Treatment of staphylococcal scalded skin syndrome

Reference

• Crossley KB, Archer GL (Eds), Churchill Livingstone, NY, USA (1997).
   Google Scholar
• Lee JC. The prospects for developing a vaccine against Staphylococcus aureus.Trends Microbial. 4,162–166 (1996).
   PubMed Web of Science ®Google Scholar
• Champion RH, Burton JL, Burns DA, Breathnach SM (Eds), Blackwell Sciences Ltd, Oxford, UK (1998).
   Google Scholar
• Hutchison JG, Green CA, Grimson TA. Nasal carriage of Staphylococcus aureus in nurses. J. Clin. Pathol 195, 10, 92-95 (1957).
   Google Scholar
• Dancer SJ, Simmons NA, Poston SM, Noble WC. Outbreak of staphylococcal scalded skin syndrome among neonates. J. Infect. 16,87–103 (1988).
   PubMed Web of Science ®Google Scholar
• Hargiss C, Larson E. The epidemiology of Staphylococcus aureus in a newborn nursery from 1970 through 1976. Pediatrics 61, 348–353 (1978).
   PubMedGoogle Scholar
• Wenzel RP, Perl TM. The significance of nasal carriage of Staphylococcus aureus and the incidence of postoperative wound infection. J. Hosp. Infect. 31,13–24 (1995).
   PubMed Web of Science ®Google Scholar
• Leyden JJ, Marples RR, Kligman AM. Staphylococcus aureus in the lesion of atopic dermatitis. Br. J. Dermatol 90,525–530 (1974).
   PubMed Web of Science ®Google Scholar
• Tuazon CU, Perez A, Kishaba T, Sheagren JN. Staphylococcus aureus among insulin-injecting diabetic patients: an increased carrier rate. J. Am. Med. Assoc. 231,1272 (1975).
   Google Scholar
• Tuazon CU, Sheagren JN. Increased rate of carriage of Staphylococcus aureus among narcotic addicts. J. Infect. Dis. 129, 725–727 (1974).
   PubMed Web of Science ®Google Scholar
• Weinke T, Schiller R, Fehrenbach FJ, Pohle HD. Association between Staphylococcus aureus nasopharyngeal colonization and septicemia in patients infected with the human immunodeficiency virus. Eur. J. Clin. Microbial Infect. Dis. 11,985–989 (1992).
   PubMed Web of Science ®Google Scholar
• Yu VL, Goetz A, Wagener M, et al. Staphylococcus aureus nasal carriage and infection in patients on hemodialysis: efficacy of antibiotic prophylaxis. N Engl J. Med 315,91–96 (1986).
   PubMed Web of Science ®Google Scholar
• Pittet D, Wenzel RP Nosocomial bloodstream infections: secular trends in rates, mortality, and contribution to total hospital deaths. Arch. Intern. Med. 155, 1177–1184 (1995).
   PubMed Web of Science ®Google Scholar
• Ayliffe GA. The progressive intercontinental spread of methicillin-resitant Staphylococcus aureus. Clin. Infect. Dis. 24\(Suppl. 1), S74—S79 (1997).
   Google Scholar
• Kallman JE, Kihlstrom J, Joberg L, Schollin J. Increase in staphylococci in neonatal septicaemia: a 14-year study. Acta Paediatr. 86,533–538 (1997).
   PubMed Web of Science ®Google Scholar
• Mehtar S. The continuing problem of 'hospital staphylococci': why? J. Chemother. 6\(Suppl. 4), 25–40 (1994).
   PubMedGoogle Scholar
• Bhakdi S, Tranum-Jensen J. a-toxin of Staphylococcus aureus. Microbial Rev. 55, 733–751 (1991).
   Google Scholar
• Marrack P, Kappler J. The staphylococcal enterotoxins and their relatives. Science 248, 705–711 (1990).
   PubMed Web of Science ®Google Scholar
• Melish ME, Glasgow LA. The staphylococcal scalded-skin syndrome. N Engl J. Med. 282,1114–1119 (1970).
   PubMed Web of Science ®Google Scholar
• •Eestablishes that the cause of staphylococcal scalded skin syndrome is a Staphylococcus aureus exotoxin.
   Google Scholar
• Ritter von Rittershain G. Die exfoliativa dermatitis jiingerer Säulinge. Centralz Kinderheilk 2,3–23 (1878).
   Google Scholar
• Almquist E. Pemphigus neonatorum, backteriologisch und epidemiologisch beleuchtet. Z Hyg. Infic. 10,253 (1891).
   Google Scholar
• Lyell A. Toxic epidermal necrolysis: an eruption resembling scalding of the skin. Br J. Dermatol 68,355–361 (1956).
   PubMed Web of Science ®Google Scholar
• Lyell A, Dick HM, Alexander JO. Outbreak of toxic epidermal necrolysis associated with staphylococci. Lancet 1, 787–789 (1969).
   Google Scholar
• Lyell A. A review of toxic epidermal necrolysis in Britain. Br. J. Dermatol 79, 662–671 (1967).
   PubMed Web of Science ®Google Scholar
• Jefferson J. Lyell's toxic epidermal necrolysis: a staphylococcal etiology? Br. Med. J. 555,802–804 (1967).
   Google Scholar
• Tyson RG, Ushinski SC, Kisilevsky R. Toxic epidermal necrolysis (the scalded skin syndrome). Its association in two cases with pathogenic staphylococci and its similarity in infancy to Ritter's disease. Am. J. Dis. Child. 111,386–392 (1966).
   PubMedGoogle Scholar
• Messaritakis J. Toxic epidermal necrolysis in children (description of 4 cases). Ann. Paediatr. 207,236–246 (1966).
   PubMedGoogle Scholar
• Lowney ED, Baublis JV, Kreye GM, et al The scalded skin syndrome in small children. Arch. Dermatol 95,359–369 (1967).
   PubMedGoogle Scholar
• Lyell A. The staphylococcal scalded skin syndrome in historical perspective: emergence of dermopathic strains of Staphylococcus aureus and discovery of the epidermolytic toxin. A review of events up to 1970. J. Am. Acad. Dermatol 9, 285–294 (1983).
   PubMedGoogle Scholar
• Melish ME, Glasgow LA, Turner MD. The staphylococcal scalded-skin syndrome: isolation and partial characterization of the exfoliative toxin. J. Infect. Dis. 125, 129–140 (1972).
   PubMed Web of Science ®Google Scholar
• Melish ME, Glasgow LA. Staphylococcal scalded skin syndrome: the expanded clinical syndrome. J. Pediatr. 78,958–967 (1971).
   PubMed Web of Science ®Google Scholar
• Kapral FA, Miller MM. Product of Staphylococcus aureus responsible for the scalded skin syndrome. Infect. Immun. 4, 541–545 (1971).
   PubMed Web of Science ®Google Scholar
• Elias PM, Fritsch P, Mittermayer H, et al. Experimental staphylococcal toxic epidermal necrolysis (TEN) in adult humans and mice. J. Lab. Clin. Med 84,414–424 (1974).
   PubMedGoogle Scholar
• Arbuthnott JP, Kent J, Lye11 A. Studies of staphylococcal toxins in relation to toxic epidermal necrolysis: the scalded skin syndrome. Br J. Dermatol 86(Suppl.), S35-539 (1972).
   Google Scholar
• Melish ME, Chen FS, Sprouse S, et al Epidermolytic toxin in staphylococcal infection: toxin levels and host response. Zentralbl Bakteriol 10(Suppl.), 287–298 (1981).
   Google Scholar
• •Important study of age and presence of antibodies against exfoliative toxin A.
   Google Scholar
• Levine G, Norden CW. Staphylococcal scalded-skin syndrome in an adult. N Engl J. Med 287,1339–1340 (1972).
   PubMedGoogle Scholar
• •First report of adult-onset staphylococcalscalded skin syndrome.
   Google Scholar
• Patel GK, Finlay AY. Staphylococcal scalded skin syndrome: diagnosis and management. Am. J. Clin. Dermatol 4,165–175 (2003).
   PubMed Web of Science ®Google Scholar
• •Clearly outlines the diagnostic criteria forstaphylococcal scalded skin syndrome.
   Google Scholar
• Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR. Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein-1. Nature Med 6,1275–1277 (2000).
   PubMed Web of Science ®Google Scholar
• •Key paper, showing that desmoglein-1 isthe target for the exfoliative toxin.
   Google Scholar
• Hanakawa Y, Schechter NM, Lin C, et al. Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J. Clin. Invest. 110, 53–60 (2002).
   PubMed Web of Science ®Google Scholar
• •Key paper, outlining the cleavage siteon desmoglein-1 in staphylococcal scalded skin syndrome.
   Google Scholar
• Amagai M. Desmoglein as a target in autoimmunity and infection. J. Am. Acad. Dermatol 48,244–252 (2003).
   PubMedGoogle Scholar
• Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR Staphylococcal exfoliative toxin B specifically cleaves desmoglein-1. J. Invest. Dermatol 118,845–850 (2002).
   PubMed Web of Science ®Google Scholar
• Salopek TG. Nikolsky's sign: is it 'dry' or is it 'wet'? Br J. Dermatol 136,762–767 (1997).
   PubMedGoogle Scholar
• Holme SA, Davies JH, Mills CM. Iatrogenic injury in childhood staphylococcal scalded skin syndrome. J. Paediatr. Child Health 39, 73–74 (2003).
   PubMedGoogle Scholar
• Reid LH, Weston WT, Humbert JR Staphylococcal scalded skin syndrome. Adult onset in a patient with deficient cell-mediated immunity. Arch Dermatol 109, 239–241 (1974).
   PubMedGoogle Scholar
• Norden CW, Mendelow H. Letter: staphylococcal scalded skin syndrome in adults. N Engl J. Med. 290,577 (1974).
   PubMedGoogle Scholar
• Fine JD, Harrist TJ, Radford MJ. Adult scalded skin syndrome fatally complicated by mixed Gram-negative sepsis and cellulitis. Cutts 27,162–167 (1981).
   PubMedGoogle Scholar
• Amon RB, Dimond RL. Toxic epidermal necrolysis: rapid differentiation between staphylococcal-and drug-induced disease. Arch. Dermatol 111,1433–1437 (1975).
   PubMedGoogle Scholar
• Falk DK, King LEJ. Criteria for the diagnosis of staphylococcal scalded skin syndrome in adults. Cutis 31,421–424 (1983).
   PubMedGoogle Scholar
• Patel GK, Varma S, Finlay AY. Staphyloccocal scalded skin syndrome in healthy adults. Br. J. Dermatol 142, 1253–1255 (2000).
   PubMed Web of Science ®Google Scholar
• Elias PM, Fritsch P, Epstein EH. Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments. Arch Dermatol 113, 207–219 (1977).
   PubMedGoogle Scholar
• Robinson ND, Hashimoto T, Amagai M, Chan LS. The new pemphigus variants. J. Am. Acad Dermatol 40,649–671 (1999).
   PubMed Web of Science ®Google Scholar
• •Good review of pemphigus and variants.
   Google Scholar
• Elsner P, Hartmann AA. Epidemiology of ET-A-and ET-B-producing staphylococci in dermatological patients. Zentrlbl. Bakterial Mikrobial Hyg. (A) 268,534 (1988).
   Google Scholar
• Dancer SJ, Noble WC. Nasal, axillary, and perineal carriage of Staphylococcus aureus among women: identification of strains producing epidermolytic toxin. J. Clin. Pathol 44,681–684 (1991).
   PubMed Web of Science ®Google Scholar
• Cribier B, Piemont Y, Grosshans E. Staphylococcal scalded skin syndrome in adults. A clinical review illustrated with a new case. J. Am. Acad. Dermatol 30, 319–324 (1994).
   PubMed Web of Science ®Google Scholar
• •Clinical review of staphylococcal scalded skin syndrome.
   Google Scholar
• Opal SM, Johnson-Winegar AD, Cross AS. Staphylococcal scalded skin syndrome in two immunocompetent adults caused by exfoliatin B-producing Staphylococcus aureus.J. Clin. Microbial 26,1283–1286 (1988).
   PubMed Web of Science ®Google Scholar
• Oyake S, Oh-i T, Koga M. Staphylococcal scalded skin syndrome in a healthy adult. J. Dermatol 28,145–148 (2001).
   PubMed Web of Science ®Google Scholar
• Jeljaszewicz J (Ed.), Gustav Fischer, Struttgart, Germany (1976).
   Google Scholar
• Haas Baker D, Wuepper KD, Rasmussen JE. Staphylococcal scalded skin syndrome: detection of antibody to epidermolytic toxin by a primary binding assay. Clin. Exp. Dermatol. 3,17–24 (1978).
   PubMedGoogle Scholar
• Wiley BB, Glasgow LA, Rogolsky M. Staphylococcal scalded-skin syndrome: development of a primary binding assay for human antibody to the exfoliative toxin. Infect. Immun. 13,513–520 (1976).
   PubMedGoogle Scholar
• Shelley ED, Shelley WB, Talanin NY. Chronic staphylococcal scalded skin syndrome. Br. J. Dermatol 139,319–324 (1998).
   PubMedGoogle Scholar
• •Case of recurrent staphylococcal scalded skin syndrome.
   Google Scholar
• Machang'u RS, Mgode G, Gisakanyi N. Recurrent staphylococcal scalded skin syndrome in children: report of two cases. East Afi: Med. J. 74,603–604 (1997).
   PubMedGoogle Scholar
• •Two cases of recurrent staphylococcal scalded skin syndrome.
   Google Scholar
• Plano LR, Adkins B, Woischnik M, Ewing R, Collins CM. Toxin levels in serum correlate with the development of staphylococcal scalded skin syndrome in a murine model. Infect. Immun. 69, 5193–5197 (2001).
   PubMedGoogle Scholar
• Lina G, Gillet Y, Vandenesch F, Jones ME, Floret D, Etienne J. Toxin involvement in staphylococcal scalded skin syndrome. Clin. Infect. Dis. 25, 1369–1373 (1997).
   PubMed Web of Science ®Google Scholar
• Donohue D, Robinson B, Goldberg NS. Staphylococcal scalded skin syndrome in a woman with chronic renal failure exposed to human immunodeficiency virus. Cutis 47,317–318 (1991).
   PubMedGoogle Scholar
• Strumia R, Bedetti A, Cavazzini L. Staphylococcal scalded-skin syndrome in AIDS. G. Ital. Dermatol. Venereal 125, 461–464 (1990).
   PubMedGoogle Scholar
• Farrell AM, Ross JS, Umasankar S, Bunker CB. Staphylococcal scalded skin syndrome in an HIV-1 seropositive man. Br. J. Dermatol 134,962–965 (1996).
   PubMed Web of Science ®Google Scholar
• Callahan EF, Adal KA, Tomecki KJ. Cutaneous non-HIV infections. Dermatol Clin. 18,497–508 (2000).
   PubMedGoogle Scholar
• Richard M, Mathieu-Serra A. Staphylococcal scalded skin syndrome in a homosexual adult. J. Am. Acad. Dermatol. 15,385–389 (1986).
   PubMedGoogle Scholar
• O'Keefe R, Dagg JH, MacKie RM. The staphylococcal scalded skin syndrome in two elderly immunocompromised patients. Br. Med J. (Clin. Res. Ed) 295,179–180 (1987).
   PubMedGoogle Scholar
• Roeb E, Schonfelder T, Matem S, et al. Staphylococcal scalded skin syndrome in an immunocompromised adult. Eur J Clin. Microbial Infict. Dis. 15,499–503 (1996).
   PubMedGoogle Scholar
• Strauss G, Mogensen AM, Rasmussen A, Kirkegaard R Staphylococcal scalded skin syndrome in a liver transplant patient. Liver Transpl Stag 3,435–436 (1997).
   PubMedGoogle Scholar
• Rothenberg R, Renna FS, Drew TM, Feingold DS. Staphylococcal scalded skin syndrome in an adult. Arch. Dermatol 108, 408–410 (1973).
   PubMedGoogle Scholar
• Ridgway HB, Lowe NJ. Staphylococcal scalded skin syndrome in an adult with Hodgkin's disease. Arch. Dermatol 115, 589–590 (1979).
   PubMedGoogle Scholar
• Goldberg NS, Ahmed T, Robinson B, Ascensao J, Horowitz H. Staphylococcal scalded skin syndrome mimicking acute graft versus host disease in a bone marrow transplant recipient. Arch. Dermatol 125, 85–87 (1989).
   PubMedGoogle Scholar
• Beers B, Wilson B. Adult staphylococcal scalded skin syndrome. Int. J Dermatol 29, 428–429 (1990).
   PubMedGoogle Scholar
• Neefe LI, Tuazon CU, Cardella TA, Sheagren JN. Staphylococcal scalded skin syndrome in adults: case report and review of the literature. Am. J Med Sci. 277,99–110 (1979).
   PubMedGoogle Scholar
• Diem E, Konrad K, Graninger W Staphylococcal scalded skin syndrome in an adult with fatal disseminated staphylococcal sepsis. Acta. Derm. Venereal 62,295–299 (1982).
   PubMedGoogle Scholar
• Fritsch P, Elias P, Varga J. The fate of staphylococcal exfoliatin in newborn and adult mice. Br J Dermatol 95,275–284 (1976).
   PubMed Web of Science ®Google Scholar
• •Key study outlining the relationshipbetween age, renal function and staphylococcal scalded skin syndrome.
   Google Scholar
• Petzelbauer P, Konrad K, Wolff K. Staphylococcal scalded skin syndrome in two adults with acute kidney failure. Hautarzt. 40,90–93 (1989).
   PubMedGoogle Scholar
• Borchers SL, Gomez EC, Isseroff RR. Generalized staphylococcal scalded skin syndrome in an anephric boy undergoing hemodialysis. Arch. Dermatol 120,912–918 (1984).
   PubMedGoogle Scholar
• Herzog JL, Sexton FM. Desquamative rash in an immunocompromised adult. Staphylococcal scalded skin syndrome (SSSS). Arch DermatoL 126,815–819 (1990).
   PubMedGoogle Scholar
• Saiag P, Caumes E, Roujeau JC, Wechsler J, Touraine R. Staphylococcal scalded skin syndrome (staphylococcal Lyell's syndrome) in adults: two cases. Ann. Dermatol Venereal 115,1164–1166 (1988).
   PubMedGoogle Scholar
• Suzuki R, Iwasaki S, Ito Y, et al. Adult staphylococcus scalded skin syndrome in a peritoneal dialysis patient. Clin. Exp. Nephrol7, 77–80 (2003).
   Google Scholar
• Sharkey MP, Muir JB. Staphylococcal scalded skin syndrome complicating acute generalized pustular psoriasis. Australas. J. Dermatol 43,199–201 (2002).
   PubMedGoogle Scholar
• Kirmani N, Tauzon CU, Murray HW, et al. Staphylococcus aureus carriage rate of patients receiving long-term hemodialyisis. Arch. Intern. Med. 138, 467–475 (1978).
   Google Scholar
• Khuong MA0, el Solh N, Chosidow , et al . Staphylococcal scaled skin syndrome in an adult: possible influence of nonsteroidal anti-inflammatory drugs. Dermatology 186,153–154 (1993).
   PubMedGoogle Scholar
• •First report of the importance of nonsteroidal anti-inflammatory drugs in staphylococcal scalded skin syndrome.
   Google Scholar
• Hardwick N, Parry CM, Sharpe GR. Staphylococcal scalded skin syndrome in an adult. Influence of immune and renal factors. Br. J. Dermatol. 132,468–471 (1995).
   PubMedGoogle Scholar
• Stevens DL. Could nonsteroidal anti-inflammatory drugs (NSAIDs) enhance the progression of bacterial infections to toxic shock syndrome? Clin. Infect. Dis. 21,977–980 (1995).
   PubMed Web of Science ®Google Scholar
• Wiley BB, Allman S, Rogolsky M, Norden CW, Glasgow LA. Staphylococcal scalded skin syndrome: potentiation by immunosuppression in mice; toxin-mediated exfoliation in a healthy adult. Infect. Immun. 9,636–640 (1974).
   PubMedGoogle Scholar
• Rudolph RL, Schwartz W, Leyden JJ. Treatment of staphylococcal toxic epidermal necrolysis. Arch. Dermatol 111, 1135–1139 (1974).
   Google Scholar
• Greenwood JE, Dunn KW, Davenport PJ. Experience with severe extensive blistering skin disease in a pediatric burns unit. Burns 26,82–87 (2000).
   PubMedGoogle Scholar
• •Role of burns units in the management of staphylococcal scalded skin syndrome.
   Google Scholar
• Curran JP, Al-Salihi FL. Neonatal staphylococcal scalded skin syndrome: massive outbreak due to an unusual phage type. Pediatrics 66,285–290 (1980).
   PubMed Web of Science ®Google Scholar
• •Report of an outbreak of staphylococcal scalded skin syndrome.
   Google Scholar
• Dave J, Reith S, Nash JQ, Marples RR, Dulake C. A double outbreak of exfoliative toxin-producing strains of Staphylococcus aureus in a maternity unit. Epidemiol. Infect. 112,103–114 (1994).
   PubMed Web of Science ®Google Scholar
• Mackenzie A, Johnson W, Heyes B, et al. A prolonged outbreak of exfoliative toxin A-producing Staphylococcus aureus in a newborn nursery. Diagn. Microbial Infect. Dis. 21,69–75 (1995).
   PubMedGoogle Scholar
• Kawabata A, Ichiyama S, Iinuma Y, Hasegawa Y, Ohta M, Shimokata K. Exfoliative toxin detection using reversed passive latex agglutination: clinical and epidemiologic applications. J. Clin. Microbial. 35,1984–1987 (1997).
   PubMedGoogle Scholar
• de Azavedo JCS, Arbuthnott JP. Assays for epidermolytic toxin of Staphylococcus aureus. Meth. Enzymol165, 333–338 (1988).
   PubMedGoogle Scholar
• Murono K, Fujita K, Yoshioka H. Detection of staphylococcal exfoliative toxin by slide latex agglutination. J. Clin. Microbial. 26,271–274 (1988).
   PubMedGoogle Scholar
• Rifai S, Barbancon V, Prevost G, et al. Synthetic exfoliative toxin A and B DNA probes for detection of toxigenic Staphylococcus aureus strains. J. Clin. Microbial. 27,504–506 (1989).
   PubMedGoogle Scholar
• Macdonald A, Smith G (Eds), The Staphylococci: proceedings of the Alexander Ogston Centennial Conference. Aberdeen University Press, Aberdeen, UK (1981).
   Google Scholar
• Hoeger PH, Elsner P. Staphylococcal scalded skin syndrome: transmission of exfoliatin-producing Staphylococcus aureus by an asymptomatic carrier. Pediatr. Infect. Dis. J.7, 340–342 (1988).
   Google Scholar
• Kaplan MH, Chmel H, Hsieh HC, Stephens A, Brinsko V. Importance of exfoliative toxin A producing Staphylococcus aureus strains isolated from clustered epidemics of neonatal pustulosis. J. Clin. Microbial 23,83–91 (1986).
   PubMedGoogle Scholar
• Adesiyun AA, Lenz W, Schaal KP. Exfoliative toxin-production by Staphylococcus aureus strains isolated from animals and human beings in Nigeria. Microbiologica 14,357–362 (1991).
   PubMedGoogle Scholar
• Loughead JL. Congenital staphylococcal scaled skin syndrome: report of a case. Pediatr. Infect. Dis. J. 11,413–414 (1992).
   PubMedGoogle Scholar
• Raymond J, Bingen E, Brahimi N, et al. Staphylococcal scalded skin syndrome in a neonate. Eur. J. Clin. Microbial Infect. Dis. 16,453–454 (1997).
   PubMedGoogle Scholar
• Murono K, Fujita K, Yoshioka H. Microbiologic characteristics of exfoliative toxin-producing Staphylococcus aureus. Pediatr. Infict. Dis. J7, 313–315 (1988).
   Google Scholar
• Bell FG, Fenton PA. Early hospital discharge and cross-infection. Lancet 342, 120 (1993).
   PubMedGoogle Scholar
• Gemmell CG. Staphylococcal scalded skin syndrome. J. Med Microbial 43,318–327 (1995).
   PubMed Web of Science ®Google Scholar
• Parker MT Some cultural characteristics of Staphylococcus aureus strains from superficial skin infections. J. Hyg (London) 56, 238–253 (1958).
   PubMedGoogle Scholar
• Dajani AS. The scalded skin syndrome: relation to phage group II staphylococci. J. Infect. Dis. 125, 548 (1972).
   PubMedGoogle Scholar
• Kondo I, Sakurai S, Sarai Y. New type of exfoliatin obtained from staphylococcal strains belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease. Infect. Immun. 10, 851–861 (1974).
   PubMed Web of Science ®Google Scholar
• Acland KM, Darvay A, Griffin C, Aali SA, Russell-Jones R Staphylococcal scalded skin syndrome in an adult associated with methicillin-resistant Staphylococcus aureus. Br J. Dermatol 140, 518–520 (1999).
   PubMed Web of Science ®Google Scholar
• •Rare occurrence of staphylococcal scalded skin syndrome with methicillin resistant Staphylococcal aureus.
   Google Scholar
• Yokota S, Imagawa T, Katakura S, Mitsuda T, Arai K Staphylococcal scalded skin syndrome caused by exfoliative toxin B-producing methicillin-resistant Staphylococcus aureus. Eur. J Pediatr 155, 722 (1996).
   PubMedGoogle Scholar
• Oono T, Kanzaki H, Yoshioka T, Arata J. Staphylococcal scalded skin syndrome in an adult. Identification of exfoliative toxin A and B genes by polymerase chain reaction. Dermatology 195, 268–270 (1997).
   PubMedGoogle Scholar
• Sato H, Tanabe T, Kuramoto M, et al Isolation of exfolitive toxin from Staphylococcus hyicus subspecies hyicus and its exfoliative activity in piglet. Vet Microbial. 27, 263–275 (1991).
   PubMedGoogle Scholar
• Sato H, Matsumori Y, Tanabe T, et al. A new type of staphylococcal exfolitative toxin isolated from a Staphylococcus aureus strain isolated from a horse with phlegmon. Infect. Immun. 62, 3780–3785 (1994).
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Nishifuji K, Sasaki M, et al. Identification of the Staphylococcus aureus ETD pathogenicity island that encodes a novel exfoliative toxin, ETD and EDIN-B. Infect. Immun. 70, 5835–5845 (2002).
   PubMed Web of Science ®Google Scholar
• Prevost G, Couppie P, Monteil H. Staphylococcal epidermolysins. Curr. Opin. Infect. Dis. 16, 71–76 (2003).
   PubMed Web of Science ®Google Scholar
• Bailey CJ, de Azavedo J, Arbuthnott JP. A comparitive study of two serotypes of epidermolytic toxin from Staphylococcus aureus. Biochem. Biophys. Acta 624, 111–120 (1980).
   PubMedGoogle Scholar
• Sakurai S, Suzuki H, Kondo I. DNA sequencing of the eta gene encoding for staphylococcal exfoliative toxin serotype A. J. Get. Microbial 134, 711–717 (1988).
   PubMedGoogle Scholar
• Lee CY, Schmidt JJ, Johnson-Winegar AD, et al Sequence determination and comparison of exfoliative toxin A and B genes from Staphylococcus aureus. J. Bacterial 169, 3904–3909 (1987).
   PubMed Web of Science ®Google Scholar
• O'Toole PW, Foster TJ. Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus. J. Bacterial 169, 3910–3915 (1987).
   PubMedGoogle Scholar
• Sakurai S, Suzuki H, Kondo I. Cloning of the gene coding for staphylococcal exfoliative toxin A and its expression in Escherichia coli. FEMS Microbial. Lett. 42, 63–67 (1987).
   Google Scholar
• Sakurai S, Suzuki H, Machida K. Rapid identification by polymerase chain reaction of staphylococcal exfoliative toxin serotype A and B genes. Microbial Immunol 39, 379–386 (1995).
   PubMed Web of Science ®Google Scholar
• Lillibridge CB, Melish ME, Glasgow LA. Site of action of exfoliative toxin in the staphylococcal scalded skin syndrome. Pediatrics 50, 728–738 (1972).
   PubMed Web of Science ®Google Scholar
• Mahoney MG, Wang Z, Rothenberger K, et al Explanation for the clinical and microscopic localisation of lesions in pemphigus foliaceus and vulgaris. J. Clin. Invest. 103, 461–468 (1999).
   PubMed Web of Science ®Google Scholar
• Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR. Staphylococcal exfoliative toxin B specifically cleaves desmoglein-1. J. Invest. Dermatol 118, 845–850 (2002).
   PubMed Web of Science ®Google Scholar
• Prevost G, Rifai S, Chaix ML, Piemont Y. Functional evidence that the Ser-195 residue of staphylococcal exfoliative toxin A is essential for biological activity. Infect. Immun. 59, 3337–3339 (1991).
   PubMedGoogle Scholar
• Barbosa JA, SaManha JVT, Garratt RC. Novel features of serine protease active sites and specificity pockets: sequence analysis and modelling studies of glutamate-specific endopeptidases and epidermolytic toxins. Protein Engl 9, 591–601 (1996).
   PubMedGoogle Scholar
• Vath GM, Earhart CA, Monie DD, Iandolo JJ, Schlievert PM, Ohlendorf DH. The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity. Biochemistry 38, 10239–10246 (1999).
   PubMed Web of Science ®Google Scholar
• Smith TP, Bailey CJ. Activity requirements of epidermolytic toxin from Staphylococcus aureus studied by an in vitro assay. Toxicon 28, 675–683 (1990).
   PubMedGoogle Scholar
• •Demonstrates that the activity of the epidermolytic toxin is calcium dependent.
   Google Scholar
• Nagar B, Overduin M, Ikura M, Rini JM. Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature 380, 360–364 (1996).
   PubMed Web of Science ®Google Scholar
• Machida K. Immunological investigations on pathogenesis of staphylococcal scalded skin syndrome. Rinsho Byori 43, 547–556 (1995).
   PubMedGoogle Scholar
• Wu H, Wang ZH, Yan A, et al Protection against pemphigus foliaceus by desmoglein-three in neonates. N Engl J. Med. 343, 31–35 (2000).
   PubMedGoogle Scholar
• Dancer SJ, Garratt R, Saldanha J, Jhoti H, Evans R. The epidermolytic toxins are serine proteases. FEBS Lett. 268, 129–132 (1990).
   PubMed Web of Science ®Google Scholar
• •Key reference showing that the exfoliativetoxin has proteolytic properties.
   Google Scholar