528
Views
2
CrossRef citations to date
0
Altmetric
Editorial

Gi/o signaling and its potential role in cardioprotection

&
Pages 785-787 | Published online: 10 Jan 2014

References

  • Lefkowitz RJ. Historical review: a brief history and personal retrospective of seven-transmembrane receptors. Trends Pharmacol. Sci.25(8), 413–422 (2004).
  • Gudermann T, Nurnberg B, Schultz G. Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function. J. Mol. Med.73(2), 51–63 (1995).
  • Wettschureck N, Offermanns S. Mammalian G proteins and their cell type specific functions. Physiol. Rev.85(4), 1159–1204 (2005).
  • Zhu M, Gach AA, Liu G et al. Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G α o* protein. Am. J. Physiol.294(3), H1335–H1347 (2008).
  • Blaxall BC, Spang R, Rockman HA, Koch WJ. Differential myocardial gene expression in the development and rescue of murine heart failure. Physiol. Genomics15(2), 105–114 (2003).
  • Feldman AM, Cates AE, Veazey WB et al. Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J. Clin. Invest.82(1), 189–197 (1988).
  • Kinane TB, Shang C, Finder JD, Ercolani L. cAMP regulates G-protein α i-2 subunit gene transcription in polarized LLC-PK1 cells by induction of a CCAAT box nuclear binding factor. J. Biol. Chem.268(33), 24669–24676 (1993).
  • Jakob H, Sigmund M, Eschenhagen T et al. Effect of captopril on myocardial β-adrenoceptor density and Gi α-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy. Eur. J. Clin. Pharmacol.47(5), 389–394 (1995).
  • Sigmund M, Jakob H, Becker H et al. Effects of metoprolol on myocardial β-adrenoceptors and Gi α-proteins in patients with congestive heart failure. Eur. J. Clin. Pharmacol.51(2), 127–132 (1996).
  • DeGeorge BR Jr, Gao E, Boucher M et al. Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Circulation117(11), 1378–1387 (2008).
  • Rebolledo B, Lai NC, Gao MH et al. Adenylylcyclase gene transfer increases function of the failing heart. Hum. Gene Ther.17(10), 1043–1048 (2006).
  • Williams ML, Hata JA, Schroder J et al. Targeted β-adrenergic receptor kinase (βARK1) inhibition by gene transfer in failing human hearts. Circulation109(13), 1590–1593 (2004).
  • Zhu W, Zeng X, Zheng M, Xiao RP. The enigma of β2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly. Circ. Res.97(6), 507–509 (2005).
  • Chesley A, Lundberg MS, Asai T et al. The β (2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3´-kinase. Circ. Res.87(12), 1172–1179 (2000).
  • Fu Y, Huang X, Zhong H et al. Endogenous RGS proteins and Gα subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ. Res.98(5), 659–666 (2006).
  • Donahue JK, Heldman AW, Fraser H et al. Focal modification of electrical conduction in the heart by viral gene transfer. Nat. Med.6(12), 1395–1398 (2000).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.