References
- Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin. Infect. Dis.29, 239–244 (1999).
- Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis.39, 309–317 (2004).
- Wenzel RP. Attributable mortality: the promise of better antimicrobial therapy. J. Infect. Dis.178, 917–919 (1998).
- Farver DK, Hedge DD, Lee SC. Ramoplanin: a lipoglycodepsipetide antibiotic. Ann. Pharmacother.39, 863–868 (2005).
- Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL. Chemistry and biology of ramoplanin: a lipo-glycodepsipeptide with potent antibiotic activity. Chem. Rev.105, 449–475 (2005).
- Montecalvo MA. Ramoplanin: a novel antimicrobial agent with the potential to prevent vancomycin-resistant enterococcal infection in high-risk patients. J. Antimicrob. Chemother.51(S3), 31–35 (2003).
- Cavalleri B, Pagani H, Volpe G, Selva E, Parenti F. A-16686, a new antibiotic from actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics. J. Antibiotic.37, 309–317 (1984).
- Pittet D, Davis CS, Li N, Wenzel RP. Identifying the hospitalized patient at risk for nosocomial bloodstream infection: a population-based study. Proc. Assoc. Am. Physicians109, 58–67 (1997).
- Davey P, Brown E, Fenelon L et al. Systematic review of antimicrobial drug prescribing in hospitals. Emerg. Infect. Dis.12, 211–216 (2006).
- Kreman T, Hu J, Pottinger J, Herwaldt LA. Survey of long-term facilities in Iowa policies and practices regarding patients with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci. Infect. Control Hosp. Epidemiol.26, 811–815 (2005).
- Mody L, Kauffman CA, McNeil SA, Galecki AT, Bradley SF. Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebo-controlled trial. Clin. Infect. Dis.37, 1467–1474 (2003).
- Simor AE, Bradley SF, Strausbaugh LJ, Crossley K, Nicolle LE; SHEA Long-Term-Care Committee. Clostridium difficile in long term-care facilities for the elderly. Infect. Control Hosp. Epidemiol.23, 696–703 (2003).
- Kluytmans-Vandenbergh MF, Kluytmans JA. Community-acquired methicillin-resistant Staphylococcus aureus: current perspectives. Clin. Microbiol. Infect.12(Suppl. 1), 9–15 (2006).
- Rybak MJ, LaPlante KL. Community-associated methicillin-resistant Staphylococcus aureus: a review. Pharmacotherapy25, 74–85 (2005).
- Genestier AL, Michallet MC, Prevost G et al. Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-dependent apoptosis of human neutrophils. J. Clin. Invest.115, 3117–3127 (2005).
- Jiang W, Wanner J, Lee RJ, Bounaud PY, Boger DL. Total synthesis of the ramoplanin A2 and ramoplanose aglycon. J. Am. Chem. Soc.125, 1877–1887 (2003).
- Pallanza R, Berti M, Scotti R, Randisi E, Arioli V. A-16686, a new antibiotic from actinoplanes. II. Biological properties. J. Antibiotic.37, 318–324 (1984).
- Ciabatti R, Kettenring JK, Winters G, Tuan G, Zerilli L, Cavalleri B. Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation. J. Antibiotic.42, 254–67 (1989).
- Somner EA, Reynolds PE. Inhibition of peptidoglycan biosynthesis by ramoplanin. Antimicrob. Agents Chemother.34, 413–419 (1990).
- Reynolds PE, Somner EA. Comparison of the target sites and mechanisms of action of glycopeptide and lipoglycodepsipeptide antibiotics. Drugs Exptl Clin. Res.16, 385–390 (1990).
- Lo MC, Men H, Branstrom A et al. A new mechanism of action proposed for ramoplanin. J. Am. Chem. Soc.122, 3540–3541 (2000).
- Hu Y, Helm JS, Chen L, Ye XY, Walker S. Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to Lipid II. J. Am. Chem. Soc.125, 8736–8737 (2003).
- Ha S, Walker D, Shi Y, Walker S. The 1.9 A crystal structure of Escherichia coli MurG, membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis. Protein Sci.9, 1045–1052 (2000).
- Chen L, Yuan Y, Helm JS et al. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. J. Am. Chem. Soc.126, 7462–7463 (2004).
- Shin D, Rew Y, Boger DL. Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex. Proc. Natl Acad. Sci. USA101, 11977–11979 (2004).
- Ling LL, Fan J, Schumacher T, Borsari B, Davey M, Puyang X. Over-expression of murG in S. aureus does not alter the ramoplanin MIC (Abstracts). Presented at: 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. IL, USA, 14–17 September (2003).
- Goossens H, Jabes D, Rossi R et al. European survey of Vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolates. J. Antimicrob. Chemother.51(Suppl. 3) 5–12 (2003).
- Mobarakai N , Quale JM, Landman D. Bactericidal activities of peptide antibiotics against multi drug-resistant Entercoccus faecium. Antimicrob. Agents Chemother.38, 385–387 (1994).
- Pelaez T, Alcala A, Alonso R et al. In vitro activity of ramoplanin against Clostridium difficile, including strains with reduced susceptibility to vancomycin or with resistance to metronidazole. Antimicrob. Agents Chemother.49, 1157–1159 (2005).
- Citron DM, Merriam CV, Tyrrell KL et al. In vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin and four other antimicrobials against international aerobic bacteria. Antimicrob. Agents Chemother.47, 2334–2338 (2003).
- de Lalla F, Romeo B, Nicolin R, Pallizzer G, Merati R, Riva E. Oral ramoplanin (R) single-dose administration in pseudomembranous colitis (PMC). Can. J. Infect. Dis.6(Suppl. 5), 452C (1995).
- Romeo B, Kaschub M, Cavenaghi L et al. Repeated doses of ramoplanin orally administered to healthy and male volunteers: tolerability, lack of absorption and effect on the stool microflora (Abstracts). Presented at: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy. DC, USA (1993).
- Wong MT, Kauffman CA, Standiford HC et al. Effective suppression of vancomycin-resistant enterococci species in asymptomatic gastrointestinal carriers by a novel glycolipodespsipeptide, ramoplanin. Clin. Infect. Dis.33, 1476–1482 (2001).
- Pullman J, Prieto J, Leach TS. Ramoplanin vs. vancomycin in the treatment of Clostridium difficile diarrhea: a Phase II study (Abstracts). Presented at: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. DC, USA, 30 October–2 November (2004).
- Bricker E, Garg R, Nelson R et al. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst. Rev.25(1), CD004610 (2005).
- Loo VG, Poirer L, Miller M et al. A predominately clonal multi-institutional outbreak of Clostridium difficile associated diarrhea with high morbidity and mortality. N. Engl. J. Med.353, 2442–2449 (2005).
Website
- Oscient Pharmaceuticals Corporation. Oscient Pharmaceuticals obtains special protocol assessment from the FDA for ramoplanin; SPA details a pivotal Phase II program of ramoplanin for the treatment of CDAD. MA, USA (2006). http://investors.oscient.com/phoenix.zhtml?c=97238&p=irol-newsArticle&ID=798141&highlight