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Drug Profile

Lapatinib in the treatment of breast cancer

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Pages 1183-1192 | Published online: 10 Jan 2014

References

  • Jensen EV, DeSombre ER, Jungblut PW. Estrogen receptors in hormone-responsive tissues and tumors. In: Endogenous Factors Influencing Host–Tumor Balance. Wissler RW, Dao TL, Wood S Jr (Eds). University of Chicago Press, IL, USA 15–30 (1967).
  • Nowell PC. The minute chromosome (Phl) in chronic granulocytic leukemia. Blut8, 65–66 (1962).
  • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science235(4785), 177–182 (1987).
  • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med.353(16), 1673–1684 (2005).
  • Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med.353(16), 1659–1672 (2005).
  • Montemurro F, Donadio M, Clavarezza M et al. Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy. Oncologist11(4), 318–324 (2006).
  • Bartsch R, Wenzel C, Hussian D et al. Analysis of trastuzumab and chemotherapy in advanced breast cancer after the failure of at least one earlier combination: an observational study. BMC Cancer6, 63–68 (2006).
  • Garcia-Saenz JA, Martin M, Puente J et al. Trastuzumab associated with successive cytotoxic therapies beyond disease progression in metastatic breast cancer. Clin. Breast Cancer6, 325–329 (2005).
  • Gelmon KA, Mackey J, Verma S et al. Use of trastuzumab beyond disease progression: observations from a retrospective review of case histories. Clin. Breast Cancer5(1), 52–58 (2004).
  • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl. J. Med.355(26), 2733–2743 (2006).
  • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell103(2), 211–225 (2000).
  • Garrett TP, McKern NM, Lou M et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation poised to interact with other ErbB receptors. Mol. Cell11(2), 495–505 (2003).
  • Jones FE, Stern DF. Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation. Oncogene18(23), 3481–3490 (1999).
  • Jones FE, Welte T, Fu XY, Stern DF. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J. Cell Biol.147(1), 77–87 (1999).
  • Harris AL, Nicholson S, Sainsbury R, Wright C, Farndon J. Epidermal growth factor receptor and other oncogenes as prognostic markers. Natl Cancer Inst. Monogr.11, 181–187 (1992).
  • Di Marco E, Pierce JH, Fleming TP et al. Autocrine interaction between TGF α and the EGF-receptor: quantitative requirements for induction of the malignant phenotype. Oncogene4(7), 831–838 (1989).
  • Seshadri R, Firgaira FA, Horsfall DJ, McCaul K, Setlur V, Kitchen P. Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group. J. Clin. Oncol.11(10), 1936–1942 (1993).
  • Vogel CL, Cobleigh MA, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J. Clin. Oncol.20(3), 719–726 (2002).
  • Cobleigh MA, Vogel CL, Tripathy D et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that progressed after chemotherapy for metastatic disease. J. Clin. Oncol.17(9), 2639–2648 (1999).
  • Esteva FJ, Valero V, Booser D et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J. Clin. Oncol.20(7), 1800–1808 (2002).
  • Burstein HJ, Harris LN, Marcom PK et al. Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter Phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J. Clin. Oncol.21(15), 2889–2895 (2003).
  • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med.344(11), 783–792 (2001).
  • Wood ER, Truesdale AT, McDonald OB et al. A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res.64(18), 6652–6659 (2004).
  • Burris HA III, Hurwitz HI, Dees EC et al. Phase I study, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol.23(23), 5305–5313 (2005).
  • Burris HA 3rd. Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist9(Suppl. 3), 10–15 (2004).
  • Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G. All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem.271(9), 5251–5257 (1996).
  • Lenferink AEG, Pinkas-Kramarski R, van de Poll MLM et al. Differential endocytic routing of homo- and hetero-dimeric erbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J.17(12), 3385–3397 (1998).
  • Bence AK, Anderson EB, Halepota MA et al. Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR–ErbB2 inhibitor, in healthy subjects. Invest. New Drugs23(1), 39–49 (2005).
  • Geyer CE, Martin A, Newstat B et al. Lapatinib (L) plus capecitabine (C) in HER2+ advanced breast cancer (ABC): genomic and updated efficacy data. Proc. Am. Soc. Clin. Oncol.25(Suppl. 18), 1035 (2007).
  • Sonpavde G. Lapatinib plus capecitabine in breast cancer. N. Engl. J. Med.356(14), 1471–1472 (2007).
  • Geyer CE, Forster J, Cameron MD. Lapatinib plus capecitabine in breast cancer. N. Engl. J. Med.356(14), 1471–1472 (2007).
  • Stein SH, Gomez HL, Chavez MA et al. Interim results of a Phase II randomized study of lapatinib (GW572016) as first-line treatment for patients with FISH-amplified advanced or metastatic breast cancer. Eur. J. Cancer3(Suppl.), 78 (2005).
  • Perez EA, Byrne JA, Hammond IW et al. Cardiac safety experience in 3127 patients treated with lapatinib. Ann. Oncol.17(Suppl. 9), 1420 (2006).
  • Kannel WB. Incidence and epidemiology of heart failure. Heart Fail. Rev.5(2), 167–173 (2000).
  • Fujimoto-Ouchi K, Sekiguchi F, More I. Preclinical study of continuous administration trastuzumab as combination therapy after disease progresses with trastuzumab monotherapy. Proc. Am. Assoc. Cancer Res.46, 5062 (2005).
  • Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med.351(4), 337–345 (2004).
  • Marty M, Cognetti F, Maraninchi D et al. Randomized Phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J. Clin. Oncol.23(19), 4265–4274 (2005).
  • Altaha R, Crowell E, Hobbs G, Higa G, Abraham J. Increased risk of brain metastasis in patients with HER-2/neu-positive breast carcinoma. Cancer103(3), 442–443 (2005).
  • Stemmler J, Kahlert S, Siekiera W et al. Brain metastases (BM) in patients treated with trastuzumab for HER overexpressing metastatic breast cancer (MBC): incidence and survival. J. Clin. Oncol.23(Suppl. 16), Abstract 1568 (2005).
  • Lin NU, Carey LA, Liu MC et al. Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer. J. Clin. Oncol.24(Suppl. 18, Part I) (2006) (Abstract 503).
  • Lin NU, Dieras V, Paul D et al. EGF105084, a Phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT). Proc. Am. Soc. Clin. Oncol.25(Suppl. 18), 1012 (2007).
  • Campone M, Bourbouloux E, Fumoleau P. Cardiac dysfunction induced by trastuzumab. Bull. Cancer91(Suppl. 3), 166–173 (2004).
  • Grazette LP, Boecker W, Matsui T et al. Inhibition of erbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J. Am. Coll. Cardiol.44(11), 2231–2238 (2004).
  • Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res.61(24), 8887–8895 (2001).
  • ECOG E1100: a Phase II trial of trastuzumab and gefitinib in patients with metastatic breast cancer that overexpress HER2/neu (erbB-2). Clin. Adv. Hematol. Oncol.1, 237 (2003).
  • Baselga J, Albanell J, Ruiz A et al. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J. Clin. Oncol.23(23), 5323–5233 (2005).
  • Rampaul RS, Pinder SE, Nicholson RI, Gullick WJ, Robertson JF, Ellis IO. Clinical value of epidermal growth factor receptor expression in primary breast cancer. Adv. Anat. Pathol.12(5), 272–273 (2005).
  • Tsutsui S, Kataoka A, Ohno S, Murakami S, Kinoshita J, Hachitanda Y. Prognostic and predictive value of epidermal growth factor receptor in recurrent breast cancer. Clin. Cancer Res.8(11), 3454–3460 (2002).
  • von Minckwitz G, Jonat W, Fasching P et al. A multicentre Phase II study on geftinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer Res. Treat.89(2), 165–172 (2005).
  • Modi S, D’Andrea G, Norton L et al. A Phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer. Clin. Breast Cancer7(3), 270–277 (2006).
  • Alimandi M, Romano A, Curia MC et al. Cooperative signaling of erbB3 and erbB2 in neoplastic transformation and human mammary carcinomas. Oncogene10(9), 1813–1821 (1995).
  • Kokai Y, Myers JN, Wada T et al. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell58(2), 287–292 (1989).
  • Xia W, Liu L-H, Ho P, Spector NL. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW72016. Oncogene23(3), 646–653 (2004).
  • Segatto O, King CR, Pierce JH, DiFiore PP, Aaronson SA. Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene. Mol. Cell Biol.8(12), 5570–5574 (1988).
  • Colomer R, Montero S, Lluch A et al. Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer. Clin. Cancer Res.6(6), 2356–2362 (2000).
  • Molina MA, Saez R, Ramsey et al. NH2-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin. Cancer Res.8(2), 347–353 (2002).
  • Hirata A, Hosoi F, Miyagawa M et al. HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. Cancer Res.65(10), 4253–4260 (2005).
  • Anido J, Matar P, Albanell J et al. ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER-overexpressing breast cancer cells. Clin. Cancer Res.9(4), 1274–1283 (2003).
  • Gamett DC, Pearson G, Cerione RA, Friedberg I. Secondary dimerization between members of the epidermal growth factor receptor family. J. Biol. Chem.272(18), 12052–12056 (1997).
  • Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science267(5205), 1782–1788 (1995).
  • Wang SC, Lien HC, Xia W et al. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor erbB-2. Cancer Cell6(3), 251–261 (2004).

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