Vitamin D: a new player in kidney transplantation?

References

• Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81
   PubMed Web of Science ®Google Scholar
• Komaba H, Fukagawa M. FGF23-parathyroid interaction: implications in chronic kidney disease. Kidney Int 2010;77:292-8
   PubMed Web of Science ®Google Scholar
• Haussler MR, Whitfield GK, Kaneko I, et al. The role of Vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev Endocr Metab Disord 2012;13(1):57-69
   PubMed Web of Science ®Google Scholar
• Kovesdy CP, Quarles LD. Fibroblast growth factor-23: what we know, what we don’t know, and what we need to know. Nephrol Dial Transplant 2013;28(9):2228-36
   PubMedGoogle Scholar
• Ravani P, Malberti F, Tripepi G, et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int 2008;75:88-95
   PubMedGoogle Scholar
• Skversky AL, Kumar J, Abramowitz MK, et al. Association of glucocorticoid use and low 25-hydroxyvitamin D levels: results from the National Health and Nutrition Examination Survey (NHANES): 2001-2006. J Clin Endocrinol Metab 2011;96(12):3838-45
   PubMed Web of Science ®Google Scholar
• Stoff B, Salisbury C, Parker D, O’Reilly Zwald F. Dermatopathology of skin cancer in solid organ transplant recipients. Transplant Rev (Orlando) 2010;24(4):172-89
   PubMedGoogle Scholar
• Stavroulopoulos A, Cassidy AM, Porter CJ, et al. Status in Renal Transplant Recipients. Am J Transplant 2007;7(11):2546-52
   PubMedGoogle Scholar
• Ewers B, Gasbjerg A, Moelgaard C Frederiksen AM, Marckmann P. Vitamin D status in kidney transplant patients: need for intensified routine supplementation. Am J Clin Nutr 2008;87:431-7
   PubMedGoogle Scholar
• Obi Y, Hamano T, Ichimaru N, et al. Vitamin D deficiency predicts decline in kidney allograft function: a prospective cohort study. J Clin Endocrinol Metab 2014;99(2):527-35
   PubMedGoogle Scholar
• Beique LC, Kline GA, Dalton B, et al. Predicting deficiency of Vitamin D in renal transplant recipients in northern climates. Transplantation 2013;95(12):1479-84
   PubMedGoogle Scholar
• Lee JR, Dadhania D, August P, et al. Circulating Levels of 25-HydroxyVitamin D and Acute Cellular Rejection in Kidney Allograft Recipients. Transplantation 2014. [Epub ahead of print]
   Google Scholar
• Mazzaferro S, Pasquali M, Pugliese F, et al. Distinct impact of Vitamin D insufficiency on calcitriol levels in chronic renal failure and renal transplant patients: a role for FGF23. J Nephrol 2012;25(6):1108-18
   PubMedGoogle Scholar
• Bienaimé F, Girard D, Anglicheau D, et al. Vitamin D status and outcomes after renal transplantation. J Am Soc Nephrol 2013;24(5):831-41
   PubMed Web of Science ®Google Scholar
• Marcén R, Jimenez S, Fernández-Rodriguez A, et al. Are low levels of 25-hydroxyvitamin D a risk factor for cardiovascular diseases or malignancies in renal transplantation? Nephrol Dial Transplant 2012;27(Suppl 4):iv47-52
   PubMedGoogle Scholar
• Ponticelli C. Ischaemia-reperfusion injury: a major protagonist in kidney transplantation. Nephrol Dial Transplant 2014;29(6):1134-40
   PubMed Web of Science ®Google Scholar
• Sezgin G, Oztürk G, Guney S, et al. Protective effect of melatonin and 1,25-dihydroxyvitamin D3 on renal ischemia-reperfusion injury in rats. Ren Fail 2013;35:374-9
   PubMed Web of Science ®Google Scholar
• Lee JW, Kim SC, Ko YS, et al. Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κB pathway in ischemia/reperfusion-induced acute kidney injury. Biochem Biophys Res Commun 2014;444(2):121-7
   PubMed Web of Science ®Google Scholar
• Chen Y, Liu W, Sun T, et al. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol 2013;190(7):3687-95
   PubMed Web of Science ®Google Scholar
• Gauzzi MC, Purificato C, Donato K, et al. Suppressive effect of 1alpha, 25-dihydroxyvitamin D3 on type I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis. J Immunol 2005;174(1):270-6
   PubMedGoogle Scholar
• Wahono CS, Rusmini H, Soelistyoningsih D, et al. Effects of 1,25(OH)2D3 in immune response regulation of systemic lupus erithematosus (SLE) patient with hypoVitamin D. Int J Clin Exp Med 2014;7(1):22-31
   PubMedGoogle Scholar
• Heine G, Niesner U, Chang H-D, et al. 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Eur J Immunol 2008;38:2210-28
   PubMed Web of Science ®Google Scholar
• Penna G, Roncari A, Amuchastegui S, et al. Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T-cells by 1, 25-dihydroxyvitamin D3. Blood 2005;106(10):3490-7
   PubMed Web of Science ®Google Scholar
• Boonstra A, Barrat FJ, Crain C, et al. 1alpha, 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T-cells to enhance the development of Th2 cells. J Immunol 2001;167(9):4974-80
   PubMed Web of Science ®Google Scholar
• Staeva-Vieira TP, Freedman LP. 1, 25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T-cells. J Immunol 2002;168(3):1181-9
   PubMedGoogle Scholar
• Linker-Israeli M, Elstner E, Klinenberg JR, et al. Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC. Clin Immunol 2001;99:82-93
   PubMed Web of Science ®Google Scholar
• Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007;179:1634-47
   PubMed Web of Science ®Google Scholar
• Schleithoff SS, Zittermann A, Tenderich G, et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2006;83:754-9
   PubMed Web of Science ®Google Scholar
• Romagnani P, Crescioli C. CXCL10: a candidate biomarker intransplantation. Clin Chim Acta 2012;413:1364-73
   PubMedGoogle Scholar
• Cockwell P. Chemoattraction of T-cells expressing CCR5, CXCR3and CX3CR1 by proximal tubular epithelial cell chemokines. Nephrol Dial Transplant 2002;17:734-44
   PubMedGoogle Scholar
• Hullett DA, Cantorna MT, Redaelli C, et al. Prolongation of allograft survival by 1,25-dihydroxyvitamin Transplantation. 1998;66:824-8
   Google Scholar
• Adorini L, Penna G, Giarratana N, Uskokovi M. Tolerogenic dendritic cells induced by Vitamin D receptor ligands enhance regulatory T-cells inhibiting allograft rejection and autoimmune diseases. J Cell Biochem 2003;88:227-33
   PubMed Web of Science ®Google Scholar
• Sagrinati C, Sottili M, Mazzinghi B, et al. Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells. Transpl Int 2010;23(9):914-23
   PubMedGoogle Scholar
• Ito I, Waku T, Aoki M, et al. A nonclassical Vitamin D receptor pathway suppresses renal fibrosis. J Clin Invest 2013;123(11):4579-94
   PubMed Web of Science ®Google Scholar
• Lowery EM, Bemiss B, Cascino T, et al. Low Vitamin D levels are associated with increased rejection and infections after lung transplantation. J Heart Lung Transplant 2012;31(7):700-7
   PubMedGoogle Scholar
• Verleden SE, Vos R, Geenens R, et al. Vitamin D deficiency in lung transplant patients: is it important? Transplantation 2012;93(2):224-9
   PubMedGoogle Scholar
• Briffa NK, Keogh AM, Sambrook PN, Eisman JA. Reduction of immunosuppressant therapy requirement in heart transplantation by calcitriol. Transplantation 2003;75(12):2133-4
   PubMed Web of Science ®Google Scholar
• Vu D, Sakharkar P, Tellez-Corrales E, et al. Association of Vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients. Mol Biol Rep 2013;40(2):933-9
   PubMedGoogle Scholar
• Kim H, Kang SW, Yoo TH, et al. The impact of pretransplant 25-hydroxy Vitamin D deficiency on subsequent graft function: an observational study. BMC Nephrol 2012;13:22
   PubMedGoogle Scholar
• Lee DR, Kong JM, Cho KI, Chan L. Impact of Vitamin D on proteinuria, insulin resistance, and cardiovascular parameters in kidney transplant recipients. Transplant Proc 2011;43(10):3723-9
   PubMedGoogle Scholar
• Ma MK, Mok MM, Yung S, et al. High prevalence of Vitamin D insufficiency in southern Chinese renal transplant recipients. Ren Fail 2012;34(8):980-4
   PubMed Web of Science ®Google Scholar
• Wolf M, Molnar MZ, Amaral AP, et al. Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality. J Am Soc Nephrol 2011;22(5):956-66
   PubMedGoogle Scholar
• Courbebaisse M, Xu-Dubois YC, Thervet E, et al. Cholecalciferol supplementation does not protect against renal allograft structural and functional deterioration: a retrospective study. Transplantation 2011;91(2):207-12
   PubMedGoogle Scholar
• Sezer S, Uyar M, Arat Z, et al. Potential effects of 1,25-dihydroxyvitamin D3 in renal transplant recipients. Transplant Proc 2005;37(7):3109-11
   PubMedGoogle Scholar
• O’Herrin JK, Hullett DA, Heisey DM, et al. A retrospective evaluation of 1,25-dihydroxyvitamin D(3) and its potential effects on renal allograft function. Am J Nephrol 2002;22(5-6):515-20
   PubMedGoogle Scholar
• Benaboud S, Urien S, Thervet E, et al. Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approach. Eur J Clin Pharmacol 2013;69(3):499-506
   PubMedGoogle Scholar
• Ojo AO. Cardiovascular complications after renal transplantation and their prevention. Transplantation 2006;82(5):603-11
   PubMed Web of Science ®Google Scholar
• Nemerovski CW, Dorsch MP, Simpson RU, et al. Vitamin D and cardiovascular disease. Pharmacotherapy 2009;29(6):691-708
   PubMedGoogle Scholar
• Baia LC, Humalda JK, Vervloet MG, et al. Fibroblast growth factor 23 and cardiovascular mortality after kidney transplantation. Clin J Am Soc Nephrol 2013;8(11):1968-78
   PubMedGoogle Scholar
• Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-Hydroxy Vitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008;168:1174-80
   PubMed Web of Science ®Google Scholar
• Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008;117:503-11
   PubMed Web of Science ®Google Scholar
• Pilz S, Marz W, Wellnitz B, et al. Association of Vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab 2008;93:3927-35
   PubMed Web of Science ®Google Scholar
• Zittermann A, Kuhn J, Dreier J, et al. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J 2013;34(18):1358-64
   PubMed Web of Science ®Google Scholar
• Anderson JL, Vanwoerkom RC, Horne BD, et al. Parathyroid hormone, Vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors? Am Heart J 2011;162(2):331-9
   PubMed Web of Science ®Google Scholar
• Krause R, Buhring M, Hopfenmuller W, et al. Ultraviolet B and blood pressure. Lancet 1998;352:709-10
   PubMed Web of Science ®Google Scholar
• Gulseth HL, Gjelstad IM, Birkeland KI, Drevon CA. Vitamin D and the metabolic syndrome. Curr Vasc Pharmacol 2013;11(6):968-84
   PubMedGoogle Scholar
• Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of Vitamin D that is effective. Am J Clin Nutr 2007;85(3):649-50
   PubMed Web of Science ®Google Scholar
• Wahl P, Wolf M. FGF23 in chronic kidney disease. Adv Exp Med Biol 2012;728:107-25
   PubMedGoogle Scholar
• Kovesdy CP, Quarles LD. The role of fibroblast growth factor-23 in cardiorenal syndrome. Nephron Clin Pract 2013;123(3-4):194-201
   PubMedGoogle Scholar
• Navarro-González JF, Donate-Correa J, Muros de Fuentes M, et al. Reduced Klotho is associated with the presence and severity of coronary artery disease. Heart 2014;100(1):34-40
   PubMed Web of Science ®Google Scholar
• Krajisnik T, Olauson H, Mirza MA, et al. Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int 2010;78(10):1024-32
   PubMed Web of Science ®Google Scholar
• Akimoto T, Kimura T, Watanabe Y, et al. The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein. Transplant Proc 2013;45:134-6
   PubMed Web of Science ®Google Scholar
• Matias PJ, Jorge C, Ferreira C, et al. Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters. Clin J Am Soc Nephrol 2010;5(5):905-11
   PubMed Web of Science ®Google Scholar
• Chitalia N, Ismail T, Tooth L, et al. Impact of Vitamin d supplementation on arterial vasomotion, stiffness and endothelial biomarkers in chronic kidney disease patients. PLoS One 2014;9(3):e91363
   Google Scholar
• Agewall S. Is impaired flow-mediated dilatation of the brachial artery a cardiovascular risk factor? Curr Vasc Pharmacol 2003;1(2):107-9
   PubMedGoogle Scholar
• Mose FH, Vase H, Larsen T, et al. Cardiovascular effects of cholecalciferol treatment in dialysis patients--a randomized controlled trial. BMC Nephrol 2014;15(1):50
   PubMedGoogle Scholar
• Kulshrestha S, Ojo AO, Luan FL. Metabolic syndrome, Vitamin D deficiency and hypoadiponectinemia among nondiabetic patients early after kidney transplantation. Am J Nephrol 2013;37(5):399-404
   PubMedGoogle Scholar
• Zheng Y, Zhu J, Zhou M, et al. Meta-analysis of long-term Vitamin D supplementation on overall mortality. PLoS One 2013;8(12):e82109
   PubMed Web of Science ®Google Scholar
• Gombart AF. The Vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol 2009;4(9):1151-65
   PubMed Web of Science ®Google Scholar
• Antal AS, Dombrowski Y, Koglin S, et al. Impact of Vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol 2011;3(1):18-22
   PubMedGoogle Scholar
• Yamshchikov AV, Desai NS, Blumberg HM, et al. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract 2009;15(5):438-49
   PubMed Web of Science ®Google Scholar
• Khoo AL, Chai L, Koenen H, et al. Translating the role of Vitamin D3 in infectious diseases. Crit Rev Microbiol 2012;38(2):122-35
   PubMed Web of Science ®Google Scholar
• Ramanathan B, Davis EG, Ross CR, Blecha E. Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect 2002;4:361-72
   PubMed Web of Science ®Google Scholar
• Wang TT, Nestel FP, Bourdeau V, et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immun 2004;173:2909-12
   PubMed Web of Science ®Google Scholar
• Cantorna MT, Hullett DA, Redaelli C, et al. 1,25-Dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density. Transplantation 1998;66(7):828-31
   PubMedGoogle Scholar
• Cholongitas E, Theocharidou E, Goulis J, et al. Review article: the extra-skeletal effects of Vitamin D in chronic hepatitis C infection. Aliment Pharmacol Ther 2012;35(6):634-46
   PubMedGoogle Scholar
• Rech MA, Fleming JN, Moore CL. 25-hydroxyvitamin d deficiency and opportunistic viral infections after kidney transplant. Exp Clin Transplant 2014;12(2):95-100
   PubMedGoogle Scholar
• Bommineni YR, Pham GH, Sunkara LT, et al. Immune regulatory activities of fowlicidin-1, a cathelicidin host defense peptide. Mol Immunol 2014;59(1):55-63
   PubMedGoogle Scholar
• Aloia JF, Li-Ng M. Re:epidemic influenza and Vitamin D. Epidemiol Infect 2007;135:1095-6
   PubMedGoogle Scholar
• Pilz S, Tomaschitz A, Obermayer-Pietsch B, et al. Epidemiology of Vitamin D insufficiency and cancer mortality. Anticancer Res 2009;29(9):3699-704
   PubMed Web of Science ®Google Scholar
• Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of Vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006;98:451-9
   PubMed Web of Science ®Google Scholar
• Mohr SB, Gorham ED, Kim J, et al. Meta-analysis of Vitamin D sufficiency for improving survival of patients with breast cancer. Anticancer Res 2014;34(3):1163-6
   PubMed Web of Science ®Google Scholar
• Gorham ED, Garland CF, Garland FC, et al. Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 2005;97:179-94
   PubMed Web of Science ®Google Scholar
• Wactawski-Wende J, Kotchen JM, Anderson GL, et al. Calcium plus Vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006;354:684-96
   PubMed Web of Science ®Google Scholar
• Chang ET, Smedby KE, Hjalgrim H, et al. Family history of hematopoietic malignancy and risk of lymphoma. J Natl Cancer Inst 2005;97:1466-74
   PubMed Web of Science ®Google Scholar
• Berwick M, Armstrong BK, Ben-Porat L, et al. Sun exposure and mortality from melanoma. J Natl Cancer Inst 2005;97:195-9
   PubMed Web of Science ®Google Scholar
• Ducloux D, Courivaud C, Bamoulid J, et al. Pretransplant serum Vitamin D levels and risk of cancer after renal transplantation. Transplantation 2008;85(12):1755-9
   PubMedGoogle Scholar