Tinidazole: from protozoa to Helicobacter pylori – the past, present and future of a nitroimidazole with peculiarities

References

• Crowell AL, Sanders-Lewis KA, Secor WE. In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis. Antimicrob. Agents Chemother. 47, 1407–1409 (2003).
   PubMed Web of Science ®Google Scholar
• •An important study which compares the in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates from patients clinically resistant to metronidazole.
   Google Scholar
• Jokipii AMM, Jokipii L. Comparative evaluation of two dosages of tinidazole in the treatment of giardiasis. Am. J. Trap. Med Hyg 27, 758–761 (1978).
   Google Scholar
• Masry NAE, Farid Z, Miner F. Treatment of giardiasis with tinidazole. Am. J. Trap. Med Hyg 27, 201–202 (1978).
   Google Scholar
• Appelbaum PC, Chatterton SA. Susceptibility of anaerobic bacteria to ten antimicrobial agents. Antimicrob. Agents Chemother 14, 371–376 (1978).
   PubMed Web of Science ®Google Scholar
• Blomquist C, Gnarpe H. Anaerobic bacteria in postoperative infections: susceptibility to metronidazole and its analogs. Drugs Exp. Clin. Res. 5, 5–9 (1979).
   Google Scholar
• Dornbusch K, Nord CE. In vitro effect of metronidazole and tinidazole on anaerobic bacteria. Med Microbial Immunal 160, 265–267 (1974).
   PubMed Web of Science ®Google Scholar
• Dublanchet A, Durieux R. Sensibilite comparee in vitro de quelques bacteries aerobies a trois derives des 5-nitro-imidazoles: le metronidazole, Fornidazole et le tinidazole. Ann. Microbial (Paris) 131A, 45–59 (1980).
   Google Scholar
• Malfertheiner P. Compliance, adverse events and antibiotic resistance in Helicobacter pylori treatment. Scand J. Gastroenterol 2,34–37 (1993).
   Google Scholar
• Moayyedi P, Chalmers DM, Axon AT Patient factors that predict failure of omeprazole, darythromycin, and tinidazole to eradicate Helicobacter pylori. J. Gastroenterol 32,24–27 (1997).
   Web of Science ®Google Scholar
• European Study Group. Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori. European Study Group on antibiotic susceptibility of Helicobacter pylori. Eur. J. Clin. Microbial Infect. Dis. 11,777-781(1992). it Packard RS. Tinidazole: a review of clinical experience in anaerobic infections.
   Google Scholar
• J. Antimicrob. Chemother. 10(Suppl. A), 65–78 (1982).
   Google Scholar
• Vàrhegyi MT Results of a field study with the trichomonacide Simplotan. Therapiewoche 23,273 (1973).
   Google Scholar
• Swarz H. International experience with a new single 2-g dose of tinidazole. Curr. Med Res. Opin. 2,181–186 (1974).
   PubMedGoogle Scholar
• Coulter JR, Turner JV. Tinidazole is mutagenic in a Salmonella ophimurium assay. Mutation Research 57,97–101 (1978).
   PubMedGoogle Scholar
• Rees PH, McGlashan HE, Mwega V Single-dose treatment of vaginal trichomoniasis with tinidazole. E. Afi: Med J. 51,782–785 (1974).
   PubMedGoogle Scholar
• Mati JKG, Fallace RJ. The treatment of trichomononal vaginitis using a single dose of tinidazole by mouth. E. Afi: Med J. 51, 883–888 (1974).
   PubMed Web of Science ®Google Scholar
• Ongom VL, Wanboka JW, Odong EAT, et al. A single oral dose treatment of Trichomonas vaginalis infection with tinidazole in Uganda. E. Afi: Med J. 51, 878–882 (1974).
   PubMed Web of Science ®Google Scholar
• Ali SE. Clinical evaluation of a single dose of tinidazole in trichomoniasis. Curr. The,: Res. 18,669–672 (1975).
   Google Scholar
• Lyng J, Christensen J. A double-blind study of the value of treatment with a single dose tinidazole of partners to females with trichomoniasis. Acta Obstet. Gynecol Scand. 60,199-201 (1981).
   Google Scholar
• Bloch B, Smyth E. The treatment of Trichomonas vaginalis vaginitis. S. Afi: Med. J. 23,455–457 (1985).
   Google Scholar
• Begum SF, Ali SE, Ali S. Short-course nitroimidazole in the treatment of vaginal trichomoniasis. Curr. The,: Res. 28, 922–926 (1980).
   Google Scholar
• O-Prasertsawat P, Jetsawangsri T Split-dose metronidazole or single dose tinidazole for the treatment of vaginal trichomoniasis. Sex. Trans. Dis. 295–297 (1992).
   PubMed Web of Science ®Google Scholar
• Sobel JD, Nyirjesy P, Brown W. Tinidazole therapy for metronidazole-resistant vaginal trichomoniasis. Clin. Infect. Dis. 33, 1341–1346 (2001).
   PubMed Web of Science ®Google Scholar
• Hager WD. Treatment of metronidazole-resistant Thrichomonas vaginalis with tinidazole: case reports of three patients. Sex. Transm. Dis. 31,343–345 (2004).
   PubMed Web of Science ®Google Scholar
• Narcisi EM, Secor WE. In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. Antimicrob. Agents Chemother. 40,1121–1125 (1996).
   Web of Science ®Google Scholar
• Ekgren J, Norling BK, Degre M. Comparison of tinidazole given as a single dose on 2 consecutive days for the treatment of nonspecific bacterial vaginosis. Gynecol. Obstet. Invest. 26, 313–317 (1988).
   PubMed Web of Science ®Google Scholar
• Carmona O, Silva H, Acosta H. Vaginitis due to Gardnerella vaginalis treatment with tinidazole. Curr. Ther. Res. 33, 898–904 (1983).
   Web of Science ®Google Scholar
• Milani M, Barcellona E, Agnello A. Efficacy of the combination of 2 g oral tinidazole and acidic buffering vaginal gel in comparison with vaginal dindamycin alone in bacterial vaginosis: a randomized, investigator-blind controlled trial. Eur. J. Obstet. Gynecol Rep rod. Biol. 109,67–71 (2003).
   PubMed Web of Science ®Google Scholar
• Jokipii AMM, Jokipii L. Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects, and drug absorption and elimination. J. Infect. Dis. 140,984–988 (1979).
   PubMed Web of Science ®Google Scholar
• Speelman P. Single-dose tinidazole for the treatment of giardiasis. Antimicrob. Agents Chemother. 27,227–229 (1985).
   PubMed Web of Science ®Google Scholar
• Levi GC, De Avila CA, Neto VA. Efficacy of various drugs for treatment of giardiasis. Am. J. Trap. Med. Hyg. 26,564–565 (1977).
   Google Scholar
• Escobedo AA, Nunez FA, Moreira I, et al. Comparison of chloroquine, albendazole and tinidazole in the treatment of children with giardiasis. Ann. Trap. Med. Parasitol 97,367–371 (2003).
   PubMed Web of Science ®Google Scholar
• Pengsaa K, Limkitticul K, Pojjaroen-anant C, et al. Single-dose therapy for giardiasis in school-age children. Southeast Asian J. Trap. Med. Public Health 33,711–717 (2002).
   PubMedGoogle Scholar
• Bakshi JS, Ghiara JM, Nanivadekar AS. How does tinidazole compare with metronidazole? Drugs 15,33–42 (1978).
   PubMed Web of Science ®Google Scholar
• •Demonstrates in a very large series of patients with amebiasis the superiority of tinidazole over metronidazole.
   Google Scholar
• Swami B, Lavakusulu D, Devi CS. Tinidazole and metronidazole in the treatment of intestinal amoebiasis. Curr. Med. Res. Opin. 5,152–156 (1977).
   PubMed Web of Science ®Google Scholar
• Misra NB A comparative study of tinidazole and metronidazole as a single daily dose for 3 days in symptomatic intestinal amoebiasis. Drugs 15,19–22 (1978).
   PubMedGoogle Scholar
• Khokhani RC, Garud AD, Deodhar KP, et al. Comparative study of tinidazole and metronidazole in amoebic liver abscess. Curr. Med. Res. Opin. 5,161–163 (1977).
   PubMed Web of Science ®Google Scholar
• Islam N and Hasan K Tinidazole and metronidazole in hepatic amoebiasis. Drugs 15,26–29 (1978).
   PubMed Web of Science ®Google Scholar
• Simjee AE, Gathiram V, Jackson TFGH, et al. A comparative trial of metronidazole vs. tinidazole in the treatment of amoebic liver abscess. S. Afi: Med. J 68,923–924 (1985).
   PubMed Web of Science ®Google Scholar
• Thoren K, Hakansson C, Bergstrom T, et al. Treatment of asymptomatic amebiasis in homosexual men. Sex. Trans. Dis. 19,72–74 (1990).
   Google Scholar
• Hunt PS, Francis JK, Peck G, et al. Tinidazole in the prevention of wound infection after elective colorectal surgery. Med. J Aust. 1, 107–109 (1979).
   Google Scholar
• Persson S, Gnarpe H. Tinidazole as preventive treatment in elective colonic surgery. Scand J. Infect. Dis. 13, 137–140 (1981).
   PubMed Web of Science ®Google Scholar
• Gruner OPN0, Baardsen A, Holter. Combined tinidazole and doxycycline prophylaxis in colorectal surgery. Scand J. Gastroenterol 59,25–28 (1980).
   Google Scholar
• Viddal KO, Semb LS. Tinidazole and doxycycline compared to doxycycline alone as prophylactic antimicrobial agents in elective colorectal surgery. Scand. J. Gastroenterol 58,21–24 (1980).
   Google Scholar
• Ofstad E, Brabrand G, Helsingen N, et al. Tinidazole and doxycycline as antimicrobials in elective colorectal surgery. Scand J. Gastroenterol 59,29–35 (1980).
   Google Scholar
• Giercksky KE, Christiansen E, Berge L, et al. Combined tinidazole and doxycycline short-term chemotherapeutic prophylaxis in gastro-intestinal surgery. Scand. Gastroenterol 59,41–44 (1980).
   Google Scholar
• Hojer H, Broete L, Nystrom O, et al. Systemic prophylaxis in colorectal surgery: a comparison between tinidazole and doxycycline. Scand J. Infect. Dis. 26,75–78 (1981).
   Google Scholar
• No authors listed. The Norwegian Gastro-Intestinal Group (NORGAS). Infectious problems in elective colorectal surgery: a multicenter study. Curr Med. Res. Opin. 11, 149–158 (1988).
   PubMed Web of Science ®Google Scholar
• ••Large study from the Norwegian StudyGroup for Colorectal Surgery that supports the use of combined tinidazole and doxycicline therapy as prophylaxis for patients undergoing colorectal surgery.
   Google Scholar
• Giercksky KE. Prevention of postoperative infections following gastrointestinal operations. Scand. J Gastroenterol 100, 26–30 (1984).
   Google Scholar
• Viitanen J, Tunturi T, Auvinen O, et al. Tinidazole prophylaxis in appendicectomies. Scand. Gastroenterol 19,111–115 (1984).
   PubMed Web of Science ®Google Scholar
• •A randomized controlled study that supports the use of tinidazole in the prophylaxis of septic complications in patients undergoing appendectomy.
   Google Scholar
• Eklund AE, Tunevall TG. Prevention of postoperative wound infection after appendectomy by local application of tinidazole: a double-blind study. World J. Surg 11, 263–266 (1987).
   Google Scholar
• Aron M, Rajeev TP, Gupta NB Antibiotic prophylaxis for transrectal needle biopsy of the prostate: a randomized controlled study. Br J. Ural 85,682–685 (2000).
   Google Scholar
• Karhunen M0, Hallstrom H, Koskela. Single dose of tinidazole in prophylaxis of infections following vaginal surgery. Antimicrob. Chemother. 8,283–290 (1981).
   Google Scholar
• Dhar KK, Dhall GI, Ayyagari A. Single dose tinidazole prophylaxis in vaginal hysterectomy. Int. J. Gynecol Obstet. 42, 117–120 (1993).
   PubMed Web of Science ®Google Scholar
• Janssens D, Peeters N, Snauweart E, et al. Tinidazole in the prevention of postoperative wound infection after hysterectomy. Antimicrob. Chemother. 10,87–94 (1982).
   Google Scholar
• Karhunen M0, Hannelin M, Koskely. Single dose of tinidazole in prophylaxis of infections following hysterectomy. Br. J. Obstet. Gynecol 87,70–72 (1980).
   PubMedGoogle Scholar
• Krohn K. Investigation of the prophylactic effect of tinidazole on the postoperative infection rate of patients undergoing vacuum aspiration. Scand. J. Infect. Dis. 26, 101–103 (1981).
   Google Scholar
• Westrom L, Svensson L, Woelner-Hansen P, et al. A clinical double-blind study on the effect of prophylactically administered single dose tinidazole on the occurrence of endometritis after first trimester legal abortion. Scand J. Infect. Dis. 26,104–109 (1981).
   Google Scholar
• Sweeney G, Watson JD, McGregor IA, et al. Successful prophylaxis with tinidazole of infection after major head and neck surgery for malignant disease. Br. J. Plastic Surgery 37,35–42 (1984).
   PubMedGoogle Scholar
• Friberg D, Lundberg C. Antibiotic prophylaxis in major head and neck surgery when clean-contaminated wounds are established. Scand. J. Infect. Dis. 70, 87–90 (1990).
   Google Scholar
• McGregor IA, Watson JD, Sweeney G, Sleigh JD. Tinidazole in smelly oropharyngeal tumours. Lancet 1, 110 (1982).
   Google Scholar
• Bystedt H, von Konow L, Nord CE. Effect of tinidazole on postoperative complications after surgical removal of impacted mandibular third molars. Scand. J. Infect. Dis. (Suppl. 26), 135–139 (1981).
   Google Scholar
• Mitchell DA. A controlled clinical trial of prophylactic tinidazole for chemoprophylaxis in third molar surgery. Br. Dent. J. 160,284–285 (1986).
   PubMed Web of Science ®Google Scholar
• Happonen R-P, Backstrom A-C, Ylipaavalniemi P. Prophylactic use of phenoxymethylpenicillin and tinidazole in mandibular third molar surgery, a comparative placebo-controlled clinical trial. Br. J. Oral Maxillofac. Surg. 28, 12–15 (1990).
   PubMed Web of Science ®Google Scholar
• Bercy P, Adriaenssen C. Effect of tinidazole on gingival inflammation and subgingival plaque. Curr. Ther. Res. 47, 306–313 (1990).
   Web of Science ®Google Scholar
• Ana JR, Okoisor FE. Tinidazole in acute ulcerative gingivitis. J. Pharm. 7,92–93 (1976).
   Google Scholar
• Lundberg C, Loenroth J, Marklund G, et al. Tinidazole in the treatment of infections of the upper respiratory tract. Scand. J. Infect. Dis. 26,130–134 (1981).
   Google Scholar
• Giamarellau H, Gazis J, Vlachos G, Michalopoulos A, Aravantinos P, Daikos G. Tinidazole in the treatment of surgical and gynecological infections. J. Antimicrob. Chemother. 10(Suppl. A), 129–136 (1982).
   Google Scholar
• Eibach HW Tinidazole for the treatment of anaerobic gynecological infections. J. Antimicrob. Chemother. 10(Suppl. A), 95–98 (1982).
   PubMed Web of Science ®Google Scholar
• Malhotra M, Sharma JB, Batra S, Arora R, Sharma S. Ciprofloxacin-tinidazole combination, fluconazole-azithromycin-secnidazole-kit and doxycyclin-metronidazole combination therapy in syndromic management of pelvic inflammatory disease: a prospective randomized controlled trial. Indian J. Med. Sci. 57,549–555 (2003).
   PubMedGoogle Scholar
• Lagast H, Klastersky J. Anaerobic infections in cancer patients — a retrospective analysis of clindamycin, tinidazole, doxycycline, cefoxitin and lamoxactam. Infection 10,144-148 (1982).
   Google Scholar
• Graham DY, Lew GM, Klein PD, et al. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. A randomized, controlled study. Ann. Intern. Med. 116, 705–708 (1992).
   PubMed Web of Science ®Google Scholar
• McColl K, Murray L, El-Omar E, et al. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl. J. Med. 339,1869–1874 (1998).
   PubMed Web of Science ®Google Scholar
• Parsonnet J, Hansen S, Rodriguez L, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J. Med. 330, 1267–1271 (1994).
   PubMed Web of Science ®Google Scholar
• Labenz J, Leverkus F, Borsch G. Omeprazole plus amoxycillin for cure of Helicobacter pylori infection: factors influencing the treatment success. Scand. J. Gastroenterol. 29,1070-1075 (1994).
   Google Scholar
• The European Helicobacter pylori Study Group. Current European concepts in the management of Helicobacter pylori infection. The Maastricht consensus report. Gut 41,8–13 (1997).
   PubMed Web of Science ®Google Scholar
• •The European Helicobacter pylori Study Group guidelines in the management of Helicobacter pylori infection.
   Google Scholar
• Lind T, Veldhuyzen van Zanten SV, Unge P, et al. Eradication of Helicobacter pylori using 1-week triple therapies combining omeprazole and two antimicrobials: the MACH 1 study. Helicobacter 1,138–144 (1996).
   PubMedGoogle Scholar
• Graham DY, Lew GM, Malaty HM, et al. Factors influencing the eradication of H. pylori with triple therapy. Gastroenterology 102,493–496 (1992).
   PubMed Web of Science ®Google Scholar
• Borody TJ, Cole P, Noonan S, et al. Recurrence of duodenal ulcer and Campylobacter pylori infection after eradication. Med. J. Aust. 151,431–435 (1989).
   PubMed Web of Science ®Google Scholar
• Tursi A, Cammarota G, Montalto M, et al. Low dose omeprazole plus clarithromycin and either tinidazole or amoxicillin for Helicobacter pylori infection. Aliment. Pharmacol. Ther. 10, 285–288 (1996).
   PubMed Web of Science ®Google Scholar
• Graham DY, Borsch GM. The who's and when's of therapy for Helicobacter pylori. Am. J. Gastroenterol. 85, 1552–1555 (1990).
   PubMed Web of Science ®Google Scholar
• Wheeldon TU, Granstrom M, Hoang TT, Phuncarg DC, Nilsson LE, Sorberg M. The importance of the level of metronidazole resistance for the success of Helicobacter pylori eradication. Aliment. Pharmacol Then 19, 1315–1321 (2004).
   Google Scholar
• •Demonstrates that the presence of resistant strains does not preclude the use of nitroimidazoles in the treatment of H. pylori infections.
   Google Scholar