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Expert Review of Molecular Diagnostics Volume 13, 2013 - Issue 8
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Key Paper Evaluations

Will droplet digital PCR become the test of choice for detecting and quantifying ocular Chlamydia trachomatis infection? Maybe not

Julius SchachterDepartment of Laboratory Medicine, University of California, San Francisco, CA 94143, USACorrespondence[email protected]
Pages 789-792 | Published online: 09 Jan 2014

References

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  • Roberts CH, Last A, Molina-Gonzalez S et al. Development and evaluation of a next-generation digital PCR diagnostic assay for ocular Chlamydia trachomatis infections. J. Clin. Microbiol. 51(7), 2195–2203 (2013).
  • Chernesky M, Jang D, Luinstra K et al. High analytical sensitivity and low rates of inhibition may contribute to detection of Chlamydia trachomatis in significantly more women by the APTIMA Combo 2 assay. J. Clin. Microbiol. 44(2), 400–405 (2006).
  • Schachter J, Moncada J, Liska S, Shayevich C, Klausner JD. Nucleic acid amplification tests in the diagnosis of chlamydial and gonococcal infections of the oropharynx and rectum in men who have sex with men. Sex Transm. Dis. 35(7), 637–642 (2008).
  • Yang JL, Schachter J, Moncada J et al. Comparison of an rRNA-based and DNA-based nucleic acid amplification test for the detection of Chlamydia trachomatis in trachoma. Br. J. Ophthalmol. 91(3), 293–295 (2007).
  • Bailey RL, Hampton TJ, Hayes LJ, Ward ME, Whittle HC, Mabey DC. Polymerase chain reaction for the detection of ocular Chlamydial infection in trachoma-endemic communities. J. Infect. Dis. 170(3), 709–712 (1994).
  • Amza A, Kadri B, Nassirou B et al. Community risk factors for ocular Chlamydia infection in Niger: pre-treatment results from a cluster-randomized trachoma trial. PLoS Negl. Trop. Dis. 6(4), e1586 (2012).
  • Gebre T, Ayele B, Zerihun M et al. Comparison of annual versus twice-yearly mass azithromycin treatment for hyper endemic trachoma in Ethiopia: a cluster-randomised trial. Lancet 379(9811), 143–151 (2012).
  • Dize L, West S, Williams JA, Van Der Pol B, Quinn TC, Gaydos CA. Comparison of the Abbott m2000 RealTime CT assay and the Cepheid GeneXpert CT/NG assay to the Roche Amplicor CT assay for detection of Chlamydia trachomatis in ocular samples from Tanzania. J Clin. Microbiol. 51(5), 1611–1613 (2013).

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