vasculitides. J Allergy Clin Immunol 2004;114(6):1353-8
  • KPolzer, TKaronitsch, TNeumann, et al. Eotaxin-3 is involved in Churg–Strauss syndrome — a serum marker closely correlating with disease activity. Rheumatology (Oxford) 2008;47(6):804-8
  • MMuschen, UWarskulat, APerniok, et al. Involvement of soluble CD95 in Churg–Strauss syndrome. Am J Pathol 1999;155(3):915-25
  • MKiene, ECsernok, AMuller, et al. Elevated interleukin-4 and interleukin-13 production by T cell lines from patients with Churg–Strauss syndrome. Arthritis Rheum 2001;44(2):469-73
  • HTaki, KShinoda, HHounoki, et al. Serum interleukin-5 levels correlate with disease activity of Churg–Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid. Scand J Rheumatol 2010;39(4):341-3
  • CTermeer, JCSimon, ESchopf. Churg–Strauss syndrome associated with fluticasone therapy. Arch Dermatol 2001;137(11):1527-8
  • BTerrier, IBieche, TMaisonobe, et al. Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg–Strauss syndrome. Blood 2010;116(22):4523-31
  • BHellmich, ECsernok, WLGross. Proinflammatory cytokines and autoimmunity in Churg–Strauss syndrome. Ann N Y Acad Sci 2005;1051:121-31
  • NTsurikisawa, HSaito, COshikata, et al. Decreases in the numbers of peripheral blood regulatory T cells, and increases in the levels of memory and activated B cells, in patients with active eosinophilic granulomatosis and polyangiitis. J Clin Immunol 2013;33(5):965-76
  • HSaito, NTsurikisawa, TTsuburai, KAkiyama. Involvement of regulatory T cells in the pathogenesis of Churg–Strauss syndrome. Int Arch Allergy Immunol 2008;146(Suppl 1):73-6
  • NTsurikisawa, HSaito, COshikata, et al. An increase of CD83+ dendritic cells ex vivo correlates with increased regulatory T cells in patients with active eosinophilic granulomatosis and polyangiitis. BMC Immunol 2014;15:32
  • HSaito, NTsurikisawa, COshikata, et al. Increased interleukin-27 production by antigen-presenting cells promotes regulatory T cell differentiation and contributes to inducing a remission in patients with eosinophilic granulomatosis with polyangiitis. Int Arch Allergy Immunol 2013;161(Suppl 2):66-74
  • HSaito, NTsurikisawa, TTsuburai, et al. Cytokine production profile of CD4+ T cells from patients with active Churg–Strauss syndrome tends toward Th17. Int Arch Allergy Immunol 2009;149(Suppl 1):61-5
  • GGuida, AVallario, SStella, et al. Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome. Clin Immunol 2008;128(1):94-102
  • MBoita, GGuida, PCircosta, et al. The molecular and functional characterization of clonally expanded CD8+ TCR BV T cells in eosinophilic granulomatosis with polyangiitis (EGPA). Clin Immunol 2014;152(1-2):152-63
  • MBoita, GRolla, RMallone, et al. Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg–Strauss syndrome. Clin Exp Rheumatol 2012;30(1 Suppl 70):S57-61
  • BJManger, FEKrapf, MGramatzki, et al. IgE-containing circulating immune complexes in Churg–Strauss vasculitis. Scand J Immunol 1985;21(4):369-73
  • AVaglio, JDStrehl, BManger, et al. IgG4 immune response in Churg–Strauss syndrome. Ann Rheum Dis 2012;71(3):390-3
  • JPunnonen, GAversa, BGCocks, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993;90(8):3730-4
  • RJFalk, RSTerrell, LACharles, JCJennette. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 1990;87(11):4115-19
  • HXiao, PHeeringa, PHu, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002;110(7):955-63
  • PHeeringa, EBrouwer, JWTervaert, et al. Animal models of anti-neutrophil cytoplasmic antibody associated vasculitis. Kidney Int 1998;53(2):253-63
  • LGuillevin, CPagnoux, RSeror, et al. The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort. Medicine (Baltimore) 2011;90(1):19-27
  • ABourgarit, PLe Toumelin, CPagnoux, et al. Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg–Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patients. Medicine (Baltimore) 2005;84(5):323-30
  • LGuillevin, PCohen, MGayraud, et al. Churg–Strauss syndrome. Clinical study and long-term follow-up of 96 patients. Medicine (Baltimore) 1999;78(1):26-37
  • PCohen, CPagnoux, AMahr, et al. Churg–Strauss syndrome with poor-prognosis factors: a prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients. Arthritis Rheum 2007;57(4):686-93
  • CRibi, PCohen, CPagnoux, et al. Treatment of Churg–Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients. Arthritis Rheum 2008;58(2):586-94
  • MSamson, XPuéchal, HDevilliers, et al. Long-term outcomes of 118 patients with eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome) enrolled in two prospective trials. J Autoimmun 2013;43:60-9
  • MSamson, XPuéchal, HDevilliers, et al. Mononeuritis multiplex predicts the need for immunosuppressive or immunomodulatory drugs for EGPA, PAN and MPA patients without poor-prognosis factors. Autoimmun Rev 2014;13(9):945-53
  • FMoosig, WLGross, KHerrmann, et al. Targeting interleukin-5 in refractory and relapsing Churg–Strauss syndrome. Ann Intern Med 2011;155(5):341-3
  • Kde Groot, LHarper, DRJayne, et al. Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial. Ann Intern Med 2009;150(10):670-80
  • DJayne, NRasmussen, KAndrassy, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 2003;349(1):36-44
  • CPagnoux, AMahr, MAHamidou, et al. Azathioprine or methotrexate maintenance for ANCA-associated vasculitis. N Engl J Med 2008;359(26):2790-803
  • TFHiemstra, MWalsh, AMahr, et al. Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial. JAMA 2010;304(21):2381-8
  • ETatsis, ASchnabel, WLGross. Interferon-alpha treatment of four patients with the Churg–Strauss syndrome. Ann Intern Med 1998;129(5):370-4
  • CMetzler, ECsernok, WLGross, BHellmich. Interferon-alpha for maintenance of remission in Churg–Strauss syndrome: a long-term observational study. Clin Exp Rheumatol 2010;28(1 Suppl 57):24-30
  • JHStone, PAMerkel, RSpiera, et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 2010;363(3):221-32
  • RBJones, JWTervaert, THauser, et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med 2010;363(3):211-20
  • LGuillevin, CPagnoux, AKarras, et al. Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med 2014;371(19):1771-80
  • RJPepper, MAFabre, CPavesio, et al. Rituximab is effective in the treatment of refractory Churg–Strauss syndrome and is associated with diminished T-cell interleukin-5 production. Rheumatology (Oxford) 2008;47(7):1104-5
  • MKoukoulaki, KGSmith, DRJayne. Rituximab in Churg–Strauss syndrome. Ann Rheum Dis 2006;65(4):557-9
  • JSaech, KOwczarzyk, SRosgen, et al. Successful use of rituximab in a patient with Churg–Strauss syndrome and refractory central nervous system involvement. Ann Rheum Dis 2010;69(6):1254-5
  • RCartin-Ceba, KAKeogh, USpecks, et al. Rituximab for the treatment of Churg–Strauss syndrome with renal involvement. Nephrol Dial Transplant 2011;26(9):2865-71
  • JThiel, FHassler, USalzer, et al. Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome). Arthritis Res Ther 2013;15(5):R133
  • AJMohammad, AHot, FArndt, et al. Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg–Strauss). Ann Rheum Dis 2014. [Epub ahead of print]
  • KFChung, SEWenzel, JLBrozek, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43(2):343-73
  • WBusse, JCorren, BQLanier, et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 2001;108(2):184-90
  • AGraziani, OQuercia, FGirelli, et al. Omalizumab treatment in patient with severe asthma and eosinophilic granulomatosis with polyangiitis. A case report. Eur Ann Allergy Clin Immunol 2014;46(6):226-8
  • DEWinchester, AJacob, TMurphy. Omalizumab for asthma. N Engl J Med 2006;355(12):1281-2
  • MEWechsler, DAWong, MKMiller, LLawrence-Miyasaki. Churg–Strauss syndrome in patients treated with omalizumab. Chest 2009;136(2):507-18
  • HGOrtega, MCLiu, IDPavord, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014;371(13):1198-207
  • EHBel, SEWenzel, PJThompson, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 2014;371(13):1189-97
  • SKim, GMarigowda, EOren, et al. Mepolizumab as a steroid-sparing treatment option in patients with Churg–Strauss syndrome. J Allergy Clin Immunol 2010;125(6):1336-43
  • MSamson, XPuéchal, HDevilliers, et al. Eosinophilic granulomatosis with polyangitis (Churg–Strauss), polyarteritis nodosa and microscopic polyangitis with no initial Five Factor Score-defined poor prognosis factors (FFS = 0): baseline factors associated with cytotoxic agent and immunomodulator prescription. Presse Méd 2013;42:666
  • BHellmich, OFlossmann, WLGross, et al. EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis. Ann Rheum Dis 2007;66(5):605-17
  • AKostianovsky, PCharles, JFAlves, et al. Immunogenicity and safety of seasonal and 2009 pandemic A/H1N1 influenza vaccines for patients with autoimmune diseases: a prospective, monocentre trial on 199 patients. Clin Exp Rheumatol 2012;30(1 Suppl 70):S83-9
  • FMoosig, JPBremer, BHellmich, et al. A vasculitis centre based management strategy leads to improved outcome in eosinophilic granulomatosis and polyangiitis (Churg–Strauss, EGPA): monocentric experiences in 150 patients. Ann Rheum Dis 2013;72(6):1011-17
  • LGuillevin, TGuittard, OBlétry, et al. Systemic necrotizing angiitis with asthma: causes and precipitating factors in 43 cases. Lung 1987;165(3):165-72
  • MRMasjedi, SFTafti, ACheraghvandi, et al. Churg–Strauss syndrome following cessation of allergic desensitization vaccination: a case report. J Med Case Rep 2010;4:188
  • EHChung, YJia, HOhnishi, et al. Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics. Ann Allergy Asthma Immunol 2014;112(3):211-16
  • MEWechsler, JMDrazen. Zafirlukast and Churg–Strauss syndrome. Chest 1999;116(1):266-7
  • MEWechsler, DFinn, DGunawardena, et al. Churg–Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest 2000;117(3):708-13
  • NNathani, MALittle, HKunst, et al. Churg–Strauss syndrome and leukotriene antagonist use: a respiratory perspective. Thorax 2008;63(10):883-8
  • THauser, AMahr, CMetzler, et al. The leucotriene receptor antagonist montelukast and the risk of Churg–Strauss syndrome: a case–crossover study. Thorax 2008;63(8):677-82
  • KAKeogh, USpecks. Churg–Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists. Am J Med 2003;115(4):284-90
  • JMarmursztejn, LGuillevin, RTrebossen, et al. Churg–Strauss syndrome cardiac involvement evaluated by cardiac magnetic resonance imaging and positron-emission tomography: a prospective study on 20 patients. Rheumatology (Oxford) 2013;52(4):642-50
  • TNeumann, BManger, MSchmid, et al. Cardiac involvement in Churg–Strauss syndrome: impact of endomyocarditis. Medicine (Baltimore) 2009;88(4):236-43
  • RMDennert, Pvan Paassen, SSchalla, et al. Cardiac involvement in Churg–Strauss syndrome. Arthritis Rheum 2010;62(2):627-34
  • LTCooper, KLBaughman, AMFeldman, et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. Eur Heart J 2007;28(24):3076-93
  • HBaccouche, AYilmaz, DAlscher, et al. Images in cardiovascular medicine. Magnetic resonance assessment and therapy monitoring of cardiac involvement in Churg–Strauss syndrome. Circulation 2008;117(13):1745-9
  • PYCourand, PCroisille, CKhouatra, et al. Churg–Strauss syndrome presenting with acute myocarditis and cardiogenic shock. Heart Lung Circ 2012;21(3):178-81
  • CWYancy, MJessup, BBozkurt, et al. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 2013;128(16):1810-52
  • KSwedberg, MKomajda, MBohm, et al. Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT). Eur J Heart Fail 2010;12(1):75-81
  • MGroh, GMasciocco, EKirchner, et al. Heart transplantation in patients with eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome). J Heart Lung Transplant 2014;33(8):842-50
  • NOka, TKawasaki, MMatsui, et al. Two subtypes of Churg–Strauss syndrome with neuropathy: the roles of eosinophils and ANCA. Mod Rheumatol 2011;21(3):290-5
  • JFCordier, VCottin, LGuillevin, et al. Eosinophilic granulomatosis with polyangiitis (Churg–Strauss). Presse Méd 2013;42(4 Pt 2):507-10
  • LGuillevin, FLhote, MGayraud, et al. Prognostic factors in polyarteritis nodosa and Churg–Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 1996;75(1):17-28
  • JKRichardson, DSandman, SVela. A focused exercise regimen improves clinical measures of balance in patients with peripheral neuropathy. Arch Phys Med Rehabil 2001;82(2):205-9
  • JRobson, HDoll, RSuppiah, et al. Damage in the ANCA-associated vasculitides: long-term data from the European Vasculitis Study group (EUVAS) therapeutic trials. Ann Rheum Dis 2015;74(1):177-84
  • MSamson, XPuéchal, HDevilliers, et al. Long-term follow-up of a randomized trial on 118 patients with polyarteritis nodosa or microscopic polyangiitis without poor-prognosis factors. Autoimmun Rev 2014;13(2):197-205
  • PCGrayson, PAMonach, CPagnoux, et al. Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis. Rheumatology (Oxford) 2014. [Epub ahead of print]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.