Epigenetic coordination of acute systemic inflammation: potential therapeutic targets

References

• Liu TF, Brown CM, El Gazzar M, et al. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol 2012;92(3):499-507
   Google Scholar
• Daniels R. Surviving the first hours in sepsis: getting the basics right (an intensivist’s perspective). J Antimicrob Chemother 2011;66(Suppl 2):ii11-23
   PubMed Web of Science ®Google Scholar
• Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013;369(9):840-51
   PubMed Web of Science ®Google Scholar
• Williams SC. After Xigris, researchers look to new targets to combat sepsis. Nat Med 2012;18(7):1001
   Google Scholar
• Horsthemke B. Waddington’s epigenetic landscape and post-Darwinian biology. Bioessays 2012;34(8):711-12
   Google Scholar
• Slack JM. Conrad Hal Waddington: the last Renaissance biologist? Nat Rev Genetics 2002;3(11):889-95
   Google Scholar
• Carson WF, Cavassani KA, Dou Y, Kunkel SL. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011;6(3):273-83
   PubMed Web of Science ®Google Scholar
• Osuchowski MF, Craciun F, Weixelbaumer KM, et al. Sepsis chronically in MARS: systemic cytokine responses are always mixed regardless of the outcome, magnitude, or phase of sepsis. J Immunol 2012;189(9):4648-56
   Google Scholar
• Gentile LF, Cuenca AG, Efron PA, et al. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg 2012;72(6):1491-501
   PubMed Web of Science ®Google Scholar
• Xiao W, Mindrinos MN, Seok J, et al. A genomic storm in critically injured humans. J Exp Med 2011;208(13):2581-90
   PubMed Web of Science ®Google Scholar
• Boomer JS, Green JM, Hotchkiss RS. The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer? Virulence 2014;5(1):45-56
   PubMed Web of Science ®Google Scholar
• Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007;447(7147):972-8
   PubMed Web of Science ®Google Scholar
• Megee PC, Morgan BA, Mittman BA, Smith MM. Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation. Science 1990;247(4944):841-5
   Google Scholar
• El Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem 2010;285(2):1259-71
   Google Scholar
• Natoli G. Tuning up inflammation: how DNA sequence and chromatin organization control the induction of inflammatory genes by NF-kappaB. FEBS lett 2006;580(12):2843-9
   Google Scholar
• Smale ST. Selective transcription in response to an inflammatory stimulus. Cell 2010;140(6):833-44
   Google Scholar
• McCall CE, El Gazzar M, Liu T, et al. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol 2011;90(3):439-46
   PubMed Web of Science ®Google Scholar
• Yan Q, Carmody RJ, Qu Z, et al. Nuclear factor-kappaB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proc Natl Acad Sci USA 2012;109(35):14140-5
   Google Scholar
• Chen X, El Gazzar M, Yoza BK, McCall CE. The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem 2009;284(41):27857-65
   Web of Science ®Google Scholar
• Wysocka M, Montaner LJ, Karp CL. Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis. J Immunol 2005;174(11):7398-402
   Google Scholar
• Unsinger J, Kazama H, McDonough JS, et al. Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol 2010;184(12):6766-72
   Google Scholar
• Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008;57(12):3239-46
   PubMed Web of Science ®Google Scholar
• Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010;72:219-46
   PubMed Web of Science ®Google Scholar
• Gillum MP, Kotas ME, Erion DM, et al. SirT1 regulates adipose tissue inflammation. Diabetes 2011;60(12):3235-45
   PubMed Web of Science ®Google Scholar
• Infantino V, Convertini P, Cucci L, et al. The mitochondrial citrate carrier: a new player in inflammation. Biochem J 2011;438(3):433-6
   Google Scholar
• O’Neill LA. A critical role for citrate metabolism in LPS signalling. Biochem J 2011;438(3):e5-6
   PubMedGoogle Scholar
• Barke RA, Brady PS, Brady LJ. The Ca2+ second messenger system and interleukin-1-alpha modulation of hepatic gene transcription and mitochondrial fat oxidation. Surgery 1991;110(2):285-94
   Google Scholar
• Liu TF, Vachharajani VT, Yoza BK, McCall CE. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem 2012;287(31):25758-69
   PubMed Web of Science ®Google Scholar
• Odegaard JI, Chawla A. The immune system as a sensor of the metabolic state. Immunity 2013;38(4):644-54
   Google Scholar
• Jones RG, Thompson CB. Revving the engine: signal transduction fuels T cell activation. Immunity 2007;27(2):173-8
   PubMed Web of Science ®Google Scholar
• Wellen KE, Thompson CB. Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell 2010;40(2):323-32
   PubMed Web of Science ®Google Scholar
• Pearce EL. Metabolism in T cell activation and differentiation. Curr Opin Immunol 2010;22(3):314-20
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324(5930):1029-33
   PubMed Web of Science ®Google Scholar
• Peyssonnaux C, Datta V, Cramer T, et al. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 2005;115(7):1806-15
   PubMed Web of Science ®Google Scholar
• Rius J, Guma M, Schachtrup C, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008;453(7196):807-11
   PubMed Web of Science ®Google Scholar
• Kim I, Rodriguez-Enriquez S, Lemasters JJ. Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 2007;462(2):245-53
   PubMed Web of Science ®Google Scholar
• Singer M. Cellular dysfunction in sepsis. Clin Chest Med 2008;29(4):655-60. viii-ix
   Google Scholar
• Bhatt AP, Jacobs SR, Freemerman AJ, et al. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proc Natl Acad Sci USA 2012;109(29):11818-23
   PubMed Web of Science ®Google Scholar
• Kubes P, Suzuki M, Granger DN. Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes. Am J Physiol 1990;258(1 Pt 1):G158-63
   Google Scholar
• Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88(11):4651-5
   PubMed Web of Science ®Google Scholar
• Jung U, Norman KE, Scharffetter-Kochanek K, et al. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J Clin Invest 1998;102(8):1526-33
   Google Scholar
• Davies PF, Manduchi E, Stoeckert CJ, et al. Emerging topic: flow-related epigenetic regulation of endothelial phenotype through DNA methylation. Vascul Pharmacol 2014. [Epub ahead of print]
   Google Scholar
• Xu Y. Transcriptional regulation of endothelial dysfunction in atherosclerosis: an epigenetic perspective. J Biomed Res 2014;28(1):47-52
   Google Scholar
• Zhou J, Li YS, Wang KC, Chien S. Epigenetic mechanism in regulation of endothelial function by disturbed flow: induction of DNA hypermethylation by DNMT1. Cell Mol Bioeng 2014;7(2):218-24
   PubMed Web of Science ®Google Scholar
• Chen D, Fang F, Yang Y, et al. Brahma-related gene 1 (Brg1) epigenetically regulates CAM activation during hypoxic pulmonary hypertension. Cardiovasc Res 2013;100(3):363-73
   Google Scholar
• Vachharajani V, Cunningham C, Yoza B, et al. Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity 2012;20(3):498-504
   Google Scholar
• Vachharajani V, Russell JM, Scott KL, et al. Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain. Microcirculation 2005;12(2):183-94
   Web of Science ®Google Scholar
• Vachharajani V, Vital S, Russell J, Granger DN. Hypertonic saline and the cerebral microcirculation in obese septic mice. Microcirculation 2007;14(3):223-31
   Web of Science ®Google Scholar
• Vachharajani V, Vital S, Russell J, et al. Glucocorticoids inhibit the cerebral microvascular dysfunction associated with sepsis in obese mice. Microcirculation 2006;13(6):477-87
   Web of Science ®Google Scholar
• Vachharajani V, Wang SW, Mishra N, et al. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation 2010;17(6):407-16
   PubMed Web of Science ®Google Scholar
• Vachharajani VT, Fu Liu T, Brown CM, et al. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. Journal of leukocyte biology, Jul 7 2014.
   Google Scholar
• Biswas SK, Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 2009;30(10):475-87
   PubMed Web of Science ®Google Scholar
• Kox M, de Kleijn S, Pompe JC, et al. Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia. Crit Care Med 2011;39(8):1866-70
   PubMed Web of Science ®Google Scholar
• Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000;403(6771):795-800
   PubMed Web of Science ®Google Scholar
• Sinclair DA, Guarente L. Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol 2014;54:363-80
   PubMed Web of Science ®Google Scholar
• Liu TF, Yoza BK, El Gazzar M, et al. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem 2011;286(11):9856-64
   PubMed Web of Science ®Google Scholar
• Yeung F, Hoberg JE, Ramsey CS, et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004;23(12):2369-80
   PubMed Web of Science ®Google Scholar
• Vaquero A, Scher M, Lee D, et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol cell 2004;16(1):93-105
   PubMed Web of Science ®Google Scholar