Current controversies and challenges in allergic rhinitis management

References

• Mygind N. Allergic rhinitis. Chem Immunol Allergy 2014;100:62-8
   PubMedGoogle Scholar
• Shaaban R, Zureik M, Soussan D, et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet 2008;372:1049-57
   PubMed Web of Science ®Google Scholar
• Khan DA. Allergic rhinitis and asthma: epidemiology and common pathophysiology. Allergy Asthma Proc 2014;35:357-61
   PubMed Web of Science ®Google Scholar
• Clatworthy J, Price D, Ryan D, et al. The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control. Prim Care Respir J 2009;18:300-5
   PubMedGoogle Scholar
• Ruokonen M, Kaila M, Haataja R, et al. Allergic rhinitis in school-aged children with asthma - still under-diagnosed and under-treated? A retrospective study in a children’s hospital. Pediatr Allergy Immunol 2010;21:e149-54
   PubMed Web of Science ®Google Scholar
• Zuberbier T, Lotvall J, Simoens S, et al. Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review. Allergy 2014;69:1275-9
   PubMed Web of Science ®Google Scholar
• de la Hoz CB, Rodriguez M, Fraj J, et al. Allergic rhinitis and its impact on work productivity in primary care practice and a comparison with other common diseases: the Cross-sectional study to evAluate work Productivity in allergic Rhinitis compared with other common dIseases (CAPRI) study. Am J Rhinol Allergy 2012;26:390-4
   PubMed Web of Science ®Google Scholar
• Hellgren J, Cervin A, Nordling S, et al. Allergic rhinitis and the common cold–high cost to society. Allergy 2010;65:776-83
   PubMed Web of Science ®Google Scholar
• Bellanti JA, Settipane RA. The burden of allergic rhinitis on patients’ quality of life. Allergy Asthma Proc 2012;33(Suppl 1):S112
   PubMedGoogle Scholar
• Small M, Piercy J, Demoly P, Marsden H. Burden of illness and quality of life in patients being treated for seasonal allergic rhinitis: a cohort survey. Clin Transl Allergy 2013;3:33
   PubMedGoogle Scholar
• Bousquet PJ, Bachert C, Canonica GW, et al. Uncontrolled allergic rhinitis during treatment and its impact on quality of life: a cluster randomized trial. J Allergy Clin Immunol 2010;126:666-8
   PubMed Web of Science ®Google Scholar
• Jauregui I, Mullol J, Davila I, et al. Allergic rhinitis and school performance. J Investig Allergol Clin Immunol 2009;19(Suppl 1):32-9
   PubMed Web of Science ®Google Scholar
• Vuurman EF, Vuurman LL, Lutgens I, Kremer B. Allergic rhinitis is a risk factor for traffic safety. Allergy 2014;69:906-12
   PubMed Web of Science ®Google Scholar
• Antonescu E, Childres N, Gardini E, et al. Written declaration on recognising the burden of allergic disease. European Parliament 2014. [Epub ahead print]
   Google Scholar
• Samolinski B, Fronczak A, Kuna P, et al. Prevention and control of childhood asthma and allergy in the EU from the public health point of view: Polish Presidency of the European Union. Allergy 2012;67:726-31
   PubMed Web of Science ®Google Scholar
• Bousquet J, Addis A, Adcock I, et al. Integrated care pathways for airway diseases (AIRWAYS-ICPs). Eur Respir J 2014;44:304-23
   PubMed Web of Science ®Google Scholar
• Bousquet J, Michel J, Standberg T, et al. The european innovation partnership on active and healthy aging: the european geriatric medicine introduces the EIP on AHA column. Eur Geriatr Med 2014;5:361-2
   Web of Science ®Google Scholar
• European academy of allergy and clinical immunology (EAACI). Beware of allergy campaign. 2015. Available from: www.bewareofallergy.com/ [Last accessed 4 April 15]
   Google Scholar
• Calderon MA, Demoly P, Gerth van WR, et al. EAACI: A european declaration on immunotherapy. designing the future of allergen specific immunotherapy. Clin Transl Allergy 2012;2:20
   PubMedGoogle Scholar
• Levetin E, Van de Water P. Changing pollen types/concentrations/distribution in the United States: fact or fiction? Curr Allergy Asthma Rep 2008;8:418-24
   PubMed Web of Science ®Google Scholar
• Bartra J, Mullol J, del CA, et al. Air pollution and allergens. J Investig Allergol Clin Immunol 2007;17(Suppl 2):3-8
   PubMed Web of Science ®Google Scholar
• Davila I, Mullol J, Bartra J, et al. Effect of pollutants upon patients with respiratory allergies. J Investig Allergol Clin Immunol 2007;17(Suppl 2):9-20
   PubMed Web of Science ®Google Scholar
• Demoly P, Bousquet PJ, Mesbah K, et al. Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care: asthma and rhinitis. Clin Exp Allergy 2013;43:881-8
   PubMed Web of Science ®Google Scholar
• Ciprandi G, Cirillo I. Monosensitization and polysensitization in allergic rhinitis. Eur J Intern Med 2011;22:e75-9
   PubMed Web of Science ®Google Scholar
• Bernstein JA. Allergic and mixed rhinitis: Epidemiology and natural history. Allergy Asthma Proc 2010;31:365-9
   PubMed Web of Science ®Google Scholar
• Hellings PW, Fokkens WJ, Akdis C, et al. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy 2013;68:1-7
   PubMed Web of Science ®Google Scholar
• Rondon C, Campo P, Zambonino MA, et al. Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis. J Allergy Clin Immunol 2014;133:1026-31
   PubMed Web of Science ®Google Scholar
• Demoly P, Chiriac AM, Berge B, Rostin M. Reasons for prescribing second generation antihistamines to treat allergic rhinitis in real-life conditions and patient response. Allergy Asthma Clin Immunol 2014;10:29
   PubMed Web of Science ®Google Scholar
• Hellings PW, Dobbels F, Denhaerynck K, et al. Explorative study on patient’s perceived knowledge level, expectations, preferences and fear of side effects for treatment for allergic rhinitis. Clin Transl Allergy 2012;2:9
   PubMedGoogle Scholar
• Ciprandi G, Incorvaia C, Scurati S, et al. Patient-related factors in rhinitis and asthma: the satisfaction with allergy treatment survey. Curr Med Res Opin 2011;27:1005-11
   PubMed Web of Science ®Google Scholar
• Mullol J, Bartra J, del CA, et al. Specialist-based treatment reduces the severity of allergic rhinitis. Clin Exp Allergy 2013;43:723-9
   PubMed Web of Science ®Google Scholar
• Pitman R, Paracha N, Parker C, et al. Episode pattern and healthcare utilisation in patients with seasonal allergic rhinitis. Allergy 2012;67:A885
   Google Scholar
• Meltzer E, Ratner P, Bachert C, et al. Clinically relevant effect of a new intranasal therapy (MP29-02) in allergic rhinitis assessed by responder analysis. Int Arch Allergy Immunol 2013;161:369-77
   PubMed Web of Science ®Google Scholar
• Price D, Scadding G, Bachert C, et al. Monotherapy failure and UK co-prescribing practices: proxy markers of unmet need in allergic rhinitis. Prim Care Res J 2015; submitted
   Google Scholar
• Navarro A, Valero A, Rosales MJ, Mullol J. Clinical use of oral antihistamines and intranasal corticosteroids in patients with allergic rhinitis. J Investig Allergol Clin Immunol 2011;21:363-9
   PubMed Web of Science ®Google Scholar
• Anolik R; Mometasone Furoate Nasal Spray With Loratadine Study Group. Clinical benefits of combination treatment with mometasone furoate nasal spray and loratadine vs monotherapy with mometasone furoate in the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2008;100:264-71
   PubMed Web of Science ®Google Scholar
• Bousquet PJ, Demoly P, Devillier P, et al. Impact of allergic rhinitis symptoms on quality of life in primary care. Int Arch Allergy Immunol 2013;160:393-400
   PubMed Web of Science ®Google Scholar
• Esteitie R, deTineo M, Naclerio RM, Baroody FM. Effect of the addition of montelukast to fluticasone propionate for the treatment of perennial allergic rhinitis. Ann Allergy Asthma Immunol 2010;105:155-61
   PubMed Web of Science ®Google Scholar
• Kim CH, Kim JK, Kim HJ, et al. Comparison of intranasal ciclesonide, oral levocetirizine, and combination treatment for allergic rhinitis. Allergy Asthma Immunol Res 2015;7:158-66
   PubMedGoogle Scholar
• Dymista summary of product characteristics. Available from: www.medicines.orguk/emc/medicine/27579 2014
   Google Scholar
• Klimek L, Bachert C, Mosges R, et al. Effectiveness of MP29-02 for the treatment of allergic rhinitis in real-life: results from a noninterventional study. Allergy Asthma Proc 2015;36:40-7
   PubMed Web of Science ®Google Scholar
• Wu KG, Li TH, Wang TY, et al. A comparative study of loratadine syrup and cyproheptadine HCL solution for treating perennial allergic rhinitis in Taiwanese children aged 2-12 years. Int J Immunopathol Pharmacol 2012;25:231-7
   PubMed Web of Science ®Google Scholar
• Potter P, Maspero JF, Vermeulen J, et al. Rupatadine oral solution in children with persistent allergic rhinitis: A randomized, double-blind, placebo-controlled study. Pediatr Allergy Immunol 2013;24:144-50
   PubMed Web of Science ®Google Scholar
• Bousquet J, Ansotegui I, Canonica GW, et al. Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review. Curr Med Res Opin 2012;28:131-9
   PubMed Web of Science ®Google Scholar
• Kim CH, Kim JK, Kim HJ, et al. Comparison of intranasal ciclesonide, oral levocetirizine, and combination treatment for allergic rhinitis. Allergy Asthma Immunol Res 2015;7:158-66
   PubMedGoogle Scholar
• Kuna P, Bachert C, Nowacki Z, et al. Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo for the symptomatic treatment of seasonal allergic rhinitis: a randomized, double-blind, parallel-group study. Clin Exp Allergy 2009;39:1338-47
   PubMed Web of Science ®Google Scholar
• Bachert C, Kuna P, Sanquer F, et al. Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients. Allergy 2009;64:158-65
   PubMed Web of Science ®Google Scholar
• Pettipher R, Hansel TT. Antagonists of the prostaglandin D2 receptor CRTH2. Drug News Perspect 2008;21:317-22
   PubMed Web of Science ®Google Scholar
• Lazewska D, Kiec-Kononowicz K. Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed) 2012;4:967-87
   PubMedGoogle Scholar
• Daley-Yates P, Ambery C, Sweeney L, et al. The efficacy and tolerability of two novel H(1)/H(3) receptor antagonists in seasonal allergic rhinitis. Int Arch Allergy Immunol 2012;158:84-98
   PubMed Web of Science ®Google Scholar
• Kiss R, Keseru GM. Histamine H4 receptor ligands and their potential therapeutic applications: an update. Expert Opin Ther Pat 2012;22:205-21
   PubMed Web of Science ®Google Scholar
• Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract 2014;2:332-40
   PubMed Web of Science ®Google Scholar
• Braido F, Sclifo F, Ferrando M, Canonica GW. New therapies for allergic rhinitis. Curr Allergy Asthma Rep 2014;14:422
   PubMed Web of Science ®Google Scholar
• Grundling C, Schimetta W, Frass M. Real-life effect of classical homeopathy in the treatment of allergies: A multicenter prospective observational study. Wien Klin Wochenschr 2012;124:11-17
   PubMed Web of Science ®Google Scholar
• Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010;126:466-76
   PubMed Web of Science ®Google Scholar
• Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008;122:S1-84
   PubMed Web of Science ®Google Scholar
• Wong GW, Miravitlles M, Chisholm A, Krishnan JA. Respiratory guidelines–which real world? Ann Am Thorac Soc 2014;11(Suppl 2):S85-91
   Google Scholar
• Harbour R, Miller J. A new system for grading recommendations in evidence based guidelines. BMJ 2001;323:334-6
   PubMed Web of Science ®Google Scholar
• Price D, Bateman ED, Chisholm A, et al. Complementing the randomized controlled trial evidence base. Evolution not revolution. Ann Am Thorac Soc 2014;11(Suppl 2):S92-8
   PubMedGoogle Scholar
• Costa DJ, Amouyal M, Lambert P, et al. How representative are clinical study patients with allergic rhinitis in primary care? J Allergy Clin Immunol 2011;127:920-6
   PubMed Web of Science ®Google Scholar
• Konstantinou GN. Pragmatic trials: how to adjust for the ‘Hawthorne effect’? Thorax 2012;67:562
   PubMed Web of Science ®Google Scholar
• Roche N, Reddel HK, Agusti A, et al. Integrating real-life studies in the global therapeutic research framework. Lancet Respir Med 2013;1:e29-30
   PubMed Web of Science ®Google Scholar
• Rawlins M. De testimonio: on the evidence for decisions about the use of therapeutic interventions. Lancet 2008;372:2152-61
   PubMed Web of Science ®Google Scholar
• Balshem H, Helfand M, Schunemann HJ, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 2011;64:401-6
   PubMed Web of Science ®Google Scholar
• Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336:924-6
   PubMed Web of Science ®Google Scholar
• Schunemann HJ, Oxman AD, Brozek J, et al. GRADE: assessing the quality of evidence for diagnostic recommendations. ACP J Club 2008;149:2
   PubMedGoogle Scholar
• Roche N, Reddel H, Martin R, et al. Quality standards for real-world research. Focus on observational database studies of comparative effectiveness. Ann Am Thorac Soc 2014;11(Suppl 2):S99-104
   PubMedGoogle Scholar
• Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-65
   PubMed Web of Science ®Google Scholar
• Bousquet J, Khaltaev N, Cruz AA, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy 2008;63(Suppl 86):8-160
   PubMed Web of Science ®Google Scholar
• Scadding GK, Durham SR, Mirakian R, et al. BSACI guidelines for the management of allergic and non-allergic rhinitis. Clin Exp Allergy 2008;38:19-42
   PubMed Web of Science ®Google Scholar
• Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c332
   PubMed Web of Science ®Google Scholar
• Okubo K, Nakashima M, Miyake N, et al. Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis. Allergy Asthma Proc 2009;30:84-94
   PubMed Web of Science ®Google Scholar
• Carr W, Bernstein J, Lieberman P, et al. A novel intranasal therapy of azelastine with fluticasone for the treatment of allergic rhinitis. J Allergy Clin Immunol 2012;129:1282-9
   PubMed Web of Science ®Google Scholar
• Chavannes N, Stallberg B, Lisspers K, et al. UNLOCK: Uncovering and Noting Long-term Outcomes in COPD to enhance knowledge. Prim Care Respir J 2010;19:408
   PubMedGoogle Scholar
• Takahashi Y, Nishida Y, Asai S. Utilization of health care databases for pharmacoepidemiology. Eur J Clin Pharmacol 2012;68:123-9
   PubMed Web of Science ®Google Scholar
• Colice G, Martin RJ, Israel E, et al. Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone. J Allergy Clin Immunol 2013;132:45-54
   PubMed Web of Science ®Google Scholar
• Kemp L, Haughney J, Barnes N, et al. Cost-effectiveness analysis of corticosteroid inhaler devices in primary care asthma management: A real world observational study. Clinicoecon Outcomes Res 2010;2:75-85
   PubMedGoogle Scholar
• EMA guideline. Guideline on the clinical development of medicinal products for the treatment of allergic rhinoconjunctivitis. Available from: www.emaeuropaed/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003554.pdf 2004
   Google Scholar
• GINA Guidelines. 2014. Available from: www.ginasthma.org/GINA-Report [Last accessed 20 April 15]
   Google Scholar
• Nathan RA, Dalal AA, Stanford RH, et al. Qualitative development of the rhinitis control assessment test (RCAT), an instrument for evaluating rhinitis symptom control. Patient 2010;3:91-9
   PubMedGoogle Scholar
• Demoly P, Calderon MA, Casale T, et al. Assessment of disease control in allergic rhinitis. Clin Transl Allergy 2013;3:7
   Google Scholar
• Fonseca JA, Nogueira-Silva L, Morais-Almeida M, et al. Control of Allergic Rhinitis and Asthma Test (CARAT) can be used to assess individual patients over time. Clin Transl Allergy 2012;2:16
   Google Scholar
• Price D, Papadopoulos N, Scadding G, et al. Assessing allergic rhinitis symptom control: results from a digital survey conducted during EAACI 2013. Presented at European Academy of Allergy and Clinical Immunology Congress, 7 – 11 June 2014, Copenhagen, Denmark
   Google Scholar
• Bousquet PJ, Combescure C, Klossek JM, et al. Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis. J Allergy Clin Immunol 2009;123:1349-54
   PubMed Web of Science ®Google Scholar
• Bousquet PJ, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines. Allergy 2007;62:367-72
   PubMed Web of Science ®Google Scholar
• Bousquet J, Bachert C, Canonica GW, et al. Efficacy of desloratadine in persistent allergic rhinitis - a GA(2)LEN study. Int Arch Allergy Immunol 2010;153:395-402
   PubMed Web of Science ®Google Scholar
• Bousquet J, Bachert C, Canonica GW, et al. Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study. Allergy 2009;64:1516-23
   PubMed Web of Science ®Google Scholar
• Available from:www.effectivenessevaluation.org
   Google Scholar