References
- Lewis DA, Lieberman JA. Catching up on schizophrenia: natural history and neurobiology. Neuron28, 325–334 (2000).
- Buchanan RW, Davis M, Goff D et al. A summary of the FDA-NIMH MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia. Schizophr. Bull.31, 5–19 (2005).
- American Psychiatric Association. Diagnostic and Statistical Manual of Nental Disorders. DSM-IV. 4th Ed. American Psychiatric Association, Washington DC, USA (1994).
- Andreasen NC. Symptoms, signs, and diagnosis of schizophrenia. Lancet346, 477–481 (1995).
- Cannon M, Jones P. Schizophrenia. J. Neurol. Neurosurg. Psychiatry60, 604–613 (1996).
- Hafner H, van der Heiden W, Behrens S et al. Causes and consequences of the gender difference in age at onset of schizophrenia. Schizophr. Bull.24, 99–113 (1998).
- Huber G. The heterogeneous course of schizophrenia. Schizophr. Res.28, 177–185 (1997).
- Brown S. Excess mortality of schizophrenia. A meta-analysis. Br. J. Psychiatry171, 502–508 (1997).
- Jablensky A. Schizophrenia: recent epidemiologic issues. Epidemiol. Rev.17, 10–20 (1995).
- Hyman S. Can neuroscience be integrated into the DSM-V? Nat. Neurosci.8, 723–732 (2007).
- Bleuler E. Dementia Praecox or the Group of Schizophrenias. International Universities Press, NY, USA (1911).
- Kraepelin E. Clinical Psychiatry: A Textbook for Students and Physicians. (Defendorf AR, Translator). Macmillan, NY, USA (1902).
- Gordon E. Brain imaging technologies: how, what, when and why? Aust. NZ J. Psychiatry33, 187–196 (1999).
- Ashburner J, Friston KJ. Voxel-based morphometry – the methods. Neuroimage11(6), 805–821 (2000).
- Good CD, Johnsrude IS, Ashburner J et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage14(1), 21–36 (2001).
- Johnstone EC, Crow TJ, Frith CD. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet2, 924–926 (1976).
- Daniel DG, Goldberg TE, Gibbons RD et al. Lack of a bimodal distribution of ventricular size in schizophrenia: a Gaussian mixture analysis of 1056 cases and controls. Biol. Psychiatry30, 887–903 (1991).
- Van Horn JD, McManus IC. Ventricular enlargement in schizophrenia. A meta-analysis of studies of the ventricle: brain ratio (VBR). Br. J. Psychiatry160, 687–697 (1992).
- Raz S, Raz N. Structural brain abnormalities in the major psychoses: a quantitative review of the evidence from computerized imaging. Psychol. Bull.108, 93–108 (1990).
- Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br. J. Psychiatry172, 110–120 (1998).
- Rapoport JL, Addingtonm AM, Frangou S. The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry10, 434–449 (2005).
- Katsetos CD, Hyde TM, Herman MM. Neuropathology of the cerebellum in schizophrenia – an update: 1996 and future directions. Biol. Psychiatry42, 213–224 (1997).
- Portas CM, Goldstein JM, Shenton ME et al. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biol. Psychiatry43, 649–659 (1998)
- Andreasen NC, Arndt S, Swayze V et al. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science266, 294–298 (1994).
- Wright IC, Rabe-Hesketh S, Woodruff PWR et al. Meta-analysis of regional brain volumes in schizophrenia. Am. J Psychiatry157, 16–25 (2000).
- Nelson MD, Saykin AJ, Flashman LA et al. Hippocampal volume reductions in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch. Gen. Psychiatry55, 433–440 (1998).
- Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain122, 593–624 (1999).
- Chakos MH, Lieberman JA, Bilder RM et al. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am. J. Psychiatry151, 1430–1436 (1994).
- Keshavan MS, Anderson S, Pettegrew JW. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J. Psychiatr. Res.28, 239–265 (1994).
- Wright IC, Ellison ZR, Sharma T et al. Mapping of grey matter changes in schizophrenia. Schizophr. Res.35, 1–14 (1999).
- Hulshoff Pol HE, Schnack HG, Mandl RC et al. Focal gray matter density changes in schizophrenia. Arch. Gen. Psychiatry58, 1118–1125 (2001).
- Sigmundsson T, Suckling J, Maier M et al. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am. J. Psychiatry158, 234–243 (2001).
- Wilke M, Kaufmann C, Grabner A et al. Gray matter-changes and correlates of disease severity in schizophrenia: a statistical parametric mapping study. Neuroimage13 ,814–824 (2001).
- Shapleske J, Rossell SL, Chitnis XA et al. A computational morphometric MRI study of schizophrenia: effects of hallucinations. Cereb. Cortex12, 1331–1341 (2002).
- Marcelis M, Suckling J, Woodruff P et al. Searching for a structural endophenotype in psychosis using computational morphometry. Psychiatry Res.122, 153–167 (2003).
- Ha TH, Youn T, Ha KS et al. Gray matter abnormalities in paranoid schizophrenia and their clinical correlates. Psychiatry Res. Neuroimag.132, 251–260 (2004).
- Hulshoff Pol HE, Schnack HG, Mandl RC et al. Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. Neuroimage21, 27–35 (2004).
- Moorhead TW, Job DE, Whalley HC et al. Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods. Neuroimage22, 188–202 (2004).
- Salgado-Pineda P, Junque C, Vendrell P et al. Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients. Neuroimage21, 840–847 (2004).
- Antonova E, Kumari V, Morris R et al. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biol. Psychiatry58, 457–467 (2005).
- Giuliani NR, Calhoun VD, Pearlson GD et al. Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophr. Res.74, 135–147 (2005).
- Neckelmann G, Specht K, Lund A et al. Morphometry analysis of grey matter volume reduction in schizophrenia: association with hallucinations. Int. J. Neurosci.116, 9–23 (2006).
- Guo ZJ, Yao L, Chen K. Regional gray matter abnormalities in patients with schizophrenia determined with optimized voxel-based morphometry. In: Medical Imaging 2006: Physiology, Function, and Structure from Medical Images. Manduca, Armando; Amini, Amir A (Eds). Proc. SPIE6143O (2006) (Abstract).
- Yamada M, Hirao K, Namiki C et al. Social cognition and frontal lobe pathology in schizophrenia: a voxel-based morphometric study. Neuroimage35, 292–298 (2007).
- Kawasaki Y, Suzuki M, Kherif F et al. Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls. Neuroimage34, 235–242 (2007).
- Ananth H, Popescu I, Critchley HD et al. Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxel-based morphometry. Am. J. Psychiatry159, 1497–1505 (2002).
- Wright IC, McGuire PK, Poline JB et al. A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia. Neuroimage2, 244–252 (1995).
- Honea R, Crow TJ, Passingham D et al. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am. J. Psychiatry,162(12), 2233–2245 (2005).
- McCarley RW, Wible CG, Frumin M et al. MRI anatomy of schizophrenia. Biol. Psychiatry45, 1099–1119 (1999).
- Shenton ME, Dickey CC, Frumin M et al. A review of MRI findings in schizophrenia. Schizophr. Res.49, 1–52 (2001).
- Okubo Y, Sajo T, Oda K. A review of MRI studies of progressive brain changes in schizophrenia. J. Ment. Dent. Sci.48, 61–67 (2001).
- Shenton ME, Kikinis R, Jolesz FA et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med.327, 604–612 (1992).
- Gur RE, Maany V, Mozley PD et al. Subcortical MRI volumes in neurolepticnaive and treated patients with schizophrenia. Am. J. Psychiatry155, 1711–1717 (1998).
- Spalletta G, Tomaiuolo F, Marino V et al. Chronic schizophrenia as a brain misconnection syndrome: a white matter voxel-based morphometry study. Schizophr. Res.64, 15–23 (2003).
- Kubicki M, Shenton ME, Salisbury DF et al. Voxel-based morphometric analysis of gray matter in first episode schizophrenia. Neuroimage17, 1711–1719 (2002).
- Paillere-Martinot M, Caclin A, Artiges E et al. Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. Schizophr. Res.50, 19–26 (2001).
- Yoneyama E, Matsui M, Kawasaki Y et al. Gray matter features of schizotypal disorder patients exhibiting the schizophrenia-related code types of the Minnesota Multiphasic Personality Inventory. Acta Psychiatr. Scand.108, 333–340 (2003).
- Job DE, Whalley HC, McConnell S et al. Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia. Schizophr. Res.64(1), 1–13 (2004).
- Salgado-Pineda P, Baeza I, Perez-Gomez M et al. Sustained attention impairment correlates to gray matter decreases in first episode neurolepticnaive schizophrenic patients. Neuroimage19, 365–375 (2003).
- Farrow TF, Whitford TJ, Williams LM et al. Diagnosis-related regional grey matter loss over two years in first episode schizophrenia and bipolar disorder. Biol. Psychiatry58, 713–723 (2005).
- Whitford TJ, Farrow TF, Gomes L et al. Grey matter deficits and symptom profile in first episode schizophrenia. Psychiatr. Res. Neuroimaging139, 229–238 (2005).
- Job DE, Whalley HC, McConnell S et al. Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry. Neuroimage17, 880–889 (2002).
- Whitford TJ, Farrow TF, Rennie CJ et al. Longitudinal changes in neuroanatomy and neural activity in early schizophrenia. Neuroreport18, 435–439 (2006).
- Spencer MD, Moorhead TWJ, McIntosh AM et al. Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: a voxel-based study. Neuroimage35, 1181–1191 (2007).
- Whitford TJ, Grieve SM, Farrow TFD et al. Volumetric white matter abnormalities in first episode schizophrenia: a longitudinal, tensor-based morphometric study. Am. J. Psychiatry164, 1082–1089 (2007).
- Pasberg AK, Baar WFC, Raabjerg Christensen AM et al. Structural brain abnormalities in early onset first-episode psychosis. J. Neural. Transm.114, 489–498 (2007).
- Zipparo L, Whitford TJ, Redoblado Hodge AM et al. Investigating the neuropsychological and neuroanatomical changes that occur over the first 2-3 years of illness in patients with first-episode schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry32(2), 531–538 (2008).
- Green M, Hugdahl K, Mitchell S. Dichotic listening during auditory hallucinations in patients with schizophrenia. Am. J. Psychiatry151, 357–362 (1994).
- Green MF, Olivieri B, Crawley JN et al. Social cognition in schizophrenia: recommendations from the measurement and treatment research to improve cognition in schizophrenia new approaches conference. Schizophr. Bull.31, 882–887 (2005).
- Adolphs, R. Social cognition and the human brain. Trends Cogn. Sci.3(12), 469–479 (1999).
- Williams LM, Whitford TJ, Flynn G et al. General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery. Schizophr. Res.99(1-3), 182–191 (2008).
- Williams LM, Gordon E. The dynamic organization of the emotional brain: responsivity, stability and instability. Neuroscientist13, 349–370 (2007).
- Williams LM, Das P, Harris AWF et al. Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am. J. Psychiatry161, 1–10 (2004).
- Williams LM, Das P, Liddell BJ et al. Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes. Psychiatry Res. Neuroimaging155, 29–44 (2007).
- Haxby JV, Hoffman EA, Gobbini MI. The distributed human neural system for face perception. Trends Cogn. Sci.4, 223–233 (2000).
- McCarthy G, Puce A, Buigen A et al. Electrophysiological studies of human face perception. II: Response properties of face-specific potentials generated in occipitotemporal cortex. Cereb. Cortex9, 431–444 (1999).
- McClure RK, Phillips I, Jazayerli R et al. Regional change in brain morphometry in schizophrenia associated with antipsychotic treatment. Psychiatry Res.148, 121–132 (2006).
- Feinberg I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J. Psychiatr. Res.17, 319–334 (1982).
- Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry44, 660–669 (1987).
- Weinberger DR. From neuropathology to neurodevelopment. Lancet346, 552–557 (1995).
- Stevens JR. Neuropathology of schizophrenia. Arch. Gen. Psychiatry39, 1131–1139 (1982).
- Kirch DG, Weinberger DR. Anatomical neuropathology in schizophrenia: post-mortem findings. In: Handbook of Schizophrenia. Nasrallah HA, Weinberger DR (Eds), Elsevier, NY, USA 325–348 (1986).
- Bruton CJ, Crow TJ, Frith CD et al. Schizophrenia and the brain: a prospective clinico-neuropathological study. Psychol. Med.20, 285–304 (1990).
- Baldessarini RJ, Hegarty JD, Bird ED et al. Meta-analysis of postmortem studies of Alzheimer’s disease-like neuropathology in schizophrenia. Neuroreport154, 861–863 (1997).
- Pierri JN, Chaudry AS, Woo TU et al. Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects. Am. J. Psychiatry156, 1709–1719 (1999).
- Arnold SE, Franz BR, Gur RC et al. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am. J. Psychiatry152, 738–748 (1995).
- Benes FM, McSparren J, Bird ED et al. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch. Gen. Psychiatry48, 996–1001 (1991).
- Benes FM, Sorensen I, Bird ED. Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophr. Bull.17, 597–608 (1991).
- Arnold SE, Lee VM-Y, Gur RE et al. Abnormal dexpression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc. Natl Acad. Sci. USA88, 10850–10854 (1991).
- Benes FM, Majocha RE, Bird ED et al. Increased vertical axon numbers in cingulate cortex of schizophrenics. Arch. Gen. Psychiatry44, 1017–1021 (1987).
- Selemon LD, Goldman-Rakic PS. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol. Psychiatry45, 17–25 (1999).
- Lidow MS, Goldman-Rakic PS, Rakic P. Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proc. Natl Acad. Sci. USA88, 10218–10221 (1991).
- Andersen SL. Trajectories of brain development: point of vulnerability or window of opportunity? Neurosci. Biobehav. Rev.27, 3–18 (2003).
- Roberts GW, Royston MC, Weinberger DR. Schizophrenia. In: Greenfield’s Neuropathology.6 th Ed. Graham DI, Lantos PL (Eds). Edward Arnold, London, UK 897–929 (1997).
- DeLisi LE. Is schizophrenia a lifetime disorder of brain plasticity, growth and aging? Schizophr. Res.23, 119–129 (1997).
- Giedd JN, Blumenthal J, Jeffries NO et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat. Neurosci.2(10), 861–863 (1999).
- Sowell ER, Thompson PM, Tessner KD et al. Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: inverse relationships during post-adolescent brain maturation. J. Neurosci.21, 8819–8829 (2001).
- Grieve S, Clark CR, Williams LM et al. Preservation of limbic and paralimbic regions with aging. Hum. Brain Mapp.25, 391–401 (2005).
- Hendry IA. The response of adrenergic neurones to axotomy and nerve growth factor. Brain Res.94, 87–97 (1975).
- Andreasen NC, O’Leary DS, Cizadlo T et al. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc. Natl Acad. Sci. USA93, 9985–9990 (1996).
- Symond MP, Harris AW, Gordon E et al. “Gamma synchrony” in first-episode schizophrenia: a disorder of temporal connectivity? Am. J. Psychiatry162, 459–465 (2005).
- Spencer KM, Nestor PG, Perlmutter R et al. Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc. Natl Acad. Sci.101, 17288–17293 (2004).
- Lee KH, Williams LM, Breakspear M et al. Synchronous gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia. Brain Res. Rev.41, 57–78 (2003).
- Whittington MA, Traub RD, Jefferys JG. Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature373, 612–615 (1995).
- Williams LM, Whitford TJ, Gordon E et al. Neural synchrony in first-episode schizophrenia: tracking relationships with grey matter and symptom profile over time. J. Psychiatry Neurosci. (In Press) (2008).
- Whitford TJ, Rennie CJ, Grieve SM et al. Brain maturation in adolescence: concurrent changes in neuroanatomy and neurophysiology. Hum. Brain Mapp.28, 228–237 (2007).
- Pantelis C, Velakoulis D, McGorry P et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet361(9354), 281–288 (2003).
- Borgwardt SJ, Riecher-Rössler A, Aston J et al. Grey matter abnormalities in people with an at risk mental state – cross-sectional and longitudinal data. Schizophr. Res.86, S11–S12 (2006).
- Lappin JM, Morgan K, Morgan C et al. Gray matter abnormalities associated with duration of untreated psychosis. Schizophr. Res.83, 145–153 (2006).
- Job DE, Whalley HC, Johnstone EC et al. Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage25, 1023–1030 (2005).
- Ohnishi T, Hashimoto R, Mori T et al. The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain129, 399–410 (2006).
- Filippini N, Scassellati C, Boccardi M et al. Influence of serotonin receptor 2A His452Ty polymorphism on brain temporal structures: a volumetric MR study. Eur. J. Hum. Genet.14, 443–449 (2006).
- Neuchterlein KH, Barch DM, Gold JM et al. Identification of separable cognitive factors in schizophrenia. Schizophr. Res.72, 29–39 (2004).
- Das P, Kemp AH, Flynn G et al. Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia. Schizophr. Res.90, 284–294 (2007).
- Gordon E, Cooper N, Rennie CJ et al. Integrative neuroscience: the role of a standardized database. Clin. EEG Neurosci.36, 64–75 (2005).