720
Views
29
CrossRef citations to date
0
Altmetric
Reviews

Therapeutic utility of antibacterial peptides in wound healing

&

References

  • Shai Y. From innate immunity to de-novo designed antimicrobial peptides. Curr Pharm Des 2002;8(9):715-25
  • Guilhelmelli F, Vilela N, Albuquerque P, et al. Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance. Front Microbiol 2013;4:353
  • Patrzykat A, Friedrich CL, Zhang L, et al. Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Antimicrob Agents Chemother 2002;46(3):605-14
  • McCafferty DG, Cudic P, Yu MK, et al. Synergy and duality in peptide antibiotic mechanisms. Curr Opin Chem Biol 1999;3(6):672-80
  • Krizsan A, Volke D, Weinert S, et al. Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome. Angew Chem Int Ed Engl 2014;53(45):12236-9
  • Kragol G, Lovas S, Varadi G, et al. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 2001;40(10):3016-26
  • Otvos LJr, Flick-Smith H, Fox M, et al. The designer proline-rich antibacterial peptide A3-APO prevents Bacillus anthracis mortality by deactivating bacterial toxins. Protein Pept Lett 2014;21(4):374-81
  • Ginsburg I. Bactericidal cationic peptides can also function as bacteriolysis-inducing agents mimicking beta-lactam antibiotics?; it is enigmatic why this concept is consistently disregarded. Med Hypotheses 2004;62(3):367-74
  • Otvos LJr. Antibacterial peptides and proteins with multiple cellular targets. J Pept Sci 2005;11(11):697-706
  • Wakabayashi H, Takase M, Tornita M. Lactoferricin derived from milk protein lactoferrin. Curr Pharm Res 2003;9(16):1277-87
  • Welkos S, Cote CK, Hahn U, et al. Humanized θ-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections. Antimicrob Agents Chemother 2011;55(9):4238-50
  • Capparelli R, De Chiara F, Nocerino N, et al. New perspectives for natural antimicrobial peptides: application as anti-inflammatory drugs in a murine model. BMC Immunol 2012;13:61
  • Upton M, Cotter P, Tagg J. Antimicrobial peptides as therapeutic agents. Int J Microbiol 2012;2012:326503
  • Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol 2009;30(3):131-41
  • Radek KA, Gallo RL. Amplifying healing: The role of antimicrobial peptides in wound repair. In: Sen CK, editor. Advances in wound care. Volume 1. Mary Ann Liebert Inc, New Rochelle, NY, USA; 2010 p. 223-9
  • Elsbach P. What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses? J Clin Invest 2003;111(11):1643-5
  • Hilchie AL, Wuerth K, Hancock RE. Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol 2013;9(12):761-8
  • Steinstraesser L, Koehler T, Jacobsen F, et al. Host defense peptides in wound healing. Mol Med 2008;14(7-8):528-37
  • Midwood KS, Williams LV, Schwarzbauer JE. Tissue repair and the dynamics of the extracellular matrix. Int J Biochem Cell Biol 2004;36(6):1031-7
  • Williamson D, Harding K. Wound healing. Medicine; 2004;32(12):4-7
  • Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 1998;176(2A Suppl):26S-38S
  • Levy O. Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. Blood 2000;96(8):2664-72
  • Power Coombs MR, Kronforst K, et al. Neonatal host defense against Staphylococcal infections. Clin Dev Immunol 2013;2013:826303
  • Shin YP, Park HJ, Shin SH, et al. Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. Antimicrob Agents Chemother 2010;54(7):2855-66
  • Bardan A, Nizet V, Gallo RL. Antimicrobial peptides and the skin. Expert Opin Biol Ther 2004;4(4):543-9
  • De Yang, Chen Q, Schmidt AP, et al. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 2000;192(7):1069-74
  • Gallo RL, Ono M, Povsic T, et al. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 1994;91(23):11035-9
  • Chaly YV, Paleolog EM, Kolesnikova TS, et al. Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur Cytokine Netw 2000;11(2):257-66
  • Yang D, Chertov O, Bykovskaia SN, et al. β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999;286(5439):525-8
  • Kesting MR, Stoeckelhuber M, Hölzle F, et al. Expression of antimicrobial peptides in cutaneous infections after skin surgery. Br J Dermatol 2010;163(1):121-7
  • Lee SC, Pan CY, Chen JY. The antimicrobial peptide, epinecidin-1, mediates secretion of cytokines in the immune response to bacterial infection in mice. Peptides 2012;36(1):100-8
  • Ostorhazi E, Holub MC, Rozgonyi F, et al. Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved. Int J Antimicrob Agents 2011;37(5):480-4
  • Schuerholz T, Doemming S, Hornef M, et al. The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study. Crit Care 2013;17(1):R3
  • Brouwer CP, Rahman M, Welling MM. Discovery and development of a synthetic peptide derived from lactoferrin for clinical use. Peptides 2011;32(9):1953-63
  • van der Does AM, Hensbergen PJ, Bogaards SJ, et al. The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity. J Immunol 2012;188(10):5012-19
  • van der Does AM, Bogaards SJ, Ravensbergen B, et al. Antimicrobial peptide hLF1-11 directs granulocyte-macrophage colony-stimulating factor-driven monocyte differentiation toward macrophages with enhanced recognition and clearance of pathogens. Antimicrob Agents Chemother 2010;54(2):811-16
  • Frohm M, Gunne H, Bergman AC, et al. Biochemical and antibacterial analysis of human wound and blister fluid. Eur J Biochem 1996;237(1):86-92
  • Gallo RL, Ono M, Povsic T, et al. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 1994;91(23):11035-9
  • He L, Marneros AG. Macrophages are essential for the early wound healing response and the formation of a fibrovascular scar. Am J Pathol 2013;182(6):2407-17
  • Risso A, Braidot E, Sordano MC, et al. BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol Cell Biol 2002;22(6):1926-35
  • Kindrachuk J, Scruten E, Attah-Poku S, et al. Stability, toxicity, and biological activity of host defense peptide BMAP28 and its inversed and retro-inversed isomers. Biopolymers 2011;96(1):14-24
  • Nijnik A, Madera L, Ma S, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol 2010;184(5):2539-50
  • Capparelli R, De Chiara F, Nocerino N, et al. New perspectives for natural antimicrobial peptides: application as antiinflammatory drugs in a murine model. BMC Immunol 2012;13:61
  • Som A, Navasa N, Percher A, et al. Identification of synthetic host defense peptide mimics that exert dual antimicrobial and anti-inflammatory activities. Clin Vaccine Immunol 2012;19(11):1784-91
  • Gonzalez-Curiel I, Trujillo V, Montoya-Rosales A, et al. 1,25-Dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model. PLoS One 2014;9(10):e111355
  • Cerovsky V, Bem R. Lucifensins, the insect defensins of biomedical importance: the story behind maggot therapy. Pharmaceuticals (Basel) 2014;7(3):251-64
  • Huang HN, Rajanbabu V, Pan CY, et al. Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries. Biomaterials 2013;34(38):10319-27
  • Steinstraesser L, Hirsch T, Schulte M, et al. Innate defense regulator peptide 1018 in wound healing and wound infection. PLoS One 2012;7(8):e39373
  • Tomioka H, Nakagami H, Tenma A, et al. Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathway. PLoS One 2014;9(3):e92597
  • Heunis TD, Smith C, Dicks LM. Evaluation of a nisin-eluting nanofiber scaffold to treat Staphylococcus aureus-induced skin infections in mice. Antimicrob Agents Chemother 2013;57(8):3928-35
  • Samy RP, Kandasamy M, Gopalakrishnakone P, et al. Wound healing activity and mechanisms of action of an antibacterial protein from the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). PLoS One 2014;9(2):e80199
  • Ostorhazi E, Rozgonyi F, Sztodola A, et al. Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. J Antimicrob Chemother 2010;65(11):2416-22
  • Petersen K, Riddle MS, Danko JR, et al. Trauma-related infections in battlefield casualties in Iraq. Ann Surg 2007;245(5):803-11
  • Ozolins M, Eady EA, Avery A, et al. Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne. Health Technol Assess 2005;9(1):iii-212
  • Guarna MM, Coulson R, Rubinchik E. Anti-inflammatory activity of cationic peptides: application to the treatment of acne vulgaris. FEMS Microbiol Lett 2006;257(1):1-6
  • Ostorhazi E, Voros E, Nemes-Nikodem E, et al. Rapid systemic and local treatments with the antibacterial peptide dimer A3-APO and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with Propionibacterium acnes and methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents 2013;42(6):537-43
  • McInturff JE, Wang SJ, Machleidt T, et al. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. J Invest Dermatol 2005;125(2):256-63
  • Popovic S, Urban E, Lukic M, et al. Peptides with antimicrobial and anti-inflammatory activities that have therapeutic potential for treatment of acne vulgaris. Peptides 2012;34(2):275-82
  • Keitel U, Schilling E, Knappe D, et al. Effect of antimicrobial peptides from Apis mellifera hemolymph and its optimized version Api88 on biological activities of human monocytes and mast cells. Innate Immun 2013;19(4):355-67
  • Plichta JK, Droho S, Curtis BJ, et al. Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. Crit Care Med 2014;42(6):e420-31
  • Krachmer JH, Mannis MJ, Holland EJ. Peptide components of tears. In: Cornea. 3rd Edition. Elsevier; 2010
  • McDermott A, Redfern R, Tran N. Increased expression of antimicrobial peptides in the corneal epithelium. during wound healing. Optom Vis Biol 10:526. American Academy of Optometry 2010
  • Kasus-Jacobi A, Noor-Mohammadi S, Griffith GL, et al. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties. J Leukoc Biol 2015;97(2):341-50
  • Sol A, Ginesin O, Chaushu S, et al. LL-37 opsonizes and inhibits biofilm formation of Aggregatibacter actinomycetemcomitans at subbactericidal concentrations. Infect Immun 2013;81(10):3577-85
  • McDermott AM. Antimicrobial compounds in tears. Exp Eye Res 2013;117:53-61
  • Tang J, Liu H, Gao C, et al. A small peptide with potential ability to promote wound healing. PLoS One 2014;9(3):e92082
  • Di Grazia A, Luca V, Segev-Zarko LA, et al. Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus. Antimicrob Agents Chemother 2014;58(5):2520-7
  • Szabo D, Ostorhazi E, Binas A, et al. The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models. Int J Antimicrob Agents 2010;35(4):357-61
  • Allan B, Buchanan RM, Hauta S, et al. Innate immune cocktail partially protects broilers against cellulitis and septicemia. Avian Dis 2012;56(4):659-69
  • Lee PH, Rudisill JA, Lin KH, et al. HB-107, a nonbacteriostatic fragment of the antimicrobial peptide cecropin B, accelerates murine wound repair. Wound Repair Regen 2004;12(3):351-8
  • Nagai T, Osaki T, Kawabata S. Functional conversion of hemocyanin to phenoloxidase by horseshoe crab antimicrobial peptides. J Biol Chem 2001;276(29):27166-70
  • Park IY, Cho JH, Kim KS, et al. Helix stability confers salt resistance upon helical antimicrobial peptides. J Biol Chem 2004;279(14):13896-901
  • Jung Kim D, Lee YW, Park MK, et al. Efficacy of the designer antimicrobial peptide SHAP1 in wound healing and wound infection. Amino Acids 2014;46(10):2333-43
  • Zhang S. Designer self-assembling peptide nanofiber scaffolds for study of 3-d cell biology and beyond. Adv Cancer Res 2008;99:335-62
  • Liu Y, Ye H, Satkunendrarajah K, et al. A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury. Acta Biomater 2013;9(9):8075-88
  • Brandenburg LO, Merres J, Albrecht LJ, et al. Antimicrobial peptides: multifunctional dugs for different applications. Polymers 2012;4:539-60
  • Gallo RL, Huttner KM. Antimicrobial peptides: an emerging concept in cutaneous biology. J Invest Dermatol 1998;111(5):739-43
  • Vogel HJ. Lactoferrin, a bird’s eye view. Biochem Cell Biol 2012;90(3):233-44
  • Duplantier AJ, van Hoek ML. The human cathelicidin antimicrobial peptide LL-37 as a potential treatment for polymicrobial infected wounds. Front Immunol 2013;4:143
  • Sorensen OE, Cowland JB, Theilgaard-Mönch K, et al. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol 2003;170(11):5583-9
  • Bowdish DM, Davidson DJ, Lau YE, et al. Impact of LL-37 on anti-infective immunity. J Leukoc Biol 2005;77(4):451-9
  • Koczulla R, von Degenfeld G, Kupatt C, et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 2003;111(11):1665-72
  • Ramos R, Silva JP, Rodrigues AC, et al. Wound healing activity of the human antimicrobial peptide LL37. Peptides 2011;32(7):1469-76
  • Lancto CA, Torres SM, Hendrickson JA, et al. Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions. Vet Dermatol 2013;24(4):414-21, e90
  • Leonard BC, Marks SL, Outerbridge CA, et al. Activity, expression and genetic variation of canine β-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs. J Innate Immun 2012;4(3):248-59
  • Leonard BC, Affolter VK, Bevins CL. Antimicrobial peptides: agents of border protection for companion animals. Vet Dermatol 2012;23(3):177-e36
  • Candille SI, Kaelin CB, Cattanach BM, et al. A β-defensin mutation causes black coat color in domestic dogs. Science 2007;318(5855):1418-23
  • Sahl WJJr, Clever H. Cutaneous scars: part I. Int J Dermatol 1994;33:681-91
  • Calderon M, Lawrence WT, Banes AJ. Increased proliferation in keloid fibroblasts wounded in vitro. J Surg Res 1996;61(2):343-7
  • Fujiwara M, Muragaki Y, Ooshima A. Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration. Br J Dermatol 2005;153(2):295-300
  • Russell SB, Russell JD, Trupin KM, et al. Epigenetically altered wound healing in keloid fibroblasts. J Invest Dermatol 2010;130(10):2489-96
  • Park HJ, Cho DH, Kim HJ, et al. Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37. J Invest Dermatol 2009;129(4):843-50
  • Gauglitz GG, Bureik D, Zwicker S, et al. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts. Skin Pharmacol Physiol 2014;28(3):115-23
  • Marr AK, Gooderham WJ, Hancock RE. Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr Opin Pharmacol 2006;6(5):468-72
  • Lipsky BA, Holroyd KJ, Zasloff M. Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin Infect Dis 2008;47(12):1537-45
  • Lamb HM, Wisemann LR. Pexiganan acetate. Drugs 1998;56(6):1047-52
  • Habets MG, Brockhurst MA. Therapeutic antimicrobial peptides may compromise natural immunity. Biol Lett 2012;8(3):416-18
  • Cassone M, Frith N, Vogiatzi P, et al. Induced resistance to the designer proline-rich antimicrobial peptide A3-APO does not involve changes in the intracellular target DnaK. Int J Pept Res Ther 2009;15:121-8
  • Fox JL. Antimicrobial peptides stage a comeback. Nat Biotechnol 2013;31:379-82
  • Bush K, Macielag M, Weidner-Wells M. Taking inventory: antibacterial agents currently at or beyond phase 1. Curr Opin Microbiol 2004;7(5):466-76
  • Rubinchik E, Dugourd D, Algara T, et al. Antimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models. Int J Antimicrob Agents 2009;34(5):457-61
  • Omiganan phase II rosacea study demonstrates. promising results. PR Newswire; 2014. October 17
  • NovaBiotics Ltd excellent unblinded novexatin Phase IIa data. Available from: www. Drugs.com [Last accessed on 30 June 2010]
  • Clinicaltrials.gov. Available from: www.clinicaltrials.gov
  • Otvos LJr, Wade JD. Peptide-based drug discovery. Front Chem 2014;2:62
  • Otvos LJr. Peptide-based drug research and development: relative Costs, comparative value. Pharmaceut Outsourcing 2014;15:16-20
  • Otvos LJr. Peptide-based drug discovery and development. Common misconceptions. Pharmaceut. Outsourcing 2014;15:40-3
  • Atkinson T. Lifestyle drug market booming. Nat Med 2002;8:909
  • Sebe I, Kállai-Szabó B, Zelkó R, et al. Polymers and formulation strategies of nanofibrous systems for drug delivery application and tissue engineering. Curr Med Chem 2015;22(5):604-17
  • Otvos LJr, Vetter SW, Koladia M, et al. The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor. Amino Acids 2014;46(4):873-82
  • Brown KL, Hancock REW. Cationic host defense (antimicrobial) peptides. Curr Opin Immunol 2006;18(10):24-30
  • Conlon JM, Mechkarska M, Lukic ML, Flatt PR. Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents. Peptides 2014;57(7):67-77

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.