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Review

Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections

Pages 21-43 | Published online: 10 Jan 2014

References

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  • •Only double-blind study that has proven the efficacy of cidofovir in the (local) treatment (as a topical gel) of papillomatous lesions.
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  • ••Spectacular regression of giant orf(ecthyma) lesion following local (cream) treatment with cidofovir.
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  • •Successful treatment with adefovir dipivoxil of chronic, lamivudine-resistant, hepatitis B virus infections.
  • Benhamou Y, Bochet M, Thibault V, et al Adefovir dipivoxil 10 mg suppresses HBV viral replication in HIV/HBV co-infected patients with lamivudine resistant HBV. Abstracts 9th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington USA, 24–28 February (2002).
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  • Marcellin P, Chang T-T, Lim SG, et al Adefovir dipivoxil for the treatment of hepatitis Be antigen-positive chronic hepatitis B. N Engl. J Med. 348,808–816 (2003).
  • ••Comprehensive study pertaining to thesuccessful treatment of chronic hepatitis B with adefovir dipivoxil, as monitored by different laboratory (histological, virological and biochemical) parameters.
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  • •Double-blind, placebo-controlled study showing HIV-1 load reduction with tenofovir disoproxil fumarate over a 48-week period.
  • Squires K, Pierone G, Berger D, etal Tenofovir DF: a 48-week final analysis from a Phase III randomized, double-blind placebo-controlled study in antiretroviral experienced patients. Abstracts 9th Conference on Retroviruses and Opportunistic Infections, Seattle, WA USA, 24–28 February (2002).
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