137
Views
29
CrossRef citations to date
0
Altmetric
Drug Profile

Bemiparin: second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism

, &
Pages 793-802 | Published online: 10 Jan 2014

References

  • Fowkes FJ, Price JF, Fowkes FG. Incidence of diagnosed deep vein thrombosis in the general population: systematic review. Eur. J. Vasc. Endovasc. Surg.25(1), 1–5 (2003).
  • McKelvie PA. Autopsy evidence of pulmonary thromboembolism. Med. J. Aust.160(3), 127–128 (1994).
  • Geerts WH, Pineo GF, Heit JA et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest126(3 Suppl.), S338–S400 (2004).
  • Segal JB, Streiff MB, Hofmann LV, Thornton K, Bass EB. Management of venous thromboembolism: a systematic review for a practice guideline. Ann. Intern. Med.146(3), 211–222 (2007).
  • Antman EM, Morrow DA, McCabe CH et al. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N. Engl. J. Med.354(14), 1477–1488 (2006).
  • Lee S, Gibson CM. Enoxaparin in acute coronary syndromes. Expert Rev. Cardiovasc. Ther.5(3), 387–399 (2007).
  • Iorio A, Guercini F, Pini M. Low-molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: meta-analysis of the randomized comparisons with oral anticoagulants. J. Thromb. Haemost.1(9), 1906–1913 (2003).
  • Lee AY, Levine MN, Baker RI et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N. Engl. J. Med.349(2), 146–153 (2003).
  • Baglin T, Barrowcliffe TW, Cohen A et al. Guidelines on the use and monitoring of heparin. Br. J. Haematol.133(1), 19–34 (2006).
  • Planès A. Review of bemiparin sodium – a new second-generation low molecular weight heparin and its applications in venous thromboembolism. Expert Opin. Pharmacother.4(9), 1551–1561 (2003).
  • García Frade LJ, Peñarrubia Ponce MJ. Chemical structure-activity ratio of the low molecular weight heparins (HBPM). Towards a second generation of low molecular weight heparins? Rev. Iberoamer. Tromb. Hemostasia13, 7–13 (2000).
  • Rocha E, Imberti D, Paschina E. Low-molecular-weight heparins: before or after surgery? New concepts and evidence: Congress report from the Sigma Tau/ROVI Satellite Symposium (Rome, Italy, 13 November 2006). Clin. Drug Investig.27(5), 357–366 (2007).
  • Chapman TM, Goa KL. Bemiparin: a review of its use in the prevention of venous thromboembolism and treatment of deep vein thrombosis. Drugs63(21), 2357–2377 (2003).
  • Depasse F, González de Suso MJ, Lagoutte I, Fontcuberta J, Borrell M, Samama MM. Comparative study of the pharmacokinetic profiles of two LMWH-bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa)-administered subcutaneously to healthy male volunteers. Thromb. Res.109(2–3), 109–117 (2003).
  • Gerotziafas GT, Petropoulou AD, Verdy E, Samama MM, Elalamy I. Effect of the anti-factor Xa and anti-factor IIa activities of low-molecular-weight heparins upon the phases of thrombin generation. J. Thromb. Haemost.5(5), 955–962 (2007).
  • Bates SM, Weitz JI. The status of new anticoagulants. Br. J. Haematol.134(1), 3–19 (2006).
  • Christidou FN, Frangia TK, Bamichas GI et al. Comparison of two low-molecular weight heparins (LMWH), tinzaparin and bemiparin, during hemodialysis. Int. J. Clin. Pharmacol. Ther.43(7), 335–338 (2005).
  • Borrell M, Antonijoan RM, Ortiz R et al. Pharmacokinetic profile of two LMWH: bemiparin 3500 IU and enoxaparin 4000 IU after sc administration in healthy volunteers (18th Congress of the International Society of Thrombosis and Haemostasis. Paris, France, 2001). Thromb. Haemost.86(Suppl.), CD3578 (2001).
  • Hoppensteadt DA, Jeske W, Fareed J, Bermes EW Jr. The role of tissue factor pathway inhibitor in the mediation of the antithrombotic actions of heparin and low-molecular-weight heparin. Blood Coagul. Fibrinolysis.6(Suppl. 1), S57–S64 (1995).
  • Falkon L, Garí M, Sáenz-Campos D, Antonijoan R, Barbanoj M, Fontcuberta J. Kinetic behaviour of the TFPI and anti-FXa effects, after the injection of a LMWH(RO-11) in healthy subjects. Thromb. Haemost.73(4), 728–729 (1995).
  • Falkon L, Garí M, Barbanoj M, Amiral J, Fontcuberta J. Tissue factor pathway inhibitor and anti-FXa kinetic profiles of a new low-molecular-mass heparin, Bemiparin, at therapeutic sc doses. Blood Coagul. Fibrinolysis9(2), 137–141 (1998).
  • Kakkar VV, Howes J, Sharma V, Kadziola Z; The Bemiparin Assessment group. A comparative, double-blind, randomized trial of a new second generation LMWH (Bemiparin) and UFH in the prevention of post-operative venous thromboembolism. Thromb. Haemost.83, 523–529 (2000).
  • Navarro-Quilis A, Castellet E, Rocha E et al. Efficacy and safety of bemiparin compared with enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty: a randomized, double-blind clinical trial. J. Thromb. Haemost.1(3), 425–432 (2003).
  • Honorato J, Gómez-Outes A, Navarro-Quilis A, Martínez-González J, Rocha E, Planès A. Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous thromboembolism in total knee replacement surgery. Pharmacoeconomics22(13), 885–894 (2004).
  • Abad JI, Gómez-Outes A, Martínez-González J et al. A prospective observational study on the effectiveness and safety of bemiparin, first dose administered 6 h after knee or hip replacement surgery. Arch. Orthop. Trauma Surg.127(8), 665–670 (2007).
  • Otero-Fernández R, Gómez-Outes A, Martínez-González J et al. Evaluation of the effectiveness and safety of bemiparin in a large population of orthopedic patients in a normal clinical practice. Clin. Appl. Thromb. Hemost.14(1), 75–83 (2008).
  • Balibrea JL, Altimiras J, Larruzea I et al. Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: an audit of practice. Int. J. Surg.5(2), 114–119 (2007).
  • Constans M, Santamaria A, Mateo J, Pujol N, Souto JC, Fontcuberta J. Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy. Int. J. Clin. Pract.61(2), 212–217 (2007).
  • Douketis JD, Johnson JA, Turpie AG. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch. Intern. Med.164(12), 1319–1326 (2004).
  • Spyropoulos AC, Turpie AG. Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation. Curr. Opin. Pulm. Med.11(5), 373–379 (2005).
  • Miras-Parra F, Navascués-Martínez E, Gómez-Outes A et al. Utilisation and safety of bemiparin, a low-molecular-weight heparin, in medical patients: a prospective, uncontrolled cohort study. Clin. Drug Investig.25(7), 463–472 (2005).
  • Prieto Seva AJ. Safety and effectiveness of bemiparin in the prevention of venous thromboembolic disease in nursing home patients. Rev. Esp. Geriatr. Gerontol.42, 20–26 (2007).
  • Rodríguez-Mañas L, Gómez-Huelgas R, Monteagudo G, Maeso R, Gómez-Outes A, Martínez-González J. Bemiparin thromboprophylaxis in elderly medical patients: the “ANCIANOS” study. J. Thromb. Haemost.5(Suppl. 2), P-T-671 (2007).
  • Kakkar VV, Gebska M, Kadziola Z et al. Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis. Thromb. Haemost.89(4), 674–680 (2003).
  • Gómez-Outes A, Rocha E, Martínez-González J, Kakkar VV. Cost effectiveness of bemiparin sodium versus unfractionated heparin and oral anticoagulants in the acute and long-term treatment of deep vein thrombosis. Pharmacoeconomics24(1), 81–92 (2006).
  • Santamaría A, Juárez S, Reche A et al. Low-molecular-weight heparin, bemiparin, in the outpatient treatment and secondary prophylaxis of venous thromboembolism in standard clinical practice: the ESFERA Study. Int. J. Clin. Pract.60(5), 518–525 (2006).
  • Lecumberri R, Rosario E, Pacho J, Rocha E; FLEBUS Investigators. Fixed-dose low-molecular-weight heparin, bemiparin, in the long-term treatment of venous thromboembolism in patients with transient risk factors in standard clinical practice: the FLEBUS study. J. Thromb. Haemost.4(11), 2504–2508 (2006).
  • Ong BS, Karr MA, Chan DK, Frankel A, Shen Q. Management of pulmonary embolism in the home. Med. J. Aust.183(5), 239–242 (2005).
  • Siragusa S, Arcara C, Malato A et al. Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients. Ann. Oncol.16(Suppl. 4), iv136–iv139 (2005).

Website

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.