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Review

Antifungal prophylaxis among allogeneic hematopoietic stem cell transplant recipients: current issues and new agents

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Pages 457-468 | Published online: 10 Jan 2014

References

  • Goodrich JM, Reed EC, Mori M et al. Clinical features and analysis of risk factors for invasive candidal infection after marrow transplantation. J. Infect. Dis.164, 731–740 (1991).
  • Lin S-J, Schranz J, Teutsch SM. Aspergillosis case-fatality rate: systematic review of the literature. Clin. Infect. Dis.32, 358–366 (2001).
  • Anaissie EJ, Kuchar RT, Rex JH et al. Fusariosis associated with pathogenic Fusarium species colonization of a hospital water system: a new paradigm for the epidemiology of opportunistic mold infections. Clin. Infect. Dis.33, 1871–1878 (2001).
  • Anaissie EJ, Stratton SL, Dignani MC et al. Pathogenic Aspergillus species recovered from a hospital water system: a 3-year prospective study. Clin. Infect. Dis.34, 780–789 (2002).
  • Anaissie EJ, Stratton SL, Dignani MC et al. Cleaning patient shower facilities: a novel approach to reducing patient exposure to aerosolized Aspergillus species and other opportunistic molds. Clin. Infect. Dis.35, e86–e88 (2002).
  • Offidani M, Corvatta L, Olivieri A et al. Infectious complications after autologous peripheral blood progenitor cell transplantation followed by G-CSF. Bone Marrow Transplant.24, 1079–1087 (1999).
  • Mossad SB, Longworth DL, Goormastic M et al. Early infectious complications in autologous bone marrow transplantation: a review of 219 patients. Bone Marrow Transplant.28, 265–271 (1996).
  • Auner HW, Sill H, Mulabecirovic A et al. Infectious complications after autologous haematopoietic stem cell transplantation: comparison of patients with acute myeloid leukemia, malignant lymphoma, and multiple myeloma. Ann. Hematol.81, 374–377 (2002).
  • Jantunen E, Salonen J, Juvonen E et al. Invasive fungal infections in autologous stem cell transplant recipients: a nation-wide study of 1188 transplanted patients. Eur. J. Haematol.73, 174–178 (2004).
  • Marr KA, Carter RA, Crippa F et al. Epidemiology and outcome of mold infections in haematopoietic stem cell transplant recipients. Clin. Infect. Dis.34, 909–917 (2002).
  • Jantunen E, Ruutu P, Niskanen L et al. Incidence and risk factors for invasive fungal infections in allogeneic BMT recipients. Bone Marrow Transplant.19, 801–808 (1997).
  • Wald A, Leisenring W, van Burik JA et al. Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation. J. Infect. Dis.175, 1459–1466 (1997).
  • Hagen EA, Stern H, Porter D et al. High rate of invasive fungal infections following nonmyeloablative allogeneic transplantation. Clin. Infect. Dis.36, 9–15 (2003).
  • Fukuda T, Boeckh M, Carter RA et al. Risks and outcomes of invasive fungal infections in recipients of allogeneic haematopoietic stem cell transplants after nonmyeloablative conditioning. Blood102, 827–933 (2003).
  • Martino R, Subira M, Rovira M et al. Invasive fungal infections after allogeneic peripheral blood stem cell transplantation: incidence and risk factors in 395 patients. Br. J. Haematol.116, 475–482 (2002).
  • Marr KA, Carter RA, Boeckh M et al. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood100, 4358–4366 (2002).
  • Singh N. Interactions between viruses in transplant recipients. Clin. Infect. Dis.40, 430–436 (2005).
  • Pfaller MA, Diekema DJ, Jones RN et al. International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J. Clin. Microbiol.39, 3254–3259 (2001).
  • Pfaller MA, Diekema DJ, Messer SA et al. Activities of fluconazole and voriconazole against 1,586 recent clinical isolates of Candida species determined by broth microdilution, disk diffusion, and E test methods: report from the ARTEMIS Global Antifungal Susceptibility Program, 2001. J. Clin. Microbiol.41, 1440–1446 (2003).
  • Wingard JR, Merz WG, Rinaldi MG et al. Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients. Antimicrob. Agents Chemother.37, 1847–1849 (1993).
  • Marr KA, White TC, van Burik JA et al. Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation. Clin. Infect. Dis.25, 908–910 (1997).
  • CDC; Infectious Diseases Society of America; American Society of Blood and Marrow Transplantation. Guidelines for preventing opportunistic infections among haematopoietic stem cell transplant recipients. Biol. Blood Marrow Transplant.6, 659–713 (2000).
  • Goodman JL, Winston DJ, Greenfield RA et al. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N. Engl. J. Med.326, 845–851 (1992).
  • Slavin MA, Osborne B, Adams R et al. Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation – a prospective randomized, double-blind study. J. Infect. Dis.171, 1545–1552 (1995).
  • Marr KA, Siedel K, Slavin MA et al. Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial. Blood96, 2055–2061 (2000).
  • Antifungal drugs. Treat Guidel. Med. Lett.3(30), 7–14 (2005).
  • Micafungin (Mycamine®) for fungal infections. Med. Lett.47, 51–52 (2005).
  • Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin. Infect. Dis.36, 630–637 (2003).
  • Denning DW. Echinocandin antifungal drugs. Lancet362, 1142–1151 (2003).
  • Marr KA, Crippa F, Leisenring W et al. Cyclophosphamide metabolism is affected by azole antifungals. Blood12(5), 552–559 (2006).
  • Marty FM, Laury CM, Cutler CS. Voriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant.36, 2708–2709 (2004).
  • Bartizal K, Gill CJ, Abruzzo GK et al. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Antimicrob. Agents Chemother.41, 2326–2332 (1997).
  • Bowman JC, Hicks PS, Kurtz MB et al. The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro.Antimicrob. Agents Chemother.46, 3001–3012 (2002).
  • Chandrasekar PH, Sobel JD. Micafungin: a new echinocandin. Clin. Infect. Dis.42, 1171–1178 (2006).
  • Powles MA, Liberator P, Anderson J et al. Efficacy of MK-991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii. Antimicrob. Agents Chemother.42, 1985–1989 (1998).
  • van Burik JAH, Ratanatharathorn V, Stepan D et al. Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing haematopoietic stem cell transplantation. Clin. Infect. Dis.39, 1407–1416 (2004).
  • De Wet N, Llanos-Cuentas A, Suleiman J et al. A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients. Clin. Infect. Dis.39, 842–849 (2004).
  • Trenschel R, Ditschkowski M, Elmaagacgli AH et al. Caspofungin as second-line therapy for fever of unknown origin or invasive fungal infection following allogeneic stem cell transplantation. Bone Marrow Transplant.35, 583–586 (2005).
  • Marr KA, Hachem R, Papanicolaou G et al. Retrospective study of the hepatic safety profile of patients concomitantly treated with caspofungin and cyclosporin A. Transpl. Infect. Dis.6, 110–116 (2004).
  • Sanz-Rodriguez C, Lopez-Duarte M, Jurado M et al. Safety of the concomitant use of caspofungin and cyclosporin A in patients with invasive fungal infections. Bone Marrow Transplant.34, 13–20 (2004).
  • Martino R, Nomdedeu J, Altes A. Successful bone marrow transplantation in patients with previous invasive fungal infections: report of four cases. Bone Marrow Transplant.13, 265–269 (1994).
  • Kruger WH, Russmann B, de Wit M et al. Haematopoietic cell transplantation of patients with a history of deep or invasive fungal infection during prophylaxis with liposomal amphotericin B. Acta Haematol.113, 104–108 (2005).
  • Mehta P, Augustson B, Krishnamurthy S et al. Successful allogeneic haematopoietic stem cell transplantation in patients with poor-risk leukaemia and prior invasive fungal infection. Bone Marrow Transplant.34, 825–826 (2004).
  • Cordonnier C, Maury S, Pautas C et al. Secondary antifungal prophylaxis with voriconazole to adhere to scheduled treatment in leukemic patients and stem cell transplant recipients. Bone Marrow Transplant.33, 943–948 (2004).
  • Cornely O, Maertens J, Winston D et al. Posaconazole vs standard azole therapy for prophylaxis of invasive fungal infections among high-risk neutropenic patients: results of a randomized, multicenter trial. Program and abstracts of the 47th American Society of Hematology. GA, USA, Abstract 1844 (2005).
  • Cornely OA, Maertens J, Winston D et al. Posaconazole vs standard azoles as antifungal prophylaxis in neutropenic patients with acute myelogenous leukemia or myelodysplastic syndrome: impact on mortality. Program and abstracts of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, USA, Abstract M-722b (2005).
  • Diekema DJ, Messer SA, Hollis RJ et al. Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi. J. Clin. Microbiol.41, 3623–3626 (2003).
  • Jantunen E, Nihtinen A, Volin L et al. Candidemia in allogeneic stem cell transplant recipients: low risk without fluconazole prophylaxis. Bone Marrow Transplant.34, 891–895 (2004).
  • Marr KA. Issues in the design of fluconazole prophylaxis trials in patients undergoing hematopoietic stem cell transplantation. Clin. Infect. Dis.39(Suppl. 4), S170–S175 (2004).
  • Kelsey SM, Goldman JM, McCann S et al. Liposomal amphotericin (AmBisome) in the prophylaxis of fungal infections in neutropenic patients: a randomized, double-blind, placebo-controlled study. Bone Marrow Transplant.23, 163–168 (1999).
  • Tollemar J, Ringden O, Andersson B et al. Randomized double-blind study of liposomal amphotericin B (Ambisome) prophylaxis of invasive fungal infections in bone marrow transplant recipients. Bone Marrow Transplant.12, 577–582 (1993).
  • Barrett JP, Vardulaki KA, Conlon C. A systematic review of the antifungal effectiveness and tolerability of amphotericin B formulations. Clin. Ther.25, 1295–1320 (2003).
  • Winston DJ, Maziarz RT, Pranatharthi H et al. Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. Ann. Intern. Med.138, 705–713 (2002).
  • Marr KA, Crippa F, Leisenring W et al. Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. Blood103, 1527–1533 (2004).
  • Bohme A, Ganser A, Hoelzer D. Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL. Ann. Hematol.71, 311–312 (1995).
  • Gillies J, Hung K, Fitzsimons E et al. Severe vincristine toxicity in combination with itraconazole. Clin. Lab. Haematol.20, 123–124 (1998).
  • Ullmann AJ, Lipton JH, Vesole DH et al. Posaconazole vs. fluconazole for the prophylaxis of invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease: results of a multicenter trial. Program and abstracts of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, USA, Abstract M-716 (2005).
  • Buell DB, Kovanda D, Drake T et al. Alternative day dosing of micafungin in the treatment of esophageal candidiasis. Program and abstracts of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, USA, Abstract M-719 (2005).
  • Hiemenz J, Cagnoni P, Simpson D et al. Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant. Antimicrob. Agents Chemother.49, 1331–1336 (2005).
  • Kontoyiannis DP, Lionakis MS, Lewis RE et al. Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases. J. Infect. Dis.191, 1350–1360 (2005).
  • Marty FM, Cosimi LA, Baden LR. Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. N. Engl. J. Med.26, 950–952 (2004).
  • Siwek GT, Dodgson KJ, de Magalhaes-Silverman M et al. Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis. Clin. Infect. Dis.39, 584–587 (2004).
  • Imhof A, Balajee SA, Fredricks DN et al. Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole. Clin. Infect. Dis.39, 743–746 (2004).
  • Vigouroux S, Morin O, Moreau P et al. Zygomycosis after prolonged use of voriconazole in immunocompromised patients with hematologic disease: attention required. Clin. Infect. Dis.40, e35–e37 (2005).
  • Girmenia C, Moleti ML, Micozzi A et al. Breakthrough Candida krusei fungemia during fluconazole prophylaxis followed by breakthrough zygomycosis during caspofungin therapy in a patient with severe aplastic anemia who underwent stem cell transplantation. J. Clin. Microbiol.43, 5395–5396 (2005).
  • Safdar A, O’Brien S, Kouri IF. Efficacy and feasibility of aerosolized amphotericin B lipid complex therapy in caspofungin breakthrough pulmonary zygomycosis. Bone Marrow Transplant.34, 467–468 (2004).
  • Walsh TJ, Teppler H, Donowitz GR et al. Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia. N. Engl. J. Med.351, 1391–1402 (2004).
  • Pavie J, Lacroix C, Hermoso DG et al. Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole or caspofungin prophylaxis. J. Clin. Microbiol.43, 4902–4904 (2005).
  • Alexander BD, Schell WA, Miller JL et al. Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole. Transplantation80, 868–871 (2005).
  • Kauffman CA. Zygomycosis: re-emergence of an old pathogen. Clin. Infect. Dis.39, 588–590 (2004).
  • Roden MM, Zaoutis TE, Buchanan WL et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin. Infect. Dis.41, 634–653 (2005).
  • Torres HA, Hachem RY, Chemaly RF et al. Posaconazole: a broad-spectrum triazole antifungal. Lancet Infect. Dis.5, 775–785 (2005).
  • Tobon AM, Arango M, Fernandez D et al. Mucormycosis (zygomycosis) in a heart–kidney transplant recipient: recovery after posaconazole therapy. Clin. Infect. Dis.36, 1488–1491 (2003).
  • van Burik JA, Hare RS, Solomon HF et al. Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. Clin. Infect. Dis.42, e61–e65 (2006).
  • Marr KA, Boeckh M, Carter RA et al. Combination antifungal therapy for invasive aspergillosis. Clin. Infect. Dis.39, 797–802 (2004).
  • Aliff TB, Maslak PG, Jurcic JG et al. Refractory Aspergillus pneumonia in patients with acute leukemia: successful therapy with combination caspofungin and liposomal amphotericin. Cancer97, 1025–1032 (2003).

Websites

  • Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients; figure 1. www.cdc.gov/mmwr/preview/mmwrhtml/ rr4910a1.htm#fig1
  • Mycamine package insert www.astellas.us/docs/mycamine.pdf
  • VFEND package insert www.pfizer.com/download/uspi_vfend.pdf
  • Blood and Marrow Transplant Clinical Research Network; National Heart, Lung and Blood Institute www.clinicaltrials.gov/ct/gui/show/ NCT00023530

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