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Review

Metabonomics and its role in drug development and disease diagnosis

, &
Pages 189-199 | Published online: 09 Jan 2014

References

  • Human Genome Program, US Department of Energy. Genomics and Its Impact on Science and Society: A 2003 Primer US Department of Energy, WA, USA (2003).
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  • Raamsdonk LM, Teusink B, Broadhurst D et al A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotechnol 19,45–50 (2001).
  • ••Important paper that describes the use ofmetabolic profiling by gas chromatographic mass spectrometry (MS) to reveal the metabolic consequences of different gene expression profiles.
  • Nicholson JK, Lindon JC, Holmes E. Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data. Xenobiotica 29,1181–1189 (1999).
  • ••Short review which introduces the conceptand definition of metabonomics.
  • Lindon JC, Nicholson JK, Holmes E, Everett JR. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn. Reson. 12, 289–320 (2000).
  • Plumb RS, Stumpf CL, Gorenstein MV et al Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development. Rapid Commun. Mass Spectmm. 16,1991–1996 (2002).
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  • Lindon JC, Nicholson JK, Everett JR. NMR spectroscopy of biofluids. Ann. Rep. NMR Spectrom. 38,1–88 (1999).
  • •Comprehensive compilation of the nuclear magnetic resonance (NMR) spectral parameters and assignments for endogenous metabolites in biofluids known at the time.
  • Lindon JC, Nicholson JK, Wilson ID. Directly-coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development. I Chromatog: B 748,233–258 (2000).
  • •Most up-to-date review of the use of the directly-coupled techniques of liquid chromatography, NMR and MS for separation and identification of components of complex mixtures.
  • Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nature Rev. Drug Discov. 1,153–161 (2002).
  • ••Recent review of the definition ofmetabonomics and its application to drug safety assessment and evaluation of functional genomics.
  • Coen M, Lenz EM, Nicholson JK, Wilson ID, Pognan F, Lindon JC. An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy. Chem. Res. Toxicol 16,295–303 (2003).
  • Lamers RJAN, Wessels ECIIII, van der Sandt IC etal A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting. NutE 133,3080–3084 (2003).
  • El-Deredy W Pattern recognition approaches in biomedical and clinical magnetic resonance spectroscopy: a review. NMI? Blamed 10,99–124 (1997).
  • Lindon JC, Holmes E, Nicholson JK. Pattern recognition methods and applications in biomedical magnetic resonance. Frog. NMR Spectmsc. 39,1–40 (2001).
  • •Comprehensive and recent review of chemometric techniques and their application in magnetic resonance spectroscopy.
  • Holmes E, Connor SC, Nicholls AW et al Identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine. Chemomet. Intel. Lab. Systems 44, 251–261 (1998).
  • Beckwith-Hall BM, Nicholson JK, Nicholls A etal Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol 11, 260–272 (1998).
  • Holmes E, Nicholls A, Lindon JC et al Chemometric models for toxicity based on NMR spectra of biofluids. Chem. Res. Tarim'. 13,471–478 (2000).
  • Bollard ME, Holmes E, Lindon JC etal Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high resolution 1H-NMR spectroscopy of urine and pattern recognition. Anal Biochem. 295,194–202 (2001).
  • Lindon JC, Nicholson JK, Holmes E et al The role of metabonomics in toxicology and its evaluation by the COMET project. Appl Phatmacol 187,137-146 (2003). Overview of the successful COMET project aimed at generating NMR spectral databases of biofluids after administration of a wide range of toxins and derivation of computer-based expert systems for prediction of toxicity.
  • Plumb R, Granger J, Stumpf C, Wilson ID, Evans JA, Lenz EM. Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences. Analyst 128,819–823 (2003).
  • Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences; application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett. 484, 169–174 (2000).
  • 't Hart BA, Vogels JTVVE, Spijksma G, Brok HPM, Polman, C, van der Greef J. H-1 NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical patterns in urine of MS patients and non-human primates with MS-like disease. J: Neurosci. 212,21–30 (2003).
  • Lamers RJAN, DeGroot J, Spies-Faber EJ etal Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs. I NutE 133, 1776–1780 (2003).
  • Maxwell RJ, Martinez-Perez I, Cerdan S etal Pattern recognition analysis of 1H-NMR spectra from perchloric acid extracts of human brain biopsies. Magn. Res. Merl 39,869–877 (1998).
  • Brindle JT, Antti H, Holmes E etal Rapid and non-invasive diagnosis of the presence and severity of coronary heart disease using1H-NMR-based metabonomics. Natum Merl 8,1439–1444 (2002).
  • ••One of the first applications ofmetabonomics in a real clinical setting, focusing on diagnosis of atherosclerosis using NMR spectroscopy of blood plasma.
  • Waters NJ, Holmes E, Williams A, Waterfield CJ, Farrant RD, Nicholson JK. NMR and pattern recognition studies on the time-related metabolic effects of CL-naphthylisothiocyanate on liver, urine and plasma in the rat: an integrative metabonomic approach. Chem. Res. Toxicol 14,1401–1412 (2001).
  • •An integrated NMR-based metabonomics study in the toxicity field using a combination of tissue and biofluid samples.

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