539
Views
49
CrossRef citations to date
0
Altmetric
Reviews

Hyperuricemia and cardiovascular disease risk

, , , &

References

  • Oda M, Satta Y, Takenaka O, Takahata N. Loss of urate oxidase activity in hominoids and its evolutionary implications. Mol Biol Evol 2002;19(5):640-53
  • Rock KL, Kataoka H, Lai J-J. Uric acid as a danger signal in gout and its comorbidities. Nature Rev Rheumatol 2012;9(1):13-23
  • Emmerson BT. Identification of the causes of persistent hyperuricaemia. Lancet 1991;337(8755):1461-3
  • Reginato AM, Mount DB, Yang I, Choi HK. The genetics of hyperuricaemia and gout. Nat Rev Rheumatol 2012;8(10):610-21
  • Yamamoto T, Moriwaki Y, Takahashi S, et al. Effect of beer on the plasma concentrations of uridine and purine bases. Metabolism 2002;51(10):1317-23
  • Torralba KD, Jesus E, Rachabattula S. The interplay between diet, urate transporters and the risk for gout and hyperuricemia: current and future directions. Int J Rheum Dis 2012;15(6):499-506
  • Choi HK, Curhan G. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 2008;336(7639):309-12
  • Wang DD, Sievenpiper JL, de Souza RJ, et al. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 2012;142(5):916-23
  • Choi HK, Liu S, Curhan G. Intake of purine‐rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 2005;52(1):283-9
  • Roddy E, Mallen CD, Doherty M. Gout. BMJ 2013.347:f5648
  • Becker B, Reinholz N, Leipert B, et al. Role of uric acid as an endogenous radical scavenger and antioxidant. Chest 1991;100(S3):176S-81S
  • Alvarez-Lario B, Macarrón-Vicente J. Is there anything good in uric acid? QJM 2011;104(12):1015-24
  • Hink HU, Santanam N, Dikalov S, et al. Peroxidase properties of extracellular superoxide dismutase role of uric acid in modulating in vivo activity. Arterioscl Thromb Vasc Biol 2002;22(9):1402-8
  • Becker BF. Towards the physiological function of uric acid. Free Rad Biol Med 1993;14(6):615-31
  • Toncev G, Milicic B, Toncev S, Samardzic G. Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood–brain barrier dysfunction. Eur J Neurol 2002;9(3):221-6
  • Ascherio A, LeWitt PA, Xu K, et al. Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol 2009;66(12):1460
  • Khosla UM, Zharikov S, Finch JL, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int 2005;67(5):1739-42
  • Ruggiero C, Cherubini A, Ble A, et al. Uric acid and inflammatory markers. Eur Heart J 2006;27(10):1174-81
  • Yu M-A, Sanchez-Lozada LG, Johnson RJ, Kang DH. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens 2010;28(6):1234-42
  • Smith RD, Yokoyama H, Averill DB, et al. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (the VIOS study). Am J Cardiovasc Drugs 2006;6(5):335-42
  • Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013;380(9859):2095-128
  • Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med 1951;34(6):1421-31
  • Beard I, John T. Serum uric acid and coronary heart disease. Am Heart J 1983;106(2):397-400
  • Agamah ES, Srinivasan SR, Webber LS, Berenson GS. Serum uric acid and its relation to cardiovascular disease risk factors in children and young adults from a biracial community: the Bogalusa Heart Study. J Lab Clin Med 1991;118(3):241-9
  • Lee J, Sparrow D, Vokonas PS, et al. Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome The Normative Aging study. Am J Epidemiol 1995;142(3):288-94
  • Bonora E, Targher G, Zenere M, et al. Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study. Int J Obes Rel Metab Dis 1996;20(11):975-80
  • Wannamethee SG, Shaper AG, Whincup PH. Serum urate and the risk of major coronary heart disease events. Heart 1997;78(2):147-53
  • Collaboration PS. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360(9349):1903-13
  • Fa M. On chronic Bright’s disease, and its essential symptoms. Lancet 1879;1:399-401
  • Selby JV, Friedman GF, Quesenberry CP. Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries. Am J Epidemiol 1990;131(6):1017-27
  • Jossa F, Farinaro E, Panico S, et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens 1994;8(9):677-81
  • Cannon PJ, Stason WB, Demartini FE, et al. Hyperuricemia in primary and renal hypertension. N Engl J Med 1966;275(9):457-64
  • Perlstein TS, Gumieniak O, Williams GH, et al. Uric acid and the development of hypertension the normative aging study. Hypertension 2006;48(6):1031-6
  • Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and meta-analysis. Arthritis Care Res 2011;63(1):102-10
  • Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001;38(5):1101-6
  • Mazzali M, Kanellis J, Han L, et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Ren Physiol 2002;282(6):F991-F7
  • Watanabe S, Kang D-H, Feng L, et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 2002;40(3):355-60
  • Syamala S, Li J, Shankar A. Association between serum uric acid and prehypertension among US adults. J Hypertens 2007;25(8):1583-9
  • Liang J, Xue Y, Zou C, et al. Serum uric acid and prehypertension among Chinese adults. J Hypertens 2009;27(9):1761-5
  • Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension 2003;42(3):247-52
  • Loeffler LF, Navas-Acien A, Brady TM, et al. Uric acid level and elevated blood pressure in US adolescents National Health and Nutrition Examination Survey, 1999–2006. Hypertension 2012;59(4):811-17
  • Park B, Park E, Cho S, et al. The association between fetal and postnatal growth status and serum levels of uric acid in children at 3 years of age. Am J Hypertens 2009;22(4):403-8
  • Alper AB, Chen W, Yau L, et al. Childhood Uric Acid Predicts Adult Blood Pressure The Bogalusa Heart Study. Hypertension 2005;45(1):34-8
  • Viazzi F, Antolini L, Giussani M, et al. Serum uric acid and blood pressure in children at cardiovascular risk. Pediatrics 2013;132(1):e93-9
  • Forman JP, Choi H, Curhan GC. Plasma uric acid level and risk for incident hypertension among men. J Am Soc Nephrol 2007;18(1):287-92
  • Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension. JAMA 2008;300(8):924-32
  • Brand F, McGee D, Kannel W, et al. Hyperuricemia as a risk factor of coronary heart disease: the Framingham Study. Am J Epidemiol 1985;121(1):11-18
  • Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141(7):637-44
  • Kagan A, Gordon T, Rhoads GG, Schiffman JC. Some factors related to coronary heart disease incidence in Honolulu Japanese men: the Honolulu Heart Study. Int J Epidemiol 1975;4(4):271-9
  • Ioachimescu AG, Brennan DM, Hoar BM, et al. Serum uric acid is an independent predictor of all‐cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study. Arthritis Rheum 2008;58(2):623-30
  • Kivity S, Kopel E, Maor E, et al. Association of serum uric acid and cardiovascular disease in healthy adults. Am J Cardiol 2013;111(8):1146-51
  • Kim SY, Guevara JP, Kim KM, et al. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res 2010;62(2):170-80
  • Kim SY, Guevara JP, Kim KM, et al. Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Care Res 2009;61(7):885-92
  • Chamorro Á, Obach V, Cervera Á, et al. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke 2002;33(4):1048-52
  • Weir CJ, Muir SW, Walters MR, Lees KR. Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke 2003;34(8):1951-6
  • Kanellis J, Johnson RJ. Editorial comment – elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective. Stroke 2003;34(8):1956-7
  • Newman EJ, Rahman FS, Lees KR, et al. Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes. Diabetes Metab Res Rev 2006;22(1):79-82
  • Huang H, Huang B, Li Y, et al. Uric acid and risk of heart failure: a systematic review and meta-analysis. Eur J Heart Fail 2013;22(1):79-82
  • Hare JM, Johnson RJ. Uric acid predicts clinical outcomes in heart failure insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology. Circulation 2003;107(15):1951-3
  • Anker SD, Doehner W, Rauchhaus M, et al. Uric acid and survival in chronic heart failure validation and application in metabolic, functional, and hemodynamic staging. Circulation 2003;107(15):1991-7
  • Levantesi G, Marfisi RM, Franzosi MG, et al. Uric acid: a cardiovascular risk factor in patients with recent myocardial infarction. Int J Cardiol 2012;167(1):262-9
  • Ndrepepa G, Braun S, Haase H-U, et al. Prognostic value of uric acid in patients with acute coronary syndromes. Am J Cardiol 2012;109(9):1260-5
  • Dutta A, Henley W, Pilling LC, et al. Uric acid measurement improves prediction of cardiovascular mortality in later life. J Am Ger Soc 2013;61(3):319-26
  • Perk J, De Backer G, Gohlke H, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012;33(13):1635-701
  • Savarese G, Ferri C, Trimarco B, et al. Changes in serum uric acid levels and cardiovascular events: a meta-analysis. Nutr Metab Cardiovasc Dis 2013;23(8):707-14
  • Reungjui S, Roncal CA, Mu W, et al. Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol 2007;18(10):2724-31
  • Høieggen A, Alderman MH, Kjeldsen SE, et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Intern 2004;65(3):1041-9
  • Noman A, Ang DS, Ogston S, et al. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet 2010;375(9732):2161-7
  • Rajendra NS, Ireland S, George J, et al. Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris. J Am Coll Cardiol 2011;58(8):820-8
  • Borghi C, Cosentino ER, Rinaldi ER, Cicero AF. Uricaemia and ejection fraction in elderly heart failure outpatients. Eur J Clin Invest 2014;44(6):573-8
  • Cicero AF, Desideri G, Grossi G, et al. Serum uric acid and impaired cognitive function in a cohort of healthy young elderly: data from the Brisighella Study. Intern Emerg Med 2014. [Epub ahead of print]
  • Cicero AF, Salvi P, D’Addato S, et al. Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study. J Hypertens 2014;32(1):57-64
  • Cicero AF, Rosticci M, Parini A, et al. Serum uric acid is inversely proportional to estimated stroke volume and cardiac output in a large sample of pharmacologically untreated subjects: data from the Brisighella Heart Study. Intern Emerg Med 2013. [Epub ahead of print]
  • Zhao G, Huang L, Song M, Song Y. Baseline serum uric acid level as a predictor of cardiovascular disease related mortality and all-cause mortality: a meta-analysis of prospective studies. Atherosclerosis 2013;231(1):61-8
  • Xu Y, Zhu J, Gao L, et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS One 2013;8(10):e78206
  • Desideri G, Castaldo G, Lombardi A, et al. Is it time to revise the normal range of serum uric acid levels? Eur Rev Med Pharmacol Sci 2014;18(9):1295-306
  • Tausche AK, Christoph M, Forkmann M, et al. As compared to allopurinol, urate-lowering therapy with febuxostat has superior effects on oxidative stress and pulse wave velocity in patients with severe chronic tophaceous gout. Rheumatol Int 2014;34(1):101-9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.