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Review

Current progress in enteropathogenic and enterohemorrhagic Escherichia coli vaccines

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Pages 483-493 | Published online: 09 Jan 2014

References

  • Valiance BA, Finlay BB. Exploitation of host cells by enteropathogenic Escherichia coil. Proc. Natl Acad. Sc]. USA 97(16), 8799–8806 (2000).
  • Frankel G, Phillips AD, Rosenshine I et al Enteropathogenic and enterohaemorrhagic Escherichia colt more subversive elements. Mal Microbial. 30(5), 911–921 (1998).
  • Nataro J, Kaper J. Diarrheagenic Escherichia colt Gun. Microbial. Rev 11142–11201 (1998).
  • DeVinney R, Gauthier A, Abe A et al Enteropathogenic Escherichia colt a pathogen that inserts its own receptor into host cells. Celiular Mal Life Sc]. 55(6-7), 961–976 (1999).
  • Viljanen MK, Peltola T, Junnila SY et al Outbreak of diarrhoea due to Escherichia coil 0111:B4 in schoolchildren and adults: association of Vi antigen-like reactivity. Lancet336(8719), 831–834 (1990).
  • Law D. Virulence factors of Escherichia coil 0157 and other Shiga toxin-producing E. colt j Appl. Mcrobiol 88(5), 729–745 (2000).
  • Armstrong GL, Hollingsworth J, Morris JG Jr. Emerging foodborne pathogens: Escherichia coil 0157:H7 as a model of entry of a new pathogen into the food supply of the developed world. Epiclemiologic Rev. 18(1), 29–51 (1996).
  • Donnenberg M. Enteropathogenic Escherichia colt In: Infections of the gastrointestinal tract Blaser M et al, (Eds) Raven Press, New York, NY, USA (1995).
  • Walterspiel JN, Ashkenazi S, Morrow AL et al. Effect of subinhibitory concentrations of antibiotics on extracellular Shiga-like toxin I. Infection 20(1), 25–29 (1992).
  • Blank TE, Zhong H, Bell AL et al Molecular variation among Type IV pilin (bfpA) genes from diverse enteropathogenic Escherichia coil strains. Infect. Immun. 68(12), 7028–7038 (2000).
  • McDaniel TK, Kaper JB. A cloned pathogenicity island from enteropathogenic Escherichia coil confers the attaching and effacing phenotype on E. col" K-12. Mal Mcrobiol 23(2), 399–407 (1997).
  • Jarvis KG, Giron JA, Jerse AE et al. Enteropathogenic Escherichia coil contains a putative Type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc. Natl Acad. Sc]. USA 92(17), 7996–8000 (1995).
  • •First demonstration that EPEC possesses a Type DI secretion system.
  • Jarvis KG, Kaper JB. Secretion of extracellular proteins by enterohemorrhagic Escherichia coil via a putative Type III secretion system. Infect. Immun. 64(11), 4826–4829 (1996).
  • Elliott SJ, Wainwright LA, McDaniel TK et al The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia co/iE2348/ 69. Mol Mcrobiol 28(1), 1–4 (1998).
  • Knutton S, Rosenshine I, Pallen MJ et al. A novel EspA-associated surface organelle of enteropathogenic Escherichia coil involved in protein translocation into epithelial cells. EM/3017(8), 2166–2176 (1998).
  • Ebel F, Podzadel T, Rohde M et al Initial binding of Shiga toxin-producing Escherichia colito host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Mol Mcrobiol 30(1), 147–161 (1998).
  • Daniell SJ, Takahashi N, Wilson R et al The filamentous Type III secretion translocon of enteropathogenic Escherichia coll. Cell Mavbiol 3(121), 865–871 (2001).
  • Sekiya K, Ohishi M, Ogino T et al Supermolecular structure of the enteropathogenic Escherichia coil Type III secretion system and its direct interaction with the EspA-sheath-like structure. Proc. Nat! Acad. Sci. USA 98(20), 11638–11643 (2001).
  • Wilson RK, Shaw RK, Daniell S et al Role of EscF, a putative needle complex protein, in the Type III protein translocation system of enteropathogenic Escherichia colt Cell Nlicrobiol 3(11), 753–762 (2001).
  • Ide T, Laarmann S, Greune L et al Characterization of translocation pores inserted into plasma membranes by Type III-secreted Esp proteins of enteropathogenic Escherichia colt Cell Nlicrobiol 3(10), 669–679 (2001).
  • Shaw RK, Daniell S, Ebel F et al EspA filament-mediated protein translocation into red blood cells. Cell Mcrobiol 3(4), 213–222 (2001).
  • Wachter C, Beinke C, Mattes M et al Insertion of EspD into epithelial target cell membranes by infecting enteropathogenic Escherichia colt Mal Nlicrobiol 31(6), 1695–1707 (1999).
  • Warawa J, Finlay BB, Kenny B. Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia colt Infect Immun. 67(10), 5538–5540 (1999).
  • DeVinney R, Stein M, Reinscheid D et al Enterohemorrhagic Escherichia coil 0157:H7 produces Tir, which is translocated to the host cell membrane but is not tyrosine phosphorylated. Infect. Immun. 67(5), 2389–2398 (1999).
  • Kenny B, DeVinney R, Stein M et al Enteropathogenic E. coil (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91(41), 511–520 (1997).
  • ••Seminal finding that EPEC translocates itsown receptor Tir into host cells.
  • DeVinney R, Puente JL, Gauthier A et al Enterohaemorrhagic and enteropathogenic Escherichia coil use a different Tir-based mechanism for pedestal formation. Mal Mcrobiol 41(6), 1445–1458 (2001).
  • Goosney DL, DeVinney R, Finlay BB. Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic &he/kb/a coil pedestals. Infect humun. 69(5), 3315–3322 (2001).
  • Luo Y, Frey EA, Pfuetzner RA et al Crystal structure of enteropathogenic Escherichia coil intimin-receptor complex. Nature 405(6790), 1073–1077 (2000).
  • ••First demonstration of crystal structure ofthe intimin—Tir complex.
  • Ray PE, Liu XH. Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome. Perliatr. Nephrol 16(10), 823–839 (2001).
  • An H, Fairbrother JM, Desautels C et al Presence of the LEE (locus of enterocyte effacement) in pig attaching and effacing Escherichia coil and characterization of eae, espA, espB and espD genes of PEPEC (pig EPEC) strain 1390. Microbial Pathogenesis 28(5), 291–300 (2000).
  • Dean-Nystrom EA, Bosworth BT, Cray WC Jr. et al Pathogenicity of Escherichia coil 0157:H7 in the intestines of neonatal calves. Infect. humun. 65(5), 1842–8 (1997).
  • Tzipori S, Gunzer F, Donnenberg MS et al The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coil infection. Infect. Immun. 63(9), 3621–3627 (1995).
  • Dean-Nystrom EA, Pohlenz JF, Moon HW etal. Escherichia coli 0157:H7 causes more-severe systemic disease in suckling piglets than in colostrum-deprived neonatal piglets./nfect. Immun. 68(4), 2356–2358 (2000).
  • Karpman D, Connell H, Svensson M et al. The role of lipopolysaccharide and Shiga-like toxin in a mouse model of Escherichia coil 0157:H7 infection. j Infect. Dis. 175(3), 611–620 (1997).
  • Taguchi H, Takahashi M, Yamaguchi H et al Experimental infection of germ-free mice with hyper-toxigenic enterohaemorrhagic Escherichia coil 0157:H7, strain 6.j Med. Nlicrobiol 51(4), 336–343 (2002).
  • Conlan JW, Perry MB. Susceptibility of three strains of conventional adult mice to intestinal colonization by an isolate of Escherichia coil 0157:H7. Can. .1. Nlicrobiol. 44(8), 800–805 (1998).
  • Woods JB, Schmitt CK, Darnell SC et al. Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coil 0157:H7 and other Shiga toxin-producing E. coil j Infect. Dis. 185(4), 550–554 (2002).
  • Cantey JR, Blake RK. Diarrhea due to Escherichia coil in the rabbit: a novel mechanism. j Infect. Dis. 135(3), 454–462 (1977).
  • Agin TS, Cantey JR, Boedeker EC et al Characterization of the eaeA gene from rabbit enteropathogenic Escherichia coil strain RDEC-1 and comparison to other eaeA genes from bacteria that cause attaching-effacing lesions. FEMS Nlicrobiol Lett. 144(2–3), 249–58 (1996).
  • Luperchio S. Molecular pathogenesis of Citrobacterrodentium and transmissible murine colonic hyperplasia. Nlicivbes Infection 3333–3340 (2001).
  • Dean-Nystrom EA, Bosworth BT, Moon HW. Pathogenesis of 0157:H7 Escherichia coil infection in neonatal calves. Adv Exp. Med Biol. 41247–41251 (1997).
  • Dean-Nystrom EA, Bosworth BT Moon HW et al Escherichia coil 0157:H7 requires intimin for enteropathogenicity in calves. Infect hrimun. 66(9), 4560–4563 (1998).
  • Bitzan M, Moebius E, Ludwig K et al High incidence of serum antibodies to Escherichia coil 0157 lipopolysaccharide in children with hemolytic-uremic syndrome. Pecliatr 119(31), 380–385 (1991).
  • Li Y, Frey E, Mackenzie AM et al. Human response to Escherichia coil 0157:H7 infection: antibodies to secreted virulence factors. Infect. Immun. 68(9), 5090–5095 (2000).
  • •First demonstration that EHEC-secreted virulence factors are recognized by the host antibody.
  • Manjarrez-Hernandez HA, Gavilanes-Parra S, Chavez-Berrocal E et al Antigen detection in enteropathogenic Escherichia coil using secretory immunoglobulin A antibodies isolated from human breast milk. Infect. Immun. 68(9), 5030–5036 (2000).
  • Loureiro I, Frankel G, Adu-Bobie J et al Human colostrum contains IgA antibodies reactive to enteropathogenic Escherichia coil virulence-associated proteins: intimin, BfpA, EspA and EspB. I Perliatr Castmenterol Nub: 27(2), 166–171 (1998).
  • Donnenberg MS, Tacket CO, James SP et al Role of the eaeA gene in experimental enteropathogenic Escherichia coil infection. Clin. Invest. 92(31), 1412–1417 (1993).
  • Tacket CO, Sztein MB, Losonsky G et al Role of EspB in experimental human enteropathogenic Escherichia coil infection. Infect. Immun. 68(6), 3689–3695 (2000).
  • •Well-performed human volunteer study with EPEC.
  • Paton JC, Paton AW. Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coil infections. Gun. Nlicrobiol Rev. 11(3), 450–479 (1998).
  • Higgins LM, Frankel G, Douce G et al Citrobacter rodentium infection in mice elicits a mucosal Thl cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect. Immun. 67(6), 3031–3039 (1999).
  • •First thorough examination of the host immune response to infection by an A/E pathogen.
  • Valiance BA, Deng W, Knodler LA et al Mice lacking T and B-lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection. Infect. Immun. 70(4), 2070–2081 (2002).
  • Proulx F, Litalien C, Turgeon JP et al. Circulating levels of transforming growth factor-betal and lymphokines among children with hemolytic uremic syndrome. Ainj IGthrey Diseases 35 (11), 29–34 (2000).
  • Ghaem-Maghami M, Simmons CP, Daniell S et al Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citmbacter rodentium. Infect. Immun. 69(9), 5597–5605 (2001).
  • •Demonstration of the usefulness of C rodentium model in testing of vaccines and the role of intimin.
  • Dean-Nystrom E, Gansheroff L, Mills M et al Vaccination of pregnant dams with intimin o 15 7 Protects Suckling Piglets from Escherichia coil 0157:H7 infection. Infect. Immun. 70(5), 2414 (2002).
  • Stewart C, Wachtel M, Mabon S et al Expression of enterohemorrhagic Escherichia coil intimin in transgenic Plants edible antiEHEC 0157:H7 vaccine candidate. In: International Symposium and Workshop on Ship Toxin-producing Escherichia coil: Lois Joy Galler Foundation for Hemolytic Uremic Syndrome, Inc. (1997).
  • Schriefer A, Maltez JR, Silva N et al Expression of a pilin subunit BfpA of the bundle-forming pilus of enteropathogenic Escherichia coil in an aroA live salmonella vaccine strain. Vaccine 17(7-8), 770–778 (1999).
  • Quintana Flores V, Campos de Souza Fernandes R, Sousa de Macedo Z et al Expression and purification of the recombinant enteropathogenic Escherichia coil vaccine candidates BfpA and EspB. Protein Expression Purification 2516–22 (2002).
  • Vieira de Silva J, Garcia A, Quintana Flores V et al Phytosecretion of enteropathogenic Escherichia coil pilin subunit a in transgenic tobacco and its suitability for early life vaccinology. Vaccine 202091–202101 (2002).
  • Konadu EY, Parke JC Jr, Tran HT et al Investigational vaccine for Escherichia coil 0157: Phase 1 study of 0157 0-specific polysaccharide-Pseudomonas aeruginosa recombinant exoprotein A conjugates in adults. I Infect. Dis. 177(2), 383–387 (1998).
  • Konadu E, Donohue-Rolfe A, Calderwood SB et al Syntheses and immunologic properties of Escherichia coil 0157 0-specific polysaccharide and Shiga toxin 1 B subunit conjugates in mice. Infect. Immun. 67(11), 6191–6193 (1999).
  • Fukuda T, Kimiya T, Takahashi M et al. Induction of protection against oral infection with cytotoxin-producing Escherichia coil 0157:H7 in mice by shiga-like toxin-liposome conjugate. Intl Arch. Allergy Immunol 116(4), 313–317 (1998).
  • Butterton JR, Ryan ET, Acheson DW et al Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coil in Vibrio cholerae vaccine strains Infect. Immun. 65(6), 2127–2135 (1997).
  • Marcato P, Mulvey G, Read RJ et al. Immunoprophylactic potential of cloned shiga toxin 2 B subunit. J Infect Dis183(3), 435–443 (2001).
  • Acheson DW, Levine MM, Kaper JB et al Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR. Infect. Immun. 64(1), 355–357 (1996).
  • Bielaszewska M, Clarke I, Karmali MA et al Localization of intravenously administered verocytotoxins (Shiga-like toxins) 1 and 2 in rabbits immunized with homologous and heterologous toxoids and toxin subunits. Infect. Immun. 65(7), 2509–2516 (1997).
  • Nakao H, Kiyokawa N, Fujimoto J et al Monoclonal antibody to Shiga toxin 2 which blocks receptor binding and neutralizes cytotoxicity. Infect. Immun. 67(11), 5717–5722 (1999).
  • Mukherjee J, Chios K, Fishwild D et al Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coil 0157:H7 infection. Infect. Immun. 70(2), 612–619 (2002).

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