References
- Brenner HD, Dencker SJ, Goldstein MJ et al. Defining treatment refractoriness in schizophrenia. Schizophr. Bull. 16, 551–561 (1990).
- Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch. Gen. Psychiatry. 45, 789–796 (1988).
- Kuipers E, Garety P, Fowler D et al. London-East Anglia randomised controlled trial of cognitive-behavioural therapy for psychosis. I: effects of the treatment phase. Br. J. Psychiatry. 171, 319–327 (1997).
- NICE. Schizophrenia: Full National Clinical Guideline On Core Interventions In Primary And Secondary Care. Gaskell and the British Psychological Society, London (2003).
- NICE. Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Adults in Primary and Secondary Care (Update). National Institute of Clinical Excellence, London, UK (2009).
- Rathod S, Phiri P, Kingdon D. Cognitive behavioral therapy for schizophrenia. Psychiat. Clin. North America 33, 527–536 (2010).
- Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373, 31–41 (2009).
- Kendall T. The rise and fall of the atypical antipsychotics. Br. J. Psychiatry. 199, 266–268 (2011).
- Geddes J, Freemantle N, Harrison P, Bebbington P. Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis. BMJ 321, 1371–1376 (2000).
- Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of second-generation antipsychotics. Arch. Gen. Psychiatry 60, 553–564 (2003).
- Hartling L, Abou-Setta AM, Dursun S, Mousavi SS, Pasichnyk D, Newton AS. Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications: a systematic review and meta-analysis. Ann. Int. Med. 157, 498–511 (2012).
- Lieberman JA, Stroup TS, McEvoy JP et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N. Engl. J. Med. 353, 1209–1223 (2005).
- Jones PB, Barnes TR, Davies L et al. Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch. Gen. Psychiatry 63, 1079–1087 (2006).
- Lieberman JA, Stroup TS. The NIMH-CATIE Schizophrenia Study: what did we learn? Am. J. Psychiatry 168, 770–775 (2011).
- Leucht S, Kissling W, Davis JM. Second-generation antipsychotics for schizophrenia: can we resolve the conflict? Psychol. Med. 39, 1591–1602 (2009).
- Citrome L. Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialised second-generation antipsychotic. Int. J. Clin Pract. 63, 1237–1248 (2009).
- Deeks ED, Keating GM. Blonanserin: a review of its use in the management of schizophrenia. CNS Drugs 24, 65–84 (2010).
- Szegedi A, Verweij P, van Duijnhoven W, Mackle M, Cazorla P, Fennema H. Meta-analyses of the efficacy of asenapine for acute schizophrenia: comparisons with placebo and other antipsychotics. J. Clin. Psychiatry 73, 1533–1540 (2012).
- Sanford M. Lurasidone : in the treatment of schizophrenia. CNS Drugs 27, 67–80 (2013).
- Schulze M, Siol O, Robaa D et al. Molecular combination of the dopamine and serotonin scaffolds yield in novel antipsychotic drug candidates – characterization by in vivo experiments. Arzneimittle Forschung Drug Res. 6, 252–260 (2012).
- Agai-Csongor E, Domany G, Nogradi K et al. Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg. Med. Chem. Lett. 22, 3437–3440 (2012).
- Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen XC. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse 65, 379–387 (2011).
- Javitt DC. Twenty-five years of glutamate in schizophrenia: are we there yet? Schizophr. Bull. 38, 911–913 (2012).
- Tuominen HJ, Tiihonen J, Wahlbeck K. Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophr. Res. 72, 225–234 (2005).
- Buchanan RW, Javitt DC, Marder SR et al. The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am. J. Psychiatry 164, 1593–1602 (2007).
- Lieberman JA, Papadakis K, Csernansky J et al. A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia. Neuropsychopharmacology 34, 1322–1329 (2009).
- Singh SP, Singh V. Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs 25, 859–885 (2011).
- Patil ST, Zhang L, Martenyi F et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat. Med. 13, 1102–1107 (2007).
- Kinon BJ, Zhang L, Millen BA et al. A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia. J. Clin. Psychopharmacol. 31, 349–355 (2011).
- Olszewski RT, Janczura KJ, Ball SR et al. NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia. Translat. Psychiatry 2, e145 (2012).
- Alberati D, Moreau JL, Lengyel J et al. Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia. Neuropharmacology 62, 1152–1161 (2012).
- Umbricht D. Glycine Transporter Type 1 (GLYT1) Inhibitor RG1678: positive results of the proof-of-concept study for the treatment of negative symptoms in schizophrenia. Neuropharmacology 35, S320–S321 (2010).
- Stone J. Glutamatergic antipsychotic drugs: a new dawn in the treatment of schizophrenia? Ther. Adv. Psychopharmacol. 1, 5–18 (2011).
- Chaudhry IB, Hallak J, Husain N, et al. Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. J. Psychopharmacology. 26, 1185–1193 (2012).
- Raedler TJ, Bymaster FP, Tandon R, Copolov D, Dean B. Towards a muscarinic hypothesis of schizophrenia. Mol. Psychiatry 12, 232–246 (2007).
- Meltzer HY. EVP-6124, an alpha-7 nicotinic partial agonist, produces positive effects on cognition, clinical function, and negative symptoms in patients with chronic schizophrenia on stable antipsychotic therapy. Neuropsychopharmacology 36, S170–S171 (2011).
- Oliveros A, Heckman MG, Del Pilar Corena-McLeod M, Williams K, Boules M, Richelson E. Sensorimotor gating in NTS1 and NTS2 null mice: effects of d-amphetamine, dizocilpine, clozapine and NT69L. J. Exp. Biology 213, 4232–2439 (2010).
- Roser P, Vollenweider FX, Kawohl W. Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists. World. J. Biol. Psychiatry 11, 208–219 (2010).
- Leweke FM, Piomelli D, Pahlisch F et al. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translat. Psychiatry 2, e94 (2012).
- Sensky T, Turkington D, Kingdon D et al. A randomized controlled trial of cognitive-behavioral therapy for persistent symptoms in schizophrenia resistant to medication. Arch. Gen. Psychiatry 57, 165–172 (2000).
- Lewis S, Tarrier N, Haddock G et al. Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes. Br. J. Psychiatry ( Suppl. 43), s91–s97 (2002).
- Turkington D, Kingdon D, Turner T. Effectiveness of a brief cognitive-behavioural therapy intervention in the treatment of schizophrenia. Br. J. Psychiatry 180, 523–527 (2002).
- Garety PA, Fowler DG, Freeman D, Bebbington P, Dunn G, Kuipers E. Cognitive--behavioural therapy and family intervention for relapse prevention and symptom reduction in psychosis: randomised controlled trial. Br. J. Psychiatry 192, 412–423 (2008).
- van der Gaag M, Stant AD, Wolters KJ, Buskens E, Wiersma D. Cognitive-behavioural therapy for persistent and recurrent psychosis in people with schizophrenia-spectrum disorder: cost-effectiveness analysis. Br. J. Psychiatry 198( Suppl. 1), 59–65, (2011).
- Wykes T, Steel C, Everitt B, Tarrier N. Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor. Schizophr. Bull. 34, 523–537 (2008).
- Gumley A, O’Grady M, McNay L, Reilly J, Power K, Norrie J. Early intervention for relapse in schizophrenia: results of a 12-month randomized controlled trial of cognitive behavioural therapy. Psychol. Med. 33, 419–431 (2003).
- Gleeson JF, Cotton SM, Alvarez-Jimenez M et al. A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients. J. Clin. Psychiatry 70, 477–486 (2009).
- Grant PM, Huh GA, Perivoliotis D, Stolar NM, Beck AT. Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia. Arch. Gen. Psychiatry (2011).
- Aggarwal M, Basu D. Cognitive therapy in patients with schizophrenia. JAMA Psychiatry 70, 543–544 (2013).
- Klingberg S, Wolwer W, Engel C et al. Negative symptoms of schizophrenia as primary target of cognitive behavioral therapy: results of the randomized clinical TONES study. Schizophr. Bull. 37( Suppl. 2), S98–S110 (2011).
- Jüni P, Altman DG, Egger M. Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ 323, 42–46 (2001).
- Chambless DL, Hollon SD. Defining empirically supported therapies. J. Consult. Clin. Psychol. 66, 7–18 (1998).
- Jensen PS, Weersing R, Hoagwood KE, Goldman E. What is the evidence for evidence-based treatments? A hard look at our soft underbelly. Ment. Health Serv. Res. 7, 53–74 (2005).
- Kirsch I. Placebo psychotherapy: synonym or oxymoron? J. Clin. Psychol. 61, 791–803 (2005).
- Bentall R. Doctoring the Mind: Why Psychiatric Treatments Fail. Allen Lane, NY, USA (2009).
- Jones C, Hacker D, Cormac I, Meaden A, Irving CB. Cognitive behaviour therapy versus other psychosocial treatments for schizophrenia. Cochrane Database Sys. Rev. 4, CD008712 (2012.)
Websites
- Lilly. Lilly stops Phase III development of pomaglumetad methionil for the treatment of schizophrenia based on efficacy results. https://investor.lilly.com/releaseDetail.cfm?ReleaseID=7030182012
- Kings College Hospital website. Minocycline and negative symptoms in schizophrenia. www.kcl.ac.uk/iop/depts/ps/research/clinicaltrials/Minocyclineandnegativesymptomsinschizophrenia.aspx,2012
- Clinical trials.gov. Efficacy, safety, and tolerability of TC-5619 as augmentation therapy to improve negative symptoms and cognition in outpatients with schizophrenia. http://clinicaltrials.gov/ct2/show/NCT01488929?term=%22schizophrenia%22+AND+%22TC-5619%22&rank=12012
- NCCMH. www.nccmh.org.uk/