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Review

Recent advances in the treatment of HIV/AIDS

Pages 197-211 | Published online: 10 Jan 2014

References

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  • •Initial clinical paper on the first FDA-approved antiretroviral medicine. It shows how far we have come in the treatment of HIV/AIDS.
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  • •Describes the Dupont-Merck 006 trial that first demonstrated the superiority of an NNRTI-based regimen over the classic PI-containing one.
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  • Dear Healthcare Professional Letter. High rate of virologic failure in patients with HIV infection treated with a once-daily triple NRTI regimen containing didanosine, lamivudine and tenofovir. Gilead Sciences, Inc. (2003).
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  • •An often cited reference, regarding the use of a structured treatment interruption in recently infected HIV patients.
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  • •• Provacative article that serves as background for Decks recent hypothesis of how to treat the ARV-experienced patient.
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  • ••The 'classic' paper demonstrating that inthe treatment of HIV, at least 95% adherence is essential to achieve virologic success.
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  • •Excellent overview of the first approved fusion inhibitor.
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  • ••Post-hoc analysis of the TORO trials,describing the patient characteristics of those likely to have the best response to T–20.
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  • ••Essential reading for any HIV practitioner.Descibes in detail the mechanisms of drug resistance tests, and the latest guidelines for using antiretroviral drug resistance testing.
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  • •First described the dynamic nature of HIV replication, the emergence of viral mutations, and implications for antiretroviral therapy. A must read for the serious HIV treater.
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  • •First paper showing the short-term usefulness of ARV drug resistance testing.
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Websites

  • The United Nations AIDS website. (Accessed March 2004) www.UNAIDS.org
  • The World Health Report 2002. World Health Organization. (Accessed March 2004) www.WHO.int/whr/2002/en.
  • Global Health-Sector Strategy for HIV/AIDS: 2003–2007. Department of HIV/AIDS. Family and Community Health. World Health Organization. (Accessed March 2004) www.who.int/en/
  • HIV/AIDS among African Americans. CDC. National Center for HIV, STD and TB Prevention Divisions of HIV/AIDS Prevention. (Accessed March 2004) www.cdc.gov/hiv/pubs/Facts/afam.htm
  • US Department of Health and Human Services Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. (Accessed March 2004) http://aidsinfo.nih.gov/guidelines
  • Cheever L. Forum for Collaborative HIV Research. What do we know about adherence levels in different populations? Adherence to HIV therapy: building a bridge to success. (Accessed March 2004) http://www.gwhealthpolicy.org.

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