90
Views
10
CrossRef citations to date
0
Altmetric
Review

Intrauterine infection with parvovirus B19 and CMV: implications in early and late gestation fetal demise

, &
Pages 651-661 | Published online: 10 Jan 2014

References

  • Martin J, Hoyert D. The national fetal death file. Semin. Perinatol. 26(1), 3–11 (2002).
  • Frøen F, Arnestad M, Frey K, Vege A, Didrik Saugstad O, Stray-Pedersen B. Risk factors for sudden intrauterine unexplained death: epidemiologic characteristics of singleton cases in Oslo, Norway, 1986–1995. Am. J. Obstet. Gynecol. 184, 694–702 (2001).
  • Cnattingius S, Stephansson O. The epidemiology of stillbirth. Semin. Perinatol. 26(1), 25–30 (2002).
  • Fretts RC, Boyd ME, Usher RH et al. The changing pattern of fetal death, 1961–1988. Obstet. Gynecol. 79(1), 35–39 (1992).
  • Goffinet F, Combier E, Bucourt M, de Caunes F, Papiernik E. Epidemiology of antepartum stillbirth in the Seine-Saint-Denis Perinatal Survey. J. Gynecol. Obstet. Biol. Reprod. 26, 153–159 (1996).
  • Weeks JW, Asrat T, Morgan MA, Nageotte M, Thomas SJ, Freeman RK. Antepartum surveillance for a history of stillbirth: when to begin? Am. J. Obstet. Gynecol. 172, 486–492 (1995).
  • Embleton ND. Fetal and neonatal death from maternally acquired infection. Paed. Perinat. Epidemiol. 15, 54–60 (2001).
  • Moyo SR, Hagerstrand I, Nystrom L et al. Stillbirths and intrauterine infection, histologic chorioamnionitis and microbiological findings. Int. J. Gynaecol. Obstet. 54(2), 115–123 (1996).
  • Gibbs RS. The origins of stillbirth: infectious diseases. Semin. Perinatol. 26(1), 75–78 (2002).
  • Horn LC, Rose I. Placental and fetal pathology in intrauterine viral infections. Intervirology 41, 219–225 (1998).
  • Yankowitz J, Weiner CP, Henderson J, Grant S, Towbin JA. Outcome of low-risk pregnancies with evidence of intraamniotic viral infection detected by PCR on amniotic fluid obtained at second trimester genetic amniocentecis. J. Soc. Gynecol. Invest. 3, 132A (1996).
  • Ignatia B, Van den Veyver LB, Ni J et al. Detection of intrauterine viral infection using the polymerase chain reaction. Mol. Gen. Metabol. 63, 85–95 (1998).
  • Wenstrom KD, Andrews WW, Bowles NE, Towbin JA, Hauth JC, Goldenberg RL. Intrauterine viral infection at the time of second trimester genetic amniocentecis. Obstet. Gynecol. 92, 420–424 (1998).
  • Redline RW. Placental inflammation. Semin. Neonatol. 9(4), 265–274 (2004).
  • Eis-Hűbinger AM, Dieck D, Schild R, Hansmann M, Schneweis KE. Parvovirus B19 infection in pregnancy. Intervirology 41, 178–184 (1998).
  • Kyriazopoulou V, Simitsopoulou M, Bondis J et al. Human parvovirus B19: immunity of Greek females and prenatal investigation of hydrops fetalis. Eur. J. Obstet. Gynecol. Reprod. Biol. 74, 157–160 (1997).
  • Valeur-Jensen AK, Pedersen CB, Westergaard T et al. Risk factors for parvovirus B19 infection in pregnancy. J. Am. Med. Assoc. 281(12), 1099–1105 (1999).
  • Gilbert GL. Parvovirus B19 infection and its significance in pregnancy. Commun. Dis. Intel. 24(Suppl.), S69–S71 (2000).
  • Yaegashi N, Niinuma T, Chisaka H et al. The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection:report of 10 cases and meta-analysis. J. Infect. 37, 28–35 (1998).
  • Gratacós E, Torres P-J, Vidal J et al. The incidence of human parvovirus B19 infection during pregnancy and its impact on perinatal outcome. J. Infect. Dis. 171, 1360–1363 (1995).
  • Levy R, Weissman A, Blomberg G, Hagay ZJ. Infection by parvovirus B19 during pregnancy: a review. Obstet. Gynecol. Surv. 52(4), 254–259 (1997).
  • Saldanha J, Minor P. Detection of human parvovirus B19 DNA in plasma pools and blood products derived from these pools: implications for efficacy and consistency of removal of B19 DNA during manufacture. Br. J. Haematol. 93, 7141–7149 (1996).
  • Cohen BJ, Beard S, Knowles WA et al. Chronic anemia due to parvovirus B19 infection in a bone marrow transplant patient after platelet transfusion. Transfusion 37, 947–952 (1997).
  • Heegaard ED, Brown KE. Human parvovirus B19. Clin. Microbiol. Rev. 15(3), 485–505 (2002).
  • Plachouras N, Stefanidis K, Andronikou S, Lolis D. Severe nonimmune hydrops fetalis and congenital corneal opacification secondary to human parvovirus B19 infection. A case report. J. Reprod. Med. 44(4), 377–380 (1999).
  • Schild RL, Plath H, Thomas P, Schulte-Wissermann H, Eis-Hubinger A, Hansmann M. Fetal parvovirus B19 infection and meconium peritonitis. Fetal Diagn. Ther. 13, 15–18 (1998).
  • Miyagawa S, Takahashi Y, Nagai A et al. Angio-oedema in a neonate with IgG antibodies to parvovirus B19 following intrauterine parvovirus B19 infection. Br. J. Dermatol. 143, 428–430 (2000).
  • Isumi H, Nunoue T, Nishida A, Takashima S. Fetal brain infection with human parvovirus B19. Pediatr. Neurol. 21, 661–663 (1999).
  • Katz VL, McCoy MC, Kuller JA, Hansen W. An association between fetal parvovirus B19 infection and fetal anomalies: a report of two cases. J. Perinatol. 13(1), 43–45 (1996).
  • Simchen MJ, Toi A, Bona M, Alkazaleh F, Ryan G, Chitayat D. Fetal hepatic calcifications: prenatal diagnosis and outcome. Am. J. Obstet. Gynecol. 187, 1617–1622 (2002).
  • Metzman R, Anand A, DeGiulio PA, Knisely AS. Hepatic disease associated with intrauterine parvovirus B19 infection in a newborn premature infant. J. Pediatr. Gastroenterol. Nutr. 9, 112–114 (1989).
  • O’Malley A, Barry-Kinsella C, Hughes C et al. Parvovirus infects cardiac myocytes in hydrops fetalis. Pediatr. Dev. Pathol. 6, 414–420 (2003).
  • Dembinski J, Eis-Hubinger AM, Maar J, Schild R, Bartmann P. Long term follow up of serostatus after maternofetal parvovirus B19 infection. Arch. Dis. Child. 88, 219–221 (2003).
  • Bendon RW. Review of some causes of stillbirth. Pediatr. Dev. Pathol. 4, 517–531 (2001).
  • Yaegashi N, Niinuma T, Chisaka H et al. Serologic study of human parvovirus B19 infection in pregnancy in Japan. J. Infect. 38, 30–35 (1999).
  • Von Kaisenberg CS, Jonat W. Fetal parvovirus B19 infection. Ultrasound Obstet. Gynecol. 18, 280–288 (2001).
  • Nunoue T, Kusuhara K, Hara T. Human fetal infection with parvovirus B19: maternal infection, time in gestation, viral persistence and fetal prognosis. Pediatr. Infect. Dis. J. 21, 1133–1136 (2002).
  • Tolfvenstam T, Papadogiannakis N, Norbeck O, Peterson K, Broliden K. Frequency of human parvovirus B19 infection in intrauterine fetal death. Lancet 357, 1494–1497 (2001).
  • Wright C, Hinchliffe SA, Taylor C. Fetal pathology in intrauterine death due to parvovirus B19 infection. Br. J. Obstet. Gynaecol. 103, 133–136 (1996).
  • Saito S. Cytokine cross-talk between mother and the embryo/placenta. J. Reprod. Immunol. 52, 15–33 (2001).
  • Lowden E, Weinstein L. Unexpected second trimester pregnancy loss due to maternal parvovirus B19 infection. South. Med. J. 90(7), 702–704 (1997).
  • Skoldebrand-Sparre L, Tolfvenstam T, Papadogianakis N, Wahren B, Broliden K, Nyman M. Parvovirus B19 infection: association with third-trimester intrauterine fetal death. Br. J. Obstet. Gynaecol. 107, 476–480 (2000).
  • Norbeck O, Papadogiannakis N, Petersson K, Hirbord T, Broliden K, Tolfvenstam T. Revised clinical presentation of parvovirus B19-associated intrauterine fetal death. Clin. Infect. Dis. 35, 1032–1038 (2002).
  • Cohen BJ, Bates CN. Evaluation of 4 commercial test kits for parvovirus B19-specific IgM. J. Virol. Methods 55, 11–25 (1995).
  • Koch WC, Harger JH, Barnstein B, Adler SP. Serologic and virologic evidence for frequent intrauterine transmission of human parvovirus B19 with a primary maternal infection during pregnancy. Pediatr. Infect. Dis. J. 17, 489–494 (1998).
  • Trotta M, Azzi A, Meli M et al. Intrauterine parvovirus B19 infection: early prenatal diagnosis is possible. Int. J. Infect. Dis. 8(2), 130–131 (2004).
  • Wermelinger MC, Oelemann WM, Lima de Mendonca MC, Naveca FG, von Hubinger MG. Detection of human parvovirus B19 infection: a study of 212 suspected cases in the state of Rio de Janeiro, Brazil. J. Clin. Virol. 25, 223–230 (2002).
  • Sohan K, Carroll S, Byrne D, Ashworth M, Soothill P. Parvovirus as a differential diagnosis of hydrops fetalis in the first trimester. Fetal Diagn. Ther. 15, 234–236 (2000).
  • Giannakopoulou CH, Hatzidaki E, Giannakopoulos K et al. Congenital infection by human parvovirus B19 ascites-anaemia. Clin. Exp. Obstet. Gynecol. 25, 92–93 (1998).
  • Cosmi E, Mari G, Delle Chiaie L et al. Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. Am. J. Obstet. Gynecol. 187, 1290–1293 (2002).
  • Hernandez-Andrade E, Scheier M, Dezerega V, Carmo A, Nicolaides K. Fetal middle cerebral artery peak systolic velocity in the investigation of non-immune hydrops. Ultrasound Obstet. Gynecol. 23, 442–445 (2004).
  • Bodéus M, Hubinont C, Goubau P. Increased risk of cytomegalovirus transmission in utero during late gestation. Obstet. Gynecol. 93, 658–660 (1999).
  • Revello MG, Zavattoni M, Furione M, Lilleri D, Gorini G, Gerna G. Diagnosis and outcome of preconceptional and periconceptional primary human cytomegalovirus infections. J. Infect. Dis. 186, 553–557 (2002).
  • Gabrielli L, Lazzarotto T, Foschini MP et al. Horizontal in utero acquisition of cytomegalovirus infection in a twin pregnancy. J. Clin. Microbiol. 41(3), 1329–1331 (2003).
  • Ahlfors K, Ivarsson S-A, Harris S. Report on a long term study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in the literature. Scand. J. Infect. Dis. 31, 443–457 (1999).
  • Gouarin S, Palmer P, Cointe D et al. Congenital HCMV infection: a collaborative and comparative study of virus detection in amniotic fluid by culture and by PCR. J. Clin. Virol. 21, 47–55 (2001).
  • Guerra B, Lazzarotto T, Quarta S et al. Prenatal diagnosis of symptomatic congenital cytomegalovirus infection. Am. J. Obstet. Gynecol. 183, 476–482 (2000).
  • Stagno S, Pass RF, Dworsky ME et al. Congenital cytomegalovirus infection: the relative importance of primary and recurrent maternal infection. N. Engl. J. Med. 306, 945 (1982).
  • Boppana SB, Rivera LB, Fowler KB, Mach M, Britt WJ. Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N. Engl. J. Med. 344, 1366–1371 (2001).
  • Saigal S, Lunyk O, Larke RPB, Chernesky MA. The outcome in children with congenital cytomegalovirus infection. Am. J. Dis. Child. 136, 896–901 (1982).
  • Griffiths PD, Baboonian C. A prospective study of primary cytomegalovirus infection during pregnancy: final report. Br. J. Obstet. Gynaecol. 91, 307–315 (1984).
  • Wen LZ, Xing W, Liu LQ, Ao LM, Chen SH, Zeng WJ. Cytomegalovirus infection in pregnancy. Int. J. Gynecol. Obstet. 79(2), 111–116 (2002).
  • Murph JR, Souza IE, Dawson JD et al. Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis of cytomegalovirus strains. Am. J. Epidemiol. 147(10), 940–947 (1998).
  • Pass RF. Cytomegalovirus. In: Principles and Practice of Paediatric Infectious Diseases (Second Edition). Long SS, Pickering LK, Prober CG (Eds), Churchill Livingstone, PA, USA, 1050–1059 (2003).
  • Fisher S, Genbacev O, Maidji E, Pereira L. Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis. J. Virol. 74(15), 6808–6820 (2000).
  • Michelson S. Human cytomegalovirus escape from immune detection. Intervirology 42, 301–307 (1999).
  • Chan G, Hemmings DG, Yurochko AD, Guillbert LJ. Human cytomegalovirus-caused damage to placental trophoblasts mediated by immediate-early-gene-induced tumor necrosis factor-α. Am. J. Pathol. 161(4), 1371–1381 (2002).
  • Harrison CJ, Caruso N. Correlation of maternal and pup NK-like activity and TNF responses against cytomegalovirus to pregnancy outcome in inbred guinea pigs. J. Med. Virol. 60, 230–236 (2000).
  • Hemmings DG, Kilani R, Nykiforuk C, Preiksaitis J, Guilbert LJ. Permissive cytomegalovirus infection of primary villous term and first trimester trophoblasts. J. Virol. 72(6), 4970–4979 (1998).
  • Revello MG, Gerna G. Pathogenesis and prenatal diagnosis of human cytomegalovirus infection. J. Clin. Virol. 29(2), 71–83 (2004).
  • Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S. Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity. J. Virol. 77(24), 13301–13314 (2003).
  • Gharavi AE, Vega-Ostertag M, Espinola RG et al. Intrautrine fetal death in mice caused by cytomegalovirus-derived peptide induced aPL antibodies. Lupus 13, 17–23 (2004).
  • Lanari M, Lazzarotto T, Papa I et al. Neonatal aortic arch thrombosis as a result of congenital cytomegalovirus infection. Pediatrics 108(6), 114 (2001).
  • Nigro G, La Torre R, Sali E et al. Intraventricular haemorrhage in a fetus with cerebral cytomegalovirus infection. Prenat. Diagn. 22, 558–561 (2002).
  • Riley HD Jr. History of the cytomegalovirus. Southern Med. J. 90, 184–190 (1997).
  • Ozono K, Mushiake S, Takeshima T, Nakayama M. Diagnosis of congenital cytomegalovirus infection by examination of pacenta: application of polymerase chain reaction and in situ hybridization. Pediatr. Pathol. Lab. Med. 17, 249–258 (1997).
  • Nelson CT, Demmler GJ. Cytomegalovirus infection in the pregnant mother, fetus and newborn infant. Clin. Perinatol. 24(1), 151–160 (1997).
  • Lipitz S, Achiron R, Zalel Y et al. Outcome of pregnancies with vertical transmission of primary cytomegalovirus infection. Obstet. Gynecol. 100, 428–433 (2002).
  • Lipitz S, Yagel S, Shalev E, Achiron R, Mashiach S, Schiff E. Prenatal diagnosis of fetal primary cytomegalovirus infection. Obstet. Gynecol. 89(5), 763–767 (1997).
  • Nigro G, Mazzocco M, Anceschi MM, La Torre R, Antonelli G, Cosmi EV. Prenatal diagnosis of fetal cytomegalovirus infection after primary or recurrent maternal infection. Obstet. Gynecol. 94(6), 909–914 (1999).
  • Inoue T, Matsumura N, Fukuoka M, Sagawa N, Fujii S. Severe congenital cytomegalovirus infection with fetal hydrops in a cytomegalovirs-seropositve healthy woman. Eur. J. Obstet. Gynecol. Reprod. Biol. 95, 184–186 (2001).
  • Gaytant MA, Rours GI, Steegers EA, Galama JM, Semmekrot BA. Congenital cytmegalovirus infection after recurrent infection: case reports and review of the literature. Eur. J. Pediatr. 162, 248–253 (2003).
  • Brown HL, Abernathy MP. Cytomegalovirus infection. Semin. Perinatol. 22, 260–266 (1998).
  • Boppana SB, Britt WJ. Antiviral antibody responses and intrauterine transmission after primary maternal cytomegalovirus infection. J. Infect. Dis. 171, 1115–1121 (1995).
  • Ruellan–Eugene G, Barjot P, Campet M et al. Evaluation of virological procedures to detect fetal human cytomegalovirus infection: avidity of IgG antibodies, virus detection in amniotic fluid and maternal serum. J. Med. Virol. 50, 9–15 (1996).
  • Grangeot-Keros L, Mayaux MJ, Lebon P et al. Value of cytomegalovirus (CMV) avidity index for the diagnosis of primary CMV infection in pregnant women. J. Infect. Dis. 175, 944–946 (1997).
  • Lazzarotto T, Varani S, Spezzacatena P et al. Maternal IgG avidity and IgM detected by blot as diagnostic tools to identify pregnant women at risk of transmitting cytomegalovirus. Viral Immunol. 13, 137–141 (2000).
  • Hagay ZJ Biran G, Ornoy A, Reece A. Congenital cytomegalovirus infection: a long-standing problem still seeking a solution. Am. J. Obstet. Gynecol. 174, 241–245 (1996).
  • Lazzarotto T, Guerra B, Spezzacatena P et al. Prenatal diagnosis of congenital cytomegalovirus infection. J. Clin. Microbiol. 36, 3540–3544 (1998).
  • Jones RN, Lynne Neale M, Beattie B, Westmoreland D, Fox JD. Development and application of a PCR-based method including an internal control for diagnosis of congenital cytomegalovirus infection. J. Clin. Microbiol. 38, 1–6 (2000).
  • Lazzarotto T, Varani S, Guerra B, Nicolosi A, Lanari M, Landini MP. Prenatal indicators of congenital cytomegalovirus infection. J. Pediatr. 137, 90–95 (2000).
  • Enders G, Bader U, Lindemann L, Schalasta G, Daiminger A. Prenatal diagnosis of cytomegalovirus infection in 189 pregnancies with known outcome. Prenat. Diagn. 21, 362–377 (2001).
  • Revello MG, Zavattoni M, Sarasini A, Percivalle E, Simoncini L, Gerna G. Human cytomegalovirus in blood of immunocompetent persons during primary infection: prognostic implications for pregnancy. J. Infect. Dis. 177, 1170–1175 (1998).
  • Rousseau T, Douvier S, Reynaud I et al. Severe fetal cytomegalic inclusion disease after documented maternal reactivation of cytomegalovirus infection during pregnancy. Prenat. Diagn. 20, 333–336 (2000).
  • Gerdts V, Snider M, Brownlie R, Babiuk LA, Griebel PJ. Oral DNA vaccination in utero induces mucosal immunity and immune memory in the neonate. J. Immunol. 168, 1877–1885 (2002).
  • Pass RF, Duliege AM, Boppana S et al. A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant. J. Infect. Dis. 180(4), 970–975 (1999).
  • Bansal GP, Hatfield JA, Dunn FE et al. Candidate recombinant vaccine for human B19 parvovirus. J. Infect. Dis. 167, 1034–1044 (1993).

Website

  • Goodrich JM, Drevets DA, Talavera F, King JW, Mylonakis E, Cunha BA. Cytomegalovirus. eMedicine Journal 3(3), (2002) www.emedicine.com/med/topic504.htm (Accessed July 2005)

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.