Use of stem cells for the treatment of multiple sclerosis

References

• Steinman L. Multiple sclerosis: a two-stage disease. Nat. Immunol.2(9), 762–764 (2001).
   PubMed Web of Science ®Google Scholar
• Einstein O, Grigoriadis N, Mizrachi-Kol R et al. Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis. Exp. Neurol.198(2), 275–284 (2006).
   PubMed Web of Science ®Google Scholar
• Einstein O, Ben-Menachem-Tzidon O, Mizrachi-Kol R et al. Survival of neural precursor cells in growth factor-poor environment: implications for transplantation in chronic disease. Glia53(4), 449–455 (2006).
   PubMedGoogle Scholar
• Gehrmann J, Banati RB, Cuzner ML, Kreutzberg GW, Newcombe J. Amyloid precursor protein (APP) expression in multiple sclerosis lesions. Glia15(2), 141–151 (1995).
   PubMed Web of Science ®Google Scholar
• Foong J, Rozewicz L, Davie CA et al. Correlates of executive function in multiple sclerosis: the use of magnetic resonance spectroscopy as an index of focal pathology. J. Neuropsychiatry Clin. Neurosci.11(1), 45–50 (1999).
   PubMed Web of Science ®Google Scholar
• Trapp BD, Peterson J, Ransohoff RM et al. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med.338(5), 278–285 (1998).
   PubMed Web of Science ®Google Scholar
• Vladimirova O, O’Connor J, Cahill A et al. Oxidative damage to DNA in plaques of MS brains. Mult. Scler.4(5), 413–418 (1998).
   PubMedGoogle Scholar
• Lovas G, Szilagyi N, Majtenyi K, Palkovits M, Komoly S. Axonal changes in chronic demyelinated cervical spinal cord plaques. Brain123(Pt 2), 308–317 (2000).
   PubMed Web of Science ®Google Scholar
• Evangelou N, Esiri MM, Smith S, Palace J, Matthews PM. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann. Neurol.47(3), 391–395 (2000).
   PubMed Web of Science ®Google Scholar
• Heins N, Englund MC, Sjoblom C et al. Derivation, characterization, and differentiation of human embryonic stem cells. Stem Cells22(3), 367–376 (2004).
   PubMed Web of Science ®Google Scholar
• Conley BJ, Young JC, Trounson AO, Mollard R. Derivation, propagation and differentiation of human embryonic stem cells. Int. J. Biochem. Cell Biol.36(4), 555–567 (2004).
   PubMed Web of Science ®Google Scholar
• Alessandri G, Pagano S, Bez A et al. Isolation and culture of human muscle-derived stem cells able to differentiate into myogenic and neurogenic cell lineages. Lancet364(9448), 1872–1883 (2004).
   PubMed Web of Science ®Google Scholar
• Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy5(5), 362–369 (2003).
   PubMed Web of Science ®Google Scholar
• Burnstein RM, Foltynie T, He X et al. Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson’s disease. Int. J. Biochem. Cell Biol.36(4), 702–713 (2004).
   PubMed Web of Science ®Google Scholar
• Bottai D, Fiocco R, Gelain F et al. Neural stem cells in the adult nervous system. J. Hematother. Stem Cell Res.12(6), 655–670 (2003).
   PubMedGoogle Scholar
• Lennon DP, Caplan AI. Isolation of human marrow-derived mesenchymal stem cells. Exp. Hematol.34(11), 1604–1605 (2006).
   PubMedGoogle Scholar
• Bernstein ID, Andrews RG, Rowley S. Isolation of human hematopoietic stem cells. Blood Cells20(1), 15–23; discussion 24 (1994).
   PubMedGoogle Scholar
• Jiang Y, Vaessen B, Lenvik T et al. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp. Hematol.30(8), 896–904 (2002).
   PubMed Web of Science ®Google Scholar
• Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI. Embryonic stem cells express neuronal properties in vitro.Dev. Biol.168(2), 342–357 (1995).
   PubMed Web of Science ®Google Scholar
• Strubing C, Ahnert-Hilger G, Shan J et al. Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech. Dev.53(2), 275–287 (1995).
   PubMed Web of Science ®Google Scholar
• Fraichard A, Chassande O, Bilbaut G et al.In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J. Cell Sci.108(Pt 10), 3181–3188 (1995).
   PubMed Web of Science ®Google Scholar
• Reubinoff BE, Itsykson P, Turetsky T et al. Neural progenitors from human embryonic stem cells. Nat. Biotechnol.19(12), 1134–1140 (2001).
   PubMed Web of Science ®Google Scholar
• Benzing C, Segschneider M, Leinhaas A, Itskovitz-Eldor J, Brustle O. Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2. Neuroreport17(16), 1675–1681 (2006).
   Google Scholar
• Kang SM, Cho MS, Seo H et al. Efficient induction of oligodendrocytes from human embryonic stem cells. Stem Cells25(2), 419–424 (2007).
   PubMed Web of Science ®Google Scholar
• Billon N, Jolicoeur C, Raff M. Generation and characterization of oligodendrocytes from lineage-selectable embryonic stem cells in vitro.Methods Mol. Biol.330, 15–32 (2006).
   PubMedGoogle Scholar
• Mueller D, Shamblott MJ, Fox HE, Gearhart JD, Martin LJ. Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage. J. Neurosci. Res.82(5), 592–608 (2005).
   PubMedGoogle Scholar
• Nistor GI, Totoiu MO, Haque N, Carpenter MK, Keirstead HS. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia49(3), 385–396 (2005).
   PubMed Web of Science ®Google Scholar
• Liu S, Qu Y, Stewart TJ et al. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc. Natl Acad. Sci. USA97(11), 6126–6131 (2000).
   PubMed Web of Science ®Google Scholar
• Srivastava AS, Shenouda S, Mishra R, Carrier E. Transplanted embryonic stem cells successfully survive, proliferate, and migrate to damaged regions of the mouse brain. Stem Cells24(7), 1689–1694 (2006).
   PubMedGoogle Scholar
• McDonald JW, Liu XZ, Qu Y et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat. Med.5(12), 1410–1412 (1999).
   PubMed Web of Science ®Google Scholar
• Brustle O, Jones KN, Learish RD et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science285(5428), 754–756 (1999).
   PubMed Web of Science ®Google Scholar
• Zeng L, Rahrmann E, Hu Q et al. Multipotent adult progenitor cells from swine bone marrow. Stem Cells24(11), 2355–2366 (2006).
   PubMed Web of Science ®Google Scholar
• Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol.19(12), 1129–1133 (2001).
   PubMed Web of Science ®Google Scholar
• Zhang PL, Izrael M, Ainbinder E et al. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol. Cell. Neurosci.31(3), 387–398 (2006).
   PubMedGoogle Scholar
• Takagi Y, Takahashi J, Saiki H et al. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J. Clin. Invest.115(1), 102–109 (2005).
   PubMed Web of Science ®Google Scholar
• Buhnemann C, Scholz A, Bernreuther C et al. Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain129(Pt 12), 3238–3248 (2006).
   PubMed Web of Science ®Google Scholar
• Bhagavati S, Xu W. Generation of skeletal muscle from transplanted embryonic stem cells in dystrophic mice. Biochem. Biophys. Res. Commun.333(2), 644–649 (2005).
   PubMedGoogle Scholar
• Kuai XL, Cong XQ, Du ZW, Bian YH, Xiao SD. Treatment of surgically induced acute liver failure by transplantation of HNF4-overexpressing embryonic stem cells. Chin. J. Dig. Dis.7(2), 109–116 (2006).
   PubMedGoogle Scholar
• Min JY, Yang Y, Sullivan MF et al. Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells. J. Thorac. Cardiovasc. Surg.125(2), 361–369 (2003).
   PubMed Web of Science ®Google Scholar
• Kim JH, Auerbach JM, Rodriguez-Gomez JA et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature418(6893), 50–56 (2002).
   PubMed Web of Science ®Google Scholar
• Carpenter M, Rao MS, Freed W, Zeng X. Derivation and characterization of neuronal precursors and dopaminergic neurons from human embryonic stem cells in vitro.Methods Mol. Biol.331, 153–167 (2006).
   PubMedGoogle Scholar
• Nishimura F, Toriumi H, Ishizaka S, Sakaki T, Yoshikawa M. Use of differentiating embryonic stem cells in the Parkinsonian mouse model. Methods Mol. Biol.329, 485–493 (2006).
   PubMedGoogle Scholar
• Brederlau A, Correia AS, Anisimov SV et al. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson’s disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells24(6), 1433–1440 (2006).
   PubMed Web of Science ®Google Scholar
• Cho YH, Kim DS, Kim PG et al. Dopamine neurons derived from embryonic stem cells efficiently induce behavioral recovery in a Parkinsonian rat model. Biochem. Biophys. Res. Commun.341(1), 6–12 (2006).
   PubMed Web of Science ®Google Scholar
• Yoshizaki T, Inaji M, Kouike H et al. Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells. Neurosci. Lett.363(1), 33–37 (2004).
   PubMedGoogle Scholar
• Bjorklund LM, Sanchez-Pernaute R, Chung S et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl Acad. Sci. USA99(4), 2344–2349 (2002).
   PubMed Web of Science ®Google Scholar
• Nakao N, Yokote H, Nakai K, Itakura T. Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson’s disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor. J. Neurosurg.92(4), 659–670 (2000).
   PubMed Web of Science ®Google Scholar
• Zhang SC. Embryonic stem cells for neural replacement therapy: prospects and challenges. J. Hematother. Stem Cell Res.12(6), 625–634 (2003).
   PubMedGoogle Scholar
• Senior K. Embryonic stem cells used to remyelinate injured rat spinal cord neurons. Lancet355(9218), 1890 (2000).
   PubMedGoogle Scholar
• Hendricks WA, Pak ES, Owensby JP et al. Predifferentiated embryonic stem cells prevent chronic pain behaviors and restore sensory function following spinal cord injury in mice. Mol. Med.12(1–3), 34–46 (2006).
   PubMed Web of Science ®Google Scholar
• Lerou PH, Daley GQ. Therapeutic potential of embryonic stem cells. Blood Rev.19(6), 321–331 (2005).
   PubMed Web of Science ®Google Scholar
• Kimura H, Yoshikawa M, Matsuda R et al. Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice. Neurol. Res.27(8), 812–819 (2005).
   PubMed Web of Science ®Google Scholar
• Grabowski M, Brundin P, Johansson BB. Fetal neocortical grafts implanted in adult hypertensive rats with cortical infarcts following a middle cerebral artery occlusion: ingrowth of afferent fibers from the host brain. Exp. Neurol.116(2), 105–121 (1992).
   PubMed Web of Science ®Google Scholar
• Grabowski M, Christofferson RH, Brundin P, Johansson BB. Vascularization of fetal neocortical grafts implanted in brain infarcts in spontaneously hypertensive rats. Neuroscience51(3), 673–682 (1992).
   PubMedGoogle Scholar
• Chopko BW, Voneida TJ. Fetal rat cerebellar fragment transplantation into adult rat forebrain lesion cavities. J. Neural Transplant. Plast.3(1), 63–69 (1992).
   PubMedGoogle Scholar
• Fiandaca MS, Gash DM. New insights and technologies in brain grafting. Clin. Neurosurg.39, 482–508 (1992).
   PubMedGoogle Scholar
• Jiao S, Wolff JA. Long-term survival of autologous muscle grafts in rat brain. Neurosci. Lett.137(2), 207–210 (1992).
   PubMedGoogle Scholar
• Wirth ED 3rd, Theele DP, Mareci TH et al.In vivo magnetic resonance imaging of fetal cat neural tissue transplants in the adult cat spinal cord. J. Neurosurg.76(2), 261–274 (1992).
   PubMedGoogle Scholar
• Deacon T, Dinsmore J, Costantini LC, Ratliff J, Isacson O. Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation. Exp. Neurol.149(1), 28–41 (1998).
   PubMed Web of Science ®Google Scholar
• Yanai J, Doetchman T, Laufer N et al. Embryonic cultures but not embryos transplanted to the mouse’s brain grow rapidly without immunosuppression. Int. J. Neurosci.81(1–2), 21–26 (1995).
   PubMedGoogle Scholar
• Drukker M, Katchman H, Katz G et al. Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells24(2), 221–229 (2006).
   PubMed Web of Science ®Google Scholar
• Wognum AW, Eaves AC, Thomas TE. Identification and isolation of hematopoietic stem cells. Arch. Med. Res.34(6), 461–475 (2003).
   PubMed Web of Science ®Google Scholar
• Huss R. Isolation of primary and immortalized CD34-hematopoietic and mesenchymal stem cells from various sources. Stem Cells18(1), 1–9 (2000).
   PubMedGoogle Scholar
• Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science284(5411), 143–147 (1999).
   PubMed Web of Science ®Google Scholar
• Lennon DP, Caplan AI. Isolation of rat marrow-derived mesenchymal stem cells. Exp. Hematol.34(11), 1606–1607 (2006).
   PubMed Web of Science ®Google Scholar
• Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science276(5309), 71–74 (1997).
   PubMed Web of Science ®Google Scholar
• Verfaillie CM. Multipotent adult progenitor cells: an update. Novartis Found. Symp.265, 55–61; discussion 61–55, 92–57 (2005).
   PubMedGoogle Scholar
• Raedt R, Pinxteren J, Van Dycke A et al. Differentiation assays of bone marrow-derived multipotent adult progenitor cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers. Exp. Neurol.203(2), 542–554 (2007).
   PubMed Web of Science ®Google Scholar
• Woodward WA, Chen MS, Behbod F, Rosen JM. On mammary stem cells. J. Cell Sci.118(Pt 16), 3585–3594 (2005).
   PubMed Web of Science ®Google Scholar
• Clarke RB. Isolation and characterization of human mammary stem cells. Cell Prolif.38(6), 375–386 (2005).
   PubMedGoogle Scholar
• Capuco AV, Ellis S. Bovine mammary progenitor cells: current concepts and future directions. J. Mammary Gland Biol. Neoplasia10(1), 5–15 (2005).
   PubMed Web of Science ®Google Scholar
• Roisen FJ, Klueber KM, Lu CL et al. Adult human olfactory stem cells. Brain Res.890(1), 11–22 (2001).
   PubMed Web of Science ®Google Scholar
• Frank MH, Sayegh MH. Immunomodulatory functions of mesenchymal stem cells. Lancet363(9419), 1411–1412 (2004).
   PubMed Web of Science ®Google Scholar
• Yu JJ, Sun X, Yuan X et al. Immunomodulatory neural stem cells for brain tumour therapy. Expert Opin. Biol. Ther.6(12), 1255–1262 (2006).
   PubMed Web of Science ®Google Scholar
• Krampera M, Pasini A, Pizzolo G et al. Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr. Opin. Pharmacol.6(4), 435–441 (2006).
   PubMed Web of Science ®Google Scholar
• Puissant B, Barreau C, Bourin P et al. Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br. J. Haematol.129(1), 118–129 (2005).
   PubMed Web of Science ®Google Scholar
• Hsu YC, Lee DC, Chiu IM. Neural stem cells, neural progenitors, and neurotrophic factors. Cell Transplant.16(2), 133–150 (2007).
   PubMed Web of Science ®Google Scholar
• Campos LS. Neurospheres: insights into neural stem cell biology. J. Neurosci. Res.78(6), 761–769 (2004).
   PubMed Web of Science ®Google Scholar
• Cameron HA, Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience61(2), 203–209 (1994).
   PubMed Web of Science ®Google Scholar
• Eriksson PS, Perfilieva E, Bjork-Eriksson T et al. Neurogenesis in the adult human hippocampus. Nat. Med.4(11), 1313–1317 (1998).
   PubMed Web of Science ®Google Scholar
• Gould E, Reeves AJ, Fallah M et al. Hippocampal neurogenesis in adult Old World primates. Proc. Natl Acad. Sci. USA96(9), 5263–5267 (1999).
   PubMed Web of Science ®Google Scholar
• Kornack DR, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc. Natl Acad. Sci. USA96(10), 5768–5773 (1999).
   PubMed Web of Science ®Google Scholar
• Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell97(6), 703–716 (1999).
   PubMed Web of Science ®Google Scholar
• Alvarez-Buylla A, Herrera DG, Wichterle H. The subventricular zone: source of neuronal precursors for brain repair. Prog. Brain Res.127, 1–11 (2000).
   PubMedGoogle Scholar
• Pluchino S, Quattrini A, Brambilla E et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature422(6933), 688–694 (2003).
   PubMed Web of Science ®Google Scholar
• Ben-Hur T, Einstein O, Mizrachi-Kol R et al. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia41(1), 73–80 (2003).
   PubMed Web of Science ®Google Scholar
• Einstein O, Fainstein N, Vaknin I et al. Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression. Ann. Neurol.61(3), 209–218 (2007).
   PubMed Web of Science ®Google Scholar
• Belmadani A, Tran PB, Ren D, Miller RJ. Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J. Neurosci.26(12), 3182–3191 (2006).
   PubMed Web of Science ®Google Scholar
• Yasuhara T, Matsukawa N, Hara K et al. Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson’s disease. J. Neurosci.26(48), 12497–12511 (2006).
   PubMed Web of Science ®Google Scholar
• Harrower TP, Tyers P, Hooks Y, Barker RA. Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson’s disease. Exp. Neurol.197(1), 56–69 (2006).
   PubMed Web of Science ®Google Scholar
• Ben-Hur T, Idelson M, Khaner H et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells22(7), 1246–1255 (2004).
   PubMed Web of Science ®Google Scholar
• Snyder BJ, Olanow CW. Stem cell treatment for Parkinson’s disease: an update for 2005. Curr. Opin. Neurol.18(4), 376–385 (2005).
   PubMed Web of Science ®Google Scholar
• Lindvall O. Parkinson disease. Stem cell transplantation. Lancet358(Suppl.), S48 (2001).
   Google Scholar
• Teng YD, Lavik EB, Qu X et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc. Natl Acad. Sci. USA99(5), 3024–3029 (2002).
   PubMed Web of Science ®Google Scholar
• Iwanami A, Kaneko S, Nakamura M et al. Transplantation of human neural stem cells for spinal cord injury in primates. J. Neurosci. Res.80(2), 182–190 (2005).
   PubMed Web of Science ®Google Scholar
• Okano H, Ogawa Y, Nakamura M et al. Transplantation of neural stem cells into the spinal cord after injury. Semin. Cell Dev. Biol.14(3), 191–198 (2003).
   PubMed Web of Science ®Google Scholar
• Pallini R, Vitiani LR, Bez A et al. Homologous transplantation of neural stem cells to the injured spinal cord of mice. Neurosurgery57(5), 1014–1025; discussion 1014–1025 (2005).
   Google Scholar
• Ogawa Y, Sawamoto K, Miyata T et al. Transplantation of in vitro expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J. Neurosci. Res.69(6), 925–933 (2002).
   PubMed Web of Science ®Google Scholar
• Cummings BJ, Uchida N, Tamaki SJ, Anderson AJ. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol. Res.28(5), 474–481 (2006).
   PubMed Web of Science ®Google Scholar
• Shihabuddin LS, Horner PJ, Ray J, Gage FH. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J. Neurosci.20(23), 8727–8735 (2000).
   PubMed Web of Science ®Google Scholar
• Doetsch F, Verdugo JM, Caille I et al. Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. J. Neurosci.22(6), 2255–2264 (2002).
   PubMedGoogle Scholar
• Marshall GP 2nd, Laywell ED, Zheng T, Steindler DA, Scott EW. In vitro-derived “neural stem cells” function as neural progenitors without the capacity for self-renewal. Stem Cells24(3), 731–738 (2006).
   PubMed Web of Science ®Google Scholar
• Gallacher L, Murdoch B, Wu DM et al. Isolation and characterization of human CD34-Lin- and CD34+Lin- hematopoietic stem cells using cell surface markers AC133 and CD7. Blood95(9), 2813–2820 (2000).
   PubMed Web of Science ®Google Scholar
• Brazelton TR, Rossi FM, Keshet GI, Blau HM. From marrow to brain: expression of neuronal phenotypes in adult mice. Science290(5497), 1775–1779 (2000).
   PubMed Web of Science ®Google Scholar
• Eglitis MA, Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc. Natl Acad. Sci. USA94(8), 4080–4085 (1997).
   PubMed Web of Science ®Google Scholar
• Locatelli F, Corti S, Donadoni C et al. Neuronal differentiation of murine bone marrow Thy-1- and Sca-1-positive cells. J. Hematother. Stem Cell Res.12(6), 727–734 (2003).
   PubMedGoogle Scholar
• Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science290(5497), 1779–1782 (2000).
   PubMed Web of Science ®Google Scholar
• Karussis DM, Vourka-Karussis U, Mizrachi-Koll R, Abramsky O. Acute/relapsing experimental autoimmune encephalomyelitis: induction of long lasting, antigen-specific tolerance by syngeneic bone marrow transplantation. Mult. Scler.5(1), 17–21 (1999).
   PubMed Web of Science ®Google Scholar
• Karussis DM, Slavin S, Ben-Nun A et al. Chronic-relapsing experimental autoimmune encephalomyelitis (CR-EAE): treatment and induction of tolerance, with high dose cyclophosphamide followed by syngeneic bone marrow transplantation. J. Neuroimmunol.39(3), 201–210 (1992).
   PubMedGoogle Scholar
• Karussis DM, Slavin S, Lehmann D et al. Prevention of experimental autoimmune encephalomyelitis and induction of tolerance with acute immunosuppression followed by syngeneic bone marrow transplantation. J. Immunol.148(6), 1693–1698 (1992).
   PubMed Web of Science ®Google Scholar
• Karussis DM, Vourka-Karussis U, Lehmann D et al. Immunomodulation of autoimmunity in MRL/lpr mice with syngeneic bone marrow transplantation (SBMT). Clin. Exp. Immunol.100(1), 111–117 (1995).
   Google Scholar
• Karussis DM, Vourka-Karussis U, Lehmann D et al. Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation. J. Clin. Invest.92(2), 765–772 (1993).
   PubMedGoogle Scholar
• van Gelder M, van Bekkum DW. Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant.18(6), 1029–1034 (1996).
   PubMed Web of Science ®Google Scholar
• van Gelder M, van Bekkum DW. Treatment of relapsing experimental autoimmune encephalomyelitis in rats with allogeneic bone marrow transplantation from a resistant strain. Bone Marrow Transplant.16(3), 343–351 (1995).
   PubMed Web of Science ®Google Scholar
• Nash RA, Bowen JD, McSweeney PA et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood102(7), 2364–2372 (2003).
   PubMed Web of Science ®Google Scholar
• Saccardi R, Kozak T, Bocelli-Tyndall C et al. Autologous stem cell transplantation for progressive multiple sclerosis: update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database. Mult. Scler.12(6), 814–823 (2006).
   PubMed Web of Science ®Google Scholar
• Mancardi GL, Saccardi R, Filippi M et al. Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS. Neurology57(1), 62–68 (2001).
   PubMed Web of Science ®Google Scholar
• Fassas A, Passweg JR, Anagnostopoulos A et al. Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study. J. Neurol.249(8), 1088–1097 (2002).
   PubMed Web of Science ®Google Scholar
• Muraro PA, Douek DC. Renewing the T cell repertoire to arrest autoimmune aggression. Trends Immunol.27(2), 61–67 (2006).
   PubMed Web of Science ®Google Scholar
• Muraro PA, Douek DC, Packer A et al. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J. Exp. Med.201(5), 805–816 (2005).
   PubMed Web of Science ®Google Scholar
• Minagawa H, Takenaka A, Itoyama Y, Mori R. Experimental allergic encephalomyelitis in the Lewis rat. A model of predictable relapse by cyclophosphamide. J. Neurol. Sci.78(2), 225–235 (1987).
   PubMedGoogle Scholar
• Miyazaki C, Nakamura T, Kaneko K, Mori R, Shibasaki H. Reinduction of experimental allergic encephalomyelitis in convalescent Lewis rats with cyclophosphamide. J. Neurol. Sci.67(3), 277–284 (1985).
   PubMed Web of Science ®Google Scholar
• Polman CH, Matthaei I, de Groot CJ et al. Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat. J. Neuroimmunol.17(3), 209–216 (1988).
   PubMedGoogle Scholar
• Chen JT, Collins DL, Atkins HL et al. Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis. Neurology66(12), 1935–1937 (2006).
   PubMed Web of Science ®Google Scholar
• Inglese M, Mancardi GL, Pagani E et al. Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J. Neurol. Neurosurg. Psychiatry75(4), 643–644 (2004).
   PubMed Web of Science ®Google Scholar
• Bossolasco P, Cova L, Calzarossa C et al. Neuro-glial differentiation of human bone marrow stem cells in vitro.Exp. Neurol.193(2), 312–325 (2005).
   PubMed Web of Science ®Google Scholar
• Oswald J, Boxberger S, Jorgensen B et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro.Stem Cells22(3), 377–384 (2004).
   PubMed Web of Science ®Google Scholar
• Talens-Visconti R, Bonora A, Jover R et al. Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J. Gastroenterol.12(36), 5834–5845 (2006).
   PubMed Web of Science ®Google Scholar
• Sanchez-Ramos J, Song S, Cardozo-Pelaez F et al. Adult bone marrow stromal cells differentiate into neural cells in vitro.Exp. Neurol.164(2), 247–256 (2000).
   PubMed Web of Science ®Google Scholar
• Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res.61(4), 364–370 (2000).
   PubMed Web of Science ®Google Scholar
• Krampera M, Glennie S, Dyson J et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood101(9), 3722–3729 (2003).
   PubMed Web of Science ®Google Scholar
• Uccelli A, Moretta L, Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur. J. Immunol.36(10), 2566–2573 (2006).
   PubMed Web of Science ®Google Scholar
• Crigler L, Robey RC, Asawachaicharn A, Gaupp D, Phinney DG. Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp. Neurol.198(1), 54–64 (2006).
   PubMed Web of Science ®Google Scholar
• Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood107(4), 1484–1490 (2006).
   PubMed Web of Science ®Google Scholar
• Sotiropoulou PA, Perez SA, Gritzapis AD, Baxevanis CN, Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells24(1), 74–85 (2006).
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand. J. Immunol.57(1), 11–20 (2003).
   PubMed Web of Science ®Google Scholar
• Deng W, Han Q, Liao L et al. Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice. DNA Cell Biol.24(7), 458–463 (2005).
   PubMed Web of Science ®Google Scholar
• Beyth S, Borovsky Z, Mevorach D et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood105(5), 2214–2219 (2005).
   PubMed Web of Science ®Google Scholar
• Augello A, Tasso R, Negrini SM et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur. J. Immunol.35(5), 1482–1490 (2005).
   PubMed Web of Science ®Google Scholar
• Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood105(4), 1815–1822 (2005).
   PubMed Web of Science ®Google Scholar
• Bartholomew A, Sturgeon C, Siatskas M et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.Exp. Hematol.30(1), 42–48 (2002).
   PubMed Web of Science ®Google Scholar
• Corcione A, Benvenuto F, Ferretti E et al. Human mesenchymal stem cells modulate B-cell functions. Blood107(1), 367–372 (2006).
   PubMed Web of Science ®Google Scholar
• Glennie S, Soeiro I, Dyson PJ, Lam EW, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood105(7), 2821–2827 (2005).
   PubMed Web of Science ®Google Scholar
• Jiang XX, Zhang Y, Liu B et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood105(10), 4120–4126 (2005).
   PubMed Web of Science ®Google Scholar
• Krampera M, Cosmi L, Angeli R et al. Role for interferon-γ in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells24(2), 386–398 (2006).
   PubMed Web of Science ®Google Scholar
• Meisel R, Zibert A, Laryea M et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood103(12), 4619–4621 (2004).
   PubMed Web of Science ®Google Scholar
• Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation76(8), 1208–1213 (2003).
   PubMed Web of Science ®Google Scholar
• Zhang W, Ge W, Li C et al. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev.13(3), 263–271 (2004).
   PubMed Web of Science ®Google Scholar
• Di Nicola M, Carlo-Stella C, Magni M et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood99(10), 3838–3843 (2002).
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp. Hematol.31(10), 890–896 (2003).
   PubMed Web of Science ®Google Scholar
• Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation75(3), 389–397 (2003).
   PubMed Web of Science ®Google Scholar
• Zappia E, Casazza S, Pedemonte E et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood106(5), 1755–1761 (2005).
   PubMed Web of Science ®Google Scholar
• Zhang J, Li Y, Chen J et al. Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp. Neurol.195(1), 16–26 (2005).
   PubMed Web of Science ®Google Scholar
• Gerdoni E, Gallo B, Casazza S et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann. Neurol.61(3), 219–227 (2007).
   PubMed Web of Science ®Google Scholar
• Inoue M, Honmou O, Oka S et al. Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord. Glia44(2), 111–118 (2003).
   PubMed Web of Science ®Google Scholar
• Karussis DM, Grigoriadis N, Ben-Hur T et al. Mesenchymal bone marrow stem cells, migrate into CNS lesions in experimental autoimmune encephalomyelitis, differentiate into neuronal and glial line and downregulate chronic EAE. Neurology64(6), A407 (2005).
   Google Scholar
• Giordano A, Galderisi U, Marino IR. From the laboratory bench to the patient’s bedside: an update on clinical trials with mesenchymal stem cells. J. Cell. Physiol.211(1), 27–35 (2007).
   PubMed Web of Science ®Google Scholar
• Chen SL, Fang WW, Ye F et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol.94(1), 92–95 (2004).
   PubMed Web of Science ®Google Scholar
• Wollert KC, Meyer GP, Lotz J et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet364(9429), 141–148 (2004).
   PubMed Web of Science ®Google Scholar
• Katritsis DG, Sotiropoulou PA, Karvouni E et al. Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter Cardiovasc. Interv.65(3), 321–329 (2005).
   PubMed Web of Science ®Google Scholar
• Perin EC, Dohmann HF, Borojevic R et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation107(18), 2294–2302 (2003).
   PubMed Web of Science ®Google Scholar
• Perin EC, Dohmann HF, Borojevic R et al. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation110(11 Suppl. 1), II213–II218 (2004).
   PubMed Web of Science ®Google Scholar
• Janssens S, Dubois C, Bogaert J et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet367(9505), 113–121 (2006).
   PubMed Web of Science ®Google Scholar
• Lunde K, Solheim S, Aakhus S et al. Autologous stem cell transplantation in acute myocardial infarction: The ASTAMI randomized controlled trial. Intracoronary transplantation of autologous mononuclear bone marrow cells, study design and safety aspects. Scand. Cardiovasc. J.39(3), 150–158 (2005).
   PubMed Web of Science ®Google Scholar
• Meyer GP, Wollert KC, Lotz J et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months’ follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation113(10), 1287–1294 (2006).
   PubMed Web of Science ®Google Scholar
• Rosenzweig A. Cardiac cell therapy – mixed results from mixed cells. N. Engl. J. Med.355(12), 1274–1277 (2006).
   PubMed Web of Science ®Google Scholar
• Welt FG, Losordo DW. Cell therapy for acute myocardial infarction: curb your enthusiasm? Circulation113(10), 1272–1274 (2006).
   PubMed Web of Science ®Google Scholar
• Ferrari G, Cusella-De Angelis G, Coletta M et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science279(5356), 1528–1530 (1998).
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Prockop DJ, Fitzpatrick LA et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat. Med.5(3), 309–313 (1999).
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Prockop DJ, Gordon PL et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood97(5), 1227–1231 (2001).
   PubMed Web of Science ®Google Scholar
• Koc ON, Day J, Nieder M et al. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant.30(4), 215–222 (2002).
   PubMed Web of Science ®Google Scholar
• Koc ON, Gerson SL, Cooper BW et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J. Clin. Oncol.18(2), 307–316 (2000).
   PubMed Web of Science ®Google Scholar
• Lazarus HM. Bone marrow transplantation in low-grade non-Hodgkin’s lymphoma. Leuk. Lymphoma17(3–4), 199–210 (1995).
   PubMed Web of Science ®Google Scholar
• Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant.16(4), 557–564 (1995).
   PubMed Web of Science ®Google Scholar
• Lazarus HM, Koc ON, Devine SM et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol. Blood Marrow Transplant.11(5), 389–398 (2005).
   PubMed Web of Science ®Google Scholar
• Lazarus HM, Winton EF, Williams SF et al. Phase I multicenter trial of interleukin 6 therapy after autologous bone marrow transplantation in advanced breast cancer. Bone Marrow Transplant.15(6), 935–942 (1995).
   PubMed Web of Science ®Google Scholar
• Mazzini L, Mareschi K, Ferrero I et al. Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis. Neurol. Res.28(5), 523–526 (2006).
   PubMed Web of Science ®Google Scholar
• Karussis D, Kassis I, Basan GS, Slavin S. Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a porposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases. J. Neurol. Sci. (2007) (Epub ahead of print).
   Google Scholar