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Drug Profile

Role of linezolid in the treatment of complicated skin and soft tissue infections

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Pages 357-366 | Published online: 10 Jan 2014

References

  • Ellis-Grosse EJ, Babinchak T, Dartois N, Rose G, Loh E. The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin–aztreonam. Clin. Infect. Dis.41(Suppl. 5), s341–s353 (2005).
  • Rennie RP, Jones RN, Mutnick AH, and the SENTRY program study group (North America). Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections: report from the SENTRY antimicrobial surveillance program (United States and Canada, 2000). Diagn. Microbiol. Infect. Dis.45, 287–293 (2003).
  • Nichols RL. Optimal treatment of complicated skin and skin structure infection. J. Antimicrob. Chemother.44, 19–23 (1999).
  • Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. Intensive Care Med.22, 387–394 (1996).
  • Dupont H, Mentec H, Sollet JP, Bleichner J. Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med.27, 355–362 (2001).
  • Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections. Chest115, 462–474 (1999).
  • Luna CM, Vujacich P, Niederman MS et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest111, 676–685 (1997).
  • Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med.156, 196–200 (1997).
  • Ruiz M, Torres A, Ewig S et al. Noninvasive versus invasive microbial investigation in ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med.162, 119–125 (2000).
  • Chambers HF. The changing epidemiology of Staphylococcus aureus? Emerg. Infect. Dis.7, 178–182 (2001).
  • Engemann JJ, Carmeli Y, Cosgrove SE et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infections. Clin. Infect. Dis.36, 592–598 (2003).
  • Rubin RJ, Harrington CA, Poon A, Dietrick K, Greene JA, Moiduddin A. The economic impact of Staphylococcus aureus infection in New York City hospitals. Emerg. Infect. Dis.5, 9–17 (1999).
  • Rybak MJ, LaPlante KL. Community-associated methicillin-resistant Staphylococcus aureus: a review. Pharmacotherapy25, 74–85 (2005).
  • CDC. Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections – Los Angeles County, California, 2002–2003. MMWR Morb. Mortal. Wkly Rep.52, 88 (2003).
  • CDC. Methicillin-resistant Staphylococcus aureus infections among competitive sports participants – Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000–2003. MMWR Morb. Mortal. Wkly Rep.52, 793–795 (2003).
  • Kazakova SV, Hageman JC, Matava M et al. A clone of methicillin-resistant Staphylococcus aureus among professional football players. N. Engl. J. Med.325, 468–475 (2005).
  • Methicillin-resistant Staphylococcus aureus infections in correctional facilities – Georgia, California, and Texas, 2001–2003. MMWR. Morb. Mortal. Wkly Rep.52, 992–996 (2003).
  • CDC. Methicillin-resistant Staphylococcus aureus skin or soft tissue infections in a state prison – Mississippi, 2000. MMWR Morb. Mortal. Wkly Rep.50, 919 (2001).
  • Ellis MW, Hospenthal DR, Dooley DP, Gray PJ, Murray CK. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin. Infect. Dis.39, 971–979 (2004).
  • Nichols RL, Graham DR, Barriere SL et al. Treatment of hospitalized patients with complicated gram-positive skin and skin structure infections: two randomized, multicenter studies of quinupristin/dalfopristin versus cefazolin, oxacillin or vancomycin. J. Antimicrob. Chemother.44, 263–273 (1999).
  • Arbeit RD, Maki D, Tally FP, Campanaro E, Eisenstein BI. The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. Clin. Infect. Dis.38, 1673–1681 (2004).
  • Lipsky BA, Stoutenburgh U. Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. J. Antimicrob. Chemother.55, 240–245 (2005).
  • Graham DR, Lucasti C, Malafaia O et al. Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clin. Infect. Dis.34, 1460–1468 (2002).
  • Fabian TC, File TM, Embil JM et al. Meropenem versus imipenem–cilastatin for the treatment of hospitalized patients with complicated skin and skin structure infections: results of a multicenter, randomized, double-blind comparative study. Surg. Infect.6, 269–282 (2005).
  • Zyvox® (linezolid) package insert. Pfizer, NY, USA (2005).
  • Moellering RC. Linezolid: the first oxazolidinone antimicrobial. Ann. Intern. Med.138, 135–142 (2003).
  • Beringer P, Nguyen M, Hoem N et al. Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings. Antimicrob. Agents Chemother.49, 3676–3681 (2005).
  • Wright DH, Pietz SL, Konstantinides FN, Rotschafer JC. Decreased in vitro fluoroquinolone concentrations after admixture with an enteral feeding formulation. J. Parenter. Enteral Nutr.24, 42–48 (2000).
  • Gee T, Ellis R, Marshall G, Andrews J, Ashby J, Wise R. Pharmacokinetics and tissue penetration of linezolid following multiple oral doses. Antimicrob. Agents Chemother.45, 1843–1886 (2001).
  • Dehghanyar P, Burger C, Zeitlanger M et al. Penetration of linezolid into soft tissue of healthy volunteers after single and multiple doses. Antimicrob. Agents Chemother.49, 2367–2371 (2005).
  • Boselli E, Breilh D, Rimmele T et al. Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumonia. Crit. Care Med.33, 1529–1533 (2005).
  • Stein GE, Schooley SL, Peloquin CA et al. Pharmacokinetics and pharmacodynamics of linezolid in obese patients with cellulites. Ann. Pharmacother.39, 427–432 (2005).
  • Brier ME, Stalker DJ, Aronoff GR et al. Pharmacokinetics of linezolid in subjects with renal dysfunction. Antimicrob. Agents Chemother.47, 2775–2780 (2003).
  • Fiaccadori E, Maggiore U, Rotelli C et al. Removal of linezolid by conventional intermittent hemodialysis, sustained low-efficiency dialysis, or continuous venovenous hemofiltration in patients with acute renal failure. Crit. Care Med.32, 2437–2442 (2004).
  • Pea F, Viale P, Lugno M et al. Linezolid disposition after standard dosage in critically ill patients undergoing continuous venovenous hemofiltration: a report of 2 cases. Am. J. Kidney Dis.44, 1071–1075 (2004).
  • Kraft MD, Pasko DA, Depestel DD et al. Linezolid clearance during continuous venovenous hemodiafiltration: a case report. Pharmacotherapy23, 1071–1075 (2003).
  • Trotman RL, Williamson JC, Shoemaker M et al. Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin. Infect. Dis.41, 1159–1166 (2005).
  • Stevens DL, Smith LG, Bruss JB et al. Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections. Antimicrob. Agents Chemother.44, 3408–3413 (2000).
  • Weigelt J, Itani K, Stevens D, Lau W, Dryden M, Knirsch C. Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections. Antimicrob. Agents Chemother.49, 2260–2266 (2005).
  • Weigelt J, Kaafarani H, Itani K, Swanson R. Linezolid eradicates MRSA better than vancomycin from surgical-site infections. Am. J. Surg.188, 760–766 (2004).
  • Wilcox M, Nathwani D, Dryden M. Linezolid compared with teicoplanin for the treatment of suspected or proven gram-positive infections. J. Antimicrob. Chemother.53, 335–344 (2004).
  • Malone DC. The role of pharmacoeconomic modeling in evidence-based and value-based formulary guidelines. J. Manag. Care Pharm.11, S7–S10 (2005).
  • Arenas-Guzman R, Tosti A, Hay R, Haneke E. Pharmacoeconomics – an aid to better decision making. J. Eur. Acad. Dermatol. Venereol.19, 34–39 (2005).
  • Paladino JA. Economics of antibiotic use policies. Pharmacotherapy24, 232S–238S (2004).
  • Stevens DL, Herr D, Lampiris H et al. Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylcoccus aureus infections. Clin. Infect. Dis.34, 1481–1490 (2002).
  • Tice AD, Hoaglund PA, Nolet B, McKinnon PS, Mozaffari E. Cost perspectives for outpatient intravenous antimicrobial therapy. Pharmacotherapy22, 63S–70S (2002).
  • Sharpe JN, Shively EH, Polk HC Jr. Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus.Am. J. Surg.189, 425–428 (2005).
  • Li Z, Willke RJ, Pinto LA et al. Comparison of length of hospital stay for patients with known or suspected methicillin-resistant Staphylococcus species infections treated with linezolid or vancomycin: a randomized multicenter trial. Pharmacotherapy21, 263–274 (2001).
  • Cosgrove SE, Qi Y, Kaye KS, Harbath S, Karchmer AW, Carmeli Y. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect. Control. Hosp. Epidemiol.26, 166–174 (2005).
  • Shorr AF, Susla GM, Kolleff MH. Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit. Care Med.32, 137–143 (2004).
  • Herrerp IA, Issa NC, Patel R. Nosocomial spread of linezolid resistant vancomycin resistant Enterococcus faecium.N. Engl. J. Med.346, 3408–3413 (2002).
  • Mutnick AH, Enne V, Jones RN. Linezolid resistance since 2001: SENTRY antimicrobial surveillance program. Ann. Pharmacother.37, 769–774 (2003).
  • Tsiodras S, Gold HS, Sakoulas G et al. Linezolid resistance is a clinical isolate of Staphylococcus aureus. [Letter]. Lancet358, 207–208 (2001).
  • Xiong L, Kloss P, Douthwaite S et al. Ozazolidinone resistance mutations in 23s rRNA of Escherichia coli reveal central region of domain V as the primary site of drug action. J. Bacteriol.182, 5325–5331 (2000).
  • Wilson P, Andrews JA, Charlesworth R et al. Linezolid resistance in clinical isolates of Staphylococcus aureus. [Letter]. J. Antimicrob. Chemother.51, 186–188 (2003).
  • Peterson DL, Pasculle AW, McCurry K. Linezolid: the first oxazolidinone antimicrobial. [Letter]. Ann. Intern. Med.139, 863–864 (2003).
  • Machado ARL, Andrade SS, Barth AL et al. The emergence of linezolid-resistance among Staphylococcus aureus from cystic fibrosis patients. Program and abstracts in the 43rd International Conference on Antimicrobial Agents and Chemotherapy. IL, USA, C2–1825 (2003).
  • Meka VG, Pillai SK, Sakoulas G et al. Linezolid resistance in sequential Staphylococcus aureus isolates associated with T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA. J. Infect. Dis.190, 311–317 (2004).
  • Meka VG, Gold HS, Cooke A et al. Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus.J. Antimicrob. Chemother.54, 818–820 (2004).
  • Peters MJ, Sarria JC. Clinical characteristics of linezolid-resistant Staphylococcus aureus infections. Am. J. Med. Sci.330, 102–105 (2005).
  • Jones RN, Ross JE, Fritsche TR, Sader HS. Oxazolidinone susceptibility patterns in 2004: report from the Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program assessing isolated from 16 countries. J. Antimicrob. Chemother.57, 279–287 (2006).
  • Wunderink RG, Cammarata SK, Oliphant TH, Kollef MH. Continuation of a randomized double blind multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia. Clin. Ther.32, 402–412 (2003).
  • Nasraway SA, Shorr AF, Kuter DJ, O’Grady N, Le VH, Cammarata SK. Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use. Clin. Infect. Dis.37, 1609–1616 (2003).
  • Attassi K, Hershberger E, Alam R et al. Thrombocytopenia associated with linezolid therapy. Clin. Infect. Dis.34, 695–698 (2002).
  • Orrick JJ, Johns T, Janelle J et al. Thrombocytopenia secondary to linezolid administration: what is the risk. Clin. Infect. Dis.35, 348–349 (2002).
  • Gerson SL, Kaplan SL, Bruss JB et al. Hematologic effects of linezolid: summary of clinical experience. Antimicrob. Agents Chemother.46, 2723–2726 (2002).
  • Spellberg B, Yoo T, Bayer AS. Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6. J. Antimicrob. Chemother.54, 832–835 (2004).
  • Lavery S, Ravi H, McDaniel WW et al. Linezolid and serotonin syndrome. Psychosomatics42, 432–434 (2001).
  • Wigen CL, Goetz MB. Serotonin syndrome and linezolid. Clin. Infect. Dis.34, 1651–1652 (2002).
  • Hachem RY, Hicks K, Huen A et al. Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clin. Infect. Dis.37, e8–e11 (2003).
  • Bernard L, Stern R, Lew D et al. Serotonin syndrome after concomitant treatment with linezolid and citalopram. Clin. Infect. Dis.36, 1197 (2003).
  • Morales-Molina JA, Mateu-de Antonio J, Grau Cerrato S et al. Probable serotonin syndrome by interaction of amitriptyline, paroxetine and linezolid. Farm. Hosp.29, 292–293 (2005).
  • Jones SL, Athan E, O’Brien D. Serotonin syndrome due to co-administration of linezolid and venlafaxine. J. Antimicrob. Chemother.54, 289–290 (2004).
  • Thomas CR, Rosenberg M, Blythe V et al. Serotonin syndrome and linezolid. J. Am. Acad. Child Adolesc. Psychiatry43, 790 (2004).
  • Tahir N. Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram. J. Am. Med. Dir. Assoc.5, 111–113 (2004).
  • Bergeron L, Boule M, Perrault S. Serotonin toxicity associated with concomitant use of linezolid. Ann. Pharmacother.39, 956–961 (2005).
  • Morales N, Vermette H. Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine. Psychosomatics46, 274–275 (2005).
  • Morales-Molina J, Mateu-de Antonia J, Marin-Casino M, Grau S. Linezolid-associated serotonin syndrome: what we can learn from cases reported so far. J. Antimicrob. Chemother.56, 1176–1178 (2005).
  • Saijo T, Hayashi K, Yamada H, Wakakura M. Linezolid-induced optic neuropathy. Am. J. Ophthalmol.139, 1114–1116 (2005).
  • Rho JP, Sia IG, Crum BA, Dekutoski MB, Trousdale RT. Linezolid-associated peripheral neuropathy. Mayo Clin. Proc.79, 927–930 (2004).
  • Baddour LM, Wilson WR, Bayer AS et al. AHA scientific statement on infective endocarditis: diagnosis, antimicrobial therapy, and management of complications. Circulation111, 3167–3184 (2005).
  • American Thoracic Society and Infectious Disease Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med.171, 388–416 (2005).
  • Allan R, Tunkel AR, Barry J et al. Practice guidelines for the management of bacterial meningitis. Clin. Infect. Dis.39, 1267–1284 (2004).
  • Stevens DL, Bisno AL, Chambers HF et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin. Infect. Dis.41, 1373–1406 (2005).
  • Spellberg B, Powers JH, Brass EP, Miller LG, Edwards JE Jr. Trends in antimicrobial drug development: implications for the future. Clin. Infect. Dis.38, 1279–1286 (2004).
  • Pace JL, Krause K, Johnston D et al. In vitro activity of telavancin against Staphylococcus aureus.Antimicrob. Agents Chemother.47, 302–304 (2004).
  • King A, Phillips I, Kaniga K. Comparative in vitro activity of telavancin (TD-6424), a rapidly, bactericidal, concentration-dependant anti-infective with multiple mechanisms of action against gram-positive bacteria. J. Antimicrob. Chemother.53, 797–803 (2004).
  • Tenover FC, Weigel LM, Appelbaum PC et al. Vancomycin-resistant Staphylcoccus aureus isolate from a patient in Pennsylvania. Antimicrob. Agents Chemother.48, 275–280 (2005).
  • Hegde S, Reyes N, Wiens T et al. Pharmacodynamics of telavancin, a novel bactericidal agent, against gram-positive bacteria. Antimicrob. Agents Chemother.38, 3043–3050 (2004).
  • Stryjewski ME, O’Riorden WD, Lau WK et al. Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria. Clin. Infect. Dis.40, 1601–1607 (2005).
  • Lin G, Credito K, Ednie LM, Appelbaum PC. Antistaphylococcal activity of dabavancin, an experimental glycopeptide. Antimicrob. Agents Chemother.49, 770–772 (2005).
  • Streit JM, Fritsche TR, Sader HS, Jones RN. Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates. Diagn. Microbiol. Infect. Dis.48, 137–143 (2004).
  • Jauregui LE, Babazadeh S, Seltzer E et al. Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections. Clin. Infect. Dis.41, 1407–1415 (2005).

Websites

  • WHO. Overcoming antimicrobial resistance. World health report on infectious disease. A message from the Director-General, WHO www.who.int/infectious-disease-report/2000/other_versions/ index-rpt2000_text.html
  • Arpida press release. Arpida ready to commence global Phase III clinical trial program for iclaprim. March 16, 2005 www.slsventure.com/press/press/ 20050316.htm
  • Arpida press release. Arpida granted IND for oral iclaprim from US FDA. July 13, 2005 www.slsventure.com/press/050713.pdf

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