References
- Kinsella K, Velkoff VA. An aging world: U.S. Census Bureau, Series P95/01-1. U.S. Government Printing Office; Washington DC: 2001
- Marik PE. Should age limit admission to the intensive care unit? Am J Hosp Palliat Care 2007;24:63-6
- Simonetti AF, Viasus D, Garcia-Vidal C, Carratalà J. Management of community-acquired pneumonia in older adults. Ther Adv Infect Dis 2014;2:3-16
- Jokinen C, Heiskanen L, Juvonen H, et al. Incidence of community-acquired pneumonia in the population of four municipalities in Eastern Europe. Am J Epidemiol 1993;137:977-88
- Kaplan V, Angus DC, Griffin MF, et al. Hospitalized community-acquired pneumonia in the elderly: age- and sex related patterns of care and outcome in the United States. Am J Respir Crit Care Med 2002;165:766-72
- Jackson ML, Neuzil KM, Thompson WW, et al. The burden of community acquired pneumonia in seniors: results of a population-based study. Clin Infect Dis 2004;39:1642-50
- Mandell L, Wunderink R, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44(Suppl 2):S27-72
- Falcone M, Blasi F, Menichetti F, et al. Pneumonia in frail older patients: an up to date. Intern Emerg Med 2012;7:415-24
- Fernández-Sabé N, Carratalà J, Rosón B, et al. Community-acquired pneumonia in very elderly patients: causative organisms, clinical characteristics, and outcomes. Medicine (Baltimore) 2003;82(3):159-69
- Castle SC, Norman DC, Yeh M, et al. Fever response in the elderly: are the older truly colder? J Am Geriatr Soc 1991;39(9):853-7
- Roghmann MC, Warner J, Mackowiak PA. The relationship between age and fever magnitude. Am J Med Sci 2001;322(2):68-70
- Riquelme R, Torres A, Wl-Ebiary M, et al. Community acquired pneumonia in the elderly. Am J Respir Crit Care Med 1997;156:1908-14
- Faulkner CM, Cox HL, Williamson JC. Clinical unique aspects of antimicrobial use in older adults. Clin Infect Dis 2005;40:997-1004
- Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections. Clin Microbiol Infect 2011;17(Suppl 6):E1-E59
- Janssens JP, Krause KH. Pneumonia in the very old. Lancet Infect Dis 2004;4(2):112-24
- Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Prevalence of methicillin-resistant S aureus as an etiology in community-acquired pneumonia. Clin Infect Dis 2012;54:1126-33
- Ruiz M, Ewing S, Marcos M, et al. Etiology of community acquired-pneumonia: impact of age, comorbidity, and severity. Am J Respir Crit Care Med 1999;160:397-405
- Ewig S, Torres A, Angeles Marcos M, et al. Factors associated with unknown aetiology in patients with community-acquired pneumonia. Eur Respir J 2002;20:1254-62
- Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement. CLSI document M100-S18. Clinical and Laboratory Standards Institute; Wayne, PA: 2008
- Antimicrobial resistance surveillance in Europe. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). 2013. Available from: www.ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-surveillance-europe-2013.pdf [Last accessed 30 November 2014]
- Yu VL, Chiou CC, Feldman C, et al. An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis 2003;37:230-7
- Peterson LR. Penicillins for treatment of pneumococcal pneumonia: does in vitro resistance really matter? Clin Infect Dis 2006;42:224-33
- Doern GV. Macrolide and ketolide resistance with Streptococcus pneumoniae. Med Clin North Am 2006;90:1109-24
- Kang CI, Song JH, Kim SH, et al. Risk factors for levofloxacin-nonsusceptible Streptococcus pneumoniae in community-acquired pneumococcal pneumonia: a nested case-control study. Eur J Clin Microbiol Infect Dis 2014;33(1):55-9
- Chen DK, McGeer A, de Azavedo JC, Low DE. Decreased susceptibility of Streptococcus pneumoniae to fluorquinolones in Canada. N Engl J Med 1999;341:233-9
- Cataldo MA, Taglietti F, Petrosillo N. Methicillin-resistant Staphylococcus aureus: a community health threat. Postgrad Med 2010;122(6):16-23
- González-Castillo J, Martín-Sánchez FJ, Llinares P, et al. Guidelines for the management of community-acquired pneumonia in the elderly patient. Rev Esp Quimioter 2014;27(1):69-86
- von Baum H, Welte T, Marre R, et al. Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: diagnosis, incidence and predictors. Eur Respir J 2010;35:598-605
- Calbo E, Romaní V, Xercavins M, et al. Risk factors for community-onset urinary tract infections due to Escherichia coli harbouring extended-spectrum beta-lactamases. J Antimicrob Chemother 2006;57(4):780-3
- American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171(4):388-416
- Micek ST, Reichley RM, Kollef MH. Health care-associated pneumonia (HCAP): empiric antibiotics targeting methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa predict optimal outcome. Medicine (Baltimore) 2011;90:390-5
- Kollef MH, Shorr A, Tabak YP, et al. Epidemiology and outcomes of health-care associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 2005;128(6):3854-62
- Shindo Y, Sato S, Maruyama E, et al. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Chest 2009;135(3):633-40
- Carratala J, Mykietiuk A, Fernandez-Sabe N, et al. Health care-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy, and clinical outcomes. Arch Intern Med 2007;167(13):1393-9
- Venditti M, Falcone M, Corrao S, et al. Outcomes of patients hospitalized with community-acquired, health care-associated, and hospital-acquired pneumonia. Ann Intern Med 2009;150(1):19-26
- Yap V, Datta D, Metersky ML. Is the present definition of health care–associated pneumonia the best way to define risk of infection with antibiotic-resistant pathogens? Infect Dis Clin N Am 2013;27:1-18
- Shorr AF, Zilberberg MD, Micek ST, et al. Prediction of infection due to antibiotic resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med 2008;168(20):2205-10
- Shorr AF, Zilberberg MD, Reichley R, et al. Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis 2012;54(2):193-8
- El Solh AA, Pietrantoni C, Bhat A, et al. Indicators of potentially drug-resistant bacteria in severe nursing home-acquired pneumonia. Clin Infect Dis 2004;39(4):474-80
- Brito V, Niederman MS. Healthcare-associated pneumonia is a heterogeneous disease, and all patients do not need the same broad-spectrum antibiotic therapy as complex nosocomial pneumonia. Curr Opin Infect Dis 2009;22(3):316-25
- Arnold FW, LaJoie AS, Brock GN, et al. Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results. Arch Intern Med 2009;169(16):1515-24
- Khanna S, Pardi DS, Aronson SL, et al. The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol 2012;107:89-95
- Dumyati G, Stevens V, Hannett GE, et al. Community-associated Clostridium difficile infections, Monroe County, New York, USA. Emerg Infect Dis 2012;18:392-400
- Brown KA, Khanafer N, Daneman N, Fisman DN. Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. Antimicrob Agents Chemother 2010;57:2326-32
- Doernberg SB, Winston LG, Deck DH, Chambers HF. Does doxycycline protect against development of Clostridium difficile infection? Clin Infect Dis 2012;55:615-20
- Di Bella S, Taglietti F, Petrosillo N. Are there reasons to prefer tetracyclines to macrolides in older patients with community-acquired pneumonia? Antimicrob Agents Chemother 2013;57(8):4093
- Wilson BZ, Anzueto A, Restrepo MI, et al. Comparison of two guideline-concordant antimicrobial combinations in elderly patients hospitalized with severe community-acquired pneumonia. Crit Care Med 2012;40(8):2310-14
- Martin-Loeches I, Lisboa T, Rodriguez A, et al. Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med 2010;36(4):612-20
- Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther 2007;82(1):87-96
- Drenth-van Maanen AC, Jansen PA, Proost JH, et al. Renal function assessment in older adults. Br J Clin Pharmacol 2013;76(4):616-23
- Blot S, Pea F, Lipman J. The effect of pathophysiology on pharmacokinetics in the critically ill patient–concepts appraised by the example of antimicrobial agents. Adv Drug Deliv Rev 2014;77:3-11
- Pea F. Plasma pharmacokinetics of antimicrobial agents in critically ill patients. Curr Clin Pharmacol 2013;8(1):5-12
- Corsonello A, Pedone C, Corica F, et al. Concealed renal failure and adverse drug reactions in older patients with type 2 diabetes mellitus. J Gerontol A Biol Sci Med Sci 2005;60(9):1147-51
- Corsonello A, Pedone C, Lattanzio F, et al. Association between glomerular filtration rate and adverse drug reactions in elderly hospitalized patients: the role of the estimating equation. Drugs Aging 2011;28(5):379-90
- Budnitz DS, Pollock DA, Weidenbach KN, et al. National surveillance of emergency department visits for outpatient adverse drug events. JAMA 2006;296(15):1858-66
- Parekh TM, Raji M, Lin YL, et al. Hypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas. JAMA Intern Med 2014;174(10):1605-12
- Corrao G, Zambon A, Bertu L, et al. Evidence of tendinitis provoked by fluoroquinolone treatment: a case-control study. Drug Saf 2006;29(10):889-96
- Baillargeon J, Holmes HM, Lin YL, et al. Concurrent use of warfarin and antibiotics and the risk of bleeding in older adults. Am J Med 2012;125(2):183-9
- Andriole VT, Haverstock DC, Choudhri SH. Retrospective analysis of the safety profile of oral moxifloxacin in elderly patients enrolled in clinical trials. Drug Saf 2005;28(5):443-52
- Morganroth J, Dimarco JP, Anzueto A, et al. A randomized trial comparing the cardiac rhythm safety of moxifloxacin vs levofloxacin in elderly patients hospitalized with community-acquired pneumonia. Chest 2005;128(5):3398-406
- Arnold LM, Nissen LR, Ng TM. Moxifloxacin and warfarin: additional evidence for a clinically relevant interaction. Pharmacotherapy 2005;25(6):904-7
- Ray WA, Murray KT, Hall K, et al. Azithromycin and the risk of cardiovascular death. N Engl J Med 2012;366:1881-90
- Mortensen EM, Halm EA, Pugh MJ, et al. Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia. JAMA 2014;311(21):2199-208
- Torres A, Blasi F, Peetermans WE, et al. The aetiology and antibiotic management of community-acquired pneumonia in adults in Europe: a literature review. Eur J Clin Microbiol Infect Dis 2014;33:1065-79
- Tacconelli E, De Angelis G, Cataldo MA, et al. Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother 2009;53(10):4264-9
- Tacconelli E, Cataldo MA, De Pascale G, et al. Prediction models to identify hospitalized patients at risk of being colonized or infected with multidrug-resistant Acinetobacter baumannii calcoaceticus complex. J Antimicrob Chemother 2008;62(5):1130-7
- Tacconelli E, De Angelis G, Cataldo MA, et al. Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis. J Antimicrob Chemother 2008;61(1):26-38
- Surveillance of antimicrobial consumption in Europe 2012. Available from: http://ecdc.europa.eu/en/publications/Publications/antimicrobial-consumption-europe-esac-net-2012.pdf [Last accessed 30 November 2014]
- Witham MD, McMurdo ME. How to get older people included in clinical studies. Drugs Aging 2007;24(3):187-96
- Provencher V, Mortenson WB, Tanguay-Garneau L, et al. Challenges and strategies pertaining to recruitment and retention of frail elderly in research studies: a systematic review. Arch Gerontol Geriatr 2014;59(1):18-24
- Saczynski JS, Darling CE, Spencer FA, et al. Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: the Worcester Heart Failure Study. J Am Geriatr Soc 2009;57(9):1587-94
- Falagas ME, Vouloumanou EK, Sgouros K, et al. Patients included in randomised controlled trials do not represent those seen in clinical practice: focus on antimicrobial agents. Int J Antimicrob Agents 2010;36(1):1-13