References
- Mandel P, Metais P. Les acides nucleiques du plasma sanguin chez lhomme. C R Seances Soc Biol Fil 1948;142(3-4):241-3
- Leon S, Shapiro B, Sklaroff D, Yaros M. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977;37(3):646-50
- Breitbach S, Sterzing B, Magallanes C, et al. Direct measurement of cell-free DNA from serially collected capillary plasma during incremental exercise. J Appl Physiol 2014;117(2):119-30
- Beiter T, Fragasso A, Hudemann J, et al. Neutrophils release extracellular DNA traps in response to exercise. J Appl Physiol 2014;117(3):325-33
- Velders M, Treff G, Machus K, et al. Exercise is a potent stimulus for enhancing circulating DNase activity. Clin Biochem 2014;47(6):471-4
- McIlroy DJ, Bigland M, White AE, et al. Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery. J Trauma Care Surg 2015;78(2):282-8
- Macher H, Egea-Guerrero JJ, Revuelto-Rey J, et al. Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury. Clin Chim Acta 2012;414:12-17
- Rodrigues Filho EM, Simon D, Ikuta N, et al. Elevated cell-free plasma DNA level as an independent predictor of mortality in patients with severe traumatic brain injury. J Neurotrauma 2014;31(19):1639-46
- Shaked G, Douvdevani A, Yair S, Zlotnik A, Czeiger D. The role of cell-free DNA measured by a fluorescent test in the management of isolated traumatic head injuries. Scand J Trauma Resusc Emerg Med 2014;22(1):21
- Wang HC, Lin YJ, Tsai NW, et al. Serial plasma deoxyribonucleic acid levels as predictors of outcome in acute traumatic brain injury. J Neurotrauma 2014;31(11):1039-45
- Hidestrand P, Hidestrand M, Stamm K, et al. Quantification of circulating donor specific cell free DNA is an exquisitely sensitive non-invasive indicator of injury to the donor heart. J Heart Lung Transplant 2013;32(4):S101-2
- Hidestrand M, Tomita-Mitchell A, Hidestrand PM, et al. Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid. J Am Coll Cardiol 2014;63(12):1224-6
- Oellerich M, Schütz E, Kanzow P, et al. Use of graft-derived cell-free DNA as an organ integrity biomarker to reexamine effective tacrolimus trough concentrations after liver transplantation. Ther Drug Monit 2014;36(2):136-40
- De Vlaminck I, Valantine HA, Snyder TM, et al. Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med 2014;6(241):241ra77
- Yi J, Zhang Y, Zhang Y, et al. Increased plasma cell-free DNA level during HTNV infection: Correlation with disease severity and virus load. Viruses 2014;6(7):2723-34
- Nyberg A, Sperber J, Lipcsey M, et al. Lung-protective ventilation suppresses plasma levels of cell-free DNA in porcine experimental postoperative sepsis. Crit Care 2014;18(Suppl 1):P292
- Avriel A, Paryente Wiessman M, Almog Y, et al. Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. PLoS One 2014;9(6):e100514
- Forsblom E, Aittoniemi J, Ruotsalainen E, et al. High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment. PLoS One 2014;9(2):e87741
- Steen SO, Iversen LV, Carlsen AL, et al. The circulating cell-free microRNA profile in systemic sclerosis is distinct from both healthy controls and systemic lupus erythematosus. J Rheumatol 2014;42(2):214-21
- Tug S, Helmig S, Menke J, et al. Correlation between cell free DNA levels and medical evaluation of disease progression in systemic lupus erythematosus patients. Cellular Immunology 2014;292(1-2):32-9
- Surmiak MP, Hubalewska-Mazgaj M, Wawrzycka-Adamczyk K, et al. Circulating mitochondrial DNA in serum of patients with granulomatosis with polyangiitis. Clin Exp Immunol 2015;181(1):150-5
- McGuire AL, Urosevic N, Chan DT, et al. The impact of chronic kidney disease and short-term treatment with rosiglitazone on plasma cell-free DNA levels. PPAR Res 2014;2014:1-8
- Al-Humood S, Zueriq R, Al-Faris L, et al. Circulating cell-free DNA in sickle cell disease: Is it a potentially useful biomarker? Arch Pathol Lab Med 2014;138(5):678-83
- Dinakaran V, Rathinavel A, Pushpanathan M, et al. Elevated levels of circulating DNA in cardiovascular disease patients: Metagenomic profiling of microbiome in the circulation. PLoS One 2014;9(8):e105221
- Gornik I, Wagner J, Gasparović V, et al. Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission. Resuscitation 2014;85(2):233-7
- Jylhävä J, Lehtimäki T, Jula A, et al. Circulating cell-free DNA is associated with cardiometabolic risk factors: the health. 2000;Atherosclerosis 2014;233(1):268-71
- Cerne D, Lukac Bajalo J. Cell-free nucleic acids as a non-invasive route for investigating atherosclerosis. Curr Pharm Des 2014;20(31):5004-9
- Fleischhacker M, Schmidt B. Circulating nucleic acids (cnas) and cancer-a survey. Biochim Biophys Acta BBARev Cancer 2007;1775(1):181-232
- Gormally E, Caboux E, Vineis P, Hainaut P. Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance. Mutat ResRev Mutat Res 2007;635(2):105-17
- Wu TL, Zhang D, Chia JH, et al. Cell-free DNA: measurement in various carcinomas and establishment of normal reference range. Clin Chim Acta 2002;321(1):77-87
- Sonnenberg A, Marciniak JY, Rassenti L, et al. Rapid electrokinetic isolation of cancer-related circulating cell-free DNA directly from blood. Clin Chem 2013;60(3):500-9
- Schwarzenbach H, Hoon DSB, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nature Reviews Cancer 2011;11(6):426-37
- Jen J, Wu L, Sidransky D. An overview on the isolation and analysis of circulating tumor DNA in plasma and serum. Ann N Y Acad Sci 2000;906(1):8-12
- Stroun M, Anker P, Lyautey J, et al. Isolation and characterization of dna from the plasma of cancer patients. European Journal of Cancer and Clinical Oncology 1987;23(6):707-12
- De Mattos-Arruda L, Weigelt B, Cortes J, et al. Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle. Ann Oncol 2014;25(9):1729-35
- Lennon AM, Wolfgang CL, Canto MI, et al. The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia? Cancer Research 2014;74(13):3381-9
- Diehl F, Schmidt K, Choti MA, et al. Circulating mutant DNA to assess tumor dynamics. Nat Med 2007;14(9):985-90
- Diehl F, Li M, Dressman D, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci 2005;102(45):16368-73
- Jylhävä J, Jylhä M, Lehtimäki T, et al. Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: The vitality 90+ study. Exp Gerontol 2012;47(5):372-8
- Rhodes A, Wort SJ, Thomas H, et al. Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care 2006;10(2):R60
- Elshimali Y, Khaddour H, Sarkissyan M, et al. The clinical utilization of circulating cell free DNA (ccfdna) in blood of cancer patients. Int J Mol Sci 2013;14(9):18925-58
- Sorenson GD, Pribish DM, Valone FH, et al. Soluble normal and mutated DNA sequences from single-copy genes in human blood. Cancer Epidemiology Biomarkers & Prevention 1994;3(1):67-71
- Vasioukhin V, Anker P, Maurice P, et al. Point mutations of the n-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br J Haematol 1994;86(4):774-9
- Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med 2014;6(224):224ra24
- Devonshire AS, Whale AS, Gutteridge A, et al. Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification. Anal Bioanal Chem 2014;406(26):6499-512
- Dawson SJ, Tsui DW, Murtaza M, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. New England Journal of Medicine 2013;368(13):1199-209
- Kin C, Kidess E, Poultsides GA, et al. Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis. Expert Rev Mol Diagn 2013;13(6):581-99
- Misale S, Yaeger R, Hobor S, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 2012;486(404):532-6
- Gevensleben H, Garcia-Murillas I, Graeser MK, et al. Noninvasive detection of her2 amplification with plasma DNA digital PCr. Clin Cancer Res 2013;19(12):3276-84
- Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med 2014;20(5):548-54
- El-Mazny A, Sayed M, Sharaf S. Human telomerase reverse transcriptase messenger rna (tert mrna) as a tumour marker for early detection of hepatocellular carcinoma. Arab J Gastroenterol 2014;15(2):68-71
- Fischer S, Gesierich S, Griemert B, et al. Extracellular rna liberates tumor necrosis factor-α to promote tumor cell trafficking and progression. Cancer Res 2013;73(16):5080-9
- Kopreski MS, Benko FA, Kwak LW, Gocke CD. Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res 1999;5(8):1961-5
- Kumarswamy R, Bauters C, Volkmann I, et al. Circulating long noncoding RNA, lipcar, predicts survival in patients with heart failure. Circ Res 2014;114(10):1569-75
- Lo KW, Lo YD, Leung SF, et al. Analysis of cell-free epstein-barr virus-associated rna in the plasma of patients with nasopharyngeal carcinoma. Clin Chem 1999;45(8):1292-4
- Munker R, Calin GA. MicroRNAs and other non-coding RNAs: Implications for cancer patients. MicroRNA in Cancer, Springer; 2013. p. 1-12
- Narita M, Saito A, Kojima A, et al. Quantification of BCR-ABL mRNA in plasma/serum of patients with chronic myelogenous leukemia. Int J Med Sci 2012;9(10):901
- Schwarzenbach H, Müller V, Milde-Langosch K, et al. Evaluation of cell-free tumour DNA and rna in patients with breast cancer and benign breast disease. Mol Biosyst 2011;7(10):2848-54
- Tani N, Ichikawa D, Ikoma D, et al. Circulating cell-free mRNA in plasma as a tumor marker for patients with primary and recurrent gastric cancer. Anticancer Res 2007;27(2):1207-12
- Zhang X, Wang C, Wang L, et al. Detection of circulating bmi-1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer. Int J Cancer 2012;131(1):165-72
- Kahlert C, Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med 2013;91(4):431-7
- Thakur BK, Zhang H, Becker A, et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res 2014;24(6):766-9
- Théry C. Exosomes: secreted vesicles and intercellular communications. F1000 biology reports 2011;3
- Hoerter JA, Krishnan V, Lionberger TA, Walter NG. siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. PLoS One 2011;6(5):e20359
- Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008;105(30):10513-18
- Kroh EM, Parkin RK, Mitchell PS, Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 2010;50(4):298-301
- Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75(5):843-54
- Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116(2):281-97
- Davis BN, Hata A. Regulation of microRNA biogenesis: A miRiad of mechanisms. Cell Commun Signal 2009;7:18-1186
- Tsimokha AS, Kulichkova VA, Karpova EV, et al. DNA damage modulates interactions between microRNAs and the 26S proteasome. Oncotarget 2014;5(11):3555
- Fuse M, Nohata N, Kojima S, et al. Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1. Int J Oncol 2011;38(4):1093-101
- Gandellini P, Profumo V, Casamichele A, et al.miR-205 regulates basement membrane deposition in human prostate: implications for cancer development. Cell Death Differ 2012;19(11):1750-60
- Li T, Li D, Sha J, et al. MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. Biochem Biophys Res Commun 2009;383(3):280-5
- Ho CS, Yap SH, Phuah NH, et al. MicroRNAs associated with tumour migration, invasion and angiogenic properties in A549 and SK-Lu1 human lung adenocarcinoma cells. Lung Cancer 2014;83(2):154-62
- Kinoshita T, Nohata N, Hanazawa T, et al. Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma. Br J Cancer 2013;109(10):2636-45
- Zha R, Guo W, Zhang Z, et al. Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma. PLoS One 2014;9(2):e87665
- Truong HH, Xiong J, Ghotra VP, et al. β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in e-cadherin-positive triple-negative breast cancer. Science Signaling 2014. 7(312):ra15
- Peter ME. Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle 2009;8(6):843-52
- Pineau P, Volinia S, McJunkin K, et al. miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci 2010;107(1):264-9
- Wurz K, Garcia RL, Goff BA, et al. MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival. Genes, Chromosomes and Cancer 2010;49(7):577-84
- Zhang J, Han L, Ge Y, et al. miR-221/222 promote malignant progression of glioma through activation of the Akt pathway. Int J Oncol 2010;36(4):913-20
- Anindo MIK, Yaqinuddin A. Insights into the potential use of microRNAs as biomarker in cancer. Int J Surg 2012;10(9):443-9
- Schwarzenbach H, Nishida N, Calin GA, Pantel K. Clinical relevance of circulating cell-free microRNAs in cancer. Nature Reviews Clinical Oncology 2014;11(3):145-56
- Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews Genetics 2010;11(9):597-610
- Cortez MA, Bueso-Ramos C, Ferdin J, et al. MicroRNAs in body fluids-the mix of hormones and biomarkers. Nature reviews Clinical oncology 2011;8(8):467-77
- Stroun M, Lyautey J, Lederrey C, et al. About the possible origin and mechanism of circulating DNA: Apoptosis and active DNA release. Clin Chim Acta 2001;313(1):139-42
- Vickers KC, Remaley AT. Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol 2012;23(2):91-7
- Tsujiura M. Liquid biopsy of gastric cancer patients: Circulating tumor cells and cell-free nucleic acids. World J Gastroenterol 2014;20(12):3265
- Alix-Panabières C, Schwarzenbach H, Pantel K. Circulating tumor cells and circulating tumor DNA. Annual Review of Medicine 2012;63(1):199-215
- Ligthart ST, Coumans FAW, Bidard FC, et al. Circulating tumor cells count and morphological features in breast, colorectal and prostate cancer. PLoS One 2013;8(6):e67148
- Ilie M, Hofman V, Long E, et al. Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. what is the best blood substrate for personalized medicine? Annals of translational medicine 2014;2:11
- Baccelli I, Schneeweiss A, Riethdorf S, et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol 2013;31(6):539-44
- He M, Crow J, Roth M, et al. Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip 2014;14(19):3773
- Gascoyne P, Shim S. Isolation of circulating tumor cells by dielectrophoresis. Cancers 2014;6(1):545-79
- Cheng J, Sheldon EL, Wu L, et al. Isolation of cultured cervical carcinoma cells mixed with peripheral blood cells on a bioelectronic chip. Anal Chem 1998;70(11):2321-6
- Shim S, Gascoyne P, Noshari J, Stemke Hale K. Dynamic physical properties of dissociated tumor cells revealed by dielectrophoretic field-flow fractionation. Integr Biol 2011;3(8):850
- Pethig R. Dielectrophoresis: Status of the theory, technology, and applications. Biomicrofluidics 2010;4(2):022811
- Gupta V, Jafferji I, Garza M, et al. ApoStream, a new dielectrophoretic device for antibody independent isolation and recovery of viable cancer cells from blood. Biomicrofluidics 2012;6(2):024133
- Huang C, Smith JP, Saha TN, et al. Characterization of microfluidic shear-dependent epithelial cell adhesion molecule immunocapture and enrichment of pancreatic cancer cells from blood cells with dielectrophoresis. Biomicrofluidics 2014;8(4):044107
- Song H, Rosano JM, Wang Y, et al. Continuous-flow sorting of stem cells and differentiation products based on dielectrophoresis. Lab on a Chip 2015;15(5):1320-8
- Sonnenberg A, Marciniak JY, Skowronski EA, et al. Dielectrophoretic isolation and detection of cancer-related circulating cell-free DNA biomarkers from blood and plasma. Electrophoresis 2014;35(12-13):1828-36
- Lo YMD, Corbetta N, Chamberlain PF, et al. Presence of fetal DNA in maternal plasma and serum. The Lancet 1997;350(9076):485-7
- Li Y, Holzgreve W, Di Naro E, et al. Cell-free DNA in maternal plasma. Ann N Y Acad Sci 2006;1075(1):81-7
- Galbiati S, Smid M, Gambini D, et al. Fetal DNA detection in maternal plasma throughout gestation. Hum Genet 2005;117(2-3):243-8
- Farina A, LeShane ES, Romero R, et al. High levels of fetal cell-free DNA in maternal serum: A risk factor for spontaneous preterm delivery. Am J Obstet Gynecol 2005;193(2):421-5
- Liu FM, Wang XY, Feng X, et al. Feasibility study of using fetal DNA in maternal plasma for non-invasive prenatal diagnosis. Acta Obstet Gynecol Scand 2007;86(5):535-41
- Norton ME, Jacobsson B, Swamy GK, et al. Cell-free DNA analysis for noninvasive examination of trisomy. N Engl J Med 2015;372(17):1589-97
- El Messaoudi S, Rolet F, Mouliere F, Thierry AR. Circulating cell free DNA: Preanalytical considerations. Clin Chim Acta 2013;424:222-30
- Clausen FB, Jakobsen TR, Rieneck K, et al. Pre-analytical conditions in non-invasive prenatal testing of cell-free fetal RHD. PLoS One 2013;8(10):e76990
- Finning K, Martin P, Summers J, et al. Effect of high throughput rhd typing of fetal DNA in maternal plasma on use of anti-RhD immunoglobulin in RhD negative pregnant women: prospective feasibility study. BMJ 2008;336(7648):816-18
- Norton S, Lechner J, Williams T, Fernando M. A stabilizing reagent prevents cell-free DNA contamination by cellular DNA in plasma during blood sample storage and shipping as determined by digital PCR. Clin Biochem 2013;46(15):1561-5
- Holmberg RC, Gindlesperger A, Stokes T, et al. Akonni TruTip and Qiagen methods for extraction of fetal circulating DNA-evaluation by real-time and digital PCR. PLoS One 2013;8(8):e73068
- Yoon KA, Park S, Lee SH, et al. Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls. J Mol Diagn 2009;11(3):182-5
- Sandhu GS, Kline BC, Stockman L, Roberts GD. Molecular probes for diagnosis of fungal infections. J Clin Microbiol 1995;33(11):2913-19
- Fong SL, Zhang JT, Lim CK, et al. Comparison of 7 methods for extracting cell-free DNA from serum samples of colorectal cancer patients. Clin Chem 2009;55(3):587-9
- Fleischhacker M, Schmidt B, Weickmann S, et al. Methods for isolation of cell-free plasma DNA strongly affect DNA yield. Clin Chim Acta 2011;412(23):2085-8
- Gahan PB. Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring. Advances in Predictive, Preventive and Personalised Medicine. Springer Science+Business Media, Dordrecht; 2015
- Barrett AN, Zimmermann BG, Wang D, et al. Implementing prenatal diagnosis based on cell-free fetal DNA: accurate identification of factors affecting fetal DNA yield. PLoS One 2011;6(10):e25202
- Sonnenberg A, Marciniak JY, McCanna J, et al. Dielectrophoretic isolation and detection of cfc-DNA nanoparticulate biomarkers and virus from blood. Electrophoresis 2013;34(7):1076-84
- Qian C, Huang H, Chen L, et al. Dielectrophoresis for bioparticle manipulation. Int J Mol Sci 2014;15(10):18281-309
- Asbury CL, van den Engh G. Trapping of DNA in nonuniform oscillating electric fields. Biophysical J 1998;74(2):1024-30
- Huang Y, Joo S, Duhon M, et al. Dielectrophoretic cell separation and gene expression profiling on microelectronic chip arrays. Anal Chem 2002;74(14):3362-71
- Krishnan R, Sullivan BD, Mifflin RL, et al. Alternating current electrokinetic separation and detection of DNA nanoparticles in high-conductance solutions. Electrophoresis 2008;29(9):1765-74
- Krishnan R, Heller MJ. An AC electrokinetic method for enhanced detection of DNA nanoparticles. J Biophotonics 2009;2(4):253-61
- Krishnan R, Dehlinger DA, Gemmen GJ, et al. Interaction of nanoparticles at the {DEP} microelectrode interface under high conductance conditions. Electrochem Commun 2009;11(8):1661-6
- Sonnenberg A, Marciniak JY, Krishnan R, Heller MJ. Dielectrophoretic isolation of DNA and nanoparticles from blood. Electrophoresis 2012;33(16):2482-90
- Li CN, Hsu HL, Wu TL, et al. Cell-free dna is released from tumor cells upon cell death: a study of tissue cultures of tumor cell lines. J Clin Lab Anal 2003;17(4):103-7
- Kanwar SS, Dunlay CJ, Simeone DM, Nagrath S. Microfluidic device (exochip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip 2014;14(11):1891