200
Views
8
CrossRef citations to date
0
Altmetric
Perspective

New cancer diagnostics and therapeutics from a ninth ‘hallmark of cancer’: symmetric self-renewal by mutated distributed stem cells

Pages 797-810 | Published online: 09 Jan 2014

References

  • Sherley JL. A new mechanism for aging: chemical ‘age spots’ in immortal DNA strands in distributed stem cells. Breast Dis. 29, 37–46 (2008).
  • Taghizadeh RR, Sherley JL. Expanding the therapeutic potential of umbilical cord blood hematopoietic stem cells. In: Perinatal Stem Cells. Cetrulo CL Cetrulo KJ, Cetrulo CL Jr (Eds). Wiley-Blackwell, Hoboken, USA, 21–40 (2009).
  • Noh M, Smith JL, Huh YH, Sherley JL. A resource for discovering specific and universal biomarkers for distributed stem cells. PLoS ONE 6(7), e22077 (2011).
  • Huh YH, Sherley JL. Molecular cloaking of H2A.Z on mortal DNA chromosomes during non-random segregation. Stem Cells 29(10), 1620–1627 (2011).
  • Huh YH, King J, Cohen J, Sherley JL. Sack-expanded hair follicle stem cells display asymmetric nuclear lgr5 expression with non-random sister chromatid segregation. Sci. Rep. 1, 175 (2011).
  • Paré J-F, Sherley JL. Culture environment-induced pluripotency of SACK-expanded tissue stem cells. J. Biomed. Biotechnol. 2011, 312457 (2011).
  • Sherley JL. Advancing renewable normal human cell assays for drug discovery. Drug Dev. Res. 74(2), 127–137 (2013).
  • Sherley JL. Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture. Stem Cells 20(6), 561–672 (2002).
  • Sherley JL. Asymmetric self-renewal: the mark of the adult stem cell. In: Stem Cell Repair and Regeneration. Habib NA Gordon MY, Levicar N, Jiao L, Thomas-Black G (Eds). Imperial College Press, London, UK, 21–28 (2005).
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5), 646–674 (2011).
  • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57–70 (2000).
  • Sherley JL. Tumor suppressor genes and cell kinetics in the etiology of malignant mesothelioma. In: Asbestos Disease Control, Vol. 21. Peters GA (Ed.). Mathew Bender & Co., Inc., Charlottesville, USA, 91–141 (2000).
  • Lajtha JG. Stem cell concepts. Differentiation 14(1–2), 23–24 (1979).
  • Potten CS, Morris RJ. Epithelial stem cells in vivo. J. Cell Sci. Suppl. 10, 45–62 (1988).
  • Loeffler M, Potten CS. Stem cells and cellular pedigrees - a conceptual introduction. In: Stem Cells. Potten CS (Ed.). Harcourt Brace & Co., San Diego, USA, 1–28 (1997).
  • Sherley JL. Mechanisms of genetic fidelity in mammalian adult stem cells. In: Tissue Stem Cells. Potten CS Clarke RB, Wilson J, Renehan AG (Eds). Taylor Francis, New York, USA, 37–54 (2006).
  • Makillop WJ, Ciampi A, Till JE, Buick BN. A stem cell model of human tumor growth: implications for tumor cell clonogenic assays. J. Natl Cancer Inst. 70(1), 9–16 (1983).
  • Knoblich, JA. Asymmetric cell division during animal development. Nat. Rev. Mol. Cell Biol. 2(1), 11–20 (2001).
  • Enver T, Heyworth CM, Dexter TM. Do stem cells play dice? Blood 92(2), 348–351 (1998).
  • Blackett N, Gordon M. “Stochastic” –40 years of use and abuse. Blood 93(9), 3148–3155 (1999).
  • Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441(7097), 1068–1074 (2006).
  • Simons BD, Clevers H. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 145(6), 851–862 (2011).
  • Inaba M, Yamashita YM. Asymmetric stem cell division: precision for robustness. Cell Stem Cell 11(4), 461–469 (2012).
  • Dehmer JJ, Garrison AP, Speck KE et al. Expansion of intestinal stem cells during murine development. PLoS ONE 6(11), e27070 (2011).
  • Yatabe Y, Tavare S, Shibata D. Investigating stem cells in human colon by using methylation patterns. Proc. Natl Acad. Sci. USA 98(19), 10839–10844 (2001).
  • Vogel H, Niewisch H, Matioli G. The self renewal probability of hemopoietic stem cells. J. Cell Physiol. 72(3), 221–228 (1968).
  • Vogel H, Niewisch H, Matioli G. Stochastic development of stem cells. J. Theor. Biol. 22(2), 249–270 (1969).
  • Matioli G, Niewisch H, Vogel H. Stochastic stem cell renewal. Rev. Eur. Etud. Clin. Biol. 15(1), 20–22 (1970).
  • Sherley JL. Adult stem cell differentiation: What does it mean? Proc. 2nd Joint EMBS/BMES Conf. 1, 741–742 (2002).
  • Yamashita YM, Fuller MT. Asymmetric centrosome behavior and the mechanisms of stem cell division. J. Cell Biol. 180(2), 261–266 (2008).
  • Chia W, Somers, WG, Wang H. Drosophila neuroblasts asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis. J. Cell Biol. 180(2), 267–272 (2008).
  • Yamashita YM, Yuan H, Cheng J, Hunt AJ. Polarity in stem cell division: asymmetric stem division in tissue homeostasis. Cold Spring Harb. Perspect. Biol. 2(1), a001313 (2010).
  • Chenn A, McConnell SK. Cleavage orientation and the asymmetric inheritance of Notch 1 immunoreactivity in mammalian neurogenesis. Cell 82(4), 631–641 (1995).
  • Wang X, Tsai J-W, Imai JH, Lian W-N, Vallee RB, Shi S-H. Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461(7266), 947–956 (2009).
  • Kretzschmar K Watt FM. Lineage tracing. Cell 148(1–2), 33–45 (2012).
  • Rompolas P, Deschene ER, Zito G et al. Live imaging of stem cell and progeny behavior in physiological hair-follicle regeneration. Nature 487(7408), 496–499 (2012).
  • Barker N, Van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell 11(4), 452–460 (2012).
  • Huang S, Law P, Francis K, Palsson BO, Ho AD. Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules. Blood 94(8), 2595–2604 (1999).
  • Conboy MJ, Karasov AO, Rando TA. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biol. 5(1), e102 (2007).
  • Kawabe Y, Wang YX, McKinnell IW, Bedford MT, Rudnicki MA. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell 11(3), 333–345 (2012).
  • Lee H-S, Crane GG, Merok JR et al. Clonal expansion of adult rat liver epithelial stem cells by suppression of asymmetric cell kinetics (SACK). Biotech. Bioeng. 83(7), 760–771(2003).
  • Bjerknes M. A test of the stochastic theory of stem cell differentiation. Biophys. J. 49(6), 1223–1227 (1986).
  • Klein AM, Nakagawa T, Ichikawa R, Yoshida S, Simons BD. Mouse germ line stem cells undergo rapid and stochastic turnover. Cell Stem Cell 7(2), 214–224 (2010).
  • Snippert HJ, Van Der Flier LG, Sato T et al. Intestinal crypt homeostasis results from neural competition between symmetrically dividing Lgr5 stem cells. Cell 143(1), 134–144 (2010).
  • Lopez-Garcia C, Klein AM, Simons BD, Winton DJ. Intestinal stem cell replacement follows a pattern of neutral drift. Science 330(6005), 822–825 (2010).
  • Klein AM, Simons BD. Universal patterns of stem cell fate in cycling adult tissues. Development 138(15), 3103–3111 (2011).
  • Tian H, Biehs B, Warming S et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478(7368), 255–259 (2011).
  • Cairns J. Mutation selection and the natural history of cancer. Nature 255(5505), 197–200 (1975).
  • Herrero-Jimenez P, Thilly G, Southam PJ et al. Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. Mutation Res. 400(1–2), 553–578 (1998).
  • Potten CS, Booth C, Hargreaves D. The small intestine as a model for evaluating adult tissue stem cell drug targets. Cell Prolif. 36(3), 115–129 (2003).
  • Potten CS, Hume WJ, Reid P, Cairns J. The segregation of DNA in epithelial stem cells. Cell 15(3), 899–906 (1978).
  • Merok JR, Lansita JA, Tunstead JR, Sherley JL. Co-segregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics. Cancer Res. 62(23), 6791–6795 (2002).
  • Potten CS, Owen G, Booth D. Intestinal stem cells protect their genomes by selective segregation of template DNA strands. J. Cell Sci. 115(Pt 11), 2381–2388 (2002).
  • Rambhatla L, Ram-Mohan S, Cheng JJ, Sherley JL. Immortal DNA strand co-segregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells. Cancer Res. 65(8), 3155–3161 (2005).
  • Karpowicz P, Morshead C, Kam A et al. Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J. Cell Biol. 170(5), 721–732 (2005).
  • Smith G. Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development 132(4), 681–687 (2005).
  • Shinin V, Gayraud-Morel B, Gomès D, Tajbakhsh S. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat. Cell Biol. 8(7), 677–687 (2006).
  • Capuco AV. Identification of putative bovine mammary epithelial stem cells by their retention of labeled DNA strands. Exp. Biol. Med. 232(10), 1381–1390 (2007).
  • Bussard KM, Boulanger CA, Kittrell FS, Behbod F, Smith GH. Immortalized, premalignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA. Breast Can. Res. 12(5), R86 (2010).
  • Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc. Natl Acad. Sci. USA 107(5), 2195–2200 (2010).
  • Hari D, Xin HW, Jaiswal K et al. Isolation of live label-retaining cells and cells undergoing asymmetric cell division via nonrandom chromosomal cosegregation from human cancers. Stem Cells Dev. 20(10), 1649–1658 (2011).
  • Kajstura J, Bai Y, Cappetta D et al. Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infracted myocardium. Circ. Res. 111(7), 894–906 (2012).
  • Sundararaman B, Avitabile D, Konstandin MH, Cottage CT, Gude N, Sussman MA. Asymmetric chromatid segregation in cardiac progenitor cells is enhanced by Pim-1 kinase. Circ. Res. 110(9), 1169–1173 (2012).
  • Xin H-W, Hari DM, Mullinax JE et al. Tumor-initiating label-retaining cancer cells in human gastrointestinal cancers undergo asymmetric cell division. Stem Cells 30(4), 591–598 (2012).
  • Lark KG, Consigli RA, Minocha HC. Segregation of sister chromatids in mammalian cells. Science 154(3753), 1202–1205 (1966).
  • Rambhatla L, Bohn SA, Stadler PB, Boyd JT, Coss RA, Sherley JL. Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics. J. Biomed. Biotech. 1(1), 27–36 (2001).
  • Potten CS, Kellet M, Roberts SA, Rew DA, Wilson GD. Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine. Gut 33(1), 71–78 (1992).
  • Sherley JL. The p53 tumor suppressor gene as regulator of somatic stem cell renewal division. Cope 12, 9–10 (1996).
  • Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea – a paradigm shift. Cancer Res. 66(4), 1883–1890 (2006).
  • Baccelli I, Trumpp A. The evolving concept of cancer and metastasis stem cells. J. Cell Biol. 198(3), 281–293 (2012).
  • Hill RP. Identifying cancer stem cells in solid tumors: case not proven. Cancer Res. 66(4), 1891–1896 (2006).
  • Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. Efficient tumor formation by single human melanoma cells. Nature 456(7222), 593–598 (2008).
  • Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 21(3), 283–296 (2012).
  • Clarke MF, Fuller M. Stem cells and cancer: two faces of eve. Cell 124(6), 1111–1115 (2006).
  • Chen J, Li Y, Yu T-S et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488(7412), 522–526 (2012).
  • Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C. Defining the mode of tumour growth by clonal analysis. Nature 488(7412), 527–530 (2012).
  • Tannenbaum E, Sherley JL, Shakhnovich EI. Evolutionary dynamics of adult stem cells: comparison of random and immortal-strand segregation mechanisms. Phys. Rev. E. Stat. Nonlin. Soft. Matter Phys. 71(4 Pt 1), 041914 (2005).
  • Walters K. Colonic stem cell data are consistent with the immortal model of stem cell division under non-random strand segregation. Cell Prolif. 42(3), 339–347 (2009).

Website

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.