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Treatment of motor fluctuations in Parkinson’s disease: recent developments and future directions

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References

  • Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov. Disord. 16(3), 448–458 (2001).
  • Chapuis S, Ouchchane L, Metz O, Gerbaud L, Durif F. Impact of the motor complications of Parkinson’s disease on the quality of life. Mov. Disord. 20(2), 224–230 (2005).
  • Hauser RA, Deckers F, Lehert P. Parkinson’s disease home diary: further validation and implications for clinical trials. Mov. Disord. 19(12), 1409–1413 (2004).
  • Kalia LV, Brotchie JM, Fox SH. Novel nondopaminergic targets for motor features of Parkinson’s disease: review of recent trials. Mov. Disord. 28(2), 131–144 (2013).
  • Schwarzschild MA, Agnati L, Fuxe K, Chen JF, Morelli M. Targeting adenosine A2A receptors in Parkinson’s disease. Trends Neurosci. 29(11), 647–654 (2006).
  • Shiozaki S, Ichikawa S, Nakamura J, Kitamura S, Yamada K, Kuwana Y. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology 147(1), 90–95 (1999).
  • Kanda T, Jackson MJ, Smith LA et al. Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. Ann. Neurol. 43(4), 507–513 (1998).
  • Abstracts of the 8th International Congress of Parkinson’s Disease and Movement Disorders. June 14-17, 2004. Rome, Italy. Mov. Disord. 19(Suppl. 9), S1–S491 (2004).
  • LeWitt PA, Guttman M, Tetrud JW et al. Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces “off” time in Parkinson’s disease: a double-blind, randomized, multicenter clinical trial (6002-US-005). Ann. Neurol. 63(3), 295–302 (2008).
  • Hauser RA, Shulman LM, Trugman JM et al. Study of istradefylline in patients with Parkinson’s disease on levodopa with motor fluctuations. Mov. Disord. 23(15), 2177–2185 (2008).
  • Mizuno Y, Hasegawa K, Kondo T, Kuno S, Yamamoto M; Japanese Istradefylline Study Group. Clinical efficacy of istradefylline (KW-6002) in Parkinson’s disease: a randomized, controlled study. Mov. Disord. 25(10), 1437–1443 (2010).
  • Mizuno Y, Kondo T; Japanese Istradefylline Study Group. Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson’s disease. Mov. Disord. 28(8), 1138–1141 (2013).
  • Pourcher E, Fernandez HH, Stacy M, Mori A, Ballerini R, Chaikin P. Istradefylline for Parkinson’s disease patients experiencing motor fluctuations: results of the KW-6002-US-018 study. Parkinsonism Relat. Disord. 18(2), 178–184 (2012).
  • Factor S, Mark MH, Watts R et al. A long-term study of istradefylline in subjects with fluctuating Parkinson’s disease. Parkinsonism Relat. Disord. 16(6), 423–426 (2010).
  • Hauser RA, Cantillon M, Pourcher E et al. Preladenant in patients with Parkinson’s disease and motor fluctuations: a phase 2, double-blind, randomised trial. Lancet Neurol. 10(3), 221–229 (2011).
  • Factor SA, Wolski K, Togasaki DM et al. Long-term safety and efficacy of preladenant in subjects with fluctuating Parkinson’s disease. Mov. Disord. 28(6), 817–820 (2013).
  • Stocchi F, Borgohain R, Onofrj M et al. A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson’s disease patients. Mov. Disord. 27(1), 106–112 (2012).
  • Barone P, Fernandez H, Ferreira J et al. Safinamide as an add-on therapy to a stable dose of a single dopamine agonist: results from a randomized, placebo-controlled, 24-week multicenter trial in early idiopathic Parkinson disease (PD) patients (MOTION Study). Neurology 80 (Meeting Abstracts 1), P01.061 (2013).
  • Schapira AH, Fox S, Hauser R et al. Safinamide add on to L-dopa: a randomized, placebo-controlled, 24-week global trial in patients with Parkin- son’s disease (PD) and motor fluctuations (SETTLE). Neurology 80 (Meeting Abstracts 1), P01.062 (2013).
  • Gregoire L, Jourdain VA, Townsend M, Roach A, Di Paolo T. Safinamide reduces dyskinesias and prolongs l-DOPA antiparkinsonian effect in parkinsonian monkeys. Parkinsonism Relat. Disord. 19(5), 508–514 (2013).
  • Murata M, Hasegawa K, Kanazawa I; Japan Zonisamide on PDSG. Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study. Neurology 68(1), 45–50 (2007).
  • Mochio S, Sengoku R, Kono Y et al. Actigraphic study of tremor before and after treatment with zonisamide in patients with Parkinson’s disease. Parkinsonism Relat. Disord. 18(7), 906–908 (2012).
  • Jenner P. Molecular mechanisms of L-DOPA-induced dyskinesia. Nat. Rev. Neurosci. 9(9), 665–677 (2008).
  • Snow BJ, Macdonald L, McAuley D, Wallis W. The effect of amantadine on levodopa-induced dyskinesias in Parkinson’s disease: a double-blind, placebo-controlled study. Clin. Neuropharmacol. 23(2), 82–85 (2000).
  • Thomas A, Iacono D, Luciano AL, Armellino K, Di Iorio A, Onofrj M. Duration of amantadine benefit on dyskinesia of severe Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 75(1), 141–143 (2004).
  • Wolf E, Seppi K, Katzenschlager R et al. Long-term antidyskinetic efficacy of amantadine in Parkinson’s disease. Mov. Disord. 25(10), 1357–1363 (2010).
  • Gasparini F, Di Paolo T, Gomez-Mancilla B. Metabotropic glutamate receptors for Parkinson’s disease therapy. Parkinsons Dis. 2013, 196028 (2013).
  • Lees A, Fahn S, Eggert KM et al. Perampanel, an AMPA antagonist, found to have no benefit in reducing “off” time in Parkinson’s disease. Mov. Disord. 27(2), 284–288 (2012).
  • Rascol O, Barone P, Behari M et al. Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone. Clin. Neuropharmacol. 35(1), 15–20 (2012).
  • Clarke CE, Cooper JA, Holdich TA, Group TS. A randomized, double-blind, placebo-controlled, ascending-dose tolerability and safety study of remacemide as adjuvant therapy in Parkinson’s disease with response fluctuations. Clin. Neuropharmacol. 24(3), 133–138 (2001).
  • Shoulson I, Penney J, McDermott M et al. A randomized, controlled trial of remacemide for motor fluctuations in Parkinson’s disease. Neurology 56(4), 455–462 (2001).
  • Mela F, Marti M, Dekundy A, Danysz W, Morari M, Cenci MA. Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson’s disease. J. Neurochem. 101(2), 483–497 (2007).
  • Johnston TH, Fox SH, McIldowie MJ, Piggott MJ, Brotchie JM. Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson’s disease. J. Pharmacol. Exp. Ther. 333(3), 865–873 (2010).
  • Berg D, Godau J, Trenkwalder C et al. AFQ056 treatment of levodopa-induced dyskinesias: results of 2 randomized controlled trials. Mov. Disord. 26(7), 1243–1250 (2011).
  • Stocchi F, Rascol O, Destee A et al. AFQ056 in Parkinson patients with levodopa-induced dyskinesia: 13-week, randomized, dose-finding study. Mov. Disord. (2013).
  • Barnum CJ, Bhide N, Lindenbach D et al. Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by alpha- and beta-adrenergic receptor antagonists in hemiparkinsonian rats. Pharmacol. Biochem. Behav. 100(3), 607–615 (2012).
  • Brotchie JM. Nondopaminergic mechanisms in levodopa-induced dyskinesia. Mov. Disord. 20(8), 919–931 (2005).
  • Halliday GM, Blumbergs PC, Cotton RG, Blessing WW, Geffen LB. Loss of brainstem serotonin- and substance P-containing neurons in Parkinson’s disease. Brain Res. 510(1), 104–107 (1990).
  • Hill MP, Brotchie JM. The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat. Br. J. Pharmacol. 128(7), 1577–1585 (1999).
  • Srinivasan J, Schmidt WJ. The effect of the alpha2-adrenoreceptor antagonist idazoxan against 6-hydroxydopamine-induced Parkinsonism in rats: multiple facets of action? Naunyn Schmiedebergs Arch. Pharmacol. 369(6), 629–638 (2004).
  • Henry B, Fox SH, Peggs D, Crossman AR, Brotchie JM. The alpha2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primate model of Parkinson’s disease. Mov. Disord. 14(5), 744–753 (1999).
  • Savola JM, Hill M, Engstrom M et al. Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease. Mov. Disord. 18(8), 872–883 (2003).
  • Lewitt PA, Hauser RA, Lu M et al. Randomized clinical trial of fipamezole for dyskinesia in Parkinson disease (FJORD study). Neurology 79(2), 163–169 (2012).
  • Olanow CW, Damier P, Goetz CG et al. Multicenter, open-label, trial of sarizotan in Parkinson disease patients with levodopa-induced dyskinesias (the SPLENDID Study). Clin. Neuropharmacol. 27(2), 58–62 (2004).
  • Goetz CG, Damier P, Hicking C et al. Sarizotan as a treatment for dyskinesias in Parkinson’s disease: a double-blind placebo-controlled trial. Mov. Disord. 22(2), 179–186 (2007).
  • Pahwa R, Factor SA, Lyons KE et al. Practice parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology. Neurology 66(7), 983–995 (2006).
  • Calandrella D, Antonini A. Pulsatile or continuous dopaminomimetic strategies in Parkinson’s disease. Parkinsonism Relat. Disord. 18(Suppl. 1), S120–S122 (2012).
  • Katzenschlager R, Hughes A, Evans A et al. Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson’s disease: a prospective study using single-dose challenges. Mov. Disord. 20(2), 151–157 (2005).
  • Cereceda-Balic F, Kleist E, Prast H, Schlimper H, Engel H, Gunther K. Description and evaluation of a sampling system for long-time monitoring of PAHs wet deposition. Chemosphere 49(3), 331–340 (2002).
  • van Laar T, van der Geest R, Danhof M, Bodde HE, Goossens PH, Roos RA. Stepwise intravenous infusion of apomorphine to determine the therapeutic window in patients with Parkinson’s disease. Clin. Neuropharmacol. 21(3), 152–158 (1998).
  • Pfeiffer RF, Gutmann L, Hull KL, Jr., Bottini PB, Sherry JH, Investigators APOS. Continued efficacy and safety of subcutaneous apomorphine in patients with advanced Parkinson’s disease. Parkinsonism Relat. Disord. 13(2), 93–100 (2007).
  • De Gaspari D, Siri C, Landi A et al. Clinical and neuropsychological follow up at 12 months in patients with complicated Parkinson’s disease treated with subcutaneous apomorphine infusion or deep brain stimulation of the subthalamic nucleus. J. Neurol. Neurosurg. Psychiatry 77(4), 450–453 (2006).
  • Tyne HL, Parsons J, Sinnott A, Fox SH, Fletcher NA, Steiger MJ. A 10 year retrospective audit of long-term apomorphine use in Parkinson’s disease. J. Neurol. 251(11), 1370–1374 (2004).
  • Antonini A, Odin P. Pros and cons of apomorphine and L-dopa continuous infusion in advanced Parkinson’s disease. Parkinsonism Relat. Disord. 15(Suppl. 4), S97–S100 (2009).
  • Pahwa R, Stacy MA, Factor SA et al. Ropinirole 24-hour prolonged release: randomized, controlled study in advanced Parkinson disease. Neurology 68(14), 1108–1115 (2007).
  • Zhang Z, Wang J, Zhang X et al. The efficacy and safety of ropinirole prolonged release tablets as adjunctive therapy in Chinese subjects with advanced Parkinson’s disease: a multicenter, double-blind, randomized, placebo-controlled study. Parkinsonism Relat. Disord. 19(11), 1022–1026 (2013).
  • Watts RL, Jankovic J, Waters C, Rajput A, Boroojerdi B, Rao J. Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease. Neurology 68(4), 272–276 (2007).
  • LeWitt PA, Lyons KE, Pahwa R, Group SPS. Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study. Neurology 68(16), 1262–1267 (2007).
  • Schapira AH, Barone P, Hauser RA et al. Extended-release pramipexole in advanced Parkinson disease: a randomized controlled trial. Neurology 77(8), 767–774 (2011).
  • Samanta J, Hauser RA. Duodenal levodopa infusion for the treatment of Parkinson’s disease. Expert Opin. Pharmacother. 8(5), 657–664 (2007).
  • Nyholm D, Nilsson Remahl AI, Dizdar N et al. Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease. Neurology 64(2), 216–223 (2005).
  • Nyholm D. Enteral levodopa/carbidopa gel infusion for the treatment of motor fluctuations and dyskinesias in advanced Parkinson’s disease. Expert Rev. Neurother. 6(10), 1403–1411 (2006).
  • Fernandez HH, Odin P. Levodopa-carbidopa intestinal gel for treatment of advanced Parkinson’s disease. Curr. Med. Res. Opin. 27(5), 907–919 (2011).
  • Fernandez HH, Vanagunas A, Odin P et al. Levodopa-carbidopa intestinal gel in advanced Parkinson’s disease open-label study: interim results. Parkinsonism Relat. Disord. 19(3), 339–345 (2013).
  • Djaldetti R, Giladi N, Hassin-Baer S, Shabtai H, Melamed E. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson’s disease: an open-label, randomized, crossover study. Clin. Neuropharmacol. 26(6), 322–326 (2003).
  • Juncos JL, Mouradian MM, Fabbrini G, Serrati C, Chase TN. Levodopa methyl ester treatment of Parkinson’s disease. Neurology 37(7), 1242–1245 (1987).
  • Lewitt PA, Ellenbogen A, Chen D et al. Actively transported levodopa prodrug XP21279: a study in patients with Parkinson disease who experience motor fluctuations. Clin. Neuropharmacol. 35(3), 103–110 (2012).
  • Hauser RA, Ellenbogen AL, Metman LV et al. Crossover comparison of IPX066 and a standard levodopa formulation in advanced Parkinson’s disease. Mov. Disord. 26(12), 2246–2252 (2011).
  • Hauser RA, Hsu A, Kell S et al. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson’s disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol. 12(4), 346–356 (2013).
  • Weaver FM, Follett K, Stern M et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA 301(1), 63–73 (2009).
  • Williams A, Gill S, Varma T et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol. 9(6), 581–591 (2010).
  • Deuschl G, Schade-Brittinger C, Krack P et al. A randomized trial of deep-brain stimulation for Parkinson’s disease. N. Engl. J. Med. 355(9), 896–908 (2006).
  • Moro E, Lozano AM, Pollak P et al. Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson’s disease. Mov. Disord. 25(5), 578–586 (2010).
  • Follett KA, Weaver FM, Stern M et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson’s disease. N. Engl. J. Med. 362(22), 2077–2091 (2010).
  • Duker AP, Espay AJ. Surgical treatment of Parkinson disease: past, present, and future. Neurol. Clin. 31(3), 799–808 (2013).
  • Rosin B, Slovik M, Mitelman R et al. Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron 72(2), 370–384 (2011).
  • Gross RE, McDougal ME. Technological advances in the surgical treatment of movement disorders. Curr. Neurol. Neurosci. Rep. 13(8), 371 (2013).
  • Schuepbach WM, Rau J, Knudsen K et al. Neurostimulation for Parkinson’s disease with early motor complications. N. Engl. J. Med. 368(7), 610–622 (2013).
  • Santos-Garcia D, de la Fuente-Fernandez R. Impact of non-motor symptoms on the quality of life of patients with Parkinson’s disease: some questions beyond research findings. J. Neurol. Sci. (2013) ( Epub ahead of print).
  • Chaudhuri KR, Martinez-Martin P, Schapira AH et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov. Disord. 21(7), 916–923 (2006).
  • Chaudhuri KR, Martinez-Martin P, Brown RG et al. The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov. Disord. 22(13), 1901–1911 (2007).
  • Honig H, Antonini A, Martinez-Martin P et al. Intrajejunal levodopa infusion in Parkinson’s disease: a pilot multicenter study of effects on nonmotor symptoms and quality of life. Mov. Disord. 24(10), 1468–1474 (2009).
  • Pursiainen V, Lyytinen J, Pekkonen E. Effect of duodenal levodopa infusion on blood pressure and sweating. Acta Neurol. Scand. 126(4), e20–e24 (2012).
  • Ray Chaudhuri K, Martinez-Martin P, Antonini A et al. Rotigotine and specific non-motor symptoms of Parkinson’s disease: post hoc analysis of RECOVER. Parkinsonism Relat. Disord. 19(7), 660–665 (2013).

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