Management of blood pressure in acute stroke

References

• Marshall J, Shaw DA. The natural history of cerebrovascular disease. BMJ. 1, 1614–1617 (1959).
   PubMedGoogle Scholar
• Yatsu FM, Zivin J. Hypertension in acute ischaemic stroke: not to treat. Arch. Neurol. 42, 999–1000 (1985).
   PubMedGoogle Scholar
• Spence JD, Del Maestro RF. Hypertension in acute ischaemic strokes—treat. Arch. Neurol. 42, 1000–1002 (1985).
   PubMedGoogle Scholar
• Ahmed N, Wahlgren NG. High initial blood pressure after acute stroke is associated with poor functional outcome. J. Intern. Med. 249, 467–473 (2001).
   PubMed Web of Science ®Google Scholar
• Chammorro A, Vila N, Ascaso C, Elices E, Schonwille W. Blood pressure and functional recovery in acute ischaemic stroke. Stroke 29, 1850–1853 (1998).
   PubMedGoogle Scholar
• Lawes CMM, Bennett DA, Feigin VL, Rodgers A. Blood pressure and stroke and overview of published reviews. Stroke 35(3), 776–785 (2004).
   PubMed Web of Science ®Google Scholar
• Bonita R. Epidemiology of stroke. Lancet 339, 342–344 (1992).
   PubMed Web of Science ®Google Scholar
• Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease. Br. Med. Bull. 50, 272–298 (1994).
   PubMed Web of Science ®Google Scholar
• Rodgers A, MacMahon S, Gamble G et al. Blood pressure and risk of stroke in patients with cerebrovascular disease. The United Kingdom Transient Ischaemic Attack Collaborative Group. BMJ. 313, 147 (1996).
   PubMed Web of Science ®Google Scholar
• Collins R, Peto R, MacMahon S. Blood pressure, stroke and coronary heart disease 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335, 827–838 (1990).
   PubMed Web of Science ®Google Scholar
• Eastern Stroke and Coronary Heart Disease Collaborative Research Group. Blood pressure, cholesterol, and stroke in eastern Asia. Lancet 352, 1801–1807 (1998).
   PubMed Web of Science ®Google Scholar
• Progress Collaborative Group. Randomised trial of a perindopril based blood pressure lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. Lancet 358, 1033–1041 (2001).
   PubMed Web of Science ®Google Scholar
• Neal B, MacMahon S, Chapman N. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists’ Collaboration. Lancet 356, 1955–1964 (2000).
   PubMed Web of Science ®Google Scholar
• Armario P, Ceresuela LM, Bello J et al. The role of blood pressure in the prognosis of acute ischaemic stroke. J. Hypertens 19(Suppl 2), s13 (2001).
   PubMed Web of Science ®Google Scholar
• Ahmed N, Wahlgren NG. High initial blood pressure after acute stroke is associated with poor functional outcome. J. Intern. Med. 249, 467–473 (2001).
   PubMed Web of Science ®Google Scholar
• Dandapani BK, Suzuki S, Kelley RE, Reyes-Iglesias Y, Duncan R. Relation between blood pressure and outcome in intracerebral hemorrhage. Stroke 26, 21–24 (1995).
   PubMed Web of Science ®Google Scholar
• Fiorelli M, Alpeovitch A, Argentino C et al. Prediction of long term outcome in the early hours following acute ischaemic stroke. Arch. Neurol. 95; 52, 250–255.
   Google Scholar
• Jorgensen H, Nakayara H, Raaschou H, Olsen T. Effect of blood pressure and diabetes mellitus on stroke progression. Lancet 344, 156–159 (1994).
   PubMed Web of Science ®Google Scholar
• Longo-Mbenza B, Tonduangu K, Muyeno K et al. Predictors of stroke – associated mortality in Africans. Rev. Epidemiol. Sante Publique 48(1), 31–39 (2000).
   PubMed Web of Science ®Google Scholar
• Carlberg B, Asplund K, Hagg E. The prognostic value of admission blood pressure in patients with acute stroke. Stroke 24, 1372–1375 (1993).
   PubMed Web of Science ®Google Scholar
• Droller H. The outlook in hemiplegia. Geriatrics 20, 630–636 (1965).
   Google Scholar
• Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke 33, 1315 (2002).
   PubMed Web of Science ®Google Scholar
• Vemmos KN, Tsiugoulis G, Spengas K et al. U shaped relationship between mortality and admission blood pressure in patients with acute stroke. J. Intern. Med. 255, 257–265 (2004).
   PubMed Web of Science ®Google Scholar
• International Society of Hypertension Writing Group. International Society of Hypertension (ISH): Statement on the management of blood pressure in acute stroke. J. Hypertens. 21, 665–672 (2003).
   PubMedGoogle Scholar
• Ohkubo T, Hozawa A, Nagai K et al. Prediction of stroke by ambulatory blood pressure monitoring versus screening blood pressure measurements in a general population: the Ohasama study. J. Hypertens. 18, 847–854 (2000).
   PubMed Web of Science ®Google Scholar
• Coats A. Reproducibility or variability of casual and ambulatory blood pressure data: implications for clinical trials. J. Hypertens. 6(Suppl. 6), S17–20 (1990).
   Google Scholar
• Robinson TG, James MA, Youde JH, Panerai RB, Potter JF. Cardiac baroreceptor sensitivity is impaired after acute stroke. Stroke 28, 1671–1676 (1997).
   PubMed Web of Science ®Google Scholar
• Robinson TG, Waddington A, Ward-Close S, Taub N, Potter JF. The predictive role of 24-hour compared to casual blood pressure levels on outcome following acute stroke. Cerebrovasc. Dis. 7, 264–272 (1997).
   Web of Science ®Google Scholar
• Robinson TG, Potter JF. Blood pressure in acute stroke (review). Age Ageing 33, 6–12 (2004).
   PubMed Web of Science ®Google Scholar
• CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet 349, 1641–1649 (1997).
   PubMed Web of Science ®Google Scholar
• International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 349, 1569–1581 (1997).
   PubMed Web of Science ®Google Scholar
• Jorgensen HS, Nakayama H, Christensen HR et al. Blood pressure in acute stroke. The Copenhagen stroke study. Cerebrovasc. Dis. 13, 204–209 (2002).
   PubMedGoogle Scholar
• Carlberg BO, Asplund K, Hagg E. Factors influencing admission blood pressure levels in patients with acute stroke. Stroke 22, 527–530 (1991).
   PubMed Web of Science ®Google Scholar
• Vemmos KN, Tsiugoulis G, Spengas K et al. U shaped relationship between mortality and admission blood pressure in patients with acute stroke. J. Intern. Med. 255, 257–265 (2004).
   PubMed Web of Science ®Google Scholar
• Quereshi A, Tuhrim S, Broderick J. Medical progress: spontaneous intracerebral haemorrhage. N. Engl. J. Med. 344, 1450–1460 (2001).
   PubMedGoogle Scholar
• Harper G, Castleden CM, Potter JF. Factors affecting changes in blood pressure after acute stroke. Stroke 25, 1726–1729 (1994).
   PubMed Web of Science ®Google Scholar
• Wallace JD, Levy LL. Blood pressure after stroke. JAMA. 246, 2177–2180 (1981).
   PubMed Web of Science ®Google Scholar
• Brodick J, Brott T, Barsan W et al. Blood pressure during the first minutes of focal cerebral ischaemia. Ann. Emerg. Med. 22, 1438–1443 (1993).
   PubMedGoogle Scholar
• Britton M, Carlsson A, de Faire U. Blood pressure course in patients with acute stroke and matched controls. Stroke 17, 861–864 (1986).
   PubMed Web of Science ®Google Scholar
• Aslanyan S, Fazekas F, Weir CJ, Horner S, Lees KR. Effect of blood pressure during the acute period of ischaemic stroke on stroke outcome: a tertiary analysis of the GAIN international trial. Stroke 34, 2420–2426 (2003).
   PubMed Web of Science ®Google Scholar
• Marcheselli S, Cavallini A, Tosi P et al. Impaired blood pressure increase in acute cardioembolic stroke. Stroke 24, 1849–1856 (2006).
   Google Scholar
• Strandgaard S, Paulson OB. Cerebral autoregulation. Stroke 15(3), 413–416 (1984).
   PubMed Web of Science ®Google Scholar
• Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc. Brain Metab. Rev. 2(2), 161–192 (1990).
   PubMedGoogle Scholar
• Olsen TS, Larsen B, Herning M, Bech Skriver ER, Lassen NA. Blood flow and vascular reactivity in collaterally perfused brain tissue. Evidence of an ischaemic penumbra in patients with acute stroke. Stroke 14, 332–341 (1983).
   PubMed Web of Science ®Google Scholar
• Barker FG, Ogilvy CS. Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: a meta-analysis. J. Neurosurg. 84, 405–414 (1996).
   PubMed Web of Science ®Google Scholar
• Mayberg MR, Batjer HH, Dacey R et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Circulation 90, 2592–2605 (1994).
   PubMed Web of Science ®Google Scholar
• Rordorf G, Koroshetz WJ, Ezzeddine MA, Segal AZ, Buonanno FS. A pilot study of drug induced hypertension for treatment of acute stroke. Neurology 6, 1210–1213 (2001).
   Google Scholar
• Rasool AHG, Rahman ARA, Choudray SR, Singh RB. Blood pressure in acute intracerebral haemorrhage. J. Hum. Hypertens 18, 187–192 (2004).
   PubMedGoogle Scholar
• Yong M, Diener HC, Kaste M, Mau J. Characteristics of Blood Pressure Profiles as predictors of long-term outcome after acute ischemic stroke. Stroke 36, 2619 (2005).
   PubMed Web of Science ®Google Scholar
• Gariballa SE, Robinson TG, Parker SG, Castleden CM. A prospective study of primary and secondary risk factor management in stroke patients. J. R. Coll. Physicians Lond. 29, 485–487 (1995).
   PubMedGoogle Scholar
• Lip GYH, Zafaris J, Farooqi IS et al. Ambulatory blood pressure monitoring in acute stroke. The West Birmingham Acute Stroke Project. Stroke 28, 31–35 (1997).
   PubMed Web of Science ®Google Scholar
• Myers M, Norris J, Hachinsky V, Weingert M, Sole M. Cardiac sequelae of acute stroke. Stroke 13, 838–842 (1982).
   PubMed Web of Science ®Google Scholar
• Myers MG, Norris JW, Hachinski VC, Sole MJ. Plasma norephinephrine in stroke. Stroke 12, 200–204 (1981).
   PubMed Web of Science ®Google Scholar
• Fassbender K, Schmidt R, Mobner R, Daffertshofer M, Hennerici M. Pattern of activation of the hypothalamic pituitary adrenal axis in acute stroke. Stroke 25, 1105–1108 (1994).
   PubMed Web of Science ®Google Scholar
• Butcher KS, Cechetto DF. Insular lesion evokes autonomic effects of stroke in normotensive and hypertensive rats. Stroke 26(3), 459–465 (1995).
   PubMedGoogle Scholar
• Arboix A, Roig H, Rossich R, Martinez EM, Garcia-Eroles L. Differences between hypertensive and non-hypertensive ischemic stroke. Eur. J. Neurol. 11, 687–692 (2004).
   PubMedGoogle Scholar
• Carlberg B, Asplund K, Hagg E. The prognostic value of admission blood pressure in patients with acute stroke. Stroke 24, 1372–1375 (1993).
   PubMed Web of Science ®Google Scholar
• Pickering TG, James GD, Body C et al. How common is white coat hypertension? JAMA. 259, 225–228 (1988).
   PubMed Web of Science ®Google Scholar
• Nadav L, Gur AY, Korczyn AD, Bornstein NM. Stroke in hospitalized patients: are there special risk factors? Cerebrovas. Dis. 13, 127–131 (2002).
   PubMed Web of Science ®Google Scholar
• Fortherby MD, Potter JF, Panayiotou B, Harper G. Blood pressure changes after stroke: abolishing the white coat effect. Stroke 24, 1422–1423 (1993).
   PubMedGoogle Scholar
• Langhorne P, Stott DJ, Robertson L et al. Medical complications after stroke: a multicenter study. Stroke 31, 1223–1229 (2000).
   PubMed Web of Science ®Google Scholar
• Yatsu FM, Zivin J. Hypertension in acute ischaemic stroke: not to treat. Arch. Neurol. 42, 999–1000 (1985).
   PubMedGoogle Scholar
• Spence JD, Del Maestro RF. Hypertension in acute ischaemic strokes—treat. Arch. Neurol. 42, 1000–1002 (1985).
   PubMedGoogle Scholar
• Marshall J, Shaw DA. The natural history of cerebrovascular disease. BMJ. 1, 1614–1617 (1959).
   PubMedGoogle Scholar
• Jorgensen H, Nakayara H, Raaschou H, Olsen T. Effect of blood pressure and diabetes mellitus on stroke progression. Lancet 344, 156–159 (1994).
   PubMed Web of Science ®Google Scholar
• Chammorro A, Vila N, Ascaso C, Elices E, Schonwille W. Blood pressure and functional recovery in acute ischaemic stroke. Stroke 29, 1850–1853 (1998).
   PubMedGoogle Scholar
• Longo-Mbenza B, Tonduangu K, Muyeno K et al. Predictors of stroke – associated mortality in Africans. Rev. Epidemiol. Sante. Publique 48(1), 31–39 (2000).
   PubMed Web of Science ®Google Scholar
• Fiorelli M, Alpeovitch A, Argentino C et al. Prediction of long-term outcome in the early hours following acute ischaemic stroke. Arch. Neurol. 95; 52, 250–255 (1995).
   Google Scholar
• Droller H. The outlook in hemiplegia. Geriatrics 20, 630–636 (1965).
   Google Scholar
• Wilmot M, Leonardi-Bee J, Bath PMW. High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertens 43, 18–24 (2004).
   PubMedGoogle Scholar
• Weaver CS, Leonardi-Bee J, Bath-Hextall FJ, Bath PM. Sample size calculations in acute stroke trials: a systematic review of their reporting, characteristics, and relationship with outcome. Stroke 35(5), 1216–1224 (2004).
   PubMedGoogle Scholar
• Ntaios G, Bath P, Michel P. Blood pressure treatment in acute ischaemic stroke: a review of studies and recommendations. Curr. Opin. Neurol. 23, 46–52 (2010).
   PubMedGoogle Scholar
• Semplicini A, Maresca A, Boscolo G et al. Hypertension in acute ischemic stroke: a compensatory mechanism or an additional damaging factor? Arch. Intern. Med. 163(2), 211–216 (2003).
   PubMed Web of Science ®Google Scholar
• Bath FJ, Bath PMW. What is the correct management of blood pressure in acute stroke? The blood pressure in acute stroke collaboration. Cerebrovasc. Dis. 7, 205–213 (1997).
   Google Scholar
• Vemmos KN, Spengos K, Tsivgoulis G et al. Factors influencing acute blood pressure values in stroke subtypes. J. Hum. Hypertens. 18(4), 253–259 (2004).
   PubMed Web of Science ®Google Scholar
• Gilligan AK, Markus R, Read S et al.; Australian Streptokinase Trial Investigators. Baseline blood pressure but not early computed tomography changes predicts major hemorrhage after streptokinase in acute ischemic stroke. Stroke 33(9), 2236–2242 (2002).
   PubMed Web of Science ®Google Scholar
• Bowes HP, Ziuin JA, Thomas GR, Thibodeaux H, Fagan SC. Acute hypertension but not thrombolysis increases incidence and severity of hemorrhagic transformation following experimental stroke in rabbits. Exp. Neurol. 141, 40–46.
   PubMedGoogle Scholar
• Sako Y, Choki J, Waki R et al. Hemorrhagic infarct induced by arterial hypertension in cat brain following MCA occlusion. Stroke 21, 585–595 (1990).
   Google Scholar
• Aslanyan S, Weir CJ, Diener HC, Kaste M, Lees KR; GAIN International Steering Committee and Investigators. Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial. Eur. J. Neurol. 11(1), 49–53 (2004).
   PubMed Web of Science ®Google Scholar
• Lisk Dr, Grotta JC, Lamki LM et al. Should hypertension be treated after stroke? A randomised controlled trial using SPECT. Arch. Neurol. 50, 855–862 (1993).
   PubMed Web of Science ®Google Scholar
• Schrader J, Luders S, Kulschewski A et al. Evaluation of Candesartan Cilextil therapy in stroke survivors. Stroke 34, 1699–1703 (2003).
   PubMed Web of Science ®Google Scholar
• Sandset EC, Bath PMW, Boysen G et al.; on behalf of the SCAST study group. The angiotensin-receptor blocker candesartan for treatments of acute stroke (SCAST): a randomized, placebo-controlled, double-blind trial. Lancet 377, 741–750 (2011).
   PubMed Web of Science ®Google Scholar
• Geeganage CM, Bath PMW. Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a meta-regression. Hypertension 54, 775–781 (2009).
   PubMed Web of Science ®Google Scholar
• Blood Pressure in Acute Stroke Collaboration (BASC). Interventions for deliberately altering blood pressure in acute stroke (Cochrane Systematic Review). Cochrane Database Syst. Rev. 2 (2006).
   Google Scholar
• Wise G, Sutter R, Burkholder J. The treatment of brain ischaemia with vasopressor drugs. Stroke 3, 135 (1972).
   PubMedGoogle Scholar
• Wise G. Vasopressor-drug therapy for complications of cerebral arteriography. N. Engl. J. Med. 282, 610–612 (1970).
   PubMedGoogle Scholar
• Mistri AK, Robinson TG, Potter JF. Pressor therapy in acute ischaemic stroke: a systematic review. Stroke 37, 1565–1571 (2006).
   PubMed Web of Science ®Google Scholar
• Rordorf G, Cramer SC, Efird JT et al. Pharmacological elevation of blood pressure in acute stroke clinical effects and safety. Stroke 28, 2133–2138 (1997).
   PubMed Web of Science ®Google Scholar
• Potter JF, Robinson TG, Ford GA et al. Controlling hypertension and hypotension immediately post-stroke (CHHIPS): a randomized, placebo-controlled, double-blind pilot trial. Lancet Neurol. 8, 48–56 (2009).
   PubMed Web of Science ®Google Scholar
• Robinson TG, Potter JF, Ford GA et al.; on behalf of the COSSACS Investigators. Effects of antihypertensive treatment after acute stroke in the Continue Or Stop post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomized, open, blinded-endpoint trial. Lancet Neurol. 9, 767–775 (2010).
   PubMed Web of Science ®Google Scholar
• Philippon J, Grob R, Dagreou F et al. Prevention of vasospasm in subarachnoid haemorrhage. A controlled study with nimodipine. Acta Neurochir. 82, 110–114 (1986).
   PubMed Web of Science ®Google Scholar
• Germano IM, Bartkowski HM, Cassel ME, Pitts LH. The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histopathological findings. J. Neurosurg. 67, 81–87 (1987).
   PubMed Web of Science ®Google Scholar
• Horn J, Limburg M. Calcium antagonists for acute ischaemic stroke (Cochrane Systematic Review). Cochrane Database Syst. Rev. 2 (2006).
   Google Scholar
• Niaz A, Nasman P, Wahlgren NG. Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. Stroke 31, 1250–1255 (2000).
   PubMedGoogle Scholar
• Franke CL, Palm R, Dalby M et al. Flunarizine in stroke treatment (FIST): a double blind placebo controlled trial in Scandinavia and the Netherlands. Acta Neurol. Scand. 93(1), 56–60 (1996).
   PubMed Web of Science ®Google Scholar
• Hakim AM, Evans AC, Berger L et al. The effect of nimodipine on the evolution of human cerebral infarction studied by PET. J. Cerebral Blood Flow Metab. 9(4), 523–534 (1989).
   PubMedGoogle Scholar
• Standefer M, Little JR. Improved neurological outcome in experimental focal cerebral ischemia treated with propranolol. Neurosurgery 18(2), 136–140 (1986).
   PubMedGoogle Scholar
• Savitz SI, Erhardt JA, Anthony JV et al. The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke. J. Cerebral Blood Flow Metab. 20(8), 1197–1204 (2000).
   PubMedGoogle Scholar
• Barer DH, Cruikshank JM, Ebrahim SB, Mitchell JR. Low dose beta blockade in acute stroke (“BEST” trial): an evaluation. BMJ. 296, 737–741 (1988).
   PubMed Web of Science ®Google Scholar
• The National Institutes of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med. 333, 1581–1587 (1995).
   PubMedGoogle Scholar
• Brott T, Lu M, Kothari R et al. Hypertension and its treatment in the NINDS rt-PA stroke trial. Stroke 29, 1504–1509 (1998).
   PubMed Web of Science ®Google Scholar
• Patel RV, Kertland HR, Jahns BE et al. Labetalol: response and safety in critically ill hemorrhagic stroke patients. Ann. Pharm. 27, 180–181 (1993).
   PubMed Web of Science ®Google Scholar
• Eames PJ, Robinson TG, Panerai RB, Potter JF. Bendrofluazide fails to reduce elevated blood pressure levels in the immediate post-stroke period. Cerebrovasc. Dis. 19, 253–259 (2005).
   PubMedGoogle Scholar
• Bath PMW, Pathansali R, Iddenden R, Bath FJ. The effect of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure and platelet function in acute stroke. Cerebrovasc. Dis. 11, 265–272 (2001).
   PubMed Web of Science ®Google Scholar
• Wilmot M, Ghadami A, Whysall B et al. Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke. Hypertension 47, 1209–1215 (2006).
   PubMedGoogle Scholar
• Cottrell JE, Patel K, Turndorf H, Ransohoff J. Intracranial pressure changes induced by sodium nitroprusside in patients with intracranial mass lesions. J. Neurosurg. 48, 329–331 (1978).
   PubMedGoogle Scholar
• Inada Y, Wada T, Sanada T et al. Protective effects of candesartan cilexitil against stroke, kidney dysfunction and cardiac hypertrophy in stroke prone spontaneously hypertensive rats. Clin. Exp. Hypertens. 19, 1079–1099 (1997).
   PubMed Web of Science ®Google Scholar
• Walters M, Muir S, Shah I, Lees KR. Effect of perindopril on cerebral vasomotor reactivity in patients with lacunar infarction. Stroke 35, 1899 (2004).
   PubMedGoogle Scholar
• Dyker AG, Grosset DG, Lees KR. Perindopril reduces blood pressure but not cerebral blood flow in patients with recent cerebral ischaemic stroke. Stroke 28, 580–583 (1997).
   PubMed Web of Science ®Google Scholar
• Walters MR, Dyker AG, Lees KR. The effect of perindopril on cerebral and renal perfusion in stroke patients with carotid disease. Cerebrovasc. Dis. 10(Suppl. 2), 75 (2000).
   Google Scholar
• Scrader J, Rothemeyer M, Luders S, Kollman K. Hypertension and stroke - the rationale behind the ACCESS trial. Basic Res. Cardiol. 93(Suppl. 2), 69–78 (1999).
   Google Scholar
• Dahlof B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U et al.; for the LIFE study group. Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction study (LIFE): a randomised trial against atenolol. Lancet 359, 995–1003 (2002).
   PubMed Web of Science ®Google Scholar
• Nazir FS, Overell JR, Bolster A, Hilditch TE, Reid JL, Lees KR. The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke. J. Hypertens. 22, 989–995 (2004).
   PubMed Web of Science ®Google Scholar
• Schrader J, Luders S, Kulschewski A et al. Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention: principle results of a prospective randomized controlled study (MOSES). Stroke 36(6), 1218–1226 (2005).
   PubMed Web of Science ®Google Scholar
• Yusuf C, Diener HC, Sacco RL et al. Telmisartan to prevent recurrent stroke and cardiovascular events. N. Engl. J. Med. 359(12), 1225–1237 (2008).
   PubMed Web of Science ®Google Scholar
• Fogelholm R, Avikainen S, Murros K. Prognostic value and determinants of first-day mean arterial pressure in spontaneous supratentorial intracerebral hemorrhage. Stroke 28(7), 1396–1400 (1997).
   PubMed Web of Science ®Google Scholar
• Powers WJ, Zazulia AR, Videen TO et al. Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology 57(1), 18–24 (2001).
   PubMed Web of Science ®Google Scholar
• ATACH Investigators. Antihypertensive treatment of acute cerebral hemorrhage. Crit. Care Med. 38, 637–648 (2010).
   PubMedGoogle Scholar
• Butcher KS, Jeerakathil T, Hill M et al. The Intracerebral haemorrhage acutely decreasing arterial pressure trial (ICH ADAPT): Final results. Stroke 44, A113 (2013).
   Google Scholar
• Anderson CS, Huang Y, Wang JG et al.; for the INTERACT Investigators. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomized pilot trial. Lancet Neurol. 7, 391–399 (2008).
   PubMed Web of Science ®Google Scholar
• Anderson CS, Heeley E, Huang Y et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N. Engl. J. Med. doi:10.1056/NEJMoa1214609 (2013).
   Google Scholar
• Bath PMW, Weaver C, Iddenden R. A trial of blood pressure reduction in stroke age. Ageing 29(6), 554–555 (2001).
   Google Scholar
• Kanji S, Corman C, Douen AG. Blood pressure management in acute stroke: comparison of current guidelines with prescribing patterns. Can. J. Neurol. Sci. 29, 125–131 (2002).
   PubMedGoogle Scholar
• Adams HP, Adams RJ, Brott T et al.; Stroke Council of the American Stroke Association. Guidelines for the early management of patients with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association. Stroke 34(4), 1056–1083 (2003).
   PubMed Web of Science ®Google Scholar
• Quinn TJ, Reid JLR. Hypertension in acute stroke. In: European Society of Hypertension, Manual of Hypertension. Chapter 44. Informa Healthcare, London, UK (2007).
   Google Scholar