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Review

Treatment options for severe sepsis and septic shock

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Pages 395-403 | Published online: 10 Jan 2014

References

  • Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit. Care Med.29, S109–S116 (2001).
  • Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med.348, 1546–1554 (2003).
  • Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time? Crit. Care Med.26, 2078–2086 (1998).
  • Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA273, 117–123 (1995).
  • Meehan TP, Fine MJ, Krumholz HM et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA278,2080–2084 (1997).
  • Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest122, 262–268 (2002).
  • Dellinger RP, Carlet JM, Masur et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit. Care Med.32, 858–873 (2004).
  • Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest115, 462–474 (1999).
  • Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest118, 146–155 (2000).
  • Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit. Care Med.31, 2742–2751 (2003).
  • Valles J, Rello J, Ochagavia A, Garnacho J, Alcala MA. Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest123, 1615–1624 (2003).
  • Ibrahim EH, Ward S, Sherman G, Schaiff R, Fraser VJ, Kollef MH. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit. Care Med.29, 1109–1115 (2001).
  • Jimenez MF, Marshall JC; International Sepsis Forum. Source control in the management of sepsis. Intensive Care Med.27(Suppl. 1), S49–S62 (2001).
  • Cochrane Injuries Group Albumin Reviewers. Human albumin administration in critically ill patients: systematic review of randomised controlled trials. Br. Med. J.317, 235–240 (1998).
  • Wilkes MM, Navickis RJ. Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials. Ann. Intern. Med.135, 149–164 (2001).
  • Roberts I, Alderson P, Bunn F, Chinnock P, Ker K, Schierhout G. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst. Rev.4, CD000567 (2004).
  • Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R; SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N. Engl. J. Med.350, 2247–2256 (2004).
  • Rivers E, Nguyen B, Havstad S et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N. Engl. J. Med.345, 1368–77 (2001).
  • Hebert PC, Wells G, Blajchman MA et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N. Engl. J. Med.340, 409–417 (1999).
  • Hayes MA, Timmins AC, Yau EH et al. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N. Engl. J. Med.330, 1717–1722 (1994).
  • Gattinoni L, Brazzi L, Pelosi P et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N. Engl. J. Med.333, 1025–1032 (1995).
  • LeDoux D, Astiz ME, Carpati CM, Rackow EC. Effects of perfusion pressure on tissue perfusion in septic shock. Crit. Care Med.28, 2729–2732 (2000).
  • Ract C, Vigue B. Comparison of the cerebral effects of dopamine and norepinephrine in severely head-injured patients. Intensive Care Med.27, 101–106 (2001).
  • van den Berghe G, de Zegher F. Anterior pituitary function during critical illness and dopamine treatment. Crit. Care Med.24, 1580–1590 (1996).
  • Ruokonen E, Takala J, Kari A, Saxen H, Mertsola J, Hansen EJ. Regional blood flow and oxygen transport in septic shock. Crit. Care Med.21, 1296–1303 (1993).
  • Marik PE, Mohedin M. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA272, 1354–1357 (1994).
  • Neviere R, Mathieu D, Chagnon JL, Lebleu N, Wattel F. The contrasting effects of dobutamine and dopamine on mucosal perfusion in septic patients. Am. J. Respir. Crit. Care Med.154, 1684–1688 (1996).
  • De Backer D, Creteur J, Silva E, Vincent JL. Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit. Care Med.31, 1659–1667 (2003).
  • Meadows D, Edwards JD, Wilkins RG et al. Reversal of intractable septic shock with norepinephrine therapy. Crit. Care Med.16, 663–667 (1988).
  • Schreuder WO, Schneider AJ, Groeneveld ABJ et al. Effect of dopamine vs norepinephrine on hemodynamics in septic shock. Chest95, 1282–1288 (1989).
  • Martin C, Papazian L, Perrin G, Saux P, Gouin F. Norepinephrine or dopamine for the treatment of hyperdynamic septic shock. Chest103, 1826–1831 (1993).
  • Martin C, Viviand X, Leone M, Thirion X. Effect of norepinephrine on the outcome of septic shock. Crit. Care Med.28, 2758–2765 (2000).
  • Sakr Y, Reinhart K, Vincent JL et al. Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely ill Patients (SOAP) Study. Crit. Care Med.34, 589–597 (2006).
  • Hollenberg SM, Ahrens TS, Annane D et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit. Care Med.32, 1928–1948 (2004).
  • Levy B, Bollaert PE, Charpentier C et al. Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study. Intensive Care Med.23, 282–287 (1997).
  • Meier-Hellmann A, Reinhart K, Bredle DL, Specht M, Spies CD, Hannemann L. Epinephrine impairs splanchnic perfusion in septic shock. Crit. Care Med.25, 399–404 (1997).
  • Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet356, 2139–2143 (2000).
  • Kellum JA, M Decker J. Use of dopamine in acute renal failure: a meta-analysis. Crit. Care Med.29, 1526–1531 (2001).
  • Landry DW, Levin HR, Gallant EM et al. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation95, 1122–1125 (1997).
  • Sharshar T, Blanchard A, Paillard M, Raphael JC, Gajdos P, Annane D. Circulating vasopressin levels in septic shock. Crit. Care Med.31, 1752–1758 (2003).
  • Sharshar T, Carlier R, Blanchard A et al. Depletion of neurohypophyseal content of vasopressin in septic shock. Crit. Care Med.30, 497–500 (2002).
  • Malay MB, Ashton RC Jr, Landry DW, Townsend RN. Low-dose vasopressin in the treatment of vasodilatory septic shock. J. Trauma47, 699–703 (1999).
  • Patel BM, Chittock DR, Russell JA, Walley KR. Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology96, 576–582 (2002).
  • Dunser MW, Mayr AJ, Ulmer H et al. Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study. Circulation107, 2313–2319 (2003).
  • van Haren FM, Rozendaal FW, van der Hoeven JG. The effect of vasopressin on gastric perfusion in catecholamine-dependent patients in septic shock. Chest124(6), 2256–2260 (2003).
  • Holmes CL, Walley KR, Chittock DR, Lehman T, Russell JA. The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series. Intensive Care Med.27, 1416–1421 (2001).
  • O’Brien A, Clapp L, Singer M. Terlipressin for norepinephrine-resistant septic shock. Lancet359, 1209–1210 (2002).
  • Morelli A, Rocco M, Conti G et al. Effects of terlipressin on systemic and regional haemodynamics in catecholamine-treated hyperkinetic septic shock. Intensive Care Med.30, 597–604 (2004).
  • Schein RMH, Sprung CL. The use of corticosteroids in the sepsis syndrome. In: Critical Care – State of the Art 1986. Volume 7. Society of Critical Care Medicine, CA, USA, 131–149 (1986).
  • Sprung CL, Caralis PV, Marcial EH et al. The effect of high-dose corticosteroids in patients with septic shock. N. Engl. J. Med.311, 1137–1143 (1984).
  • Bone RC, Fisher CJ, Clemmer TP et al. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N. Engl. J. Med.317, 653–658 (1987).
  • The Veterans Administration Systemic Sepsis Cooperative Study Group: effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of sepsis. N. Engl. J. Med.317, 659–665 (1987).
  • Cronin L, Cook DJ, Carlet J et al. Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit. Care Med.23, 1430–1439 (1995).
  • Lefering R, Neugebauser EA. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit. Care Med.23, 1294–1303 (1995).
  • Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA283, 1038–1045 (2000).
  • Bollaert P-E, Charpentier C, Levy B et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit. Care Med.26, 645–650 (1998).
  • Briegel J, Forst H, Haller M et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit. Care Med.27, 723–732 (1999).
  • Annane D, Sebille V, Charpentier C et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA288, 862–871 (2002).
  • Keh D, Boehnke T, Weber-Cartens S et al. Immunologic and hemodynamic effects of “low-dose” hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am. J. Respir. Crit. Care Med.167, 512–520 (2003).
  • Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. Br. Med. J.329, 480 (2004).
  • Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann. Intern. Med.141, 47–56 (2004).
  • Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill. Chest122, 1784–1796 (2002).
  • Thaler LM, Blevins LS Jr. The low dose (1-microg) adrenocorticotropin stimulation test in the evaluation of patients with suspected central adrenal insufficiency. J. Clin. Endocrinol. Metab.83, 2726–2729 (1998).
  • Warren BL, Eid A, Singer P et al. Caring for the critically ill patient: high-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA286, 1869–1878 (2001).
  • Abraham E, Reinhart K, Opal S et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA290, 238–247 (2003).
  • Faust SN, Levin M, Harrison OB et al. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N. Engl. J. Med.345, 408–416 (2001).
  • Bernard GR, Vincent JL, Laterre PF et al. Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med.344, 699–709 (2001).
  • Bernard GR, Margolis BD, Shanies HM et al.; Extended Evaluation of Recombinant Human Activated Protein C United States Investigators. Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis. Chest125, 2206–2216 (2004).
  • Siegel JP. Assessing the use of activated protein C in the treatment of severe sepsis. N. Engl. J. Med.347, 1030–1034 (2002).
  • Abraham E, Laterre P-F, Garg R et al. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N. Engl. J. Med.353, 1332–1341 (2005).
  • Van den Berghe G, Wouters P, Weekers F et al. Intensive insulin therapy in the critically ill patients. N. Engl. J. Med.345, 1359–1367 (2001).
  • Van den Berghe G, Wilmer A, Hermans G et al. Intensive insulin therapy in the medical ICU. N. Engl. J. Med.354, 449–461 (2006).
  • Levy MM, Pronovost PJ, Dellinger RP et al. Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome. Crit. Care Med.32, S595–S597 (2004).

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