Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment

References

• Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001;69(3):89-95
   PubMed Web of Science ®Google Scholar
• Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med 2011;12(2):165-73
   PubMed Web of Science ®Google Scholar
• Marshall JC, Reinhart K; International Sepsis F. Biomarkers of sepsis. Crit Care Med 2009;37(7):2290-8
   PubMed Web of Science ®Google Scholar
• Puntmann VO. How-to guide on biomarkers: biomarker definitions, validation and applications with examples from cardiovascular disease. Postgrad Med J 2009;85(1008):538-45
   PubMed Web of Science ®Google Scholar
• Dupuy AM, Philippart F, Pean Y, et al. Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections. Ann Intensive Care 2013;3(1):22
   PubMed Web of Science ®Google Scholar
• Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003;31(4):1250-6
   PubMed Web of Science ®Google Scholar
• Vincent JL, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009;302(21):2323-9
   PubMed Web of Science ®Google Scholar
• Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34(6):1589-96
   PubMed Web of Science ®Google Scholar
• Pierrakos C, Vincent JL. Sepsis biomarkers: a review. Crit Care 2010;14(1):R15
   PubMed Web of Science ®Google Scholar
• Jiyong J, Tiancha H, Wei C, Huahao S. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 2009;35(4):587-95
   PubMedGoogle Scholar
• Wojno ED, Hunter CA. New directions in the basic and translational biology of interleukin-27. Trends Immunol 2012;33(2):91-7
   PubMed Web of Science ®Google Scholar
• Bosmann M, Ward PA. Modulation of inflammation by interleukin-27. J Leukoc Biol 2013;94(6):1159-65
   PubMed Web of Science ®Google Scholar
• Pflanz S, Timans JC, Cheung J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002;16(6):779-90
   PubMed Web of Science ®Google Scholar
• Villarino AV, Larkin J 3rd, Saris CJ, et al. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. J Immunol 2005;174(12):7684-91
   PubMedGoogle Scholar
• Wirtz S, Tubbe I, Galle PR, et al. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med 2006;203(8):1875-81
   PubMed Web of Science ®Google Scholar
• Wong HR, Cvijanovich NZ, Hall M, et al. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care 2012;16(5):R213
   PubMed Web of Science ®Google Scholar
• Wong HR, Lindsell CJ, Lahni P, et al. Interleukin 27 as a sepsis diagnostic biomarker in critically ill adults. Shock 2013;40(5):382-6
   PubMed Web of Science ®Google Scholar
• Wong HR, Liu KD, Kangelaris KN, et al. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care 2014. [Epub ahead of print]
   Google Scholar
• Krumbiegel D, Anthogalidis-Voss C, Markus H, et al. Enhanced expression of IL-27 mRNA in human newborns. Pediatr Allergy Immuniol 2008;19(6):513-16
   PubMed Web of Science ®Google Scholar
• Eugen-Olsen J, Gustafson P, Sidenius N, et al. The serum level of soluble urokinase receptor is elevated in tuberculosis patients and predicts mortality during treatment: a community study from Guinea-Bissau. Int J Tuberc Lung Dis 2002;6(8):686-92
   PubMed Web of Science ®Google Scholar
• Ostergaard C, Benfield T, Lundgren JD, Eugen-Olsen J. Soluble urokinase receptor is elevated in cerebrospinal fluid from patients with purulent meningitis and is associated with fatal outcome. Scand J Infect Dis 2004;36(1):14-19
   PubMed Web of Science ®Google Scholar
• Donadello K, Scolletta S, Taccone FS, et al. Soluble urokinase-type plasminogen activator receptor as a prognostic biomarker in critically ill patients. J Crit Care 2014;29(1):144-9
   PubMed Web of Science ®Google Scholar
• Wittenhagen P, Kronborg G, Weis N, et al. The plasma level of soluble urokinase receptor is elevated in patients with Streptococcus pneumoniae bacteraemia and predicts mortality. Clin Microbiol Infect 2004;10(5):409-15
   PubMed Web of Science ®Google Scholar
• Molkanen T, Ruotsalainen E, Thorball CW, Jarvinen A. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis 2011;30(11):1417-24
   PubMed Web of Science ®Google Scholar
• Huttunen R, Syrjanen J, Vuento R, et al. Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study. J Intern Med 2011;270(1):32-40
   PubMed Web of Science ®Google Scholar
• Hoffmann JJ. Neutrophil CD64 as a sepsis biomarker. Biochem Med 2011;21(3):282-90
   PubMed Web of Science ®Google Scholar
• Hoffmann JJ. Neutrophil CD64: a diagnostic marker for infection and sepsis. Clin Chem Lab Med 2009;47(8):903-16
   PubMed Web of Science ®Google Scholar
• Cid J, Aguinaco R, Sanchez R, et al. Neutrophil CD64 expression as marker of bacterial infection: a systematic review and meta-analysis. J Infect 2010;60(5):313-19
   PubMed Web of Science ®Google Scholar
• Livaditi O, Kotanidou A, Psarra A, et al. Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis. Cytokine 2006;36(5-6):283-90
   PubMed Web of Science ®Google Scholar
• Ulla M, Pizzolato E, Lucchiari M, et al. Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care 2013;17(4):R168
   PubMed Web of Science ®Google Scholar
• Romualdo LG, Torrella PE, Gonzalez MV, et al. Diagnostic accuracy of presepsin (soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the Emergency Department. Clin Biochem 2014;47(7-8):505-8
   PubMed Web of Science ®Google Scholar
• Masson S, Caironi P, Spanuth E, et al. Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care 2014;18(1):R6
   PubMed Web of Science ®Google Scholar
• Endo S, Suzuki Y, Takahashi G, et al. Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis: a multicenter prospective study. J Infect Chemother 2014;20(1):30-4
   PubMed Web of Science ®Google Scholar
• Rhodes A, Wort SJ, Thomas H, et al. Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care 2006;10(2):R60
   PubMed Web of Science ®Google Scholar
• Saukkonen K, Lakkisto P, Pettila V, et al. Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock. Clin Chem 2008;54(6):1000-7
   PubMedGoogle Scholar
• Dwivedi DJ, Toltl LJ, Swystun LL, et al. Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Crit Care 2012;16(4):R151
   PubMed Web of Science ®Google Scholar
• Forsblom E, Aittoniemi J, Ruotsalainen E, et al. High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment. PLoS One 2014;9(2):e87741
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116(2):281-97
   PubMed Web of Science ®Google Scholar
• Wang HJ, Wang BZ, Zhang PJ, et al. Identification of four novel serum protein biomarkers in sepsis patients encoded by target genes of sepsis-related miRNAs. Clin Sci 2014;126(12):857-67
   Google Scholar
• Tacke F, Roderburg C, Benz F, et al. Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients. Crit Care Med 2014;42(5):1096-104
   PubMed Web of Science ®Google Scholar
• Wang JF, Yu ML, Yu G, et al. Serum miR-146a and miR-223 as potential new biomarkers for sepsis. Biochem Biophys Res Commun 2010;394(1):184-8
   PubMed Web of Science ®Google Scholar
• Gibot S, Bene MC, Noel R, et al. Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med 2012;186(1):65-71
   PubMed Web of Science ®Google Scholar
• Wong HR, Salisbury S, Xiao Q, et al. The pediatric sepsis biomarker risk model. Crit Care 2012;16(5):R174
   PubMed Web of Science ®Google Scholar
• Wong HR, Weiss SL, Giuliano JS Jr, et al. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One 2014;9(1):e86242
   PubMed Web of Science ®Google Scholar
• Wong HR, Weiss SL, Giuliano JS Jr, et al. The temporal version of the pediatric sepsis biomarker risk model. PLoS One 2014;9(3):e92121
   PubMed Web of Science ®Google Scholar
• Wong HR, Lindsell CJ, Pettila V, et al. A multibiomarker-based outcome risk stratification model for adult septic shock. Crit Care Med 2014;42(4):781-9
   PubMed Web of Science ®Google Scholar
• Alder MN, Lindsell CJ, Wong HR. The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology. Expert Rev Anti Infect Ther 2014;12(7):809-16
   PubMed Web of Science ®Google Scholar
• Olsen D, Jorgensen JT. Companion diagnostics for targeted cancer drugs - clinical and regulatory aspects. Front Oncol 2014;4:105
   PubMedGoogle Scholar
• Meisel C, Schefold JC, Pschowski R, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009;180(7):640-8
   PubMed Web of Science ®Google Scholar
• Safety and efficacy of polymyxin b hemoperfusion (PMX) for septic shock. Available from: www.clinicaltrials.gov/ct2/results?term=NCT01046669&Search=Search
   Google Scholar
• Bossuyt PM, Reitsma JB, Bruns DE, et al. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD Initiative. Ann Intern Med 2003;138(1):40-4
   PubMed Web of Science ®Google Scholar
• Rifai N, Gillette MA, Carr SA. Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 2006;24(8):971-83
   PubMed Web of Science ®Google Scholar
• Maslove DM, Wong HR. Gene expression profiling in sepsis: timing, tissue, and translational considerations. Trends Mol Med 2014;20(4):204-13
   PubMed Web of Science ®Google Scholar
• Mickiewicz B, Vogel HJ, Wong HR, Winston BW. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med 2013;187(9):967-76
   PubMed Web of Science ®Google Scholar