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Review

Progress in the treatment of a neglected infectious disease: visceral leishmaniasis

Pages 279-292 | Published online: 10 Jan 2014

References

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  • ••Comprehensive statement of currentclinical status of visceral infection and what will be needed in the future to improve management.
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  • •Results indicated that responses to treatment in VL vary by region (India > Kenya > Brazil).
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  • •• Randomized controlled trial indicating that responses to both pentavalent antimony and amphotericin B are impaired in HIV-associated VL.
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  • •Experimental rationale for targeting IL-10 for inhibition as a form of immunotherapy for visceral infection.
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  • •Clinical demonstration supporting the targeting IL-10 for inhibition as a future immunotherapeutic approach in VL.
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  • Murray HW interleukin-10 receptor blockade-pentavalent antimony treatment in experimental visceral leishmaniasis (submitted).

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