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The FilmArray® respiratory panel: an automated, broadly multiplexed molecular test for the rapid and accurate detection of respiratory pathogens

Pages 779-788 | Published online: 09 Jan 2014

References

  • Woodwell DA, Cherry DK. National ambulatory medical care survey: 2002 summary. Adv. Data. (346), 1–44 (2004).
  • Juven T, Mertsola J, Waris M et al. Etiology of community-acquired pneumonia in 254 hospitalized children. Pediatr. Infect. Dis. J. 19(4), 293–298 (2000).
  • Koskenvuo M, Mottonen M, Rahiala J et al. Respiratory viral infections in children with leukemia. Pediatr. Infect. Dis. J. 27(11), 974–980 (2008).
  • Ginocchio CC, Zhang F, Manji R et al. Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak. J. Clin. Virol. 45(3), 191–195 (2009).
  • Lee JW, Kang HJ, Park JD, Shin HY, Ahn HS. Early pulmonary complications after hematopoietic stem cell transplantation in pediatric patients: association with cytomegalovirus infection. J. Pediatr. Hematol. Oncol. 31(8), 545–551 (2009).
  • Kamboj M, Sepkowitz KA. Nosocomial infections in patients with cancer. Lancet Oncol. 10(6), 589–597 (2009).
  • Mahony JB. Detection of respiratory viruses by molecular methods. Clin. Microbiol. Rev. 21(4), 716–747 (2008).
  • Sullivan SJ, Jacobson RM, Dowdle WR, Poland GA. 2009 H1N1 influenza. Mayo Clin. Proc. 85(1), 64–76 (2010).
  • Boeckh M. The challenge of respiratory virus infections in hematopoietic cell transplant recipients. Br. J. Haematol. 143(4), 455–467 (2008).
  • Bowden RA. Respiratory virus infections after marrow transplant: the Fred Hutchinson Cancer Research Center experience. Am. J. Med. 102(3A), 27–30; discussion 42–23 (1997).
  • Champlin RE, Whimbey E. Community respiratory virus infections in bone marrow transplant recipients: the M.D. Anderson Cancer Center experience. Biol. Blood Marrow Transplant. 7( Suppl.), 8S–10S (2001).
  • Chemaly RF, Ghosh S, Bodey GP et al. Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center. Medicine (Baltimore) 85(5), 278–287 (2006).
  • Ison MG, Hayden FG. Viral infections in immunocompromised patients: what's new with respiratory viruses? Curr. Opin. Infect. Dis. 15(4), 355–367 (2002).
  • Yorita KL, Holman RC, Sejvar JJ, Steiner CA, Schonberger LB. Infectious disease hospitalizations among infants in the United States. Pediatrics 121(2), 244–252 (2008).
  • Lieberman D. Management of respiratory infections in the elderly. Expert Rev. Anti Infect. Ther. 1(3), 505–516 (2003).
  • Srinivasan A, Wang C, Yang J et al. Parainfluenza virus infections in children with hematologic malignancies. Pediatr. Infect. Dis. J. 30(10), 855–899 (2011).
  • Srinivasan A, Wang C, Yang J, Shenep JL, Leung WH, Hayden RT. Symptomatic parainfluenza virus infections in children undergoing hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 17(10), 1520–1527 (2011).
  • Renaud C, Campbell AP. Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients. Curr. Opin. Infect. Dis. 24(4), 333–343 (2011).
  • Iroh Tam PY. Approach to common bacterial infections: community-acquired pneumonia. Pediatr. Clin. North Am. 60(2), 437–453 (2013).
  • A revision of the systerm of nomenclature for influenza viruses: a WHO memorandum. Bull World Health Organ. 58(4), 585–591 (1980).
  • Atmar RLaL S.E. Influenza Viruses. In: Manual of Clinical Microbiology. Versalovic J ( Ed.). ASM Press, Washington DC, USA (2011).
  • Palmer SM, Jr., Henshaw NG, Howell DN, Miller SE, Davis RD, Tapson VF. Community respiratory viral infection in adult lung transplant recipients. Chest 113(4), 944–950 (1998).
  • Vilchez RA, McCurry K, Dauber J et al. Influenza virus infection in adult solid organ transplant recipients. Am. J. Transplant. 2(3), 287–291 (2002).
  • Hall CB. Respiratory syncytial virus and parainfluenza virus. N. Engl. J. Med. 344(25), 1917–1928 (2001).
  • Hall CB, Weinberg GA, Iwane MK et al. The burden of respiratory syncytial virus infection in young children. N. Engl. J. Med. 360(6), 588–598 (2009).
  • Nichols WG, Gooley T, Boeckh M. Community-acquired respiratory syncytial virus and parainfluenza virus infections after hematopoietic stem cell transplantation: the Fred Hutchinson Cancer Research Center experience. Biol. Blood Marrow Transplant. 7( Suppl.) 11S–15S (2001).
  • Henrickson KJ. Parainfluenza viruses. Clin. Microbiol. Rev. 16(2), 242–264 (2003).
  • Chemaly RF, Hanmod SS, Rathod DB et al. The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation. Blood 119(12), 2738–2745 (2012).
  • Vilchez RA, McCurry K, Dauber J et al. The epidemiology of parainfluenza virus infection in lung transplant recipients. Clin. Infect. Dis. 33(12), 2004–2008 (2001).
  • Falsey AR, Erdman D, Anderson LJ, Walsh EE. Human metapneumovirus infections in young and elderly adults. J. Infect. Dis. 187(5), 785–790 (2003).
  • Kamboj M, Gerbin M, Huang CK et al. Clinical characterization of human metapneumovirus infection among patients with cancer. J. Infect. 57(6), 464–471 (2008).
  • Kumar D, Humar A. Respiratory viral infections in transplant and oncology patients. Infect. Dis. Clin. North Am. 24(2), 395–412 (2010).
  • Larcher C, Geltner C, Fischer H, Nachbaur D, Muller LC, Huemer HP. Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology. J. Heart Lung Transplant. 24(11), 1891–1901 (2005).
  • Weinberg A, Lyu DM, Li S, Marquesen J, Zamora MR. Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients. Transpl. Infect. Dis. 12(4), 330–335 (2010).
  • Ison MG. Adenovirus infections in transplant recipients. Clin. Infect. Dis. 43(3), 331–339 (2006).
  • Bruno B, Gooley T, Hackman RC, Davis C, Corey L, Boeckh M. Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol. Blood Marrow Transplant. 9(5), 341–352 (2003).
  • Ljungman P. Treatment of adenovirus infections in the immunocompromised host. Eur. J. Clin. Microbiol Infect. Dis. 23(8), 583–588 (2004).
  • Echavarria M. Adenoviruses in immunocompromised hosts. Clin. Microbiol. Rev. 21(4), 704–715 (2008).
  • Palmenberg AC, Spiro D, Kuzmickas R et al. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science 324(5923), 55–59 (2009).
  • Brownlee JW, Turner RB. New developments in the epidemiology and clinical spectrum of rhinovirus infections. Curr. Opin. Pediatr. 20(1), 67–71 (2008).
  • Jacobs SE, Lamson DM, St George K, Walsh TJ. Human rhinoviruses. Clin. Microbiol. Rev. 26(1), 135–162 (2013).
  • Kraft CS, Jacob JT, Sears MH, Burd EM, Caliendo AM, Lyon GM. Severity of human rhinovirus infection in immunocompromised adults is similar to that of 2009 H1N1 influenza. J. Clin. Microbiol. 50(3), 1061–1063 (2012).
  • Pabbaraju KaF J.D. Coronaviruses. In: Manual of Clinical Microbiology. Versalovic J ( Ed.). ASM Press, Washington DC, USA (2011).
  • Milano F, Campbell AP, Guthrie KA et al. Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients. Blood 115(10), 2088–2094 (2010).
  • Oosterhof L, Christensen CB, Sengelov H. Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient. Bone Marrow Transplant. 45(6), 1115–1116 (2010).
  • Pene F, Merlat A, Vabret A et al. Coronavirus 229E-related pneumonia in immunocompromised patients. Clin. Infect Dis. 37(7), 929–932 (2003).
  • Cunha BA. The atypical pneumonias: clinical diagnosis and importance. Clin. Microbiol. Infect. 12( Suppl. 12), 12–24 (2006).
  • von Konig CH, Halperin S, Riffelmann M, Guiso N. Pertussis of adults and infants. Lancet Infect. Dis. 2(12), 744–750 (2002).
  • Baer G, Engelcke G, Abele-Horn M, Schaad UB, Heininger U. Role of Chlamydia pneumoniae and Mycoplasma pneumoniae as causative agents of community-acquired pneumonia in hospitalised children and adolescents. Eur. J. Clin. Microbiol. Infect. Dis. 22(12), 742–745 (2003).
  • Hallander HO, Gnarpe J, Gnarpe H, Olin P. Bordetella pertussis, Bordetella parapertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae and persistent cough in children. Scand. J. Infect. Dis. 31(3), 281–286 (1999).
  • Ginocchio CC. Detection of respiratory viruses using non-molecular based methods. J. Clin. Virol. 40( Suppl. 1), S11–S14 (2007).
  • Kuypers J, Campbell AP, Cent A, Corey L, Boeckh M. Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients. Transpl. Infect. Dis. 11(4), 298–303 (2009).
  • Redelman-Sidi G, Sepkowitz KA, Huang CK et al. 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients. J. Infect. 60(4), 257–263 (2010).
  • Sails AD, Saunders D, Airs S, Roberts D, Eltringham G, Magee JG. Evaluation of the Cepheid respiratory syncytial virus and influenza virus A/B real-time PCR analyte specific reagent. J. Virol. Methods. 162(1–2), 88–90 (2009).
  • Beck ET, Jurgens LA, Kehl SC et al. Development of a rapid automated influenza A, influenza B, and respiratory syncytial virus A/B multiplex real-time RT-PCR assay and its use during the 2009 H1N1 swine-origin influenza virus epidemic in Milwaukee, Wisconsin. J. Mol. Diagn. 12(1), 74–81 (2010).
  • Murali S, Langston AA, Nolte FS, Banks G, Martin R, Caliendo AM. Detection of respiratory viruses with a multiplex polymerase chain reaction assay (MultiCode-PLx Respiratory Virus Panel) in patients with hematologic malignancies. Leuk. Lymphoma. 50(4), 619–624 (2009).
  • Hayden RT, Gu Z, Rodriguez A et al. Comparison of two broadly multiplexed PCR systems for viral detection in clinical respiratory tract specimens from immunocompromised children. J. Clin. Virol. 53(4), 308–313 (2012).
  • Pierce VM, Hodinka RL. Comparison of the GenMark Diagnostics eSensor respiratory viral panel to real-time PCR for detection of respiratory viruses in children. J. Clin. Microbiol. 50(11), 3458–3465 (2012).
  • Popowitch EB, O'Neill SS, Miller MB. Comparison of the Biofire Film Array RP, Genmark eSensor RVP, Luminex xTAG RVPv1, and Luminex xTAG RVP fast multiplex assays for detection of respiratory viruses. J. Clin. Microbiol. 51(5), 1528–1533 (2013).
  • Merante F, Yaghoubian S, Janeczko R. Principles of the xTAG respiratory viral panel assay (RVP Assay). J. Clin. Virol. 40( Suppl. 40), S31–S35 (2007).
  • Pabbaraju K, Wong S, Tokaryk KL, Fonseca K, Drews SJ. Comparison of the Luminex xTAG respiratory viral panel with xTAG respiratory viral panel fast for diagnosis of respiratory virus infections. J. Clin. Microbiol. 49(5), 1738–1744 (2011).
  • Poritz MA, Blaschke AJ, Byington CL et al. FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection. PLoS One 6(10), e26047 (2011).
  • BioFire Diagnostics Inc. FilmArray® Operator’s Manual RUO. BioFire Diagnostics Inc., Salt Lake City UT, USA (2010)
  • Datta V, Hayden, RT. In vitro nucleic acid amplification techniques. In: Molecular Microbiology, Diagnostic Principles and Practice. Persing D ( Ed.). ASM Press, Washington DC, USA 33–61 (2011).
  • Babady NE, Mead P, Stiles J et al. Comparison of the Luminex xTAG RVP Fast assay and the Idaho Technology FilmArray RP assay for detection of respiratory viruses in pediatric patients at a cancer hospital. J. Clin. Microbiol. 50(7), 2282–2288 (2012).
  • Loeffelholz MJ, Pong DL, Pyles RB et al. Comparison of the FilmArray Respiratory Panel and Prodesse real-time PCR assays for detection of respiratory pathogens. J. Clin. Microbiol. 49(12), 4083–4088 (2011).
  • Rand KH, Rampersaud H, Houck HJ. Comparison of two multiplex methods for detection of respiratory viruses: FilmArray RP and xTAG RVP. J. Clin. Microbiol. 49(7), 2449–2453 (2011).
  • Pierce VM, Elkan M, Leet M, McGowan KL, Hodinka RL. Comparison of the Idaho Technology FilmArray system to real-time PCR for detection of respiratory pathogens in children. J. Clin. Microbiol. 50(2), 364–371 (2012).
  • Renaud C, Crowley J, Jerome KR, Kuypers J. Comparison of FilmArray Respiratory Panel and laboratory-developed real-time reverse transcription-polymerase chain reaction assays for respiratory virus detection. Diagn. Microbiol. Infect. Dis. 74(4), 379–383 (2012).
  • Hammond SP, Gagne LS, Stock SR et al. Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods. J. Clin. Microbiol. 50(10), 3216–3221 (2012).
  • Bush JL, Zhang, F, Elsayed, H et al. Evaluation of the Biofire FilmArray Respiratory panel v1.6 and v1.7 for the detection of respiratory viruses. Presented at: 29th Clinical Virology Symposium. Daytonna Beach, FL, USA 2013.
  • Mack K, Salamon D, Madison J et al. Evaluation of a modified version of the FilmArray Respiratory panel (RUO v1.7) for detection of adenovirus from nasopharyngeal specimens. Presented at: 29th Clinical Virology Symposium. Daytonna Beach, FL, USA 2013.
  • Xu M, Qin X, Astion ML et al. Implementation of filmarray respiratory viral panel in a core laboratory improves testing turnaround time and patient care. Am. J. Clin. Pathol. 139(1), 118–123 (2013).
  • Couturier MR, Barney T, Alger G et al. Evaluation of the FilmArray(R) Respiratory Panel for clinical use in a large children's hospital. J. Clin. Lab Anal. 27(2), 148–154 (2013).
  • US National Archives and Records Administration. Code of Federal Regulations. Title 42, CFR 493.17. Test Categorization. 1993. Washington, DC, USA.

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