Tissue regeneration in stroke: cellular and trophic mechanisms

References

• Stahnisch FW, Nitsch R. Santiago Ramón y Cajal’s concept of neuronal plasticity: the ambiguity lives on. Trends Neurosci 2002;25:589-91
   PubMed Web of Science ®Google Scholar
• Altman J. Autoradiographic and histological studies of postnatal neurogenesis. II. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in infant rats, with special reference to postnatal neurogenesis in some brain regions. J Comp Neurol 1966;128:431-73
   Web of Science ®Google Scholar
• Altman J. Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol 1969;137:433-57
   PubMed Web of Science ®Google Scholar
• Kaplan MS, Hinds JW. Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 1977;197:1092-4
   PubMed Web of Science ®Google Scholar
• Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-10
   PubMed Web of Science ®Google Scholar
• Kukekov VG, Laywell ED, Suslov O, et al. Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol 1999;156:333-44
   PubMed Web of Science ®Google Scholar
• Duan X, Kang E, Liu CY, et al. Development of neural stem cell in the adult brain. Curr Opin Neurobiol 2008;18:108-15
   Google Scholar
• Ma DK, Bonaguidi MA, Ming GL, Song H. Adult neural stem cells in the mammalian central nervous system. Cell Res 2009;19:672-82
   PubMed Web of Science ®Google Scholar
• Shimada IS, Peterson BM, Spees JL. Isolation of locally derived stem/progenitor cells from the peri-infarct area that do not migrate from the lateral ventricle after cortical stroke. Stroke 2010;41:e552-60
   PubMed Web of Science ®Google Scholar
• Wang Y, Rudd AG, Wolfe CD. Age and ethnic disparities in incidence of stroke over time: the South London Stroke Register. Stroke 2013;44:3298-304
   PubMed Web of Science ®Google Scholar
• Gilgun-Sherki Y, Streifler JY. Cell replacement therapy in acute stroke: current state. In: Stem cell and gene-based therapy. Springer-Verlag London Limited; London: 2006
   Google Scholar
• Green AR. Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly. Br J Pharmacol 2008;153(Suppl 1)):S325-38
   Google Scholar
• Hung MCh, Hsieh ChL, Hwang JS, et al. Estimation of the long-term care needs of stroke patients by integrating functional disability and survival. PLoS One 2013;8:e75605
   Google Scholar
• Kalladka D, Muir KW. Brain repair: cell therapy in stroke. Stem Cells Cloning 2014;7:31-44
   PubMedGoogle Scholar
• Jivan K, Ranchod K, Modi G. Management of ischaemic stroke in the acute setting: review of the current status. Cardiovasc J Afr 2013;24:88-94
   Google Scholar
• Bivard A, Lin L, Parsonsb MW. Review of stroke thrombolytics. J Stroke 2013;15:90-8
   PubMed Web of Science ®Google Scholar
• Paczkowska E, Gołąb-Janowska M, Bajer-Czajkowska A, et al. Increased circulating endothelial progenitor cells in patients with hemorrhagic and ischemic stroke: the role of Endothelin-1. J Neurol Sci 2013;325:90-9
   PubMed Web of Science ®Google Scholar
• Courties G, Moskowitz MA, Nahrendorf M. The innate immune system after ischemic injury — lessons to be learned from the heart and brain. JAMA Neurol 2014;71:233-6
   PubMedGoogle Scholar
• Yoo SW, Chang DY, Lee HS, et al. Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β. Neurobiol Dis 2013;58:249-57
   PubMed Web of Science ®Google Scholar
• Shichita T, Ago T, Kamouchi M, et al. Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke. J Neurochem 2012;123(Suppl 2)):29-38
   PubMedGoogle Scholar
• Ren X, Akiyoshi K, Dziennis S, et al. Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci 2011;31:8556-63
   PubMedGoogle Scholar
• Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 2010;10:826-37
   PubMed Web of Science ®Google Scholar
• Zhang Q, Raoof M, Chen Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010;464:104-7
   PubMed Web of Science ®Google Scholar
• Rivest S. Regulation of innate immune responses in the brain. Nat Rev Immunol 2009;9:429-39
   PubMed Web of Science ®Google Scholar
• Zheng K, Kim JY, Ma H, et al. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. J Cereb Blood Flow Metab 2008;28:53-63
   PubMed Web of Science ®Google Scholar
• Nunes MC, Roy NS, Keyoung HM, et al. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 2003;9:439-47
   PubMed Web of Science ®Google Scholar
• Imayoshi I, Sakamoto M, Ohtsuka T, et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 2008;11:1153-61
   PubMed Web of Science ®Google Scholar
• Doetsch F. A niche for adult neural stem cells. Curr Opin Genet Dev 2003;13:543-50
   PubMed Web of Science ®Google Scholar
• Pastrana E, Cheng LC, Doetsch F. Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. Proc Natl Acad Sci USA 2009;106:6387-92
   PubMed Web of Science ®Google Scholar
• Christie KJ, Turnley AM. Regulation of endogenous neural stem/progenitor cells for neural repair—factors that promote neurogenesis and gliogenesis in the normal and damaged brain. Front Cell Neurosci 2013;6:70
   PubMedGoogle Scholar
• Jin K, Minami M, Lan JQ, et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 2001;98:4710-15
   PubMed Web of Science ®Google Scholar
• Jiang W, Gu W, Brännström T, et al. Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion. Stroke 2001;32:1201-7
   PubMed Web of Science ®Google Scholar
• Cayre M, Canoll P, Goldman JE. Cell migration in the normal and pathological postnatal mammalian brain. Prog. Neurobiol 2009;88:41-63
   Google Scholar
• Young CC, Brooks KJ, Buchan AM, Szele FG. Cellular and molecular determinants of stroke-induced changes in subventricular zone cell migration. Antioxid Redox Signal 2011;14:1877-88
   PubMedGoogle Scholar
• Kreuzberg M, Kanov E, Timofeev O, et al. Increased subventricular zone-derived cortical neurogenesis after ischemic lesion. Exp Neurol 2011;226:90-9
   Google Scholar
• Blizzard C A, Chuckowree JA, King AE, et al. Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity. Cereb Cortex 2011;21:281-91
   PubMed Web of Science ®Google Scholar
• Buffo A, Rite I, Tripathi P, et al. Origin and progeny of reactive gliosis: a source of multipotent cells in the injured brain. Proc Natl Acad Sci USA 2008;105:3581-6
   PubMed Web of Science ®Google Scholar
• Carlén M, Meletis K, Göritz C, et al. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci 2009;12:259-67
   PubMed Web of Science ®Google Scholar
• Danilov AI, Kokaia Z, Lindvall O. Ectopic ependymal cells in striatum accompany neurogenesis in a rat model of stroke. Neuroscience 2012;214:159-70
   PubMed Web of Science ®Google Scholar
• Paczkowska E, Kucia M, Koziarska D, et al. Clinical evidence that very small embryonic-like stem cells are mobilized into peripheral blood in patients after stroke. Stroke 2009;40:1237-44
   PubMed Web of Science ®Google Scholar
• Kucia M, Reca R, Campbell FR, et al. A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow. Leukemia 2006;20:857-69
   PubMed Web of Science ®Google Scholar
• Yu X, Chen D, Zhang Y, et al. Overexpression of CXCR4 in mesenchymal stem cells promotes migration, neuroprotection and angiogenesis in a rat model of stroke. J Neurol Sci 2012;316:141-9
   PubMed Web of Science ®Google Scholar
• Borlongan CV, Glover LE, Tajiri N, et al. The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Prog Neurobiol 2011;95:213-28
   PubMed Web of Science ®Google Scholar
• Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 2004;35:2390-5
   PubMed Web of Science ®Google Scholar
• Kawada H, Takizawa S, Takanashi T, et al. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation 2006;113:701-10
   PubMed Web of Science ®Google Scholar
• Paczkowska E, Larysz B, Rzeuski R, et al. Human hematopoietic stem/progenitor-enriched CD34(+) cells are mobilized into peripheral blood during stress related to ischemic stroke or acute myocardial infarction. Eur J Haematol 2005;75:461-7
   PubMed Web of Science ®Google Scholar
• Hennemann B, Ickenstein G, Sauerbruch S, et al. Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult. Cytotherapy 2008;10:303-11
   PubMed Web of Science ®Google Scholar
• Salati S, Zini R, Bianchi E, et al. Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells. Stem Cells 2008;26:950-9
   PubMedGoogle Scholar
• Shen Q, Goderie SK, Jin L, et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 2004;304:1338-40
   PubMed Web of Science ®Google Scholar
• Chopp M, Li Y, Zhang J. Plasticity and remodeling of brain. J Neurol Sci 2008;265:97-101
   PubMed Web of Science ®Google Scholar
• Thored P, Wood J, Arvidsson A, et al. Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke 2007;38:3032-9
   PubMed Web of Science ®Google Scholar
• Taguchi A, Soma T, Tanaka H, et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 2004;114:330-8
   PubMed Web of Science ®Google Scholar
• Arenillas JF, Sobrino T, Castillo J, Dávalos A. The role of angiogenesis in damage and recovery from ischemic stroke. Curr Treat Options Cardiovasc Med 2007;9:205-12
   PubMedGoogle Scholar
• Marshall RS, Zarahn E, Alon L, et al. Early imaging correlates of subsequent motor recovery after stroke. Ann Neurol 2009;65:596-602
   PubMed Web of Science ®Google Scholar
• Grau AJ, Ruf A, Vogt A, et al. Increased fraction of circulating activated platelets in acute and previous cerebrovascular ischemia. Thromb Haemost 1998;80:298-301
   PubMed Web of Science ®Google Scholar
• Browder T, Folkman J, Pirie-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chem 2000;275:1521-4
   PubMed Web of Science ®Google Scholar
• Gear AR, Camerini D. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation 2003;10:335-50
   PubMed Web of Science ®Google Scholar
• Rafii DC, Psaila B, Butler J, et al. Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 2008;28:217-22
   PubMed Web of Science ®Google Scholar
• Ding X, Li Y, Liu Z, et al. The sonic hedgehog pathway mediates brain plasticity and subsequent functional recovery after bone marrow stromal cell treatment of stroke in mice. J. Cereb. Blood Flow Metab 2013;21:1015-24
   Google Scholar
• Huang W, Mo X, Qin C, et al. Transplantation of differentiated bone marrow stromal cells promotes motor functional recovery in rats with stroke. Neurol Res 2013;21:320-8
   Google Scholar
• Tsai MJ, Tsai SK, Hu BR, et al. Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats. J Biomed Sci 2014;21:5
   PubMed Web of Science ®Google Scholar
• Lee JS, Hong JM, Moon GJ, et al. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 2010;21:1099-106
   Google Scholar
• Chen X, Li Y, Wang L, et al. Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 2002;21:275-9
   Google Scholar
• Paczkowska E, Kaczyńska K, Pius-Sadowska E, et al. Humoral activity of cord blood-derived stem/progenitor cells: implications for stem cell-based adjuvant therapy of neurodegenerative disorders. PLoS One 2013;8:e83833
   PubMedGoogle Scholar
• Lindholm P, Saarma M. Novel CDNF/MANF family of neurotrophic factors. Dev Neurobiol 2010;70:360-71
   PubMed Web of Science ®Google Scholar
• Sohn J, Selvaraj V, Wakayama K, et al. PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci 2012;32:12152-64
   PubMed Web of Science ®Google Scholar
• Pius-Sadowska E, Machaliński B. Role of neurotrophins/neurotrophin receptors axis in regulation of neuron al homeostasis. Adv Cell Biol 2014;41:285-314
   Google Scholar
• Huang EJ, Reichardt L. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001;24:677-736
   PubMed Web of Science ®Google Scholar
• Saarma M, Sariola H. Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF). Microsc Res Tech 1999;45:292-302
   PubMed Web of Science ®Google Scholar
• Brown CE, Boyd JD, Murphy TH. Longitudinal in vivo imaging reveals balanced and branch-specific remodeling of mature cortical pyramidal dendritic arbors after stroke. J Cereb Blood Flow Metab 2009;30:783-91
   PubMedGoogle Scholar
• Ueno Y, Chopp M, Zhang L, et al. Axonal outgrowth and dendritic plasticity in the cortical peri-infarct area after experimental stroke. Stroke 2012;43:2221-8
   PubMed Web of Science ®Google Scholar
• Sist B, Fouad K, Winship IR. Plasticity beyond peri-infarct cortex: spinal up regulation of structural plasticity, neurotrophins, and inflammatory cytokines during recovery from cortical stroke. Exp Neurol 2014;252:47-56
   PubMed Web of Science ®Google Scholar
• Sulejczak D, Ziemlińska E, Czarkowska-Bauch J, et al. Focal photothrombotic lesion of the rat motor cortex increases BDNF levels in motor-sensory cortical areas not accompanied by recovery of forelimb motor skills. J Neurotrauma 2007;24:1362-77
   PubMedGoogle Scholar
• Di Lazzaro V, Profice P, Pilato F, et al. BDNF plasma levels in acute stroke. Neurosci Lett 2007;422:128-30
   PubMed Web of Science ®Google Scholar
• Kokaia Z, Zhao Q, Kokaia M, et al. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp Neurol 1995;136:73-88
   PubMed Web of Science ®Google Scholar
• Keiner S, Witte OW, Redecker C. Immunocytochemical detection of newly generated neurons in the perilesional area of cortical infarcts after intraventricular application of brain-derived neurotrophic factor. J Neuropathol Exp Neurol 2009;68:83-93
   PubMedGoogle Scholar
• Grade S, Weng YC, Snapyan M, et al. Brain-derived neurotrophic factor promotes vasculature-associated migration of neuronal precursors toward the ischemic striatum. PLoS One 2013;8:e55039
   Google Scholar
• Kokaia Z, Andsberg G, Yan Q, Lindvall O. Rapid alterations of BDNF protein levels in the rat brain after focal ischemia: evidence for increased synthesis and anterograde axonal transport. Exp Neurol 1998;154:289-301
   PubMedGoogle Scholar
• Bejot Y, Prigent-Tessier A, Cachia C, et al. Time-dependent contribution of non-neuronal cells to BDNF production after ischemic stroke in rats. Neurochem Int 2011;58:102-11
   PubMed Web of Science ®Google Scholar
• Qin L, Jing D, Parauda S, et al. An adaptive role for BDNF val66met polymorphism in motor recovery in chronic stroke. J Neurosci 2014;34:2493-502
   PubMed Web of Science ®Google Scholar
• Vilkki J, Lappalainen J, Juvela S, et al. Relationship of the Met allele of the brain-derived neurotrophic factor Val66Met polymorphism to memory after aneurysmal subarachnoid hemorrhage. Neurosurgery 2008;63:198-203
   PubMed Web of Science ®Google Scholar
• Mirowska-Guzel D, Gromadzka G, Czlonkowski A, Czlonkowska A. BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF-196 G& GT ; A corresponds to early neurological deficit in hemorrhagic stroke. J Neuroimmunol 2012;249:71-5
   PubMed Web of Science ®Google Scholar
• Chan KM, Lam DT, Pong K, et al. Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion. Neurochem Res 1996;21:763-7
   PubMedGoogle Scholar
• Chung JY, Kim MW, Bang MS, Kim M. Increased expression of neurotrophin 4 following focal cerebral ischemia in adult rat brain with treadmill exercise. PLoS One 2013;8:e52461
   Google Scholar
• Zhang J, Shi Q, Yang P, et al. Neuroprotection of neurotrophin-3 against focal cerebral ischemia/reperfusion injury is regulated by hypoxia-responsive element in rats. Neuroscience 2012;222:1-9
   PubMed Web of Science ®Google Scholar
• Cristofaro B, Stone OA, Caporali A, et al. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol 2010;30:1143-50
   PubMedGoogle Scholar
• Machaliński B, Łażewski-Banaszak P, Dąbkowska E, et al. [The role of neurotrophic factors in regeneration of the nervous system]. Neurol Neurochir Pol 2012;46:579-90
   PubMed Web of Science ®Google Scholar
• Kitagawa H, Hayashi T, Mitsumoto Y, et al. Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats. Stroke 1998;29:1417-22
   PubMed Web of Science ®Google Scholar
• Zhang WR, Hayashi T, Iwai M, et al. Time dependent amelioration against ischemic brain damage by glial cell line-derived neurotrophic factor after transient middle cerebral artery occlusion in rat. Brain Res 2001;903:253-6
   PubMed Web of Science ®Google Scholar
• Zhang WR, Sato K, Iwai M, et al. Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat. Brain Res 2002;947:140-5
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Ahlenius H, Thored P, et al. Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats. Stroke 2006;37:2361-7
   PubMed Web of Science ®Google Scholar
• Turrini P, Gaetano C, Antonelli A, et al. Nerve growth factor induces angiogenic activity in a mouse model of hindlimb ischemia. Neurosci Lett 2002;32:109-12
   Google Scholar
• Kermani P, Rafii D, Jin D, et al. Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest 2005;115:653-63
   PubMed Web of Science ®Google Scholar
• Lin KC, Chung HY, Wu CY, et al. Constraint-induced therapy versus control intervention in patients with stroke: a functional magnetic resonance imaging study. Am J Phys Med Rehabil 2010;89:177-85
   PubMed Web of Science ®Google Scholar
• Arenillas JF, Sobrino T, Castillo J, Davalos A. The role of angiogenesis in damage and recovery from ischemic stroke. Curr Treat Options Cardiovasc Med 2007;9:205-12
   PubMedGoogle Scholar
• Jin KL, Mao XO, Nagayama T, et al. Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3’-kinase/Akt signaling by global cerebral ischemia in the rat. Neuroscience 2000;100:713-17
   PubMed Web of Science ®Google Scholar
• Hayashi T, Abe K, Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J Cerebr Blood Flow Metab 1998;18:887-95
   PubMed Web of Science ®Google Scholar
• Kiprianova I, Schindowski K, von Bohlen und Halbach O, et al. Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2. Exp Neurol 2004;189:252-60
   PubMedGoogle Scholar
• Bogousslavsky J, Victor SJ, Salinas EO. Fiblast (trafermin) in acute stroke: results of the European-Australian Phase II/III safety and efficacy trial. Cerebrovasc Dis 2002;14:239-51
   PubMed Web of Science ®Google Scholar
• Wang ZL, Cheng SM, Ma MM. Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia. Neurosci Lett 2008;446:30-5
   PubMed Web of Science ®Google Scholar
• Watanabe T, Okuda Y, Nonoguchi N, et al. Postischemic intraventricular administration of FGF-2 expressing adenoviral vectors improves neurologic outcome and reduces infarct volume after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2004;24:1205-13
   PubMed Web of Science ®Google Scholar
• Meng Z, Li M, He Q, et al. Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia. Neuroscience 2014;267:135-46
   PubMed Web of Science ®Google Scholar
• Lee HJ, Lim IJ, Lee MC, Kim SU. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model. J Neurosci Res 2010;88:3282-94
   PubMed Web of Science ®Google Scholar
• Machalińska A, Kawa M, Pius-Sadowska E, et al. Long-term. neuroprotective effects of NT-4-engineered mesenchymal stem cells injected intravitreally in a mouse model of acute retinal injury. Invest Ophthalmol Vis Sci 2013;54:8292-305
   PubMedGoogle Scholar
• Lindvall O, Kokaia Z. Stem cell research in stroke: how far from the clinic? Stroke 2011;42:2369-75
   PubMed Web of Science ®Google Scholar
• Lindvall O, Kokaia Z. Neurogenesis following stroke affecting the adult brain. In: Gage F, Kempermann G, Song H, editors. Adult Neurogenesis. Cold Spring Harbor: NY: Laboratory Press; 2008. 549-70
   Google Scholar
• Jozwiak S, Habich A, Kotulska K, et al. Intracerebroventricular transplantation of cord blood-derived neural progenitors in a child with severe global brain ischemic injury. Cell Medicine, Part B of Cell Transplantation 2010;1:71-80
   Google Scholar
• Janowski M, Walczak P, Kropiwnicki T, et al. Long-term MRI cell tracking after intraventricular delivery in a patient with global cerebral ischemia and prospects for magnetic navigation of stem cells within the CSF. PLoS One 2014;9:97631
   Google Scholar