454
Views
49
CrossRef citations to date
0
Altmetric
Symposium Papers

Decoding multiple sclerosis: an update on genomics and future directions

Pages 11-19 | Published online: 29 Nov 2013

References

  • Johnson BA, Oksenberg JR. Chapter 235.2. The role of genetics in multiple sclerosis. In: Scriver’s Online Metabolic and Molecular Bases of Inherited Disease (OMMBID). Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A ( Eds). McGraw-Hill, NY, USA (2012).
  • International Multiple Sclerosis Genetics Consortium. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357(9), 851–862 (2007).
  • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), 661–678 (2007).
  • Comabella M, Craig DW, Camiña-Tato M et al. Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. PLoS ONE 3(10), e3490 (2008).
  • Baranzini SE, Wang J, Gibson N et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum. Mol. Genet. 15:767–778 (2009).
  • Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat. Genet. 41(7), 824–828 (2009).
  • Jakkula E, Leppä V, Sulonen AM et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am. J. Hum. Genet. 86(2), 285–291 (2010).
  • Sanna S, Pitzalis M, Zoledziewska M et al. Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat. Genet. 42(6), 495–497 (2010).
  • International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476(7359), 214–219 (2011).
  • Matesanz F, González-Pérez A, Lucas M et al. Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1. PLoS ONE 7(5), e36140 (2012).
  • Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 9(7), 516–526 (2008).
  • Cortes A, Brown MA. Promise and pitfalls of the Immunochip. Arthritis Res. Ther. 13(1), 101 (2011).
  • International Multiple Sclerosis Genetics Consortium. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 45, 1353–1360 (2013).
  • Gourraud PA, McElroy JP, Caillier SJ et al. Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann. Neurol. 69(1), 65–74 (2011).
  • Isobe N, Gourraud PA, Harbo HF et al. Genetic risk variants in African Americans with multiple sclerosis. Neurology 81(3), 219–227 (2013).
  • Gregory SG, Schmidt S, Seth P et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat. Genet. 39(9), 1083–1091 (2007).
  • Maier LM, Lowe CE, Cooper J et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 5(1), e1000322 (2009).
  • Gregory AP, Dendrou CA, Attfield KE et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 488(7412), 508–511 (2012).
  • De Jager PL, Baecher-Allan C, Maier LM et al. The role of the CD58 locus in multiple sclerosis. Proc. Natl Acad. Sci. USA 106(13), 5264–5269 (2009).
  • De Jager PL, Jia X, Wang J et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 41(7), 776–782 (2009).
  • Couturier N, Bucciarelli F, Nurtdinov RN et al. Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility. Brain 134(Pt 3), 693–703 (2011).
  • Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J. Immunol. 187(6), 3286–3291 (2011).
  • Martin D, Pantoja C, Fernandez-Minan A et al. Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat. Struct. Mol. Biol. 18(6), 708–715 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.