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Review

Treatment options for paracoccidioidomycosis and new strategies investigated

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Pages 251-262 | Published online: 10 Jan 2014

References

  • Bernard G, Franco M. Paracoccidioidomycosis. In: Medical Mycology – Topley & Wilson’s Microbiology and Microbial Infections (10th Edition). Merz WG, Hay RJ (Eds). ASM Press, Washington, DC, USA 28, 541–559 (2005).
  • Wanke B, Londero AT. Epidemiology and paracoccidioidomycosis infection. In: Paracoccidioidomycosis. Franco M (Ed.). CRC Press, Boca Raton, FL, USA, 109–120 (1994).
  • Restrepo A, McEwen JG, Castaneda E. The habitat of Paracoccidioides brasiliensis: how far from solving the riddle? Med. Mycol.39, 233–241 (2001).
  • Bagagli E, Sano A, Coelho AS et al. Isolation of Paracoccidioides brasiliensis from armadillos (Dasypus novemcinctus) captured in an endemic area of paracoccidioidomycosis. Am. J. Trop. Med. Hyg.58, 505–512 (1998).
  • Ricci G, Mota FT, Wakamatsu A et al. Canine paracoccidioidomycosis. Med. Mycol.42, 379–383 (2004).
  • Corte AC, Svoboda WK, Navarro IT et al. Paracoccidioidomycosis in wild monkeys from Parana State, Brazil. Mycopathologia164, 225–228 (2007).
  • Franco M, Montenegro MR, Mendes RP et al. Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev. Soc. Bras. Med. Trop.20, 129–132 (1987).
  • Camargo ZP, Franco MF. Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis. Rev. Iberoam. Micol.17, 41–48 (2000).
  • Bernard G, Kavakama J, Mendes-Giannini MJS et al. Contribution to the natural history of paracoccidioidomycosis: identification of primary pulmonary infection in the severe acute form of the disease – a case report. Clin. Infect. Dis.40, 1–4 (2005).
  • Blotta MHSL, Mamoni RL, Oliveira J et al. Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. Am. J. Trop. Med. Hyg.61, 390–394 (1999).
  • Franco M, Mendes RP, Moscardi-Bacchi M et al. Paracoccidioidomycosis. In: Bailliere’s Clinical Tropical Medicine and Communicable Diseases. Tropical Fungal Infections. Baillière T (Ed.). London, UK 185–220 (1989).
  • Goldani LZ, Sugar AM. Paracoccidioidomycosis and AIDS: an overview. Clin. Infect. Dis.21, 1275–1281 (1995).
  • Zavascki AP, Biernardt JC, Severo LC. Paracoccidioidomycosis in organ transplant recipient: case report. Rev. Inst. Med. Trop. Sao Paulo46, 279–281 (2004).
  • Brummer L, Castaneda E, Restrepo A. Paracoccidioidomycosis: an update. Clin. Microbiol. Rev.6, 89–117 (1993).
  • Pereira RM, Bucaretchi F, Barison EM et al. Paracoccidioidomycosis in children: clinical presentation, follow up and outcome. Rev. Inst. Med. Trop. Sao Paulo46, 127–131 (2004).
  • Negroni R. Paracoccidioidomycosis (South American blastomycosis, Lutz’s mycosis). Int. J. Dermatol.32, 847–859 (1993).
  • Mendes RP, Negroni R, Arechavala A. Treatment and control of cure. In: Paracoccidioidomycosis. Franco M, Lacaz CS (Eds). CRC Press, Boca Raton, FL, USA 373–92 (1994).
  • Franco L, Najvar L, Gomez L et al. Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host. Am. J. Trop. Med. Hyg.58, 424–430 (1998).
  • Tobón AM, Agudelo CA, Osorio ML et al. Residual pulmonary abnormalities in adult patients with chronic paracoccidioidomycosis: prolonged follow-up after itraconazole therapy. Clin. Infect. Dis.37, 898–904 (2003).
  • Campos EP, Padovani CR, Cataneo AMJ. Paracoccidioidomicose: estudo radiológico e pulmonar de 58 casos. Rev. Inst. Med. Trop. Sao Paulo33, 267–276 (1991).
  • Bethlem EP, Capone D, Maranhão B et al. Paracoccidioidomycosis. Curr. Opin. Pulm. Med.5, 319–325 (1999).
  • Del Negro G, Melo EHL, Rodbard D et al. Limited adrenal reserve in paracoccidioidomycosis: cortisol and aldosterone response to 1–24 ACTH. Clin. Endocrinol.13, 553–559 (1980).
  • Onate JM, Tobón AM, Restrepo A. Insuficiencia suprarenal secundaria a paracoccidioidomicosis. Biomedica22, 280–286 (2002).
  • Colombo AL, Faiçal S, Kater CE. Systematic evaluation of the adrenocortical function in patients with paracoccidioidomycosis. Mycopathologia127, 89–93 (1994).
  • Coutinho ZF, Silva D, Lazera M et al. Paracoccidioidomycosis mortality in Brazil (1980–1995). Cad. Saude Publica18, 1441–1454 (2002).
  • Bittencourt JIM, Oliveira RM, Coutinho ZF. Paracoccidioidomycosis mortality in the state of Parana, Brazil, 1980–1998. Cad. Saúde Publica21, 1856–1864 (2005).
  • Camargo ZP, Gesztezi JL, Saraiva ECO et al. Monoclonal antibody capture enzyme immunoassay (ELISA) for detection of Paracoccidioides brasiliensis antibodies in paracoccidioidomycosis. J. Clin. Microbiol.32, 2377–2381 (1994).
  • Martins R, Marques S, Alves M et al. Serological follow up of patients with paracoccidioidomycosis treated with itraconazole using dot-blot, ELISA and western-blot . Rev. Inst. Med. Trop. Sao Paulo39, 261–269 (1997).
  • Gómez BL, Figueroa JI, Hamilton AJ et al. Antigenemia in patients with paracoccidioidomycosis: detection of the 87-kilodalton determinant during and after antifungal therapy. J. Clin. Microbiol.36, 3309–3316 (1998).
  • Mendes-Giannini MJS, Bueno JP, Shikanai-Yasuda MA et al. Detection of the antigen 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis. J. Clin. Microbiol.27, 2842–2845 (1989).
  • Marques-da-Silva SH, Colombo AL, Blotta MHSL et al. Detection of circulating gp43 antigen in serum, cerebrospinal fluid and bronchoalveolar lavage of patients with paracoccidioidomycosis. J. Clin. Microbiol.41, 3675–3680 (2003).
  • Marques-da-Silva SH, Queiroz-Telles F, Colombo AL et al. Monitoring gp43 antigenemia in paracoccidioidomycosis patients during treatment. J. Clin. Microbiol.42, 2419–2424 (2004).
  • Montoyama AB, Venancio EJ, Brandao GO et al. Molecular identification of Paracoccidioides brasiliensis by PCR amplification of ribosomal DNA. J. Clin. Microbiol.38, 3106–3109 (2000).
  • Gomes GM, Cisalpino PS, Taborda CP, Camargo ZP. PCR for diagnosis of paracoccidioidomycosis. J. Clin. Microbiol.33, 1652–1654 (2000).
  • San Blas G, Nino-Vega G, Barreto L et al. Primers for clinical detection of Paracoccidiodes brasiliensis. J. Clin. Microbiol.43, 4255–4257 (2005).
  • Borelli D. Terapia de la paracoccidioidomicosis. Valor actual de los antigos tratamientos. Rev. Arg. Micol. (Suppl.), 13–20 (1987).
  • Paniago AM, Aguiar JI, Aguiar ES et al. Paracoccidioidomycosis: a clinical and epidemiological study of 422 cases observed in Mato Grosso do Sul. Rev. Soc. Bras. Med. Trop.36, 455–459 (2003).
  • Elias J Jr, dos Santos AC, Carlotti CG Jr et al. Central nervous system paracoccidioidomycosis: diagnosis and treatment. Surg. Neurol.63(Suppl. 1), S13–S21 (2005).
  • Almeida SM, Queiroz-Telles F, Teive HA et al. Central nervous system paracoccidioidomycosis: clinical features and laboratorial findings. J. Infect.48, 193–198 (2004).
  • Dillon NL, Sampaio SA, Habermann et al. Delayed results of treatment of paracoccidioidomycosis with amphotericin B plus sulfonamides versus amphotericin B alone. Rev. Inst. Med. Trop. Sao Paulo28, 263–266 (1986).
  • Negroni R, Rubstein P, Hermann A et al. Results of miconazole therapy in twenty-eight patients with paracoccidioidomycosis (South American blastomycosis). Proc. R. Soc. Med.76, 24–28 (1977).
  • Maertens JA. History of the development of azole derivatives. Clin. Microbiol. Infect.10(Suppl. 1), 1–10 (2004).
  • Del Negro G. Ketoconazole in paracoccidioidomycosis. A long-term therapy study with prolonged follow-up. Rev. Inst. Med. Trop. Sao Paulo24, 27–39 (1982).
  • Restrepo A, Gomez I, Cano LE et al. Treatment of paracoccidioidomycosis with ketoconazole: a three-year experience. Am. J. Med.74, 48–52 (1983).
  • Naranjo MS, Trujillo M, Munera MI et al. Treatment of paracoccidioidomycosis with itraconazole. J. Med. Vet. Mycol.28, 67–76 (1990).
  • Shikanai-Yasuda MA, Bernard G, Higaki Y et al. Randomized trial with itraconazole, ketoconazole, and sulfadiazine in paracoccidioidomycosis. Med. Mycol.40, 411–417 (2002).
  • Diaz M, Negroni R, Montero-Gei F et al. A Pan-American 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host. Pan-American Study Group. Clin. Infect. Dis.14(Suppl. 1), S68–S76 (1992).
  • Shikanai-Yasuda MA, Queiroz-Telles F, Mendes RP et al. Guidelines in Paracoccidioidomycosis. Rev. Soc. Bras. Med.Trop. Sao Paulo39, 297–310 (2006).
  • Deresinski SC, Stevens D. Caspofungin. Clin. Infect. Dis.36, 1445–1457 (2003).
  • Denning D. Echinocandin antifungal drugs. Lancet362, 1143–1151 (2003).
  • Queiroz-Telles F, Goldani LZ, Schlamm HT et al. An open-label comparative pilot study of oral voriconazole and itraconazole for long-term treatment of paracoccidioidomycosis. Clin. Infect. Dis.45, 1462–1469 (2007).
  • Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin. Infect. Dis.36, 630–637 (2003).
  • Bjarnsholt T, Jensen PO, Rasmussen TB et al. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology151, 3873–3880 (2005).
  • Yoshida H, Iwata N, Katsuzaki H et al. Antimicrobial activity of a compound isolated from an oil-macerated garlic extract. Biosci. Biotechnol. Biochem.62, 1014–1017 (1998).
  • Terrasson J, Xu B, Li M et al. Activities of Z-ajoene against tumour and viral spreading in vitro. Fund. Clin. Pharmacol.21, 281–289 (2007).
  • Walder R, Kalvatchev Z, Apitz-Castro R. Selective in vitro protection of SIVagm-induced cytolysis by ajoene, [(E)-(Z)-4,5, 9-trithiadodeca-1,6,11-triene-9 oxide]. Biomed. Pharmacother.52, 229–235 (1998).
  • Ghazanfari T, Hassan ZM, Khamesipour A. Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic (Allium sativum) treatment. J. Ethnopharmacol.103, 333–337 (2006).
  • Urbina JA, Marchan E, Lazardi K et al. Inhibition of phosphatidylcholine biosynthesis and cell proliferation in Trypanosoma cruzi by ajoene, an antiplatelet compound isolated from garlic. Biochem. Pharmacol.45, 2381–2387 (1993).
  • Ledezma E, DeSousa L, Jorquera A et al. Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis. Mycoses39, 393–395 (1996).
  • Apitz-Castro R, Cabrera S, Cruz MR, Ledezma E, Jain MK. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb. Res.32, 155–169 (1983).
  • Teranishi K, Apitz-Castro R, Robson SC, Romano E, Cooper DK. Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene. Xenotransplantation10, 374–379 (2003).
  • Yoshida S, Kasuga S, Hayashi N, Ushiroguchi T, Matsuura H, Nakagawa S. Antifungal activity of ajoene derived from garlic. Appl. Environm. Microbiol.53, 615–617 (1987).
  • San-Blas G, San-Blas F, Gil F, Marino L, Apitz-Castro R. Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene. Antimicrob. Agents Chemother.33, 1641–1644 (1989).
  • San-Blas G, Urbina JA, Marchan E, Contreras LM, Sorais F, San-Blas F. Inhibition of Paracoccidioides brasiliensis by ajoene is associated with blockade of phosphatidylcholine biosynthesis. Microbiology143, 1583–1586 (1997).
  • Thomaz L, Apitz-Castro R, Marques AF, Travassos LR, Taborda CP. Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. Med. Mycol.46(2), 113–118 (2008).
  • Maesaki S. Drug delivery system of anti-fungal and parasitic agents. Current Pharmaceut. Des.8, 433–440 (2002).
  • Ribeiro-Costa RM, Alves AJ, Santos NP et al.In vitro and in vivo properties of usnic acid encapsulated into PLGA-microspheres. J. Microencapsul.21, 371–384 (2004).
  • Rivera PA, Martinez-Oharriz MC, Rubio M, Irache JM, Espuelas S. Fluconazole encapsulation in PLGA microspheres by spray-drying. J. Microencapsul.21, 203–211 (2004).
  • Kassab R, Parrot-Lopez H, Fessi H, Menaucourt J, Bonaly RJ, Coulon J. Molecular recognition by Kluyveromyces of amphotericin B-loaded, galactose-tagged, poly (lactic acid) microspheres. Bioorgan. Med. Chem.10, 1767–1775 (2002).
  • Multhoff G. Heat shock proteins in immunity. Handb. Exp. Pharmacol.172, 279–304 (2006).
  • Thompson SJ, Francis JN, Siew LK et al. An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis. J. Immunol.160, 4628–4634 (1998).
  • Novellino L, Castelli C, Parmiani GA. Listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol. Immunother.54, 187–207 (2005).
  • Purcell AW, McCluskey J, Rossjohn J. More than one reason to rethink the use of peptides in vaccine design. Nature Revs.6, 404–414 (2007).
  • Pietersz CA, Pouniotis DS, Apostolopoulos V. Design of peptide-based vaccines for cancer. Curr. Med. Chem.13, 1591–1607 (2006).
  • Aguilar JC, Rodriguez EG. Vaccine adjuvants revisited. Vaccine25, 3752–3762 (2007).
  • Puccia R, Schenkman S, Gorin PA, Travassos LR. Exocellular components of Paracoccidioides brasiliensis: identification of a specific antigen. Infect. Immun.53, 199–206 (1986).
  • Taborda CP, Juliano MA, Puccia R, Franco M, Travassos LR. Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in Balb/c mice. Infect. Immun.66, 786–793 (1998).
  • Travassos LR, Taborda CP, Iwai LK, Cunha-Neto E, Puccia R. The gp43 from Paracoccidioides brasiliensis: a major diagnostic antigen and vaccine candidate. In: The Mycota XII Human Fungal Pathogens. Domer JE, Kobayashi GS (Eds). Springer-Verlag Berlin-Heidelberg, Germany 279–296 (2004).
  • Morais FV, Barros TF, Fukada MK, Cisalpino PS, Puccia R. Polymorphism in the gene coding for the immunodominant antigen gp43 from the pathogenic fungus Paracoccidioides brasiliensis. J. Clin. Microbiol.38, 3960–3966 (2000).
  • Iwai LK, Yoshida M, Sidney J et al.In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of Paracoccidioides brasiliensis frequently recognized in primary peripheral blood mononuclear cell responses from sensitized individuals. Mol. Med.9, 209–219 (2003).
  • Iwai LK, Yoshida M, Sadahiro A et al. T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals. Clin. Vaccine Immunol.14, 474–476 (2007).
  • Travassos LR, Rodrigues EG, Iwai LK, Taborda CP. Attempts at a peptide vaccine against paracoccidioidomycosis, adjuvant to chemotherapy. Mycopathologia (2007) (In Press).
  • Pinto AR, Puccia R, Diniz SN et al. DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from Paracoccidioides brasiliensis. Vaccine18, 3050–3058 (2000).
  • Marques AF, da Silva MB, Juliano MA, Travassos LR, Taborda CP. Peptide immunization as an adjuvant to chemotherapy in mice challenged intratracheally with virulent yeast cells of Paracoccidioides brasiliensis.Antimicrob. Agents Chemother.50, 2814–2819 (2006).
  • Mattos Grosso D, Almeida SR, Mariano M, Lopes JD. Characterization of gp70 and anti-gp70 monoclonal antibodies in Paracoccidioides brasiliensis pathogenesis. Infect. Immun.71, 6534–6542 (2003).
  • Taborda CP, Nakaie CR, Cilli EM et al. Synthesis and immunological activity of a branched peptide carrying the T-cell epitope of gp43, the major exocellular antigen of Paracoccidioides brasiliensis. Scand. J. Immunol.59, 58–65 (2004).
  • Marschutz MK, Zauner W, Mattner F et al. Improvement of the enzymatic stability of a cytotoxic T-lymphocyte-epitope model peptide for its oral administration. Peptides23, 1727–1733 (2002).

Patent

  • Amaral AC, Bocca AL, Ribeiro A et al. Formulação nanoencapsulada da droga anfotericina B com ácido dimercaptosuccínico em polímero de ácido poli (lático-co-glicólico) para o tratamento de micoses. Patent deposited, Brazil, INPI, PI0700446–0 (2007).

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