646
Views
27
CrossRef citations to date
0
Altmetric
Reviews

Antibiotic-lock therapy: a clinical viewpoint

&

References

  • Sotir MJ, Lewis C, Bisher EW, Ray SM, Soucie JM, Blumberg HM. Epidemiology of device-associated infections related to a long-term implantable vascular access device. Infect. Control. Hosp. Epidemiol. 20, 187–191 (1999).
  • Maki DG, Kluger DM, Crnich CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo. Clin. Proc. 81, 1159–1171 (2006).
  • Mermel LA, Allon M, Bouza E et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin. Infect. Dis. 49, 1–45 (2009).
  • Bestul MB, Vandenbussche HL. Antibiotic lock technique: review of the literature. Pharmacotherapy 25, 211–227 (2005).
  • Segarra-Newnham M, Martin-Cooper EM. Antibiotic lock technique: a review of the literature. Ann. Pharmacother. 39, 311–318 (2005).
  • Del Pozo JL. Role of antibiotic lock therapy for the treatment of catheter-related bloodstream infections. Int. J. Artif. Organs. 32, 678–688 (2009).
  • Messing B, Peitra-Cohen S, Debure A, Beliah M, Bernier JJ. Antibiotic-lock technique: a new approach to optimal therapy for catheter-related sepsis in home-parenteral nutrition patients. JPEN J. Parenter. Enteral Nutr. 12, 185–189 (1988).
  • Messing B. Catheter-sepsis during home parenteral nutrition: use of the antibiotic-lock technique. Nutrition 14, 466–468 (1998).
  • Capdevila JA, Segarra A, Planes AM et al. Successful treatment of haemodialysis catheter-related sepsis without catheter removal. Nephrol. Dial. Transplant. 8, 231–234 (1993).
  • Benoit JL, Carandang G, Sitrin M, Arnow PM. Intraluminal antibiotic treatment of central venous catheter infections in patients receiving parenteral nutrition at home. Clin. Infect. Dis. 21, 1286–1288 (1995).
  • Carratalà J. The antibiotic-lock technique for therapy of ‘highly needed’ infected catheters. Clin. Microbiol. Infect. 8, 282–289 (2002).
  • Viale P, Pagani L, Petrosillo N et al. Antibiotic lock-technique for the treatment of catheter-related bloodstream infections. J. Chemother. 15, 152–156 (2003).
  • Rao JS, O’Meara A, Harvey T, Breatnach F. A new approach to the management of Broviac catheter infection. J. Hosp. Infect. 22, 109–116 (1992).
  • Johnson DC, Johnson FL, Goldman S. Preliminary results treating persistent central venous catheter infections with the antibiotic lock technique in pediatric patients. Pediatr. Infect. Dis. J. 13, 930–931 (1994).
  • Krzywda EA, Andris DA, Edmiston CE Jr, Quebbeman EJ. Treatment of Hickman catheter sepsis using antibiotic lock technique. Infect. Control. Hosp. Epidemiol. 16, 596–598 (1995).
  • Krishnasami Z, Carlton D, Bimbo L et al. Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. Kidney Int. 61, 1136–1142 (2002).
  • Guedon C, Nouvellon M, Lalaude O, Lerebours E. Efficacy of antibiotic-lock technique with teicoplanin in staphylococcus epidermidis catheter-related sepsis during long-term parenteral nutrition. JPEN J. Parenter. Enteral Nutr. 26, 109–113 (2002).
  • Donlan RM. Biofilm elimination on intravascular catheters: important considerations for the infectious disease practitioner. Clin. Infect. Dis. 52, 1038–1045 (2011).
  • Pascual A. Pathogenesis of catheter-related infections: lessons for new designs. Clin. Microbiol. Infect. 8, 256–264 (2002).
  • Marr KA, Sexton DJ, Conlon PJ, Corey GR, Schwab SJ, Kirkland KB. Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis. Ann. Intern. Med. 127, 275–280 (1997).
  • O’Horo JC, Silva GL, Safdar N. Anti-infective locks for treatment of central line-associated bloodstream infection: a systematic review and meta-analysis. Am. J. Nephrol. 34, 415–422 (2011).
  • Cremieux AC, Maziere B, Vallois JM et al. Evaluation of antibiotic diffusion into cardiac vegetations by quantitative autoradiography. J. Infect Dis. 159, 938–944 (1989).
  • Stewart PS, Davison WM, Steenbergen JN. Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm. Antimicrob. Agents Chemother. 53, 3505–3507 (2009).
  • Raad I, Hanna H, Jiang Y et al. Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Antimicrob. Agents Chemother. 51, 1656–1660 (2007).
  • Fernández-Hidalgo N, Gavaldà J, Almirante B et al. Evaluation of linezolid, vancomycin, gentamicin and ciprofloxacin in a rabbit model of antibiotic-lock technique for Staphylococcus aureus catheter-related infection. J. Antimicrob. Chemother. 65, 525–530 (2010).
  • Van Praagh AD, Li T, Zhang S et al. Daptomycin antibiotic lock therapy in a rat model of staphylococcal central venous catheter biofilm infections. Antimicrob. Agents Chemother. 55, 4081–4089 (2011).
  • Domínguez-Herrera J, Docobo-Pérez F, López-Rojas R et al. Efficacy of daptomycin versus vancomycin in an experimental model of foreign-body and systemic infection caused by biofilm producers and methicillin-resistant Staphylococcus epidermidis. Antimicrob. Agents Chemother. 56, 613–617 (2012).
  • Anthony TU, Rubin LG. Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (ports). Antimicrob. Agents Chemother. 43, 2074–2076 (1999).
  • Fernandez-Hidalgo N, Almirante B, Calleja R et al. Antibiotic-lock therapy for long-term intravascular catheter-related bacteraemia: results of an open, non-comparative study. J. Antimicrob. Chemother. 57, 1172–1180 (2006).
  • Maya ID, Carlton D, Estrada E, Allon M. Treatment of dialysis catheter-related Staphylococcus aureus bacteremia with an antibiotic lock: a quality improvement report. Am. J. Kidney Dis. 50, 289–295 (2007).
  • Walraven CJ, Lee SA. Antifungal lock therapy. Antimicrob. Agents Chemother. 57, 1–8 (2013).
  • Poole CV, Carlton D, Bimbo L, Allon M. Treatment of catheter-related bacteraemia with an antibiotic lock protocol: effect of bacterial pathogen. Nephrol. Dial. Transplant. 19, 1237–1244 (2004).
  • Fortún J, Grill F, Martín-Dávila P et al. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic-lock therapy. J. Antimicrob. Chemother. 58, 816–821 (2006).
  • Del Pozo JL, Rodil R, Aguinaga A et al. Daptomycin lock therapy for grampositive long-term catheter-related bloodstream infections. Int. J. Clin. Pract. 66, 305–308 (2012).
  • Del Pozo JL, Alonso M, Serrera A, Hernaez S, Aguinaga A, Leiva J. Effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections. Diagn. Microbiol. Infect. Dis. 63, 208–212 (2009).
  • Funalleras G, Fernández-Hidalgo N, Borrego A et al. Effectiveness of antibiotic-lock therapy for long-term catheter-related bacteremia due to Gram-negative bacilli: a prospective observational study. Clin. Infect. Dis. 53, e129–e132 (2011).
  • Joshi AJ, Hart PD. Antibiotic catheter locks in the treatment of tunneled hemodialysis catheter-related blood stream infection. Semin. Dial. 26, 223–226 (2013).
  • Cornely OA, Bassetti M, Calandra T, et al. ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin. Microbiol. Infect. 18(Suppl. 7), 19–37 (2012).
  • Mascio CT, Alder JD, Silverman JA. Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells. Antimicrob. Agents. Chemother. 51, 4255–4260 (2007).
  • Broom J, Woods M, Allworth A, et al. Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: results from a prospective trial. Scand. J. Infect. Dis. 40, 399–406 (2008).
  • McGrath EJ, Salloum R, Chen X, et al. Short-dwell ethanol lock therapy in children is associated with increased clearance of central line-associated bloodstream infections. Clin. Pediatr. (Phila). 50, 943–951 (2011).
  • Onland W, Shin CE, Fustar S, Rushing T, Wong WY. Ethanol-lock technique for persistent bacteremia of long-term intravascular devices in pediatric patients. Arch. Pediatr. Adolesc. Med. 160, 1049–1053 (2006).
  • Sloobe L, Doorduijn JK, Luqtenburg PJ, et al. Prevention of catheter-related bacteremia with a daily ethanol lock in patients with tunnelled catheters. a randomized, placebo-controlled trial. PLoS ONE 5, e10840 (2010).
  • Bradshaw JH, Puntis JW. Taurolidine and catheter-related bloodstream infection: a systematic review of the literature. J. Pediatr. Gastroenterol. Nutr. 47, 179–186 (2008).
  • Dümichen MJ, Seeger K, Lode HN, et al. Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies. J. Hosp. Infect. 80, 304–309 (2012).
  • Turakhia MH, Cooksey KE, Characklis WG. Influence of a calcium-specific chelant of biofilm removal. Appl. Environ. Microbiol. 46, 1236–1238 (1983).
  • Raad II, Fang X, Keutgen XM, Jiang Y, Sherertz R, Hachem R. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections. Curr. Opin. Infect. Dis. 21, 385–392 (2008).
  • Bookstaver PB, Williamson JC, Tucker BK, Raad II, Sherertz RJ. Activity of novel antibiotic lock solutions in a model against isolates of catheter-related bloodstream infections. Ann. Pharmacother. 43, 210–219 (2009).
  • Raad I, Rosenblatt J, Reitzel R, Jiang Y, Dvorak T, Hachem R. Chelator-based catheter-solutions in eradicating organisms in biofilm. Antimicrob. Agents. Chemother. 57, 586–588 (2013).
  • Chauhan A, Lebeaux D, Ghigo JM, Beloin C. Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy. Antimicrob. Agents. Chemother. 56, 6310–6318 (2012).
  • Allison KR, Brynildsen MP, Collins JJ. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature. 473(7346), 216–220 (2011).
  • Cirioni O, Giacometti A, Ghiselli R, et al. RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections. J. Infect. Dis. 193, 180–186 (2006).
  • Lewis K. Riddle of biofilm resistance. Antimicrob. Agents. Chemother. 45, 999–1007 (2001).
  • Boles BR, Horswill AR. Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog. 4, e1000052 (2008).
  • Fey PD. Modality of bacterial growth presents unique targets: how do we treat biofilm-mediated infections? Curr. Opin. Microbiol. 13, 610–615 (2010).
  • Cobrado L, Azevedo MM, Silva-Dias A, Ramos JP, Pina-Vaz C, Rodrigues AG. Cerium, chitosan and hamamelitannin as novel biofilm inhibitors? J. Antimicrob. Chemother. 67, 1159–1162 (2012).
  • Ebert T, Smith S, Pancari G et al. Development of a rat central venous catheter model for evaluation of vaccines to prevent Staphylococcus epidermidis and Staphylococcus aureus early biofilms. Hum. Vaccin. 7, 630–638 (2011).
  • Mansouri MD, Hull RA, Stager CE, Cadle RM, Darouiche RO. In vitro activity and durability of a combination of an antibiofilm and an antibiotic against vascular catheter colonization. Antimicrob. Agents. Chemother. 57, 621–625 (2013).
  • Castagnola E, Ginocchio F. Rescue therapy of difficult-to-treat indwelling central venous catheter-related bacteremias in cancer patients: a review for practical purposes. Expert. Rev. Anti. Infect. Ther. 11, 179–186 (2013).
  • Messing B, Man F, Colimon R, Thuillier F, Beliah M. Antibiotic-lock technique is an effective treatment of bacterial catheter-related sepsis during parenteral nutrition. Clin. Nutr. 9, 220–225 (1990).
  • Williams N, Carlson GL, Scott NA, Irving MH. Incidence and management of catheter-related sepsis in patients receiving home parenteral nutrition. Br. J. Surg. 81, 392–394 (1994).
  • McCarthy A, Byrne M, Breathnach F, O’Meara A. “In-situ” teicoplanin for central venous catheter infection. Ir. J. Med. Sci. 164:125–127 (1995).
  • Capdevila JA, Segarra A, Planes AM et al. Long-term follow-up of patients with catheter-related bacteremia treated without catheter removal. Clin. Microbiol. Infect. 4, 472–476 (1998).
  • Domingo P, Fontanet A, Sánchez F, Allende L, Vazquez G. Morbidity associated with long-term use of totally implantable ports in patients with AIDS. Clin. Infect. Dis. 29, 346–351 (1999).
  • Piketty C, Hoï AB, Gilquin J et al. Failure of antibiotic therapy in Staphylococcus epidermidis infection of implantable venous access devices in patients with AIDS, as documented by molecular typing. Clin. Microbiol. Infect. 5, 190–194 (1999).
  • Boorgu R, Dubrow AJ, Levin NW et al. Adjunctive antibiotic/anticoagulant lock therapy in the treatment of bacteremia associated with the use of a subcutaneously implanted hemodialysis access device. ASAIO J. 46, 767–770 (2000).
  • Fourcade J, Mallaval FO, Raffenot D, Mercier D, Maret J, Morel B. [Value of an antibiotic lock for the prevention of bacteremia recurrence from central catheters in chronic hemodialysis]. Nephrologie 22, 457–458 (2001).
  • Longuet P, Douard MC, Arlet G, Molina JM, Benoit C, Leport C. Venous access port--related bacteremia in patients with acquired immunodeficiency syndrome or cancer: the reservoir as a diagnostic and therapeutic tool. Clin. Infect. Dis. 32, 1776–1783 (2001).
  • Bailey E, Berry N, Cheesbrough JS. Antimicrobial lock therapy for catheter-related bacteraemia among patients on maintenance haemodialysis. J. Antimicrob. Chemother. 50, 615–617 (2002).
  • Santarpia L, Pasanisi F, Alfonsi L et al. Prevention and treatment of implanted central venous catheter (CVC) - related sepsis: a report after six years of home parenteral nutrition (HPN). Clin. Nutr. 21, 207–211 (2002).
  • Reimund JM, Arondel Y, Finck G, Zimmermann F, Duclos B, Baumann R. Catheter-related infection in patients on home parenteral nutrition: results of a prospective survey. Clin. Nutr. 21, 33–38 (2002).
  • Cuntz D, Michaud L, Guimber D, Husson MO, Gottrand F, Turck D. Local antibiotic lock for the treatment of infections related to central catheters in parenteral nutrition in children. JPEN. J. Parenter. Enteral Nutr. 26, 104–108 (2002).
  • Vardhan A, Davies J, Daryanani I, Crowe A, McClelland P. Treatment of haemodialysis catheter-related infections. Nephrol. Dial. Transplant. 17, 1149–1150 (2002).
  • Koldehoff M, Zakrzewski JL. Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients. Int. J. Antimicrob. Agents 24, 491–495 (2004).
  • De Sio L, Jenkner A, Milano GM et al. Antibiotic lock with vancomycin and urokinase can successfully treat colonized central venous catheters in pediatric cancer patients. Pediatr. Infect. Dis. J. 23, 963–965 (2004).
  • Rijnders BJ, Van Wijngaerden E, Vandecasteele SJ, Stas M, Peetermans WE. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic lock: randomized, placebo-controlled trial. J. Antimicrob. Chemother. 55, 90–94 (2005).
  • Sánchez-Muñoz A, Aguado JM, López-Martín A et al. Usefulness of antibiotic-lock technique in management of oncology patients with uncomplicated bacteremia related to tunneled catheters. Eur. J. Clin. Microbiol. Infect. Dis. 24, 291–293 (2005).
  • Bernardi M, Cavaliere M, Cesaro S. [The antibiotic-lock therapy in oncoematology pediatric unit]. Assist. Inferm. Ric. 24, 127–131 (2005).
  • Lee HR, Lee YK, Song YL et al. Treatment of catheter-related bacteremia with an antibiotic lock protocol in hemodialysis patients. Korean J. Nephrol. 24, 903–911 (2005).
  • Souza Dias MB, Habert AB, Borrasca V et al. Salvage of long-term central venous catheters during an outbreak of Pseudomonas putida and Stenotrophomonas maltophilia infections associated with contaminated heparin catheter-lock solution. Infect. Control Hosp. Epidemiol. 29, 125–140 (2008).
  • Del Pozo JL, García Cenoz M, Hernáez S et al. Effectiveness of teicoplanin versus vancomycin lock therapy in the treatment of port-related coagulase-negative staphylococci bacteraemia: a prospective case-series analysis. Int. J. Antimicrob. Agents 34, 482–485 (2009).
  • Beigi AA, Khansoltani S, Masoudpour H, Atapour AA, Eshaghian A, Khademi EF. Influence of intralumenal and antibiotic-lock of vancomycin on the rate of catheter removal in the patients with permanent hemodialysis catheters. Saudi. J. Kidney. Dis. Transpl. 21, 54–58 (2010).
  • Blackwood RA, Klebin KC, Micel LN, et al. Ethanol locks therapy for resolution of fungal catheter infections. Pediatr. Infect. Dis. J. 30, 1105–1107 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.